Reviewing What is Known of the Mechanisms of Taurine Supplementation Relevant to Aging and Metabolism
Taurine is a semi-essential amino acid. Dietary taurine supplementation has been shown to modestly slow aging in mice, though as for all such interventions there is always the question of whether it will prove to be less useful in humans, and also whether these results in mice will be disproved by the much more rigorous Interventions Testing Program (ITP), once that group gets around to assessing taurine supplementation. Few of the numerous interventions thought to modestly slow aging in mice on the basis of earlier research actually held up once subjected to the ITP degree of experimental rigor.
Speculatively, taur...
Source: Fight Aging! - December 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Wound Sensor Patch Indicates Healing Status
Researchers at the National University of Singapore have created a wound sensor patch that measures various wound biomarkers that can indicate would healing. Chronic wounds are an ongoing problem for many patients, and developing new ways to monitor and treat these painful lesions would be very useful. This battery-free wound patch contains five colorimetric sensors that change color in response to various wound biomarkers. These include temperature, pH, trimethylamine, uric acid, and wound moisture levels. The patch is intended to be imaged using a smartphone camera, where an AI-powered app analyses the color change to di...
Source: Medgadget - July 24, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Diagnostics Medicine Surgery NUSingapore Source Type: blogs
Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
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Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Correlation Between a Worse Gut Microbiome and Aging of the Heart
The state of the gut microbiome may be as influential on health as exercise. The balance of microbial populations changes with age, in detrimental ways, for reasons that are not fully understood. The decline of the immune system, responsible for gardening the gut microbiome and defending intestinal tissue, may be one of the more important factors. With age, microbial populations producing beneficial metabolites decline in number, while populations contributing to chronic inflammation grow in number. There are interventions, such as fecal microbiota transplant, that can reverse these changes in a lasting way to improve heal...
Source: Fight Aging! - October 7, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging.
A Popular Science Article on the State of Epigenetic Clocks
https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/
This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Gut Microbiome Produces Metabolites that Affect Immune Cells in the Brain
Researchers here review the evidence for metabolites produced by the gut microbiome to influence the behavior of innate immune cells in the brain. The gut microbiome changes in composition with age, altering the production of metabolites and inflammatory signaling in ways that degrade tissue function throughout the body. Fixing the many resulting issues at the source by introducing a youthful mix of microbes to the aging gut is a tempting path forward, likely relatively straightforward to achieve via fecal microbiota transplantation from young individuals to old individuals. This short-cut would hopefully evade the onerous...
Source: Fight Aging! - September 30, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Red Meat Increases Cardiovascular Risk via Raised TMAO Production by the Gut Microbiome
More research into aging and the gut microbiome is taking place these days. A greater investment into this line of research will, as illustrated here, likely lead to a greater knowledge of the mechanisms underlying the known correlations between diet and age-related conditions. That red meat consumption increases cardiovascular risk is quite well established from epidemiological data, and here researchers outline their view of why this happens. One might contrast this with the present consensus, which is that red meat consumption increases lipid levels in the bloodstream, thereby accelerating atherosclerosis and consequent...
Source: Fight Aging! - December 31, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, January 4th 2021
The objective of this study is to quantify the overall and cancer type-specific risks of subsequent primary cancers (SPCs) among adult-onset cancer survivors by first primary cancer (FPC) types and sex. Among 1,537,101 survivors (mean age, 60.4 years; 48.8% women), 156,442 SPC cases and 88,818 SPC deaths occurred during 11,197,890 person-years of follow-up (mean, 7.3 years). Among men, the overall risk of developing any SPCs was statistically significantly higher for 18 of the 30 FPC types, and risk of dying from any SPCs was statistically significantly higher for 27 of 30 FPC types as compared with risks in the general po...
Source: Fight Aging! - January 3, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
A Look Back at 2020: Progress Towards the Treatment of Aging as a Medical Condition
While I suspect that COVID-19 will feature prominently in most retrospectives on 2020, I'll say only a little on it. The data on mortality by year end, if taken at face value, continues to suggest that the outcome will fall at the higher end of the early estimates of a pandemic three to six times worse than a bad influenza year, ten times worse than a normal influenza year. The people who die are near entirely the old, the co-morbid, and the immunocompromised. They die because they are suffering the damage and dysfunction of aging. Yet the societal conversation and the actions of policy makers ignore this.
