Provision and Need for Medicine Information in Asia and Africa: A Scoping Review of the Literature
AbstractPublished reviews of written medicine information (WMI) have mainly drawn on studies published in high-income countries, including very few Asian or African studies. We therefore set out to scope the research literature to determine the extent and type of studies concerning WMI for patients/consumers across these two continents. We sought empirical studies published between January 2004 and December 2019, conducted in any Asian or African country, as defined by the United Nations, in English or with an English abstract. The majority of the 923 papers identified were from high-income countries. We retained 26 papers...
Source: Drug Safety - March 5, 2021 Category: Drugs & Pharmacology Source Type: research

COVID-19 in the light of current clinical eye research
Eur J Ophthalmol. 2021 Mar 3:1120672121998911. doi: 10.1177/1120672121998911. Online ahead of print.ABSTRACTCOVID-19 is a disease caused by a SARS-CoV-2 virus infection first reported in Wuhan city, Chinese province of Hubei, in December 2019. Previously known as 2019 Novel Coronavirus (2019-nCoV) respiratory disease, COVID-19 was declared official name by the World Health Organization (WHO) as COVID-19 in February 2020. By July 2nd, 2020 10,818,005 confirmed cases with 519,467 COVID-19 deaths worldwide. The aim of this review article is to inform the audience of what is available in the current literature on how COVID-19 ...
Source: European Journal of Ophthalmology - March 4, 2021 Category: Opthalmology Authors: Mashael Al-Namaeh Source Type: research

Guidelines for contributors
Bull World Health Organ. 2021 Jan 1;99(1):75-76. doi: 10.2471/BLT.21.960121.NO ABSTRACTPMID:33658738 | PMC:PMC7924900 | DOI:10.2471/BLT.21.960121 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Source Type: research

Improving the implementation of kangaroo mother care
Bull World Health Organ. 2021 Jan 1;99(1):69-71. doi: 10.2471/BLT.20.252361. Epub 2020 Oct 28.NO ABSTRACTPMID:33658737 | PMC:PMC7924893 | DOI:10.2471/BLT.20.252361 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Tedbabe Degefie Hailegebriel Anne-Marie Bergh Nabila Zaka Jung Min Roh Fatima Gohar Samia Rizwan Atnafu Getachew Asfaw Mohammad Heidarzadeh Willibald Zeck Source Type: research

Fish hooks and gumboots: the language of pregnancy prevention in northern Malawi
Bull World Health Organ. 2021 Jan 1;99(1):67-68. doi: 10.2471/BLT.20.250456. Epub 2020 Oct 28.NO ABSTRACTPMID:33658736 | PMC:PMC7924892 | DOI:10.2471/BLT.20.250456 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Aisha Nandini Zoe Dasgupta Dorothy Makoka Zein Dudha Naia Stephenson Amelia C Crampin Source Type: research

Disease severity classification and COVID-19 outcomes, Republic of Korea
Bull World Health Organ. 2021 Jan 1;99(1):62-66. doi: 10.2471/BLT.20.257758. Epub 2020 Oct 28.ABSTRACTPROBLEM: The surge in coronavirus disease 2019 (COVID-19) cases overwhelmed the health system in the Republic of Korea.APPROACH: To help health-care workers prioritize treatment for patients with more severe disease and to decrease the burden on health systems caused by COVID-19, the government established a system to classify disease severity. Health-care staff in city- and provincial-level patient management teams classified the patients into the different categories according to the patients' pulse, systolic blood press...
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Kyung-Bok Son Tae-Jin Lee Seung-Sik Hwang Source Type: research

Survival after out-of-hospital cardiac arrest, Viet Nam: multicentre prospective cohort study
CONCLUSION: Improvements are needed in the emergency medical services in Viet Nam such as increasing bystander cardiopulmonary resuscitation and public access defibrillation, and improving ambulance and post-resuscitation care.PMID:33658734 | PMC:PMC7924896 | DOI:10.2471/BLT.20.269837 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Son N Do Chinh Q Luong Dung T Pham Chi V Nguyen Tra T Ton Thao Tn Pham Quoc Ta Hoang Hanh T Hoang Dat T Nguyen Dai Q Khuong Quan H Nguyen Tuan A Nguyen Hanh Tm Pham My H Nguyen Bryan F McNally Marcus Eh Ong Anh D Nguyen Source Type: research

