Drinking water quality and risk for human health in Pelengana commune, Segou, Mali.
The objective of this work is to evaluate the level of pollution of different drinking water sources consumed and its link with health in Pelengana commune, Mali. Samples of water were taken from various sources, namely, hand pumps, boreholes, dug wells, and shallow wells for physical, chemical, heavy metals, and bacteriological analyses, using American Public Health Association (APHA) Standard Techniques. Results revealed that the nitrate-nitrogen (NO3-N) values of the water samples from the different water sources had concentrations exceeding the United States Environmental Protection Agency's (US-EPA) regulation of 10 m...
Source: Journal of Water and Health - July 19, 2019 Category: Environmental Health Tags: J Water Health Source Type: research

General practice recruitment - a survey of awareness and influence of the Scottish Targeted Enhanced Recruitment Scheme (TERS).
This study aimed to evaluate awareness and influence of the TERS initiative on programme choice in Scotland in August 2017. A survey was developed and sent to GP trainees taking up a GPST post in August 2017. Ninety-five out of 245 doctors responded (response rate of 39%). Almost two-thirds (65.3%) were aware of TERS at the time of application and this was via word of mouth and from the National Recruitment Office website. Only 21% of GPSTs aware of TERS were influenced by it in their choice of training location. The locations of family, spouse or partner, and of pre-existing geographical preferences were more influential ...
Source: Education for Primary Care - July 19, 2019 Category: Primary Care Tags: Educ Prim Care Source Type: research

Colorectal cribriform comedo-type adenocarcinoma: a distinct subtype with poor prognosis?
Authors: Díaz Del Arco C, Domínguez Serrano I, Fernández Aceñero MJ Abstract Colorectal cancer is one of the most commonly diagnosed cancers in the world. It is a heterogeneous disease with several histologic subtypes, and some of them are associated with adverse prognostic factors. Cribriform comedo-type adenocarcinoma (CCA) has been included as a colorectal adenocarcinoma subtype in the last World Health Organization (WHO) classification of gastrointestinal system tumors. Some authors have linked this subtype to an adverse prognosis, but to the best of our knowledge there is only one p...
Source: Acta Gastro-Enterologica Belgica - July 19, 2019 Category: Gastroenterology Tags: Acta Gastroenterol Belg Source Type: research

Sequence and Observer Variability in Gadoxectic Acid-Enhanced MRI Lesion Measurements in Hepatocellular Carcinoma
ConclusionThere is high interobserver and intersequence reliability despite small differences between observers based on experience level. Our results suggest that accurate measurements can be made on arterial phase despite the possibility of indistinct margins. Lesions, however, are more likely to be missed on diffusion-related sequences. (Source: Academic Radiology)
Source: Academic Radiology - July 19, 2019 Category: Radiology Source Type: research

Clinical, histopathological, and molecular analyses of IDH -wild-type WHO grade II –III gliomas to establish genetic predictors of poor prognosis
This study analyzed the genetic and other features ofIDH-wt LGGs to develop a subclassification that can be used to predict their prognosis. Clinical, histopathological, and genetic features of 35 cases of diffuseIDH-wt astrocytoma andIDH-wt anaplastic astrocytoma were analyzed. The following genetic factors were examined: mutations ofB-rapidly accelerated fibrosarcoma,telomerase reverse transcriptase promoter (TERTp),histone 3 family 3A, andalpha-thalassemia/mental retardation syndrome,X-linked; and copy number aberrations. In the univariate analysis, the following factors were associated with poor overall survival (OS): ...
Source: Brain Tumor Pathology - July 19, 2019 Category: Neurology Source Type: research

Performance of two simplified HBV treatment criteria (TREAT-B score and WHO guidelines) in Burkina Faso, West Africa
To achieve the World Health Organization (WHO) ’s global strategy of eliminating hepatitis B virus (HBV) infection by 2030, it is vital to scale up screening, clinical staging and treatment services in low- and middle-income countries (LMICs) which account for the largest proportion of people living with chronic HBV infection worldwide.1 Altho ugh both screening tests for hepatitis B surface antigen (HBsAg) and generic antiviral medicines are now available at affordable prices in LMICs, access to the conventional diagnostic tests to examine treatment eligibility (liver biopsy/FibroScan®/HBV DNA) is still limited ...
Source: Journal of Hepatology - July 19, 2019 Category: Gastroenterology Authors: Yusuke Shimakawa, Pauline Boucheron, Li êm Binh Luong Nguyen, Maud Lemoine, Roger Sombié Tags: Letter to the Editor Source Type: research

