International Journal of Hematology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Decade-long WT1-specific CTLs induced by WT1 peptide vaccination
CONCLUSION: The WT1 peptide vaccine induced an immune response that persists for more than 10 years, even after cessation of vaccination in the CML patient.PMID:38427208 | DOI:10.1007/s12185-024-03723-1 (Source: International Journal of Hematology)
Source: International Journal of Hematology - March 1, 2024 Category: Hematology Authors: Tatsuya Suwabe Yasuhiko Shibasaki Suguru Tamura Takayuki Katagiri Kyoko Fuse Tori Ida-Kurasaki Takashi Ushiki Hirohito Sone Miwako Narita Masayoshi Masuko Source Type: research

Predictive factors for L-asparaginase hypersensitivity in pediatric acute lymphoblastic leukemia
CONCLUSIONS: Children with ALL who require re-exposure to L-asparaginase after 52-week interruption or who have received L-asparaginase for ≥ 15 exposure days are at risk of developing L-asparaginase hypersensitivity. Further management strategies in this setting should be evaluated.PMID:38421487 | DOI:10.1007/s12185-024-03725-z (Source: International Journal of Hematology)
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Chane Choed-Amphai Jiraporn Khorana Lalita Sathitsamitphong Rungrote Natesirinilkul Pimlak Charoenkwan Source Type: research

The pathogenesis of cancer-associated thrombosis
Int J Hematol. 2024 Feb 29. doi: 10.1007/s12185-024-03735-x. Online ahead of print.ABSTRACTPatients with cancer have a higher risk of venous thromboembolism (VTE), including deep vein thrombosis (DVT) and pulmonary embolism (PE), compared to the general population. Cancer-associated thrombosis (CAT) is a thrombotic event that occurs as a complication of cancer or cancer therapy. Major factors determining VTE risk in cancer patients include not only treatment history and patient characteristics, but also cancer type and site. Cancer types can be broadly divided into three groups based on VTE risk: high risk (pancreatic, ova...
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Kohei Tatsumi Source Type: research

First report of familial mixed phenotype acute leukemia: shared clinical characteristics, Philadelphia translocation, and germline variants
Int J Hematol. 2024 Feb 29. doi: 10.1007/s12185-024-03724-0. Online ahead of print.ABSTRACTWhile our understanding of the molecular basis of mixed phenotype acute leukemia (MPAL) has progressed over the decades, our knowledge is limited and the prognosis remains poor. Investigating cases of familial leukemia can provide insights into the role of genetic and environmental factors in leukemogenesis. Although familial cases and associated mutations have been identified in some leukemias, familial occurrence of MPAL has never been reported. Here, we report the first cases of MPAL in a family. A 68-year-old woman was diagnosed ...
Source: International Journal of Hematology - February 29, 2024 Category: Hematology Authors: Yuka Shiozawa Shinya Fujita Yasuhito Nannya Seishi Ogawa Naho Nomura Toru Kiguchi Nobuo Sezaki Himari Kudo Takaaki Toyama Source Type: research

Influence of FOXP3 single-nucleotide polymorphism after allogeneic hematopoietic stem cell transplantation
Int J Hematol. 2024 Feb 28. doi: 10.1007/s12185-024-03726-y. Online ahead of print.ABSTRACTThe impact of FOXP3 single-nucleotide polymorphisms (SNP) on clinical outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains poorly understood. We investigated the relationship between a FOXP3 SNP (rs3761548) and clinical outcomes in 91 patients with hematological malignancies after allo-HSCT. Multivariate analysis showed that risk of severe chronic graft-versus-host disease (cGVHD) was significantly higher in patients with the FOXP3-3279C/A or FOXP3-3279A/A genotype than those with the FOXP3-3279C/C ge...
Source: International Journal of Hematology - February 28, 2024 Category: Hematology Authors: Kai Kuroiwa Misuzu Sato Hinako Narita Reiko Okamura Yuka Uesugi Yohei Sasaki Shotaro Shimada Megumi Watanuki Shun Fujiwara Yukiko Kawaguchi Nana Arai Kouji Yanagisawa Keiichi Iezumi Norimichi Hattori Source Type: research

Prevalence of thalassemia-carrier couples and fertility risk assessment
This study aimed to determine the epidemiological characteristics of thalassemia in couples at childbearing age and assess the neonatal risk of thalassemia in this subpopulation. A cohort of 4481 couples at childbearing age were recruited for thalassemia carrier screening by both traditional hematological tests and next-generation sequencing. Of them, 1314 (14.66%) thalassemia carriers were identified, including 857 (9.76%) α-thalassemia, 391 (4.36%) β-thalassemia, and 48 (0.54%) composite α and β-thalassemia. A total of 12 α-globin gene alterations and 16 β-globin mutations were detected, including four novel thalas...
Source: International Journal of Hematology - February 27, 2024 Category: Hematology Authors: Liu-Song Wu Xi Luo Mei Tan Li-Jun Zhang Hong-Fang Luo Ge Huang Pei Huang Jindong Chen Yan Chen Source Type: research

Long-term lymphocyte subset number reconstitution is unique but comparable between umbilical cord blood and unrelated bone marrow transplantation
In this study, we analyzed lymphocyte subset (LST) number to determine the long-term recovery timeline. We included 36 U-CBT and 10 unrelated bone marrow transplantation (U-BMT) recipients who survived more than 2 years after transplantation, and followed them for up to 10 years post-transplant. Recovery kinetics in the early phase post-transplant was different for each LST. Recovery of CD19+ B cells was faster after U-CBT than after U-BMT in the first 5 years after transplantation. Although CD4+ T cells increased in the first several months after U-CBT, long-term cell count recovery was impaired in approximately 20% of pa...
Source: International Journal of Hematology - February 26, 2024 Category: Hematology Authors: Keiko Tsumita Shinsuke Takagi Yuki Asano-Mori Otoya Watanabe Michiho Shindo Kyosuke Yamaguchi Mitsuhiro Yuasa Kosei Kageyama Daisuke Kaji Yuki Taya Aya Nishida Kazuya Ishiwata Hisashi Yamamoto Hideki Araoka Go Yamamoto Shigeyoshi Makino Atsushi Wake Naoyu Source Type: research

Effects of human herpesvirus 6B reactivation on cognitive function in cord blood transplant recipients: a prospective multicenter study
Int J Hematol. 2024 Feb 26. doi: 10.1007/s12185-024-03714-2. Online ahead of print.ABSTRACTThis prospective multicenter study aimed to determine the effects of human herpesvirus-6B (HHV-6B) reactivation on central nervous system (CNS) function in cord blood transplant (CBT) recipients. Our focus was to track HHV-6B reactivation and evaluate its association with delirium and cognitive function, specifically in the domains of verbal memory, attention/processing speed, and quality of life (QOL). A cohort of 38 patients participated in this study. Of the 37 patients evaluated, seven (18.9%) developed delirium, with six of thes...
Source: International Journal of Hematology - February 26, 2024 Category: Hematology Authors: Masao Ogata Kumi Oshima Kuniko Takano Rie Kawano Yasunori Ueda Takashi Imamura Yukinori Nakamura Takahiro Okada Tomomi Toubai Toshimitsu Ueki Nobuhiko Uoshima Hiroyuki Ishida Akihito Shinohara Sachiko Seo Takahiro Fukuda Masatoshi Inagaki Source Type: research