Implications for farmers of measures to reduce sugars consumption
CONCLUSION: A global opportunity exists for public health leadership to bring together the health, economic, environmental and agriculture sectors to collaborate and build capacity for promotion of alternative livelihoods for sugar farmers. Lessons regarding strategy and the importance of political economy factors can be learnt from tobacco control measures. Further research to quantify the impact of reductions in sugars consumption would provide useful insights for designing policies to complement and strengthen efforts to improve diets and health.PMID:33658733 | PMC:PMC7924891 | DOI:10.2471/BLT.19.249177 (Source: Bulleti...
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Anne Marie Thow Raphael A Lencucha Kieron Rooney Stephen Colagiuri Manfred Lenzen Source Type: research

Progress towards elimination of mother-to-child transmission of hepatitis  B virus infection in China: a modelling analysis
CONCLUSION: Our results highlight how high-quality national data can be combined with modelling in monitoring the elimination of MTCT of HBV. By demonstrating the impact of increased interventions on target achievement dates, we anticipate that other high-burden countries will be motivated to strengthen HBV prevention policies.PMID:33658732 | PMC:PMC7924890 | DOI:10.2471/BLT.19.248146 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Zheng Hui Shevanthi Nayagam Polin Chan Wang Fuzhen Mark Thursz Yin Zundong Miao Ning Sun Xiaojin Fuqiang Cui Zhang Guomin Timothy B Hallett Source Type: research

Fadi Meroueh: responding to the health needs of prisoners
Bull World Health Organ. 2021 Jan 1;99(1):8-9. doi: 10.2471/BLT.21.030121.ABSTRACTFadi Meroueh talks to Andréia Azevedo Soares about ensuring health equity and harm reduction services in prisons, and the challenges presented by the COVID-19 pandemic.PMID:33658731 | PMC:PMC7924899 | DOI:10.2471/BLT.21.030121 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Source Type: research

School closures and teenage pregnancy
Bull World Health Organ. 2021 Jan 1;99(1):6-7. doi: 10.2471/BLT.21.020121.ABSTRACTPandemic-related school closures are impacting the sexual and reproductive health and rights of adolescent girls. Lynn Eaton reports.PMID:33658730 | PMC:PMC7924898 | DOI:10.2471/BLT.21.020121 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Source Type: research

Public health round-up
Bull World Health Organ. 2021 Jan 1;99(1):4-5. doi: 10.2471/BLT.21.010121.NO ABSTRACTPMID:33658729 | PMC:PMC7924897 | DOI:10.2471/BLT.21.010121 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Source Type: research

Ensuring equitable access to vaccines for refugees and migrants during the COVID-19 pandemic
Bull World Health Organ. 2021 Jan 1;99(1):3-3A. doi: 10.2471/BLT.20.267690.NO ABSTRACTPMID:33658728 | PMC:PMC7924895 | DOI:10.2471/BLT.20.267690 (Source: Bulletin of the World Health Organization)
Source: Bulletin of the World Health Organization - March 4, 2021 Category: International Medicine & Public Health Authors: Jozef Bartovic Siddharta Sankar Datta Santino Severoni Veronika D'Anna Source Type: research

Composite performance indicators for helmet and seat-belt enforcement as imprecise data
CONCLUSIONS: Both RSPIs are applicable with slight differences that were in the order of countries and the ease of reading the results. We also found that each method has different strengths and that the FDEA-based CIs method is more accurate and more in line with the inputs than the IDEA-based CIs method.PMID:33661065 | DOI:10.1080/15389588.2021.1877277 (Source: Traffic Injury Prevention)
Source: Traffic Injury Prevention - March 4, 2021 Category: Accident Prevention Authors: Azdasheer Barhoum Hamid Reza Behnood Source Type: research

GSE168184 Mechanisms of drugs-resistance in small cell lung cancer
Contributor : Kentaro SuinaSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensLung cancer is the leading cause of cancer mortality and is classified by the World Health Organization into two broad histological subtypes. Non –small cell lung cancer (NSCLC), including adenocarcinoma, squamous cell carcinoma, and large cell carcinoma, accounts for ~85% of all lung cancer cases, with the remaining 15% of cases being due to small cell lung cancer (SCLC), which arises from neuroendocrine cells in the lung. Although most SC LC tumors are initially responsive to chemotherapy and radiation,...
Source: GEO: Gene Expression Omnibus - March 4, 2021 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research

Airborne infections and emergency surgery: The COVID-19 pandemic perspective
Varun SureshJournal of Indian Association of Pediatric Surgeons 2021 26(2):76-88 COVID-19 which emerged in Wuhan, China has rapidly spread all over the globe and the World Health Organisation has declared it a pandemic. COVID-19 disease severity shows variation depending on demographic characteristics like age, history of chronic illnesses such as cardio-vascular/renal/respiratory disease; pregnancy; immune-suppression; angiotensin converting enzyme inhibitor medication use; NSAID use etc but the pattern of disease spread is uniform – human to human through contact, droplets and fomites. Up to 3.5% of health car...
Source: Journal of Indian Association of Pediatric Surgeons - March 4, 2021 Category: Surgery Authors: Varun Suresh Source Type: research

