Assessment of lisdexamfetamine on executive function in rats: A translational cognitive research
Exp Neurol. 2024 Feb 8;374:114718. doi: 10.1016/j.expneurol.2024.114718. Online ahead of print.ABSTRACTExecutive function, including working memory, attention and inhibitory control, is crucial for decision making, thinking and planning. Lisdexamfetamine, the prodrug of d-amphetamine, has been approved for treating attention-deficit hyperactivity disorder and binge eating disorder, but whether it improves executive function under non-disease condition, as well as the underlying pharmacokinetic and neurochemical properties, remains unclear. Here, using trial unique non-matching to location task and five-choice serial reacti...
Source: Experimental Neurology - February 9, 2024 Category: Neurology Authors: Chen Jian-Min Wang Zhi-Yuan Liu Ke Zhang Cheng Wu Shi-Xuan Cao Yi-Wei Lu Guan-Yi Song Rui Zhuang Xiao-Mei Li Jin Wu Ning Source Type: research
Eating Disorders
Emerg Med Clin North Am. 2024 Feb;42(1):163-179. doi: 10.1016/j.emc.2023.06.024. Epub 2023 Aug 14.ABSTRACTAnorexia nervosa (AN) and bulimia nervosa (BN) are easily missed in the emergency department, because patients may present with either low, normal, or increased BMI. Careful examination for signs of purging and excessive use of laxatives and promotility agents is important. Careful examination for and documentation of dental erosions, posterior oropharyngeal bruising, Russel's sign, and salivary and parotid gland inflammation are clues to the purging behavior. Treatment for AN should include cognitive behavioral therap...
Source: The Medical Clinics of North America - November 17, 2023 Category: General Medicine Authors: Diane L Gorgas Source Type: research
Eating Disorders
Emerg Med Clin North Am. 2024 Feb;42(1):163-179. doi: 10.1016/j.emc.2023.06.024. Epub 2023 Aug 14.ABSTRACTAnorexia nervosa (AN) and bulimia nervosa (BN) are easily missed in the emergency department, because patients may present with either low, normal, or increased BMI. Careful examination for signs of purging and excessive use of laxatives and promotility agents is important. Careful examination for and documentation of dental erosions, posterior oropharyngeal bruising, Russel's sign, and salivary and parotid gland inflammation are clues to the purging behavior. Treatment for AN should include cognitive behavioral therap...
Source: The Medical Clinics of North America - November 17, 2023 Category: General Medicine Authors: Diane L Gorgas Source Type: research
Correction: Secondary outcomes and qualitative findings of an open-label feasibility trial of lisdexamfetamine dimesylate for adults with bulimia nervosa
(Source: Journal of Eating Disorders)
Source: Journal of Eating Disorders - November 16, 2023 Category: Eating Disorders & Weight Management Source Type: research
Medical Cannabis Legalization: No Contribution to Rising Stimulant
Rates in the USA
This study aimed to determine if MC legalization increased prescription
stimulant distribution.
Methods Information on the distribution of methylphenidate, amphetamine,
and lisdexamfetamine for 2006 to 2021 was extracted from the Drug Enforcement
Administration’s comprehensive database and the three-year
population-corrected slopes of stimulant distribution before and after MC
program implementation were compared.
Results We found a significant main effect of time
(p<0.001); however, contrary to the hypothesis, the sales status
of statesâ€...
Source: Pharmacopsychiatry - October 26, 2023 Category: Psychiatry Authors: Alexander, Garrett D. Cavanah, Luke R. Goldhirsh, Jessica L. Huey, Leighton Y. Piper, Brian J. Tags: Original Paper Source Type: research
Cost-effectiveness and budget impact analysis of lisdexamfetamine versus methylphenidate for patients under 18 with attention-deficit/hyperactivity disorder in Iran
Lisdexamfetamine (LDX) and Methylphenidate (MPH) are stimulant agents that have been shown to provide significant benefits in the management of attention-deficit/hyperactivity disorder (ADHD) in patients. (Source: Child and Adolescent Psychiatry and Mental Health)
Source: Child and Adolescent Psychiatry and Mental Health - October 10, 2023 Category: Psychiatry Authors: Amirmohammad Tajik, Shekoufeh Nikfar, Sepideh Elyasi, Omid Rajabi and Mehdi Varmaghani Tags: Research Source Type: research
Efficacy of stimulants for preschool attention-deficit/hyperactivity disorder: A systematic review and meta-analysis
CONCLUSIONS: Our findings demonstrated that stimulants are efficacious in reducing ADHD symptoms among preschool children. Clinicians should consider the use of stimulants when making treatment recommendations for preschoolers with ADHD.PMID:37720577 | PMC:PMC10501696 | DOI:10.1002/jcv2.12146 (Source: Adv Data)
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Luisa S Sugaya Luis C Farhat Pietro Califano Guilherme V Polanczyk Source Type: research
The Use of Lisdexamfetamine to Treat ADHD in a Patient with Stimulant (Methamphetamine) Use Disorder
CONCLUSION: Our patient's ADHD was successfully treated with lisdexamfetamine. Not only did the patient's ADHD symptoms improve, but his cravings for stimulants were relieved. ADHD is common among patients with stimulant use disorder. Patients with ADHD and stimulant use disorder should not necessarily forgo pharmacologic treatment with stimulants for concerns of abuse. Due to its unique pharmacokinetic profile, lisdexamfetamine is a feasible treatment for patients with ADHD and a history of stimulant use disorder.PMID:37609571 | PMC:PMC10442178 | DOI:10.1155/2023/5574677 (Source: Case Reports in Psychiatry)
Source: Case Reports in Psychiatry - August 23, 2023 Category: Psychiatry Authors: J Levine H Swanson Source Type: research
