Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its metabolite in aquatic organisms
In this study, we tested to what extent bioconcentration of an anxiolytic drugs (temazepam and oxazepam) is affected by two temperature regimes (10 and 20 °C) and how the temperature affects the temazepam biotransformation and subsequent accumulation of its metabolite (oxazepam) in aquatic organisms. We used European perch (Perca fluviatilis) and dragonfly larvae (Sympetrum sp.), which represent predator and prey species of high ecological relevance in food chains of boreal and temperate aquatic ecosystems. Experimental organisms were exposed to target pharmaceuticals at a range of concentrations (0.2-6 µg L-1) to study ...
Source: Environment International - June 17, 2021 Category: Environmental Health Authors: D Cerveny J Fick J Klaminder E S McCallum M G Bertram N A Castillo T Brodin Source Type: research
Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its metabolite in aquatic organisms
In this study, we tested to what extent bioconcentration of an anxiolytic drugs (temazepam and oxazepam) is affected by two temperature regimes (10 and 20 °C) and how the temperature affects the temazepam biotransformation and subsequent accumulation of its metabolite (oxazepam) in aquatic organisms. We used European perch (Perca fluviatilis) and dragonfly larvae (Sympetrum sp.), which represent predator and prey species of high ecological relevance in food chains of boreal and temperate aquatic ecosystems. Experimental organisms were exposed to target pharmaceuticals at a range of concentrations (0.2-6 µg L-1) to study ...
Source: Environment International - June 17, 2021 Category: Environmental Health Authors: D Cerveny J Fick J Klaminder E S McCallum M G Bertram N A Castillo T Brodin Source Type: research
Challenges in the Treatment of Restless Legs Syndrome: A Case Report
This report demonstrates a challenging case of RLS in the setting of psychiatric comorbidities, development of augmentation, and polypharmacy.PMID:34032164 | DOI:10.1177/21501327211019590 (Source: Primary Care)
Source: Primary Care - May 25, 2021 Category: Primary Care Authors: Audrey Umbreit Shirshendu Sinha Bhanu Prakash Kolla Meghna P Mansukhani Source Type: research
Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018
CONCLUSION: Overall, BZD prescriptions in Australia declined from 2011-2018. However, the prescription of some of these drugs increased for patients with a recently recorded insomnia diagnosis. This is concerning because of potential adverse effects and risk of dependence.PMID:33950853 | DOI:10.3399/BJGP.2021.0054 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 5, 2021 Category: Primary Care Authors: Mumtaz Begum David Gonzalez-Chica Carla Bernardo Amelia Woods Nigel Stocks Source Type: research
Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018
CONCLUSION: Overall, BZD prescriptions in Australia declined from 2011-2018. However, the prescription of some of these drugs increased for patients with a recently recorded insomnia diagnosis. This is concerning because of potential adverse effects and risk of dependence.PMID:33950853 | DOI:10.3399/BJGP.2021.0054 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 5, 2021 Category: Primary Care Authors: Mumtaz Begum David Gonzalez-Chica Carla Bernardo Amelia Woods Nigel Stocks Source Type: research
Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018
CONCLUSION: Overall, BZD prescriptions in Australia declined from 2011-2018. However, the prescription of some of these drugs increased for patients with a recently recorded insomnia diagnosis. This is concerning because of potential adverse effects and risk of dependence.PMID:33950853 | DOI:10.3399/BJGP.2021.0054 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 5, 2021 Category: Primary Care Authors: Mumtaz Begum David Gonzalez-Chica Carla Bernardo Amelia Woods Nigel Stocks Source Type: research
Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018
CONCLUSION: Overall, BZD prescriptions in Australia declined from 2011-2018. However, the prescription of some of these drugs increased for patients with a recently recorded insomnia diagnosis. This is concerning because of potential adverse effects and risk of dependence.PMID:33950853 | DOI:10.3399/BJGP.2021.0054 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 5, 2021 Category: Primary Care Authors: Mumtaz Begum David Gonzalez-Chica Carla Bernardo Amelia Woods Nigel Stocks Source Type: research
Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018
CONCLUSION: Overall, BZD prescriptions in Australia declined from 2011-2018. However, the prescription of some of these drugs increased for patients with a recently recorded insomnia diagnosis. This is concerning because of potential adverse effects and risk of dependence.PMID:33950853 | DOI:10.3399/BJGP.2021.0054 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 5, 2021 Category: Primary Care Authors: Mumtaz Begum David Gonzalez-Chica Carla Bernardo Amelia Woods Nigel Stocks Source Type: research
Trends in the prescription of drugs used for insomnia in Australian general practice, 2011-2018
CONCLUSION: Overall, BZD prescriptions in Australia declined from 2011-2018. However, the prescription of some of these drugs increased for patients with a recently recorded insomnia diagnosis. This is concerning because of potential adverse effects and risk of dependence.PMID:33950853 | DOI:10.3399/BJGP.2021.0054 (Source: The British Journal of General Practice)
Source: The British Journal of General Practice - May 5, 2021 Category: Primary Care Authors: Mumtaz Begum David Gonzalez-Chica Carla Bernardo Amelia Woods Nigel Stocks Source Type: research
Exposure via biotransformation: Oxazepam reaches predicted pharmacological effect levels in European perch after exposure to temazepam
Ecotoxicol Environ Saf. 2021 Apr 23;217:112246. doi: 10.1016/j.ecoenv.2021.112246. Online ahead of print.ABSTRACTIt is generally expected that biotransformation and excretion of pharmaceuticals occurs similarly in fish and mammals, despite significant physiological differences. Here, we exposed European perch (Perca fluviatilis) to the benzodiazepine drug temazepam at a nominal concentration of 2 µg L-1 for 10 days. We collected samples of blood plasma, muscle, and brain in a time-dependent manner to assess its bioconcentration, biotransformation, and elimination over another 10 days of depuration in clean water. We obser...