IJERPH, Vol. 18, Pages 2569: Preventive Behavioral Insights for Emerging Adults: A Survey during the COVID-19 Pandemic
This study aimed to examine factors related to preventive behaviors of emerging adults during the COVID-19 pandemic. A descriptive online survey design was used. Data were collected using a self-administrated, 28-item questionnaire completed by 239 undergraduate students from a university in Seoul, South Korea. The questionnaire was developed based on previous studies and the guidelines of the World Health Organization about COVID-19 preventive behaviors. The mean age of participants was 21.97 years, and the average score for COVID-19 preventive behaviors was 4.13 (SD: ±0.42) on a 5-point scale. Hierarchical regress...
Source: International Journal of Environmental Research and Public Health - March 4, 2021 Category: Environmental Health Authors: Park Kim Kim Tags: Article Source Type: research

Cost-effectiveness of the national dog rabies prevention and control program in Mexico, 1990 –2015
ConclusionsAnnual dog rabies vaccination campaigns have eliminated the transmission of dog-to-dog rabies and dog-mediated human rabies deaths in Mexico. According to World Health Organization standards, our results show that the national program of rabies control in Mexico has been highly cost-effective. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - March 4, 2021 Category: Tropical Medicine Authors: Jes ús Felipe González-Roldán Source Type: research

Community-directed distributors —The “foot soldiers” in the fight to control and eliminate neglected tropical diseases
by Uche V. Amazigo, Stephen G. A. Leak, Honorat G. M. Zoure, Chukwu Okoronkwo, Maimouna Diop Ly, Sunday Isiyaku, Andy Crump, Joseph C. Okeibunor, Boakye Boatin The neglected tropical diseases (NTDs) affect hundreds of millions of people, predominantly in rural, often difficult-to-access areas, poorly served by national health services. Here, we review the contributions of 4.8 million community-directed distributors (CDDs) of medicines over 2 decades in 1 46,000 communities in 27 sub-Saharan African countries to control or eliminate onchocerciasis and lymphatic filariasis (LF). We examine their role in the control of other...
Source: PLoS Neglected Tropical Diseases - March 4, 2021 Category: Tropical Medicine Authors: Uche V. Amazigo Source Type: research

Heterogeneity of PD-L1 expression in lung adenocarcinoma metastasis is related to histopathological subtypes
Lung adenocarcinoma is the most frequent primary tumor of the lungs often discovered at the stage of metastasis. Lung adenocarcinoma is often composed of different subtypes with distinct architectural patterns. Most lung adenocarcinomas are composed of at least two histopathological patterns and were formerly recognized in the 2004 World Health Organization (WHO) classification as mixed subtype[1]. Lung adenocarcinomas metastases are also frequently composed of different histopathological patterns[2]. (Source: Lung Cancer)
Source: Lung Cancer - March 4, 2021 Category: Cancer & Oncology Authors: Fabien Forest, Fran çois Casteillo, Vanessa Da Cruz, Violaine Yvorel, Tiphanie Picot, François Vassal, Olivier Tiffet, Michel Péoc’h Source Type: research

Physiological and Immunological Causes of the Susceptibility of Chronic Inflammatory Patients to COVID-19 Infection: Focus on Diabetes
The coronavirus disease 2019 (COVID-19) pandemic has recently emerged, which was then spread rapidly in more than 190 countries worldwide so far. According to the World Health Organization, 3,232,062 global cases of COVID-19 were confirmed on April 30th with a mortality rate of 3.4%. Notably, the symptoms are almost similar to those of flu such as fever, cough, and fatigue. Unfortunately, the global rates of morbidity and mortality caused by this disease are more and still increasing on a daily basis. The rates for patients suffering from inflammatory diseases like diabetes, is even further, due to their susceptibility to ...
Source: Frontiers in Endocrinology - March 4, 2021 Category: Endocrinology Source Type: research

Regional differences in general practitioners ’ behaviours regarding influenza vaccination: a cross-sectional study
The World Health Organization recommends vaccination rates of 75% against seasonal influenza for patients over 65  years old. In the 2013/2014 season, the German vaccination rates ranged between 14 and 65%. Thi... (Source: BMC Health Services Research)
Source: BMC Health Services Research - March 4, 2021 Category: General Medicine Authors: Jonathan Arlt, Kristina Flaegel, Katja Goetz and Jost Steinhaeuser Tags: Research article Source Type: research

