A study on combination of non-ablative local RFA with PD-1 and angiogenesis blocking to prolong survival through improvement of immune microenvironment in advanced Hepatocellular Carcinoma
Int Immunopharmacol. 2024 May 10;134:112144. doi: 10.1016/j.intimp.2024.112144. Online ahead of print.ABSTRACTRadiofrequency ablation (RFA), an effective local treatment method for early-stage Hepatocellular Carcinoma (HCC), combined with PD-1 blocking and anti-angiogenic therapy is being extensively explored in advanced HCC, however, the definite results and underlying mechanisms still remain to be elucidated. Therefore, whether non-ablative RFA-based combined therapy can play a synergistic anti-tumor effect through improving tumor immune microenvironment was investigated by us in HCC mouse models. Our results showed that...
Source: International Immunopharmacology - May 11, 2024 Category: Allergy & Immunology Authors: Tianlin Xiao Sheng Hu Shuang Dong Qian Cai Wei Gong Yang Zhang Cheng Long Xiaoyu Li Source Type: research
A study on combination of non-ablative local RFA with PD-1 and angiogenesis blocking to prolong survival through improvement of immune microenvironment in advanced Hepatocellular Carcinoma
Int Immunopharmacol. 2024 May 10;134:112144. doi: 10.1016/j.intimp.2024.112144. Online ahead of print.ABSTRACTRadiofrequency ablation (RFA), an effective local treatment method for early-stage Hepatocellular Carcinoma (HCC), combined with PD-1 blocking and anti-angiogenic therapy is being extensively explored in advanced HCC, however, the definite results and underlying mechanisms still remain to be elucidated. Therefore, whether non-ablative RFA-based combined therapy can play a synergistic anti-tumor effect through improving tumor immune microenvironment was investigated by us in HCC mouse models. Our results showed that...
Source: International Immunopharmacology - May 11, 2024 Category: Allergy & Immunology Authors: Tianlin Xiao Sheng Hu Shuang Dong Qian Cai Wei Gong Yang Zhang Cheng Long Xiaoyu Li Source Type: research
Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) presenting as subacute psychosis: Case report and literature review
Key Clinical MessageClinicians should consider autoimmune thyroiditis in patients presenting with neuropsychiatric symptoms and promptly initiate appropriate investigations and treatment, such as corticosteroids, to improve clinical outcomes. (Source: Clinical Case Reports)
Source: Clinical Case Reports - May 11, 2024 Category: General Medicine Authors: Elabbass A. Abdelmahmuod,
Noor Jasim,
Buthaina Ibrahim,
Marwa Mokhtar Tags: CASE REPORT Source Type: research
Colchicine for the prevention of atrial fibrillation: Why do some studies say ‘yes’, and others say ‘no’?
Conditions provoking atrial fibrosis and atrial electrical conduction slowing can lead to the development of atrial fibrillation (AF), the most common cardiac arrhythmia [1]. AF risk factors include aging and conditions such as obesity, diabetes, thyroiditis, pulmonary arterial hypertension, or myocardial infarction [2,3,4]. Radiofrequency catheter ablation (RFCA) is a recognized intervention to treat AF [5]. Paradoxically, RFCA is designated among the important causes of postoperative AF (POAF) recurrence [6]. (Source: International Journal of Cardiology)
Source: International Journal of Cardiology - May 8, 2024 Category: Cardiology Authors: Abir Attia, Roddy Hiram Source Type: research
A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease
CONCLUSIONS: This MR analysis concluded that selenium was not linked to AIT, AIH, or GD risk. Therefore, indiscriminate selenium supplementation is not advisable for AITD patients without concurrent selenium deficiency.PMID:38708455 | DOI:10.26355/eurrev_202404_36011 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2024 Category: Drugs & Pharmacology Authors: C Hu Y-F Yu K-K Tong G Hu J-Y Wu X-Y Yang S-Y Bai R Yu Y-Y Li Source Type: research
A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease
CONCLUSIONS: This MR analysis concluded that selenium was not linked to AIT, AIH, or GD risk. Therefore, indiscriminate selenium supplementation is not advisable for AITD patients without concurrent selenium deficiency.PMID:38708455 | DOI:10.26355/eurrev_202404_36011 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 6, 2024 Category: Drugs & Pharmacology Authors: C Hu Y-F Yu K-K Tong G Hu J-Y Wu X-Y Yang S-Y Bai R Yu Y-Y Li Source Type: research
A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease
CONCLUSIONS: This MR analysis concluded that selenium was not linked to AIT, AIH, or GD risk. Therefore, indiscriminate selenium supplementation is not advisable for AITD patients without concurrent selenium deficiency.PMID:38708455 | DOI:10.26355/eurrev_202404_36011 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - May 6, 2024 Category: Drugs & Pharmacology Authors: C Hu Y-F Yu K-K Tong G Hu J-Y Wu X-Y Yang S-Y Bai R Yu Y-Y Li Source Type: research
A Mendelian randomization study of the effect of selenium on autoimmune thyroid disease
CONCLUSIONS: This MR analysis concluded that selenium was not linked to AIT, AIH, or GD risk. Therefore, indiscriminate selenium supplementation is not advisable for AITD patients without concurrent selenium deficiency.PMID:38708455 | DOI:10.26355/eurrev_202404_36011 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - May 6, 2024 Category: Drugs & Pharmacology Authors: C Hu Y-F Yu K-K Tong G Hu J-Y Wu X-Y Yang S-Y Bai R Yu Y-Y Li Source Type: research