Source: Ecotoxicology and Environmental Safety - April 26, 2021 Category: Environmental Health Authors: Daniel Cerveny Jerker Fick Jonatan Klaminder Michael G Bertram Tomas Brodin Source Type: research
Molecules, Vol. 26, Pages 2372: Fully Automated Synthesis of Novel TSPO PET Imaging Ligand [18F]Fluoroethyltemazepam
Conclusion: This automated procedure may be used as basis for future production of [18F]F-FETEM for preclinical PET imaging studies. (Source: Molecules)
Source: Molecules - April 19, 2021 Category: Chemistry Authors: Dario Fiorenza Emanuele Nicolai Carlo Cavaliere Ferdinando Fiorino Giovanna Esposito Marco Salvatore Tags: Article Source Type: research
Gene alteration in zebrafish exposed to a mixture of substances of abuse
Environ Pollut. 2021 Feb 24;278:116777. doi: 10.1016/j.envpol.2021.116777. Online ahead of print.ABSTRACTA recent surge in the use and abuse of diverse prescribed psychotic and illicit drugs necessitates the surveillance of drug residues in source water and the associated ecological impacts of chronic exposure to the aquatic organism. Thirty-six psychotic and illicit drug residues were determined in discharged wastewater from two centralized municipal wastewater treatment facilities and two wastewater receiving creeks for seven consecutive days in Kentucky. Zebrafish (Danio rerio) larvae were exposed to the environmental r...
Source: Environmental Pollution - March 10, 2021 Category: Environmental Health Authors: B Subedi S Anderson T L Croft E C Rouchka M Zhang D R Hammond-Weinberger Source Type: research
Gene alteration in zebrafish exposed to a mixture of substances of abuse
Environ Pollut. 2021 Feb 24;278:116777. doi: 10.1016/j.envpol.2021.116777. Online ahead of print.ABSTRACTA recent surge in the use and abuse of diverse prescribed psychotic and illicit drugs necessitates the surveillance of drug residues in source water and the associated ecological impacts of chronic exposure to the aquatic organism. Thirty-six psychotic and illicit drug residues were determined in discharged wastewater from two centralized municipal wastewater treatment facilities and two wastewater receiving creeks for seven consecutive days in Kentucky. Zebrafish (Danio rerio) larvae were exposed to the environmental r...
Source: Environmental Pollution - March 10, 2021 Category: Environmental Health Authors: B Subedi S Anderson T L Croft E C Rouchka M Zhang D R Hammond-Weinberger Source Type: research
Vasorelaxant effects of benzodiazepines, non-benzodiazepine sedative-hypnotics, and tandospirone on isolated rat arteries.
In conclusion, the direct vasodilatory effects of these drugs may be involved in the mechanisms underlying their adverse effects. Additionally, the decreased BP observed in persons who take BDZs or non-BDZs may be partly due to direct vasodilation.
PMID: 33220270 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)
Source: European Journal of Pharmacology - November 18, 2020 Category: Drugs & Pharmacology Authors: Kagota S, Morikawa K, Ishida H, Chimoto J, Maruyama-Fumoto K, Yamada S, Shinozuka K Tags: Eur J Pharmacol Source Type: research
Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo
ConclusionsThis study demonstrates that imperatorin inhibits the metabolism of diazepam both in vitro and in vivo. These results indicated that more attention should be paid when taking diazepam together with food or herbs containing IMP, although further investigation is still needed. (Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - September 15, 2020 Category: Drugs & Pharmacology Source Type: research