Ebola in the DRC one year later – Boiling the Frog?
The outbreak of Ebola virus disease in the Democratic Republic of the Congo (DRC), of which the World Health Organization (WHO) was first notified on August 1, 2018, is now approaching the first anniversary of its initial detection. At the fourth meeting of the Emergency Committee of the WHO regarding this epidemic on July 17, the Director General of the WHO, at the recommendation of the Committee, declared a Public Health Emergency of International Concern (PHEIC). What were the conditions that led the Committee to recommend the declaration at this point, after 3 prior meetings failed to reach the same result despite mult...
Source: International Journal of Infectious Diseases - July 19, 2019 Category: Infectious Diseases Authors: Susan McLellan, Mark G. Kortepeter, Nahid Bhadelia, Erica S. Shenoy, Lauren M. Sauer, Maria G. Frank, Theodore J. Cieslak Tags: Editorial Source Type: research

Hemorrhagic stroke following viper bites and delayed antivenom administration: three case reports from the Western Brazilian Amazon
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Bedbugs: Unwelcome Travel Companions
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

An unusual dark macular lesion in the plantar region of a child
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Bone involvement in paracoccidioidomycosis
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Old Paradigms and New Challenges motto of ChagasLeish 2017: a speech at the opening ceremony of MedTrop 2017 and ChagasLeish 2017
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

New sequence types of Acinetobacter baumannii in two emergency hospitals in the Central-West region of Brazil
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Are waste pickers at risk for hepatitis B and C infections because of poverty or environmental exposures?
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients. (Source: Revista da Sociedade Brasileira de Medicina Tropical)
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

 Targeting Glycemic Level in Gestational Diabetes Mellitus to that of Normal Pregnancy would result in a better Maternal-Fetal Outcome.
 Targeting Glycemic Level in Gestational Diabetes Mellitus to that of Normal Pregnancy would result in a better Maternal-Fetal Outcome. J Assoc Physicians India. 2019 Apr;67(4):66-70 Authors: Seshiah V, Kapur A, Balaji V, Shah SN, Das AK, Diwakar H, Banerjee S, Anjalakshi C Abstract Abstract: Women with a history of Gestational Diabetes Mellitus (GDM) are at increased risk of future diabetes and related Non-Communicable Diseases (NCD) as are their offspring. "Transgenerational transmission occurs". Independent of genetic risk, offspring of hyperglycaemic pregnancies are at increased risk...
Source: Journal of the Association of Physicians of India - July 18, 2019 Category: General Medicine Tags: J Assoc Physicians India Source Type: research

Psychometric Evaluation of the Major Depression Inventory (MDI) as a Depression Severity Scale in Chinese Patients With Coronary Artery Disease. Findings From the MEDEA FAR-EAST Study.
Conclusions: The MDI was proved to be a highly reliable and satisfactory valid diagnostic screening tool to assess depression in Chinese cardiac patients. (Source: Frontiers in Psychiatry)
Source: Frontiers in Psychiatry - July 18, 2019 Category: Psychiatry Source Type: research

Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal
This study illustrates the relevance of the dissemination of MDR strains, and suggests that identification of these types of bacterial strains in both human and veterinary settings is of significant relevance in order to understand and implement combined control strategies for MDR bacteria in animals and humans. (Source: Frontiers in Microbiology)
Source: Frontiers in Microbiology - July 18, 2019 Category: Microbiology Source Type: research

The Future of Gaming Disorder Research and Player Protection: What Role Should the Video Gaming Industry and Researchers Play?
AbstractIn May 2019, the World Health Organization (WHO) officially included gaming disorder (GD) in the eleventh revised edition of the International Classification of Diseases. Although the video game industry does not accept the WHO ’s decision to class GD as a genuine mental disorder, there is now arguably an onus on the video game industry to develop and undertake responsible gaming initiatives aimed at player protection and harm minimization. The present paper argues that the gaming industry does not have to “reinvent th e wheel” as there are many responsible gaming tools and initiatives used by the...
Source: International Journal of Mental Health and Addiction - July 18, 2019 Category: Addiction Source Type: research

