Impact of virtual supervised tooth brushing on caries experience and quality of life among primary school children: study protocol for a randomized controlled trial
DiscussionVirtual education as well as some health consultation through the pandemic period had enabled an effective IT infrastructure in Saudi Arabia. Virtual supervised tooth brushing is a proposed initiative. It is also an opportunity for targeting a large portion of the population with a high level of disease as a quarter of the Saudi population is younger than 15 years. This project should provide high level evidence on the effectiveness of virtual supervised tooth brushing. The findings should potentially inform policies related to the continuation/implementation of school-based programs in Saudi Arabia.Trial registr...
Source: Trials - February 20, 2023 Category: Research Source Type: clinical trials
The effects of Digital Buddy programme on older adults ’ mental well-being: study protocol for a multi-centre, cluster randomized controlled trial
This study will employ a multi-centre, cluster-randomized, two-parallel-group, noninferiority, controlled trial design with a 1:1 group allocation ratio. In the intervention group, a Digital Buddy (i.e. a young volunteer) is assigned to a group of older adults in a 1:10 ratio. A series of training sessions for a minimum of 23 h will be provided to the older adults by Digital Buddy, who will also follow through the intervention period with the older participants. The training contents include ICT and mental health care knowledge and skills. The whole intervention period will last for 6 months between 14 sessions. In the c...
Source: Trials - February 7, 2023 Category: Research Source Type: clinical trials
The COMFORT trial: a randomised control trial comparing group-based COMpassion-FOcussed therapy and breathing pattern ReTraining with treatment as usual on the psychological functioning of patients diagnosed with cancer recurrence during COVID
DiscussionTo our knowledge, this protocol describes the first RCT which directly examines the effect of a group-based psychological intervention on Irish patients experiencing cancer recurrence in the context of COVID-19. The outcome of this trial is likely to be twofold: It will determine if the psychological intervention achieves its primary objective of distress amelioration 3 months post-intervention and to establish the feasibility of delivering this intervention in a virtual format.Trial registrationClinicalTrials.gov NCT05518591. Registered on 25 August 2022. All items from the World Health Organization Trial Regi...
Source: Trials - February 6, 2023 Category: Research Source Type: clinical trials
Cannabis-opioid interaction in the treatment of fibromyalgia pain: an open-label, proof of concept study with randomization between treatment groups: cannabis, oxycodone or cannabis/oxycodone combination —the SPIRAL study
DiscussionThe trial is designed to determine whether self-titration of oxycodone and cannabis will reduce side effects in chronic pain patients with fibromyalgia.Trial registration {2a and 2b}EU trial register 2019 –001861-33, URLhttps://www.clinicaltrialsregister.eu, on July 17, 2019; World Health Organization International Clinical Trials Research Platform NL7902, URLhttps://trialsearch.who.int, on July 26, 2019. (Source: Trials)
Source: Trials - January 27, 2023 Category: Research Source Type: clinical trials
A cluster-randomized, placebo-controlled trial to evaluate the efficacy of a spatial repellent (Mosquito Shield ™) against Aedes-borne virus infection among children ≥ 4–16 years of age in the Gampaha District, Sri Lanka: study protocol (the AEGIS program)
DiscussionThe trial will serve as an efficacy assessment of SR products in South Asia. Results will be submitted to the World Health Organization Vector Control Advisory Group for assessment of public health value towards an endorsement to recommend inclusion of SRs in ABV control programs.Trial registrationSri Lanka Clinical Trial RegistrySLCTR/2022/018. Registered on July 1, 2022.ClinicalTrials.govNCT05452447. Registered on July 11, 2022.The Universal Trial Number is U1111-1275-3055. (Source: Trials)
Source: Trials - January 4, 2023 Category: Research Source Type: clinical trials
WHO adopts antibodies created by Lankenau researchers as a standard to ensure quality control of polio vaccines worldwide
WYNNEWOOD, Pa., Dec. 9, 2022. Human antibodies cloned by scientists at the Lankenau Institute for Medical Research (LIMR), part of Main Line Health, have been adopted by the World Health Organization as a crucial part of its plan to permanently... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - December 9, 2022 Category: Pharmaceuticals Source Type: clinical trials
Cluster randomised control trial protocol for estimating the effectiveness and cost-effectiveness of a complex intervention to increase care home staff influenza vaccination rates compared to usual practice (FLUCARE)
This study aims to estimate the effectiveness and cost-effectiveness of a theory-informed intervention to improve care home staff vaccination rates compared to routine practice.Set in care homes with both nursing and residential focus, and a range of ownership status, only homes providing long stay care to older people with a staff vaccination rate below 40% are eligible to participate. Participation expressions of interest will be sought using a variety of approaches prior to seeking consent.The primary outcome measure is the proportion of staff vaccinated at 6 months, with secondary outcome measures being proportion vacc...
Source: Trials - December 9, 2022 Category: Research Source Type: clinical trials
WHO Updates Emergency Use Listing for Novavax Nuvaxovid COVID-19 Vaccine as a Primary Series in Adolescents and as a Booster in Adults
GAITHERSBURG, Md., Nov. 29, 2022. Novavax, Inc., a biotechnology company dedicated to developing and commercializing next-generation vaccines for serious infectious diseases, today announced that the World Health Organization (WHO) has issued an... (Source: Drugs.com - Clinical Trials)
Source: Drugs.com - Clinical Trials - November 29, 2022 Category: Pharmaceuticals Source Type: clinical trials
Association Between Antidepressant Use and Falls in Older Adults: Analysis of the World Health Organization Global Database
Conditions: Antidepressants Causing Adverse Effects in Therapeutic Use; Fall Intervention: Drug: Antidepressive Agents Sponsor: University Hospital, Caen Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 28, 2022 Category: Research Source Type: clinical trials
