A multi-centered trial investigating gestational treatment with ursodeoxycholic acid compared to metformin to reduce effects of diabetes mellitus (GUARD): a randomized controlled trial protocol
DiscussionThis trial has the potential to identify a potential new treatment for women with GDM. If successful, a future large multi-center trial will be designed to investigate where decisions can be personalized to identify which women will respond more effectively to UDCA than alternatives to improve maternal and baby outcomes.Trial registrationClinicalTrials.gov NCT04407650. (Source: Trials)
Source: Trials - July 19, 2022 Category: Research Source Type: clinical trials
The high-volume haemodiafiltration vs high-flux haemodialysis registry trial (H4RT): a multi-centre, unblinded, randomised, parallel-group, superiority study to compare the effectiveness and cost-effectiveness of high-volume haemodiafiltration and high-flux haemodialysis in people with kidney failure on maintenance dialysis using linkage to routine healthcare databases for outcomes
This study compares the clinical- and cost-effectiveness of high-volume HDF compared with high-flux HD in the treatment of kidney failure.MethodsThis is a UK-based, multi-centre, non-blinded randomised controlled trial. Adult patients already receiving HD or HDF will be randomised 1:1 to high-volume HDF (aiming for 21+ L of substitution fluid adjusted for body surface area) or high-flux HD. Exclusion criteria include lack of capacity to consent, life expectancy less than 3 months, on HD/HDF for less than 4 weeks, planned living kidney donor transplant or home dialysis scheduled within 3 months, prior intolerance of HDF and...
Source: Trials - June 27, 2022 Category: Research Source Type: clinical trials
Protocol paper: multi-Centre randomised controlled trial evaluating a pre-clinic diabetes assessment and mapped care planning intervention amongst adults with type 1, type 2 or pre-diabetes
DiscussionResults from the study will provide valuable insights into patient-professional communication practices within routine care and recommendations will be made, as necessary, for improvements to that. If the intervention is shown to be clinically and cost-effective, the feedback from participants and healthcare professionals will be used to make any improvements prior to its deployment to support improved communication and associated health outcomes.Ethics and disseminationThe trial was approved by the Wales REC7 Research Ethics Committee (21/WA/0020). Results will be disseminated through national and international ...
Source: Trials - June 20, 2022 Category: Research Source Type: clinical trials
The RAFT ECT Study
Condition: Major Depressive Episode Interventions: Procedure: Frontoparietal Ultrabrief Right Unilateral (UBRUL-FP) electroconvulsive therapy; Procedure: Temporoparietal Ultrabrief Right Unilateral (UBRUL-TP) electroconvulsive therapy Sponsors: The George Institute; National Health and Medical Research Council, Australia; Ramsay Clinic Albert Road, Australia; Ramsay Clinic Lakeside, Australia; Ramsay Clinic Northside, Australia; Gold Coast Hospital and Health Service; Augusta University; Medical University of South Carolina; The University of New South Wales...
Source: ClinicalTrials.gov - June 2, 2022 Category: Research Source Type: clinical trials