WHO declares international emergency over DRC Ebola outbreak
The World Health Organization is calling for international support to help stop the Ebola outbreak in the Democratic Republic of the Congo from spreading (Source: New Scientist - Health)
Source: New Scientist - Health - July 18, 2019 Category: Consumer Health News Source Type: research

Changes in the prevalence of overweight, obesity, and severe obesity between 2010 and 2017 in preschoolers: A population ‐based study
SummaryWe evaluated changes in overweight, obesity, and severe obesity in a population of 4 ‐ to 6‐year‐olds from 2010 to 2017. Anthropometric data were collected during children's preschool immunization visits in Edmonton and Calgary, Alberta, Canada. Body mass index (BMI), BMIz scores, and weight status categories were based on the World Health Organization criteria. Across 8 years, we examined population ‐level data from 161 114 children in which the prevalence of overweight (17.8%‐15.7%;P
Source: Pediatric Obesity - July 18, 2019 Category: Eating Disorders & Weight Management Authors: Geoff D.C. Ball, Anamaria Savu, Padma Kaul Tags: SHORT COMMUNICATION Source Type: research

Carbamazepine versus phenytoin monotherapy for epilepsy: an individual participant data review.
CONCLUSIONS: Moderate-certainty evidence provided by this systematic review does not show any differences between carbamazepine and phenytoin in terms of effectiveness (retention) or efficacy (seizure recurrence and seizure remission) for individuals with focal onset or generalised onset seizures.However, some of the trials contributing to the analyses had methodological inadequacies and inconsistencies, which may have had an impact on the results of this review. We therefore do not suggest that results of this review alone should form the basis of a treatment choice for a person with newly-onset seizures. We did not find ...
Source: Cochrane Database of Systematic Reviews - July 18, 2019 Category: General Medicine Authors: Nevitt SJ, Marson AG, Tudur Smith C Tags: Cochrane Database Syst Rev Source Type: research

Spending on World Health Organization essential medicines in Medicare Part D, 2011-15: retrospective cost analysis
(Source: BMJ)
Source: BMJ - July 17, 2019 Category: General Medicine Source Type: research

Comparison of quality of life and depression between hematopoietic stem cell transplantation survivors and their spouse caregivers.
Conclusion: This study found that there were no significant differences in QoL or level of depression between HSCT survivors and their spouse caregivers. Family income, gender, and co-morbidities showed significant association with spouse caregiver distress. PMID: 31309093 [PubMed] (Source: Blood Research)
Source: Blood Research - July 17, 2019 Category: Hematology Tags: Blood Res Source Type: research

Systematic Review of Hypertension and Diabetes Burden, Risk Factors, and Interventions for Prevention and Control in Malawi: The NCD BRITE Consortium
Publication date: June 2019Source: Global Heart, Volume 14, Issue 2Author(s): Alemayehu Amberbir, Sabrina H. Lin, Joshua Berman, Adamson Muula, Darren Jacoby, Emily Wroe, Cecilia Maliwichi-Nyirenda, Victor Mwapasa, Amelia Crampin, Martha Makwero, Emmanuel Singogo, Sam Phiri, Stephen Gordon, Sheldon W. Tobe, Jones Masiye, Brad Newsome, Mina Hosseinipour, Moffat J. Nyirenda, Joep J. van OosterhoutAbstractRecent studies have found an increasing burden of noncommunicable diseases in sub-Saharan Africa. A compressive search of PubMed, Medline, EMBASE, and the World Health Organization Global Health Library databases was underta...
Source: Global Heart - July 17, 2019 Category: Cardiology Source Type: research

Impact of the World Health Organization Surgical Safety Checklist on Patient Safety
The incidence of surgical complications has remained largely unchanged over the past two decades. Inherent complexity in surgery, new technology possibilities, increasing age and comorbidity in patients may contribute to this. Surgical safety checklists may be used as some of the tools to prevent such complications. Use of checklists may reduce critical workload by eliminating issues that are already controlled for. The global introduction of the World Health Organization Surgical Safety Checklist aimed to improve safety in both anesthesia and surgery and to reduce complications and mortality by better teamwork, communicat...
Source: Anesthesiology - July 17, 2019 Category: Anesthesiology Source Type: research