Cardiovascular disease risk profile and management practices in 45 low-income and middle-income countries: A cross-sectional study of nationally representative individual-level survey data
ConclusionsThis study found underuse of guideline-indicated BP medication in people with elevated CVD risk and overuse by people with lower CVD risk. Country-specific targeted policies are needed to help improve the identification and management of those at highest CVD risk. (Source: PLoS Medicine)
Source: PLoS Medicine - March 4, 2021 Category: Internal Medicine Authors: David Peiris Source Type: research

The exposure risk to COVID-19 in most affected countries: A vulnerability assessment model
by Adriana Nascimento Santos Cartaxo, Francisco Iran Cartaxo Barbosa, Paulo Henrique de Souza Bermejo, Marina Figueiredo Moreira, David Nadler Prata The world is facing the coronavirus pandemic (COVID-19), which began in China. By August 18, 2020, the United States, Brazil, and India were the most affected countries. Health infrastructure and socioeconomic vulnerabilities may be affecting the response capacities of these countries. We compared official indicators to identify which vulnerabilities better determined the exposure risk to COVID-19 in both the most and least affected countries. To achieve this purpose, we coll...
Source: PLoS One - March 4, 2021 Category: Biomedical Science Authors: Adriana Nascimento Santos Cartaxo Source Type: research

Breast cancer detection by dedicated breast positron emission tomography according to the World Health Organization classification of breast tumors
Publication date: Available online 3 March 2021Source: European Journal of Surgical OncologyAuthor(s): Shinsuke Sasada, Yuri Kimura, Norio Masumoto, Akiko Emi, Takayuki Kadoya, Koji Arihiro, Morihito Okada (Source: European Journal of Surgical Oncology (EJSO))
Source: European Journal of Surgical Oncology (EJSO) - March 3, 2021 Category: Surgery Source Type: research

Overview of the Haematological Effects of COVID-19 Infection
Adv Exp Med Biol. 2021;1321:163-172. doi: 10.1007/978-3-030-59261-5_14.ABSTRACTFrom its early origins, COVID-19 has spread extensively and was declared a global pandemic by the World Health Organization in March of 2020. Although initially thought to be predominantly a respiratory infection, more recent evidence points to a multisystem systemic disease which is associated with numerous haematological and immunological disturbances in addition to its other effects. Here we review the current knowledge on the haematological effects of COVID-19.PMID:33656722 | DOI:10.1007/978-3-030-59261-5_14 (Source: Advances in Experimental...
Source: Advances in Experimental Medicine and Biology - March 3, 2021 Category: Research Authors: T M Wiggill E S Mayne J L Vaughan S Louw Source Type: research

EBV Positive Mucocutaneous Ulcer (EBVMCU): Single Center Series of Three Cases and Review of Literature
Ann Clin Lab Sci. 2021 Jan;51(1):124-130.ABSTRACTEBV positive mucocutaneous ulcer (EBVMCU) is a newly recognized clinicopathologic entity in the 2017 World Health Organization (WHO) classification. Patients frequently present with an isolated ulcerative lesion in mucosal and cutaneous sites with immunosuppression as the main risk factor. The disease typically follows an indolent clinical course. Herein we describe a series of three patients diagnosed with EBVMCU. Histopathologic examination of these cases shows ulceration in mucosal or cutaneous surface with a substantial number of large atypical transformed cells in the b...
Source: Annals of Clinical and Laboratory Science - March 3, 2021 Category: Laboratory Medicine Authors: Fei Fei Vishnu Reddy Deniz Peker Chirag Patel Sameer Al Diffalha Source Type: research

Critical analysis on the use of cholecalciferol as a COVID-19 intervention: a narrative review
CONCLUSIONS: Current studies on vitamin D used for purposes other than bone health promotion cannot be taken as support to justify its use in a disease as recent as COVID-19. Studies of greater robustness, with higher levels of clinical evidence, need to be conducted. Rational use of this vitamin needs to be ensured, thereby minimizing the impacts on the patient and the public healthcare system.PMID:33656132 | DOI:10.1590/1516-3180.2020.0532.02112020 (Source: Sao Paulo Medical Journal)
Source: Sao Paulo Medical Journal - March 3, 2021 Category: General Medicine Authors: Stephanye Carolyne Christino Chagas Francisca Sueli Monte Moreira Irla Carla Fran ça Barbosa Osvaldo de Sousa Leal J únior Leila Bastos Leal Davi Pereira de Santana Source Type: research

