Fight Aging! Newsletter, June 19th 2017
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span.
Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 18, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Update on the Effects on PAPP-A Knockout on Longevity in Mice
This study is the first to show that downregulation of PAPP-A expression in adult mice can significantly extend life span.
Importantly, this beneficial longevity phenotype is distinct from the dwarfism of long-lived PAPP-A KO, Ames dwarf, Snell dwarf and growth hormone receptor (GHR) KO mice with germ-line mutations. Thus, downregulation of PAPP-A expression joins other treatment regimens, such as resveratrol, rapamycin and dietary restriction, which can extend life span when started in mice as adults. In a recent study, inducible knockdown of the GHR in young adult female mice increased maximal, but not median, lif...
Source: Fight Aging! - June 13, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Why Bother?
For some reason I have had a similar conversation with different women on the same topic: why take tamoxifen or aromatase inhibitors after initial breast cancer treatment. Aromatase inhibitors are Arimidex (anastrozole), Aromasin (exemestane), and Femara (letrozole)The conversations all boil down to:What if I get side effects? They have heard they are awful and could cause them some real problems. But if you don ' t even try them how will you know if you will experience the side effects?What exactly do they do? They don ' t really understand that they would reduce their recurrence risk by being on themWhy do I have to be o...
Source: Caroline's Breast Cancer Blog - March 8, 2017 Category: Cancer & Oncology Tags: doctors medications side effects Source Type: blogs
Understanding GP attitudes to cancer preventing drugs
This report aims to increase understanding of GP attitudes towards offering cancer preventing drugs and it found that nearly half of GP respondents were unaware of the potential benefits of tamoxifen, a drug that can potentially prevent breast cancer among women with a clear family history of the disease. Despite low levels of awareness, three quarters of respondents were willing to prescribe it but required greater support from specialists in secondary care.ReportSummaryPress release (Source: Health Management Specialist Library)
Source: Health Management Specialist Library - February 13, 2017 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Tags: Quality of care and clinical outcomes Source Type: blogs
A Really Good Reason For Not Eating Tofu
I have been aided in avoiding tofu by the confusion over whether eating soy contributes to breast cancer growth. I really hate tofu. My mother fed it to us as children and I didn ' t like it then and I don ' t like it now. I might eat a little bit in my hot and sour soup but I will never order a dish which is tofu based.But now (finally) we have clarification on the soy or no soy for women with breast cancer:The issue is eating soy products seems to give women protection from breast cancer. Asian countries where soy products are eaten regularly have much lower rates of breast cancer than the US. But the estrogen-similar st...
Source: Caroline's Breast Cancer Blog - February 3, 2017 Category: Cancer & Oncology Tags: breast cancer cancer recurrence cancer risk soy tofu Source Type: blogs
News I Didn't Want To Hear or Dumb A$$ Cancer Cells
This isn ' t political news but it is really news that I didn ' t want to hear. Tamoxifen and AIs (Aromatase Inhibitors - Femara, Aromasin, etc) work by cutting off the supply of estrogen which feeds cancer cells. However thenew research (because we need new research forever) shows that cancer cells can evolve to develop their own food supply if it is cut off by the treatment." Approximately 70% of breast cancers are estrogen receptor positive which means they feed on the hormone estrogen. Breast cancer drugs such as tamoxifen and the aromatase inhibitors work by limiting access to estrogen thereby starving the cancer...
Source: Caroline's Breast Cancer Blog - January 25, 2017 Category: Cancer & Oncology Tags: breast cancer bonds breast cancer treatment Source Type: blogs
The Science of Doping: Gaming Hormones, Asthma Drugs, and More
From WSJ: Doctors often prescribe tamoxifen to breast cancer patients to keep their tumors from growing. But the drug is also used by doping athletes looking to get ahead of the competition. How does it give them an edge, biologically? Watch the video below:Earlier this year, British cyclist Simon Yates was caught up in a doping controversy related to terbutaline, a common asthma medication. Athletes can take the inhaled version if they get a doctor's note. But current testing methods can't differentiate between this and other banned versions. Watch the video below:Related:The Science of Doping: How Testosterone-Boosting D...