Influences of Vitamin A on Vaccine Immunogenicity and Efficacy
Vitamin A deficiencies and insufficiencies are widespread public health concerns in developing countries, and may be gaining prevalence in industrialized nations. To combat vitamin A deficiency (VAD), the World Health Organization recommends high-dose vitamin A supplementation (VAS) in children 6-59 months of age in locations where VAD is endemic. This practice has significantly reduced all-cause death and diarrhea-related mortalities in children, and may have in some cases improved immune responses toward pediatric vaccines. However, VAS studies have yielded conflicting results, perhaps due to influences of baseline vitam...
Source: Frontiers in Immunology - July 17, 2019 Category: Allergy & Immunology Source Type: research

Controlling factors and mechanism of groundwater quality variation in semiarid region of South India: an approach of water quality index (WQI) and health risk assessment (HRA)
AbstractThe study region comprises fractured granitic, basaltic and lateritic aquifer system constituted by Precambrian rocks. Groundwater is the primary source for drinking and household needs. Its quality is a big issue in the three aquifers, which are mostly of human health concern. Many developing regions suffer from lack of safe drinking water, thereby health problems arise in many parts of the regions, and Telangana state is one of them. For this reason, 194 groundwater samples were collected and analyzed for fluoride, nitrate, chloride and other physicochemical parameters. The concentrations of fluoride (F−), ...
Source: Environmental Geochemistry and Health - July 17, 2019 Category: Environmental Health Source Type: research

Dosing pole recommendations for lymphatic filariasis elimination: A height-weight quantile regression modeling approach
Conclusions/SignificanceUsing a novel modeling approach, we developed a simple dosing pole that would markedly reduce underdosing for DEC and IVM in MDA programs compared to current WHO recommended height or age-based dosing. (Source: PLoS Neglected Tropical Diseases)
Source: PLoS Neglected Tropical Diseases - July 17, 2019 Category: Tropical Medicine Authors: Charles W. Goss Source Type: research

In Reply to: Alawi. “Using rare diseases as teaching models to increase awareness”
Two important publications have recently highlighted the study of rare diseases and the collaboration of studying these conditions.1,2 A rare disease affects fewer than 200,000 people in the United States, less than 250,000 people in the European Union and under 50,000 patients in Japan.1 The concept of rare disease, according to the World Health Organization and adopted by the Ministry of Health of Brazil, refers to a disorder that affects up to 65 people in every 100,000 individuals, i.e. 1.3 for every 2,000 people (http://portalms.saude.gov.br/saude-de-a-z/doencas-raras). (Source: Oral Surgery, Oral Medicine, Oral Patho...
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - July 17, 2019 Category: ENT & OMF Authors: Herc ílio Martelli Júnior Tags: Letter To The Editor Source Type: research

Moving Away from the "Medical Model": The Development and Revision of the World Health Organization's Classification of Disability.
Moving Away from the "Medical Model": The Development and Revision of the World Health Organization's Classification of Disability. Bull Hist Med. 2019;93(2):241-269 Authors: Hogan AJ Abstract Recently, there has been a prominent call in the history of medicine for greater engagement with disability perspectives. In this article, I suggest that critiques of the so-called medical model have been an important vehicle by which alternative narratives of disability entered the clinical arena. Historians of medicine have rarely engaged with the medical model beyond descriptive accounts of it. I ar...
Source: Medical History - July 16, 2019 Category: History of Medicine Authors: Hogan AJ Tags: Bull Hist Med Source Type: research

Significance of Lymph Node Metastasis in Resectable Well-differentiated Pancreatic Neuroendocrine Tumor
Conclusions World Health Organization 2017 classification was the most independent prognostic factor in patients with resectable well-differentiated PanNETs. Patients with G2 and higher-grade tumors require lymph node dissection to improve prognosis. (Source: Pancreas)
Source: Pancreas - July 16, 2019 Category: Gastroenterology Tags: Original Articles Source Type: research