Occupational Therapists' Perspective on the International Classification of Functioning, Disability and Health Core Sets (ICF-CS) for Schizophrenia
CONCLUSIONS AND RELEVANCE: The ICF Core Sets for schizophrenia were validated from the perspective of occupational therapists and are potentially useful tools for clinical practice because they cover a wide variety of problems that occupational therapists deal with in interventions with people with schizophrenia.WHAT THIS ARTICLE ADDS: The ICF-CSs for schizophrenia are useful guides for describing and classifying functioning, disability, and health to aid occupational therapy intervention with people with schizophrenia. Occupational therapists are essential in the rehabilitation of this client population, and their perspec...
Source: The American Journal of Occupational Therapy - March 3, 2021 Category: Occupational Health Authors: Laura Nu ño Georgina Guilera Morris Bell Emilio Rojo Juana G ómez-Benito Caterina Calder ón Maite Barrios Source Type: research

IJERPH, Vol. 18, Pages 2473: IDTWO: A Protocol for a Randomised Controlled Trial of a Web-Based Mental Health Intervention for Australians with Intellectual Disability
erine Boydell People with intellectual disability (ID) experience higher rates of mental illness and reduced access to appropriate care and treatment. Tailored electronic mental health (eMH) programs offer opportunities to address these disparities. The aim of this study is to examine whether a fully automated and self-guided eMH program tailored to the needs of people with ID can reduce symptoms of anxiety and depression and improve daily functioning in people with borderline-to-mild ID. Australians with borderline-to-mild ID, aged 16 years and older with mild-to-moderate depression and/or anxiety symptoms will be eli...
Source: International Journal of Environmental Research and Public Health - March 3, 2021 Category: Environmental Health Authors: Peter A. Baldwin Victoria Rasmussen Julian N. Trollor Jenna L. Zhao Josephine Anderson Helen Christensen Katherine Boydell Tags: Study Protocol Source Type: research

An Adaptable Framework for Factors Contributing to Medication Adherence: Results from a Systematic Review of 102 Conceptual Frameworks
ConclusionOur conceptual models can be utilized as a guide for clinicians and researchers in identifying the facilitators and barriers to medication adherence and developing future interventions to improve medication adherence.Protocol RegistrationPROSPERO Identifier: CRD42020181316 (Source: Journal of General Internal Medicine)
Source: Journal of General Internal Medicine - March 3, 2021 Category: Internal Medicine Source Type: research

IJERPH, Vol. 18, Pages 2511: Physical Activity during the First COVID-19-Related Lockdown in Italy
eer Groneberg Banzer The spread of the COVID-19 virus was met by a strict lockdown in many countries around the world, with the closure of all physical activity (PA) facilities and limitations on moving around freely. The aim of the present online survey was to assess the effect of lockdown on physical activity in Italy. Physical activity was assessed using the European Health Interview Survey questionnaire. A total of 1500 datasets were analyzed. Differences between conditions were tested with a chi²-based (Χ2) test for categorical variables, and with the Student’s t-test for paired data. A fixed ...
Source: International Journal of Environmental Research and Public Health - March 3, 2021 Category: Environmental Health Authors: F üzéki Schr öder Carraro Merlo Reer Groneberg Banzer Tags: Article Source Type: research

IJERPH, Vol. 18, Pages 2481: Positive Externalities of Climate Change Mitigation and Adaptation for Human Health: A Review and Conceptual Framework for Public Health Research
Beyer Anthropogenic climate change is adversely impacting people and contributing to suffering and increased costs from climate-related diseases and injuries. In responding to this urgent and growing public health crisis, mitigation strategies are in place to reduce future greenhouse gas emissions (GHGE) while adaptation strategies exist to reduce and/or alleviate the adverse effects of climate change by increasing systems’ resilience to future impacts. While these strategies have numerous positive benefits on climate change itself, they also often have other positive externalities or health co-benefits. This kno...
Source: International Journal of Environmental Research and Public Health - March 3, 2021 Category: Environmental Health Authors: Jean C. Bikomeye Caitlin S. Rublee Kirsten M. M. Beyer Tags: Review Source Type: research

Prevention and management of physical health conditions in adults with severe mental disorders: WHO recommendations
People with severe mental disorders (SMD) experience premature mortality mostly from preventable physical causes. The World Health Organization (WHO) have recently produced guidelines on the prevention and man... (Source: International Journal of Mental Health Systems)
Source: International Journal of Mental Health Systems - March 3, 2021 Category: Psychiatry Authors: Petra C. Gronholm, Neerja Chowdhary, Corrado Barbui, Jayati Das-Munshi, Kavitha Kolappa, Graham Thornicroft, Maya Semrau and Tarun Dua Tags: Guideline Source Type: research

