Molecular Genetic Study on HAND2 Gene Promoter in Ventricular Septal Defect
Int Heart J. 2023;64(6):1140-1147. doi: 10.1536/ihj.22-721.ABSTRACTVentricular septal defect (VSD), the most common type of congenital heart disease (CHD), is primarily caused by cardiac dysplasia. Heart and neural crest derivatives expressed 2 (HAND2) participates in developing the right heart. The loss of HAND2 expression in humans is closely connected with ventricular septal defects. We used a case-control study to analyze the genetic variations in the HAND2 promoter region in VSD patients and controls. Some statistical analysis methods were used to analyze the association of single nucleotide polymorphisms (SNPs) with ...
Source: International Heart Journal - November 29, 2023 Category: Cardiology Authors: Meikun Li Yahui Cai Shuchao Pang Bo Yan Source Type: research