Optimizing Pediatric Dosing Recommendations and Treatment Management of Antiretroviral Drugs Using Therapeutic Drug Monitoring Data in Children Living With HIV
Discussion and conclusion: Pediatric ARV dosing is frequently based on data obtained from small studies and is often simplified to facilitate dosing in the context of a public health approach. Pharmacokinetic parameters of pediatric ARVs are subject to high interpatient variation and this leads to a potential risk of underdosing or overdosing when drugs are used in real life. To ensure optimal use of ARVs and validate dosing recommendations for children, it is essential to monitor ARV dosing more thoroughly with larger sample sizes and to include diverse subpopulations. Therapeutic drug monitoring data generated in child...
Source: Therapeutic Drug Monitoring - July 16, 2019 Category: Drugs & Pharmacology Tags: Review Article Source Type: research

Growing Global Alcohol Use
Increasing alcohol use worldwide threatens to derail the World Health Organization ’s (WHO’s) goal of cutting alcohol use by 10% by 2025, according to a study in The Lancet. (Source: JAMA)
Source: JAMA - July 16, 2019 Category: General Medicine Source Type: research

Updated WHO nomenclature of head and neck lesions and associated imaging findings
This article reviews the imaging features of head and neck lesions with updated 2017 World Health Organization (WHO) nomenclature. The major WHO changes include refined terminology of existing entities, descriptions of new tumor types, elimination of defunct categories, and updated biological characterization of various tumor types. In particular, the updates pertaining to the following conditions will be reviewed: tumors of the oral cavity and oropharynx, including HPV-positive or HPV-negative squamous cell carcinoma, small cell carcinoma; tumors of the hypopharynx, larynx, trachea, and parapharyngeal space, including nom...
Source: Insights into Imaging - July 16, 2019 Category: Radiology Source Type: research

Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia
In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via the serrated pathway. Studies have focused on clarification of categories and molecular features of serrated polyps, as well as endoscopic detection and risk assessment. Guidelines from the World Health Organization propose assigning serrated polyps to categories of hyperplastic polyps, traditional serrated adenomas (TSAs), and sessile serrated lesions (SSLs). TSAs and SSLs are precursors to colorectal cancer. (Source: Gastroenterology)
Source: Gastroenterology - July 16, 2019 Category: Gastroenterology Authors: Seth D. Crockett, Iris Nagtegaal Source Type: research

Ineligibility for the PACIFIC trial in unresectable stage III non-small cell lung cancer patients
ConclusionsOur study revealed the clinical characteristics and prognoses of patients who became ineligible for the PACIFIC trial after CRT. Physicians should be careful while prescribing CRT for patients with characteristics such as old age, male gender, and radiation therapy with V20  ≥ 35%. (Source: Cancer Chemotherapy and Pharmacology)
Source: Cancer Chemotherapy and Pharmacology - July 15, 2019 Category: Cancer & Oncology Source Type: research

Needs-based planning for the oral health workforce - development and application of a simulation model
The World Health Organization ’s global strategy on human resources for health includes an objective to align investment in human resources for health with the current and future needs of the population. Althou... (Source: Human Resources for Health)
Source: Human Resources for Health - July 15, 2019 Category: Health Management Authors: Susan Ahern, Noel Woods, Olivier Kalmus, Stephen Birch and Stefan Listl Tags: Research Source Type: research

Elimination of onchocerciasis in Africa by 2025: the need for a broad perspective
ConclusionsProgrammatic treatment and evaluation approaches, pioneered in the Americas, are the most efficient among the existing tools for elimination, and their broader use could catalyze the successful elimination of this disease in Africa. (Source: Infectious Diseases of Poverty)
Source: Infectious Diseases of Poverty - July 15, 2019 Category: Infectious Diseases Source Type: research

Pre-Exposure Prophylaxis for HIV Prevention in Women: Current Status and Future Directions
AbstractPre-exposure prophylaxis (PrEP) is a promising intervention to prevent HIV acquisition, with benefits both to the individual and to population-level health. PrEP is an opportunity to complement ongoing public health efforts to eliminate HIV. For women, PrEP can also serve as a gateway to access sexual and reproductive health (SRH) services. Clinical efficacy of PrEP was initially reported in women using a 1% tenofovir vaginal gel in 2010, followed by an efficacy trial of oral PrEP using TDF/FTC in men who have sex with men (MSM). Since then, further trials have reported efficacy in oral PrEP containing tenofovir in...
Source: Drugs - July 15, 2019 Category: Drugs & Pharmacology Source Type: research

