GSE127944 In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [eCLIPseq]
Contributors : Laura P de Rooij ; Ana Vujovic ; Sampath Loganathan ; Brian Yee ; Ava K Chahi ; Derek C Chan ; Amanda Tajik ; Sasan Zandi ; Nicholas Wong ; Stefan Aigner ; John E Dick ; Mark D Minden ; Daniel Schramek ; Gene W Yeo ; Kristin J HopeSeries Type : OtherOrganism : Mus musculusRNA binding protein (RBP)-directed post-transcriptional control of stem cell fate represents an underexplored mechanism driving hematopoietic stemness and transformation. We show that a unique set of RBPs are specifically enriched in leukemic stem cells (LSCs) of human primary acute myeloid leukemia (AML) but repressed in normal hem...
Source: GEO: Gene Expression Omnibus - January 18, 2023 Category: Genetics & Stem Cells Tags: Other Mus musculus Source Type: research
GSE127743 In vivo CRISPR screening unveils RNA binding protein dependencies for leukemic stem cells and identifies ELAVL1 as a potential therapeutic target [RNA-seq]
Contributors : Laura P de Rooij ; Ana Vujovic ; Sampath Loganathan ; Brian A Yee ; Ava K Chahi ; Derek C Chan ; Amanda Tajik ; Sasan Zandi ; Nicholas Wong ; Stefan Aigner ; John E Dick ; Mark D Minden ; Daniel Schramek ; Gene W Yeo ; Kristin J HopeSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusRNA binding protein (RBP)-directed post-transcriptional control of stem cell fate represents an underexplored mechanism driving hematopoietic stemness and transformation. We show that a unique set of RBPs are specifically enriched in leukemic stem cells (LSCs) of human primary acute myel...
Source: GEO: Gene Expression Omnibus - January 18, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
Biological Features of CD5+ CD19+ B1 Cell and Natural IgM (VH4-34) in Chronic Lymphocytic Leukemia vs. Multiple Sclerosis
Iran J Allergy Asthma Immunol. 2022 Dec 24;21(6):670-676. doi: 10.18502/ijaai.v21i6.11527.ABSTRACTChronic lymphocytic leukemia (CLL) is the clonal expansion of mature CD5+ B cells and the most common lymphoproliferative disease in adults (B1-CLL). B1 cells' anti-inflammatory effects include the production of natural IgM (nIgM) by the spleen and bone marrow, decreased inflammatory cytokines as a primary response to maintaining tissue homeostasis, and enhanced release of transforming growth factor β (TGFβ). We used the flow cytometry technique in peripheral blood from patients with CLL and multiple sclerosis (MS) to immuno...
Source: Iranian Journal of Allergy, Asthma and Immunology - January 14, 2023 Category: Allergy & Immunology Authors: Shaghayegh Pezeshki Mir Hadi Jazayeri Bahram Chahardouli Nader Tajik Seyyed Massood Nabavi Mahdi Akbarzadeh Source Type: research