Scoping review of the World Health Organization ’s underlying equity discourses: apparent ambiguities, inadequacy, and contradictions
Given the heightened rhetorical prominence the World Health Organization has afforded to equity in the past half-century, it is important to better understand how equity has been referred to and its conceptual... (Source: International Journal for Equity in Health)
Source: International Journal for Equity in Health - March 3, 2021 Category: International Medicine & Public Health Authors: Michelle M. Amri, Genevi ève Jessiman-Perreault, Arjumand Siddiqi, Patricia O’Campo, Theresa Enright and Erica Di Ruggiero Tags: Review Source Type: research

An international collaborative study to establish the WHO 3rd International Standard for Thrombin: Communication from the ISTH SSC subcommittee on factor XIII and fibrinogen
J Thromb Haemost. 2021 Mar;19(3):852-858. doi: 10.1111/jth.15207.ABSTRACTThe calibration of thrombin products relies on the World Health Organization (WHO) 2nd International Standard (IS) for Thrombin (01/580) which defines the international unit (IU) for thrombin potency. With stocks of the 2nd IS (01/580) running low, an international collaborative study was organized to calibrate a replacement. Twenty laboratories from 13 countries took part in the study and measured the potency of two candidate replacement standards (coded 01/578 and 19/188) relative to the 2nd IS. In total, 111 valid assays were returned, which were a...
Source: Thrombosis and Haemostasis - March 2, 2021 Category: Hematology Authors: Matthew Locke Colin Longstaff Peter Rigsby Source Type: research

Coronavirus and its terrifying inning around the globe: The pharmaceutical cares at the main frontline
Chemosphere. 2021 Feb 16;275:129968. doi: 10.1016/j.chemosphere.2021.129968. Online ahead of print.ABSTRACTA novel coronavirus (2019-nCoV) is an acute life-threatening disease, emerged in China, which imposed a potentially immense toll in terms of public health emergency due to high infection rate and has a devastating economic impact that attracts the world's attention. After that, on January 30, 2020, it was officially declared as a global pandemic by World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) recognized it as a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a...
Source: Chemosphere - March 2, 2021 Category: Chemistry Authors: Muneeb Ullah Abdul Wahab Sumbul Saeed Shahid Ullah Khan Haider Ali Shah Humayun Banzeer Ahsan Abbasi Shah Saud Khalid Naveed Sher Aslam Khan Shah Fahad Source Type: research

Coronavirus and its terrifying inning around the globe: The pharmaceutical cares at the main frontline
Chemosphere. 2021 Feb 16;275:129968. doi: 10.1016/j.chemosphere.2021.129968. Online ahead of print.ABSTRACTA novel coronavirus (2019-nCoV) is an acute life-threatening disease, emerged in China, which imposed a potentially immense toll in terms of public health emergency due to high infection rate and has a devastating economic impact that attracts the world's attention. After that, on January 30, 2020, it was officially declared as a global pandemic by World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) recognized it as a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a...
Source: Chemosphere - March 2, 2021 Category: Chemistry Authors: Muneeb Ullah Abdul Wahab Sumbul Saeed Shahid Ullah Khan Haider Ali Shah Humayun Banzeer Ahsan Abbasi Shah Saud Khalid Naveed Sher Aslam Khan Shah Fahad Source Type: research

Correlation between polio immunization coverage and overall morbidity and mortality for COVID-19: an epidemiological study
Environ Sci Pollut Res Int. 2021 Mar 2. doi: 10.1007/s11356-021-12861-6. Online ahead of print.ABSTRACTWe conducted the current analysis to determine the potential role of polio vaccination in the context of the spread of COVID-19. Data were extracted from the World Health Organization's (WHO) Global Health Observatory data repository regarding the polio immunization coverage estimates and correlated to the overall morbidity and mortality for COVID-19 among different countries. Data were analyzed using R software version 4.0.2. Mean and standard deviation were used to represent continuous variables while we used frequencie...
Source: Environmental Science and Pollution Research International - March 2, 2021 Category: Environmental Health Authors: Marwa Adel Afify Rakan M Alqahtani Mohammed Abdulrahman Mohammed Alzamil Faten Abdulrahman Khorshid Sumayyah Mohammad Almarshedy Sana Ghazi Alattas Talal Nabeel Alrawaf May Bin-Jumah Mohamed M Abdel-Daim Mohammad Almohideb Source Type: research