Efficacy, immunogenicity and safety of the AS04 ‐HPV‐16/18 vaccine in Chinese women aged 18‐25 years: End‐of‐study results from a phase II/III, randomised, controlled trial
ConclusionsThis is the first large ‐scale randomized clinical trial of HPV vaccination in China. High and sustained vaccine efficacy against HPV‐16/18‐associated infection and cervical lesions was demonstrated up to Month 72. The vaccine had an acceptable safety profile. Combined with screening, prophylactic HPV vaccination cou ld potentially reduce the high burden of HPV infection and cervical cancer in China.Trial registrationNCT00779766. (Source: Cancer Medicine)
Source: Cancer Medicine - July 15, 2019 Category: Cancer & Oncology Authors: Feng ‐Cai Zhu, Shang‐Ying Hu, Ying Hong, Yue‐Mei Hu, Xun Zhang, Yi‐Ju Zhang, Qin‐Jing Pan, Wen‐Hua Zhang, Fang‐Hui Zhao, Cheng‐Fu Zhang, Xiaoping Yang, Jia‐Xi Yu, Jiahong Zhu, Yejiang Zhu, Feng Chen, Qian Zhang, Hong Wang Tags: ORIGINAL RESEARCH Source Type: research

Human Papillomavirus and Infertility.
Conclusions. HPV may have an impact in spermatogenesis, because an HPV infection was more frequently detected in men with abnormal sperm parameters. High-risk HPV 52 was the most common genotype among couples undergoing IVF treatment. PMID: 31311196 [PubMed - in process] (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - July 15, 2019 Category: Universities & Medical Training Authors: Jeršovienė V, Gudlevičienė Ž, Rimienė J, Butkauskas D Tags: Medicina (Kaunas) Source Type: research

Genetic Underpinnings of Renal Cell Carcinoma With Leiomyomatous Stroma
Renal cell carcinoma (RCC) with leiomyomatous stroma is a provisional category of RCC in the 2016 World Health Organization Classification of Tumors of the Urinary System. Microscopic examination of hematoxylin and eosin–stained sections reveals this entity to be well-circumscribed with tubulopapillary growth of cells with clear cytoplasm in a background of leiomyomatous stroma. Herein we describe the genetic features of 15 University of Chicago Medical Center archived cases with hematoxylin and eosin histology matching the provisional diagnosis. Immunohistochemical (IHC) stains revealed 1/15 of these tumors to be cl...
Source: The American Journal of Surgical Pathology - July 13, 2019 Category: Pathology Tags: Original Articles Source Type: research

An Overview of Surgical Site Infection in Low- and Middle-Income Countries: the Role of Recent Guidelines, Limitations, and Possible Solutions
AbstractPurpose of reviewThe purpose of this manuscript is to review preventive strategies for surgical site infection (SSI) in low- and middle-income countries (LMIC) and how the recent World Health Organization (WHO) guidelines, along with the Centers for Disease Control (CDC) recommendations on SSI prevention, may be implemented on these settings, considering frequent limitations and possible solutions.Recent findingsSurgical site infection (SSI) is the most common postoperative complication and in LMIC is the first cause among healthcare-associated infections (HAI). SSIs are largely preventable if there is a standardiz...
Source: Current Treatment Options in Infectious Diseases - July 13, 2019 Category: Infectious Diseases Source Type: research

Part I – Ectoparasites: Scabies
Scabies is an ectoparasitic dermatosis caused by Sarcoptes scabiei var. hominis and is a public health issue in all countries regardless of socioeconomic status. In high-income countries, delays in diagnosis can lead to institutional outbreaks while in low- and middle-income countries, poor access to healthcare contributes to disease undertreatment and long-term systemic sequelae. With scabies now recognized as a neglected tropical disease by the World Health Organization, increased awareness and systematic efforts are addressing gaps in diagnosis and treatment that impede scabies control. (Source: Journal of the American ...
Source: Journal of the American Academy of Dermatology - July 13, 2019 Category: Dermatology Authors: Cristina Thomas, Sarah J. Coates, Daniel Engelman, Olivier Chosidow, Aileen Y. Chang Source Type: research

