A genetic profiling guideline to support diagnosis and clinical management of lymphomas
AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas....
Source: Clinical and Translational Oncology - April 22, 2024 Category: Cancer & Oncology Source Type: research
A taste alteration-related scale assesses megestrol to improve chemotherapy-induced anorexia
ConclusionThe proficient efficacy evaluation of megestrol in enhancing appetite, mitigating malnutrition likelihood, and improving the quality of life of chemotherapy-induced anorexic patients can be achieved through taste-related scales. (Source: Supportive Care in Cancer)
Source: Supportive Care in Cancer - April 22, 2024 Category: Cancer & Oncology Source Type: research
A genetic profiling guideline to support diagnosis and clinical management of lymphomas
AbstractThe new lymphoma classifications (International Consensus Classification of Mature Lymphoid Neoplasms, and 5th World Health Organization Classification of Lymphoid Neoplasms) include genetics as an integral part of lymphoma diagnosis, allowing better lymphoma subclassification, patient risk stratification, and prediction of treatment response. Lymphomas are characterized by very few recurrent and disease-specific mutations, and most entities have a heterogenous genetic landscape with a long tail of recurrently mutated genes. Most of these occur at low frequencies, reflecting the clinical heterogeneity of lymphomas....
Source: Clinical and Translational Oncology - April 19, 2024 Category: Cancer & Oncology Source Type: research
Impacts of gait freeze on quality of life in Parkinson ’s disease, from the perspectives of patients and their carers
ConclusionsThis study shows that FoG is a significant detriment to the QoL of PwP, from the perspectives of patients and carers. This method of assessing FoG and QoL using online questionnaires has potential to enhance the reach and flexibility of this type of research. These findings will inform future studies on larger cohorts and highlight unmet clinical needs in PwP. (Source: Irish Journal of Medical Science)
Source: Irish Journal of Medical Science - April 19, 2024 Category: General Medicine Source Type: research
Ten years of hand hygiene excellence: a summary of outcomes, and a comparison of indicators, from award-winning hospitals worldwide
ConclusionTen years after its inception, the HHEA proves to be a valuable hand hygiene improvement programme in healthcare facilities worldwide. Consistent results were provided by the different hand hygiene indicators and the HHSAF score represents a valuable proxy measure of hand hygiene compliance. (Source: Antimicrobial Resistance and Infection Control)
Source: Antimicrobial Resistance and Infection Control - April 19, 2024 Category: Infectious Diseases Source Type: research
Haem iron versus ferrous iron salts to treat iron deficiency anaemia in Gambian children: protocol for randomised controlled trial {1}
The World Health Organization recommends universal iron supplementation for children aged 6 –23 months in countries where anaemia is seen in over 40% of the population. Conventional ferrous salts have low effic... (Source: Trials)
Source: Trials - April 19, 2024 Category: General Medicine Authors: Mamadou Bah, Hans Verhoef, Emmanuel Okoh, Abdoulie Bah, Andrew M. Prentice and Carla Cerami Tags: Study protocol Source Type: research
A call for sex-positive epidemiology
Am J Epidemiol. 2024 Apr 17:kwae054. doi: 10.1093/aje/kwae054. Online ahead of print.ABSTRACTThe World Health Organization specifies that sexual health requires the potential for pleasurable and safe sexual experiences. Yet epidemiologic research into sexual pleasure and other positive sexual outcomes has been scant. In this commentary, we aim to support the development and adoption of sex-positive epidemiology, which we define as epidemiology that incorporates the study of pleasure and other positive features alongside sexually transmitted infections and other familiar negative outcomes. We first call epidemiologists' att...
Source: Am J Epidemiol - April 18, 2024 Category: Epidemiology Authors: Julia C Bond Jessie V Ford Source Type: research
Bioacoustics in population control of insects of medical importance: A review
J Vector Borne Dis. 2024 Apr 12. doi: 10.4103/JVBD.JVBD_204_23. Online ahead of print.ABSTRACTVector transmitted diseases are accountable for more than 17% of all infectious disease cases worldwide according to World Health Organization. Insect vectors play a key role in transmitting diseases and loss of lives. Modified and advanced vector control strategies with chemical insecticides are needed as vectors are resistant to a particular insecticide. Moreover, chemical control is cost-inductive and may give rise to health issues. In this review, bioacoustics have been narrated as a novel technology for eco-friendly and cost-...