Animal models for the study of depressive disorder
CNS Neurosci Ther. 2021 Mar 1. doi: 10.1111/cns.13622. Online ahead of print.ABSTRACTDepressive disorder is one of the most widespread forms of psychiatric pathology, worldwide. According to a report by the World Health Organization, the number of people with depression, globally, is increasing dramatically with each year. Previous studies have demonstrated that various factors, including genetics and environmental stress, contribute to the risk of depression. As such, it is crucial to develop a detailed understanding of the pathogenesis of depressive disorder and animal studies are essential for identifying the mechanisms...
Source: CNS Neuroscience and Therapeutics - March 2, 2021 Category: Neuroscience Authors: Juhyun Song Young-Kook Kim Source Type: research

An international collaborative study to establish the WHO 3rd International Standard for Thrombin: Communication from the ISTH SSC subcommittee on factor XIII and fibrinogen
J Thromb Haemost. 2021 Mar;19(3):852-858. doi: 10.1111/jth.15207.ABSTRACTThe calibration of thrombin products relies on the World Health Organization (WHO) 2nd International Standard (IS) for Thrombin (01/580) which defines the international unit (IU) for thrombin potency. With stocks of the 2nd IS (01/580) running low, an international collaborative study was organized to calibrate a replacement. Twenty laboratories from 13 countries took part in the study and measured the potency of two candidate replacement standards (coded 01/578 and 19/188) relative to the 2nd IS. In total, 111 valid assays were returned, which were a...
Source: Thrombosis and Haemostasis - March 2, 2021 Category: Hematology Authors: Matthew Locke Colin Longstaff Peter Rigsby Source Type: research

Coronavirus and its terrifying inning around the globe: The pharmaceutical cares at the main frontline
Chemosphere. 2021 Feb 16;275:129968. doi: 10.1016/j.chemosphere.2021.129968. Online ahead of print.ABSTRACTA novel coronavirus (2019-nCoV) is an acute life-threatening disease, emerged in China, which imposed a potentially immense toll in terms of public health emergency due to high infection rate and has a devastating economic impact that attracts the world's attention. After that, on January 30, 2020, it was officially declared as a global pandemic by World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) recognized it as a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a...
Source: Chemosphere - March 2, 2021 Category: Chemistry Authors: Muneeb Ullah Abdul Wahab Sumbul Saeed Shahid Ullah Khan Haider Ali Shah Humayun Banzeer Ahsan Abbasi Shah Saud Khalid Naveed Sher Aslam Khan Shah Fahad Source Type: research

Coronavirus and its terrifying inning around the globe: The pharmaceutical cares at the main frontline
Chemosphere. 2021 Feb 16;275:129968. doi: 10.1016/j.chemosphere.2021.129968. Online ahead of print.ABSTRACTA novel coronavirus (2019-nCoV) is an acute life-threatening disease, emerged in China, which imposed a potentially immense toll in terms of public health emergency due to high infection rate and has a devastating economic impact that attracts the world's attention. After that, on January 30, 2020, it was officially declared as a global pandemic by World Health Organization (WHO). The International Committee on Taxonomy of Viruses (ICTV) recognized it as a Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) a...
Source: Chemosphere - March 2, 2021 Category: Chemistry Authors: Muneeb Ullah Abdul Wahab Sumbul Saeed Shahid Ullah Khan Haider Ali Shah Humayun Banzeer Ahsan Abbasi Shah Saud Khalid Naveed Sher Aslam Khan Shah Fahad Source Type: research

Clinical profiles of silent corticotroph adenomas compared with silent gonadotroph adenomas after adopting the 2017 WHO pituitary classification system
AbstractPurposeSilent corticotroph adenomas (SCAs) can be redefined according to the 2017 World Health Organization pituitary classification system with the introduction of T ‑PIT, a transcription factor. We studied the clinical features of these redefined SCAs.Methods We compared 112 patients with SCAs and 198 patients with silent gonadotroph adenomas (SGAs) who underwent surgery from January 2019 to May 2020.Results The prevalence of SCAs increased from 21.3 to 30.2% under the new classification rules. T-PIT-positive, adrenocorticotropic hormone-negative SCAs and T-PIT-positive, adrenocorticotropic hormone-positive S...
Source: Pituitary - March 2, 2021 Category: Endocrinology Source Type: research

Prospective Clinical Pilot Study to Evaluate the Effect of Prosthodontic Rehabilitation on Psychological Status and Quality of Life in Maxillectomy Patients: An Indian Experience
AbstractThe purpose of the study was to assess psychological status (PS) and quality of life (QOL) before surgical resection of maxilla (T0), 2  weeks after resection (T1), 2 weeks after use of intermediate obturator (T2), before (T3) and 12 weeks after use of definitive obturator (T4). 20 participants, planned for resection of maxilla and subsequent prosthodontic rehabilitation were enrolled. Assessment was done using Hospital Anxiety a nd Depression Scale (HADS) (HADS-A: anxiety and HADS-D: depression) for PS, World Health Organization Quality of Life BREF (WHOQOL-BREF) and European Organization for Resear...
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - March 2, 2021 Category: ENT & OMF Source Type: research