Determining the frequency of iron overload at diagnosis in de novo acute myeloid leukemia patients with multilineage dysplasia or myelodysplasia-related changes: a case control study
AbstractAcute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) is a new disease category, which was defined as a separate entity in the World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues. While pre-treatment iron overload in patients with myelodysplastic syndrome has been previously studied, its relationship with AML-MRC has not been studied. We aimed to investigate the relationship between serum iron tests compatible with iron overload and the diagnosis of multilineage dysplasia (MLD) and AML with myelodysplasia-related changes (AML-MRC) in AML patients diagnosed...
Source: Journal of Hematopathology - July 13, 2019 Category: Pathology Source Type: research

How current risk assessment and risk management methods for drinking water in The Netherlands cover the WHO water safety plan approach.
This study could be of interest to both managers of large water utilities and decision makers. The assessment was performed by means of a policy review and interviews with two to four staff members involved in RA/RM from all ten Dutch drinking water companies combined with a joint workshop. The drinking water companies are well aware of the potential hazards and risks that can influence the drinking water quality. To guarantee the supply of safe and sufficient drinking water, the Dutch drinking water sector uses six different legally required RA/RM approaches. This study shows that by using the six legally required RA/RM a...
Source: International Journal of Hygiene and Environmental health - July 13, 2019 Category: Environmental Health Authors: van den Berg HHJL, Friederichs L, Versteegh JFM, Smeets PWMH, de Roda Husman AM Tags: Int J Hyg Environ Health Source Type: research

[Eumycetoma due to Fusarium chlamydosporum : Case report und review of the literature].
Authors: Malisiewicz B, Uhrlaß S, Nenoff P, Schöfer H Abstract Eumycetomas are chronic purulent infections by (mold) fungi that affect the skin and subcutaneous tissue and are associated with a granulomatous inflammatory reaction. An affection of deeper structures is possible and can lead to amputation. In most cases, the distal lower limbs are affected. The clinically similar actinomycetoma is caused by gram-positive, filamentous bacteria. Both diseases are subsumed as mycetomas and have been classified by the World Health Organization as "neglected tropical diseases". Eumycetomas are endemic ...
Source: Der Hautarzt: Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete - July 12, 2019 Category: Dermatology Tags: Hautarzt Source Type: research

Impact of Dexmedetomidine on Long-term Outcomes After Noncardiac Surgery in Elderly: 3-Year Follow-up of a Randomized Controlled Trial
Objectives: The aim was to compare the long-term outcomes of low-dose dexmedetomidine versus placebo in a randomized controlled trial (ChiCTR-TRC-10000802). Background: Low-dose dexmedetomidine infusion decreased delirium occurrence within 1 week after surgery in elderly admitted to the intensive care unit (ICU) after noncardiac surgery, but the long-term outcome of this intervention is unknown. Methods: Patients or their family members were telephone-interviewed for a 3-year follow-up data collection of survival, cognitive function assessed with the modified Telephone Interview for Cognitive Status, and quality of...
Source: Annals of Surgery - July 12, 2019 Category: Surgery Tags: ORIGINAL ARTICLES Source Type: research

Sports Contribute to Total Moderate to Vigorous Physical Activity in School Children
Conclusion Schoolchildren spent less than one-third of PE and OYS in MVPA. PE and OYS were found to support children and adolescents to engage sufficiently in MVPA as recommended by the World Health Organization. (Source: Medicine and Science in Sports and Exercise)
Source: Medicine and Science in Sports and Exercise - July 12, 2019 Category: Sports Medicine Tags: EPIDEMIOLOGY Source Type: research

Clinical Performance of Human Papillomavirus Testing and Visual Inspection With Acetic Acid in Primary, Combination, and Sequential Cervical Cancer Screening in China
Conclusions When VIA performs relatively poorly and HPV testing is available, adding VIA to sequential (ie, HPV followed by VIA triage) or primary (HPV-VIA cotesting) screening does not significantly improve CIN-2+ detection beyond primary HPV screening alone. Sequential screening (ie, HPV followed by VIA triage) reduces sensitivity too low for population-based screening programs. The HPV viral loads could offer an alternative low-resource country triage strategy. (Source: Sexually Transmitted Diseases)
Source: Sexually Transmitted Diseases - July 12, 2019 Category: Sexual Medicine Tags: Original Studies Source Type: research