Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of oesophageal varices: study protocol for a randomised controlled trial
DiscussionThe BOPPP trial aims to investigate the clinical and cost-effectiveness of carvedilol in patients with cirrhosis and small oesophageal varices to determine whether this non-selective beta-blocker can prevent or reduce hepatic decompensation. There is clinical equipoise on whether intervening in cirrhosis, at an earlier stage of portal hypertension, with NSBB therapy is beneficial. Should the trial yield a positive result, we anticipate that the administration and use of carvedilol will become widespread with pathways developed to standardise the administration of the medication in primary care.Ethics and dissemin...
Source: Trials - April 16, 2024 Category: Research Source Type: clinical trials
PREMs In Vascular SurgERy Enhancement Study
Conditions: Vascular Diseases; Patient Empowerment; Patient Satisfaction; Patient Engagement; Surgery Sponsors: Cardiff and Vale University Health Board; Welsh Value in Health Centre (WViHC); Centre for Healthcare Evaluation, Device Assessment, and Research (CEDAR) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2024 Category: Research Source Type: clinical trials
Drone Delivered Defibrillators (The 3D Project).
Conditions: Cardiac Arrest, Out-Of-Hospital Interventions: Behavioral: Interviews and simulation Sponsors: University of Warwick; Welsh Ambulance Service NHS Trust Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - March 28, 2024 Category: Research Source Type: clinical trials
The IMPROVE trial: study protocol for a pragmatic cluster randomised controlled trial to assess the effectiveness of using lay health workers to improve uptake and completion of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease
DiscussionImproving outcomes for chronic obstructive pulmonary disease and access to PR are priorities for the UK National Health Service (NHS) in its long-term plan. The trial hypothesis is that volunteer PR buddies, who are recruited and trained by local PR teams, are an effective and cost-effective way to improve the uptake and completion rates of PR. The trial is pragmatic, since it will test whether the intervention can be incorporated into NHS PR services. Information obtained in this trial may be used to influence policy on the use of PR buddies in PR and other similar services in the NHS.Trial registrationISRCTN126...
Source: Trials - March 19, 2024 Category: Research Source Type: clinical trials
Comparative Effectiveness Study of Two Forms of Ketamine for Treatment-resistant Depression
Conditions: Treatment Resistant Depression Interventions: Drug: Esketamine group; Drug: Racemic ketamine Sponsors: The George Institute; The University of New South Wales Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 26, 2024 Category: Research Source Type: clinical trials
Anti-psychotic Drug Prescribing Patterns Within Specialist Adult ID Services in England and Wales
Conditions: Intellectual Disability Sponsors: University of Plymouth; Peninsula Clinical Trials Unit Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 2, 2024 Category: Research Source Type: clinical trials
A Computer-aided (CADx ）System in Real-time Characterization of Colorectal Ulcerative Diseases
Conditions: Colorectal Ulcers; Computer-aided System Interventions: Diagnostic Test: Colonoscopy images and videos Sponsors: Nanfang Hospital, Southern Medical University; Prince of Wales Hospital, Shatin, Hong Kong; ZhuHai Hospital; Wuxi People ' s Hospital; The Second Affiliated Hospital of the Chinese University of Hong Kong (Shenzhen) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials
Accuracy of Computer-aided (CADx) System in Real-time Characterization of Colorectal Ulcerative Diseases
Conditions: Colorectal Ulcers; Computer-aided System Interventions: Diagnostic Test: Test images and videos Sponsors: Nanfang Hospital, Southern Medical University; Prince of Wales Hospital, Shatin, Hong Kong; Longgang District People ' s Hospital; ZhuHai Hospital; Wuxi People ' s Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 17, 2024 Category: Research Source Type: clinical trials
The Short-term Effects of PRISMA on Mental Health
Conditions: Psychological Distress; Anxiety; Depression; Suicidal Ideation Interventions: Behavioral: PRISMA Sponsors: University of Zurich; ETH Zurich; The University of New South Wales Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 9, 2024 Category: Research Source Type: clinical trials
AusCADASIL: An Australian Cohort of CADASIL
Conditions: Cadasil Sponsors: Perminder Sachdev; Prince of Wales Hospital, Sydney; John Hunter Hospital; St Vincent ' s Hospital - Sydney, Australia; Royal Brisbane and Women ' s Hospital; Melbourne Health; The University of Queensland Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 28, 2023 Category: Research Source Type: clinical trials
Immunotherapy Targeting of Cytomegalovirus Antigens in Glioblastoma
Conditions: Glioblastoma Interventions: Drug: PEP-CMV vaccine Sponsors: Charlotte Lemech; The University of New South Wales Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 15, 2023 Category: Research Source Type: clinical trials
Multicenter Evaluation of Near Vision and Outdoor Time in Kids Study
Conditions: Myopia Interventions: Device: Vivior Sponsors: The University of New South Wales; Queensland University of Technology; New England College of Optometry; State University of New York College of Optometry; University of California, Berkeley Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 6, 2023 Category: Research Source Type: clinical trials
NEO-adjuvant Chemo-immunotherapy in Pancreatic Cancer
Conditions: Pancreatic Cancer Interventions: Drug: Durvalumab; Drug: Oxaliplatin; Drug: Irinotecan; Drug: Calcium folinate (leucovorin); Drug: Fluorouracil; Drug: Pegylated G-CSF Sponsors: Australasian Gastro-Intestinal Trials Group; The University of New South Wales; Walter and Eliza Hall Institute of Medical Research Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 23, 2023 Category: Research Source Type: clinical trials
P-OMICs-flow: Integrating Precision Oncology Into Clinical Programs
Conditions: Cancer Interventions: Other: P-OMICs-flow services Sponsors: The University of New South Wales Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 11, 2023 Category: Research Source Type: clinical trials
Healthy Body & Mind Program for Older Adults Living With Osteoarthritis and Cognitive Decline
Conditions: Cognitive Decline; Osteoarthritis Interventions: Other: Healthy Body& Mind Program Sponsors: The University of New South Wales Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 6, 2023 Category: Research Source Type: clinical trials