Source: Journal of Vector Borne Diseases - April 18, 2024 Category: Infectious Diseases Authors: Udita Mandal Joydeep Dutta Source Type: research
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research
Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research
Implementation and evaluation of the centering pregnancy group prenatal care model in pregnant women with diabetes: a convergent parallel mixed methods study protocol
Diabetes during pregnancy has negative effects on both mothers and their fetuses. To improve perinatal outcomes and women ’s experience of care, the World Health Organization (WHO) suggests implementing health ... (Source: Reproductive Health)
Source: Reproductive Health - April 18, 2024 Category: OBGYN Authors: Mahsa Maghalian, Fatemeh Abbasalizadeh, Sakineh Mohammad-Alizadeh-Charandabi, Solmaz Ghanbari-Homaie and Mojgan Mirghafourvand Tags: Study Protocol Source Type: research
Bayesian modeling of post-vaccination serological data suggests that yearly vaccination of dog aged < 2 years old is efficient to stop rabies circulation in Cambodia
The objective of this study was to assess the short and long-term vaccination-induced immunity in Cambodian dogs under field conditions, and to propose optimized vaccination strategies. A cohort of 351 dogs was followed at regular time points following primary vaccination only (PV) or PV plus single booster (BV). Fluorescent antibody virus neutralization test (FAVNT) was implemented to determine the neutralizing antibody titer against rabies and an individual titer ≥0·5 IU/mL indicated protection. Bayesian modeling was used to evaluate the individual duration of protection against rabies and the efficacy of two differen...
Source: PLoS Neglected Tropical Diseases - April 18, 2024 Category: Tropical Medicine Authors: Heidi Auerswald Source Type: research
Skin Aging Research Enters a New Era in China
This report proposed that to maintain good health throughout the life cycle, the skin, in particular, needs special attention. In 2022, the government of China, which has one-fifth of the world’s ol der population, created a “Healthy Aging” Plan to improve the well-being of its elderly citizens. (Source: Journal of Investigative Dermatology)
Source: Journal of Investigative Dermatology - April 18, 2024 Category: Dermatology Authors: Mengting Chen, Ji Li, Yuecen Ding, Chengfeng Zhang Tags: News and Perspectives Source Type: research
How does maternal anemia affect the levels of umb ılıcal cord braın-derıved neurotrophıc factor?
Iron deficiency anemia affects billions of people worldwide, and without anemia, iron deficiency is even the most common nutritional deficiency [1,2] Anemia is a global health problem which children and pregnant women throughout the world. World Health Organization estimates that 42% of children who are younger than 5 years of age and 40% of pregnant women have anemia [1]. Enlargement of the maternal red blood cell mass during pregnancy and the Growing placenta and the fetus triples the amount of iron needed [2]. (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)
Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology - April 18, 2024 Category: OBGYN Authors: G ökçe İpek Aytok, Asuman Akkaya Fırat, İlke Mungan Akın, Ayşegül Özel Tags: Full length article Source Type: research
Characteristics of primary care practices associated with patient education during COVID-19: results of the cross-sectional PRICOV-19 study in 38 countries
In response to the COVID-19 pandemic, the World Health Organization established a number of key recommendations such as educational activities especially within primary care practices (PCPs) which are a key co... (Source: BMC Family Practice)
Source: BMC Family Practice - April 18, 2024 Category: Primary Care Authors: Delphine Kirkove, Sara Willems, Esther Van Poel, Nadia Dardenne, Anne-Fran çoise Donneau, Elodie Perrin, Cécile Ponsar, Christian Mallen, Neophytos Stylianou, Claire Collins, Rémi Gagnayre and Benoit Pétré Tags: Research Source Type: research
