The AWED trial (Applying Wolbachia to Eliminate Dengue) to assess the efficacy of Wolbachia -infected mosquito deployments to reduce dengue incidence in Yogyakarta, Indonesia: study protocol for a cluster randomised controlled trial
This study protocol describes the first trial to measure the efficacy ofWolbachia in reducing dengue virus transmission in the field.Methods/designThe study is a parallel, two-arm, non-blinded cluster randomised controlled trial conducted in a single site in Yogyakarta, Indonesia. The aim is to determine whether large-scale deployment ofWolbachia-infectedAe. aegypti mosquitoes leads to a measurable reduction in dengue incidence in treated versus untreated areas. The primary endpoint is symptomatic, virologically confirmed dengue virus infection of any severity. The 26 km2 study area was subdivided into 24 contiguous cluste...
Source: Trials - May 31, 2018 Category: Research Source Type: clinical trials
Safety and Tolerability of an Antibody Against Zika Virus (Tyzivumab) in Humans
Condition: Treatment of Acute Zika Virus Infection Intervention: Drug: Tyzivumab Sponsors: Tychan Pte Ltd.; Duke-NUS Graduate Medical School; Singapore Clinical Research Institute; National University, Singapore; National University Hospital, Singapore Enrolling by invitation (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 23, 2018 Category: Research Source Type: clinical trials