Source: Clinical Cases and Images - Blog - August 29, 2016 Category: Universities & Medical Training Tags: Sports WSJ Source Type: blogs
That Er+/Pr+ Thing
So I haven always known (well since my diagnosis - before my diagnosis what I knew about breast cancer wouldn't fill a post-it) that have a hormone receptor positive breast cancer had a lot of impact on your treatment protocol. But I didn't know that much about how that worked.Now I am learning more. In the past, estrogen was considered to be the indicator of breast cancer diagnosis. When estrogen was detector at a biopsy, it was considered an indicator of breast cancer. Now it has been determined that progesterone has a big impact as well."Previous studies have demonstrated that estrogen receptors react to the primary fem...
Source: Caroline's Breast Cancer Blog - June 28, 2016 Category: Cancer & Oncology Tags: breast cancer breast cancer treatment hormone receptor status Source Type: blogs
The human cost of breast cancer screening
This article originally appeared in Forbes.
Image credit: Shutterstock.com
Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how. (Source: Kevin, M.D. - Medical Weblog)
Source: Kevin, M.D. - Medical Weblog - September 18, 2015 Category: Journals (General) Authors: Peter Ubel, MD Tags: Conditions Cancer Source Type: blogs
Sen. Bernie Sanders Announces "Prescription Drug Affordability Act of 2015"
Pushes for Lower Drug Prices Through Variety of Measures Including Drug Pricing Transparency; Allowing Part D Negotiations; Imports Of Cheaper Drugs from Canada; Increased Fraud Penalties
Taking a break from campaigning for President, Sen. Bernie Sanders (I-VT) and House Oversight and Government Reform Committee Ranking Member Elijah Cummings (D-MD) introduced legislation to address high prescription drug prices called the “Prescription Drug Affordability Act of 2015.” Announcing the Act, Sandars said: “the American people pay, by far, the highest prices for prescription drugs in the entire world...
Source: Policy and Medicine - September 15, 2015 Category: American Health Authors: Thomas Sullivan Source Type: blogs
MKSAP: 54-year-old woman asking advice about bone health
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 54-year-old woman comes to the office for advice regarding maintaining bone health. She has no history of fracture. The patient recently had a lumpectomy and radiation therapy to treat breast cancer, is currently taking tamoxifen, and will begin taking an aromatase inhibitor in 2 months. She underwent menopause at age 52 years and has persistent hot flushes. Her risk factors for osteoporosis include a slim body habitus and a mother who had a hip fracture at age 67 years.
Physical examination findings, includin...
Source: Kevin, M.D. - Medical Weblog - March 21, 2015 Category: Journals (General) Authors: mksap Tags: Conditions Endocrinology Source Type: blogs
NT3 and Regeneration from Noise-Induced Deafness
Deafness due to noise exposure is apparently due in part to destruction of specific forms of synapses linking hair cells and nerve cells. Researchers are here manipulating cells in search of ways to boost the regrowth of these synapses:
NT3 is crucial to the body's ability to form and maintain connections between hair cells and nerve cells, the researchers demonstrate. This special type of connection, called a ribbon synapse, allows extra-rapid communication of signals that travel back and forth across tiny gaps between the two types of cells. "It has become apparent that hearing loss due to damaged ribbon synapses is a v...
Source: Fight Aging! - October 21, 2014 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
WIH Researchers Examine Role of Hormone HE4 in Patient Responses to Ovarian Cancer Treatment
Researchers at Women & Infants’ Hospital of Rhode Island recently published the results of an investigation into the role of hormone HE4 in patient responses to ovarian cancer treatment. (Source: Libby's H*O*P*E*)
Source: Libby's H*O*P*E* - September 19, 2014 Category: Cancer & Oncology Authors: Paul Cacciatore Tags: Anti-Estrogen Therapy Discoveries Preclinical Testing fulvestrant hormone HE4 ivermectin ovarian cancer Richard G. Moore MD tamoxifen Women & Infants Hospital Source Type: blogs