There is ...
Source: Fight Aging! - December 31, 2020 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Fight Aging! Newsletter, July 13th 2020
In conclusion, sitting for prolonged periods of time without interruption is unfavorably associated with DBP and HDL cholesterol.
Exercise Slows Inappropriate Growth of Blood Vessels in a Mouse Model of Macular Degeneration
https://www.fightaging.org/archives/2020/07/exercise-slows-inappropriate-growth-of-blood-vessels-in-a-mouse-model-of-macular-degeneration/
Excessive growth of blood vessels beneath the retina is a proximate cause of blindness in conditions such as macular degeneration. Researchers here provide evidence for physical activity to be influential in the pace at which this process of tissu...
Source: Fight Aging! - July 12, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Aging Gut Microbiome Produces More Trimethylamine, Harming Arterial Function
In recent years academic interest has grown in the study of the gut microbiome. Researchers are making inroads into understanding the considerable influence of these microbial populations over the progression of health and aging. The gut microbiome may be as influential as physical activity in these matters. The balance of microbial populations shifts unfavorably over time, for reasons that are yet to be fully mapped and understood. This leads to greater numbers of inflammatory microbes, or those that produce harmful byproducts, and fewer microbes that produce beneficial metabolites. Researchers have identified some of the...
Source: Fight Aging! - July 8, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Rethinking the Chemical Reaction as a Graph: Imaginary Transition Structures and Beyond
ConclusionImaginary Transition Structures, and more broadly reaction graphs, offer a powerful abstraction for working with reactions. By encoding starting materials, products, and atom/bond mappings in a single graph, reaction analyses can take advantage of the same techniques developed for molecular graphs over the last 50 years. The appearance of the first study combining machine learning autoencoders with reaction graphs may foreshadow a renaissance in reaction cheminformatics, with reaction graphs leading the way. (Source: Depth-First)
Source: Depth-First - February 24, 2020 Category: Chemistry Authors: Richard L. Apodaca Source Type: blogs
Changes in the Gut Microbiome as the Cause of Inflammation and Oxidative Stress Leading to Vascular Dysfunction
Chronic inflammation and oxidative stress disrupt the function of smooth muscle cells in blood vessel walls. This is one of the contributing causes of vascular stiffness with age, alongside cross-links, calcification, and loss of elastin, all of which alter the structural properties of blood vessel tissue to produce a reduction in elasticity. There is the question of the relative importance of these contributions, a question that exists for most aspects of aging at the present time, lacking easy ways to remove only one contributing factor to assess the outcome. Nonetheless, the research results noted here suggest that smoo...
Source: Fight Aging! - March 22, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Top 10 Medical Innovations for 2014 - According to Cleveland Clinic
Here is the list of the Top 10 Medical Innovations for 2014 according to Cleveland Clinic:
No. 9. TMAO (trimethylamine N-oxide) is produced by the body when your gut bacteria digest choline, which is found in egg yolks, red meat and dairy products. TMAO may serve as a screening tool for predicting future risks of heart attack, stroke and death. Heart experts believe this discovery could lead to personalized nutrition recommendations to help patients reduce their cardiovascular risk:
Retinal Prosthesis System: 2014 Medical Innovation No. 1 - YouTube http://bit.ly/1ccURh1
Genome-guided Solid Tumor Diagnostics: 2014 Medi...
Source: Clinical Cases and Images - Blog - October 23, 2013 Category: Professors and Educators Tags: Video Cleveland Clinic Source Type: blogs
Top medicine articles for June-July 2013
Here are my suggestions for some of the top articles in medicine for June-July 2013:
Does Cigarette Smoking Make You Ugly and Old? Am. J. Epidemiol. Association of smoking and facial wrinkling may convince young persons not to begin smoking & older smokers to quit http://buff.ly/16g6NJe
"I COUGH" mnemonic: Reducing Postoperative Pulmonary Complications http://buff.ly/1e7ln6J
Perioperative beta blockers linked to lower 30-day mortality in patients with 2 or more Revised Cardiac Risk Index http://buff.ly/14PlJQq
"Trimethylamine-N-oxide (TMAO) is the new enemy within. We make it in our bowels" http://buff.ly/ZiM7KA
...
Source: Clinical Cases and Images - Blog - July 31, 2013 Category: Professors and Educators Tags: Health News of the Day Source Type: blogs