IJERPH, Vol. 18, Pages 2444: A Review of Registered Randomized Controlled Trials for the Prevention of Obesity in Infancy
ouise A. Baur Childhood overweight and obesity is a worldwide public health issue. Our objective was to describe planned, ongoing and completed randomized controlled trials (RCTs) designed for the prevention of obesity in early childhood. Two databases (World Health Organization International Clinical Trials Registry Platform, ClinicalTrials.gov) were searched to identify RCTs with the primary aim of preventing childhood obesity and at least one outcome related to child weight. Interventions needed to start in the first two years of childhood or earlier, continue for at least 6 months postnatally, include a component r...
Source: International Journal of Environmental Research and Public Health - March 2, 2021 Category: Environmental Health Authors: Seema Mihrshahi Danielle Jawad Louise Richards Kylie E. Hunter Mahalakshmi Ekambareshwar Anna Lene Seidler Louise A. Baur Tags: Review Source Type: research

Sensors, Vol. 21, Pages 1699: Cicada Wing Inspired Template-Stripped SERS Active 3D Metallic Nanostructures for the Detection of Toxic Substances
This article introduces a bioinspired, cicada wing-like surface-enhanced Raman scattering (SERS) substrate based on template-stripped crossed surface relief grating (TS-CSRG). The substrate is polarization-independent, has tunable nanofeatures and can be fabricated in a cleanroom-free environment via holographic exposure followed by template-stripping using a UV-curable resin. The bioinspired nanostructures in the substrate are strategically designed to minimize the reflection of light for wavelengths shorter than their periodicity, promoting enhanced plasmonic regions for the Raman excitation wavelength at 632.8 nm over a...
Source: Sensors - March 2, 2021 Category: Biotechnology Authors: Srijit Nair Juan Gomez-Cruz Gabriel Ascanio Aristides Docoslis Ribal Georges Sabat Carlos Escobedo Tags: Communication Source Type: research

Do adult patients with diabetes mellitus living in rural part of Ethiopia and having poor social support have disproportionately poor self-care practice? A systematic review and meta-analysis
Diabetes Mellitus (DM) is a chronic metabolic chaos of glucose homeostasis that linked with short and long-term vascular and nonvascular complications leading to other chronic illnesses and death [1 –3]. It’s the rapid mounting of non-communicable disease throughout the world [4,5]. DM characterized by hyperglycemia attributed to poor performance of anabolic hormone (insulin), which regulates the body’s ability to metabolize and uptake glucose to generate energy [6–8]. Its extent has re ached epidemic; the World Health Organization (WHO) predicts that developing countries will bear the brunt of this...
Source: Primary Care Diabetes - March 2, 2021 Category: Primary Care Authors: Fikadu Ambaw Yehualashet, Eleni Tesfaye Tegegne, Amare Demsie Ayele, Wubet Worku Takele Tags: Review Source Type: research

Medial Extension of Medial Sphenoid Wing Meningioma from the Anterior Clinoid Line: Does It Truly Affect the Surgical Outcome?
Conclusion The degree of medial extension of MSWM from the AC line has no statistically significant correlation with major postoperative complications, extent of resection, or clinical outcome. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part B: Skull Base)
Source: Journal of Neurological Surgery Part B: Skull Base - March 2, 2021 Category: Neurosurgery Authors: Arab, Ala Hawsawi, Aysha Bafaquh, Mohammed Orz, Yasser AlYamany, Mahmoud Alobaid, Abdullah Tags: Original Article Source Type: research

Depressive Symptoms and Quality of Life in a Sample of Italian Women with a Diagnosis of Fibromyalgia: The Role of Attachment Styles
CONCLUSIONS: Our study demonstrates that, when evaluating the impact of FM on the QoL of women, it is important to consider the complexity of the variables that are at play. Insecure attachment styles and depressive symptoms seem to increase the likelihood of the psycho-social-somatic malaise in FM women.PMID:33643667 | PMC:PMC7902149 | DOI:10.1155/2021/5529032 (Source: Depression Research and Treatment)
Source: Depression Research and Treatment - March 1, 2021 Category: Psychiatry Authors: Cristina Sechi Loredana Lucarelli Laura Vismara Source Type: research