Pancreatic Cancer Detection Consortium: Research Units (U01 Clinical Trial Optional)
Funding Opportunity PAR-21-334 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for the Research Units (RUs), one of the two scientific components of the Pancreatic Cancer Detection Consortium (PCDC), to conduct research on early detection of pancreatic ductal adenocarcinoma (PDAC) and characterization of its precursor lesions to identify those patients who are at high risk of progression to cancer. The PCDC will continue to address one of the four research priorities identified in the National Cancer Institute's 2014 Scientific Framework ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - September 16, 2021 Category: Research Source Type: funding
Translational and Basic Science Research in Early Lesions (TBEL) Coordinating and Data Management Center (U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-21-055 from the NIH Guide for Grants and Contracts. The TBEL program aims to integrate basic and translational cancer research concepts to examine the direct causal relationships and interactions of an early lesion, its microenvironment, and host-systemic factors as co-organizers of tumor initiation (or suppression) and malignant progression. The ultimate goals of the TBEL program are to further understand the biological and pathophysiological mechanisms driving or restraining precancers and early cancers and facilitate biology-backed precision prevention approaches. The responsibilities of th...
Source: NIH Funding Opportunities (Notices, PA, RFA) - August 31, 2021 Category: Research Source Type: funding
Investigator Initiated Research in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed)
Funding Opportunity PAR-21-255 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early-stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical ge...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 29, 2021 Category: Research Source Type: funding
Investigator Initiated Research in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed)
Funding Opportunity PAR-21-254 from the NIH Guide for Grants and Contracts. The purpose of this funding opportunity announcement (FOA) is to invite applications for a broad range of research efforts in computational genomics, data science, statistics, and bioinformatics relevant to one or both of basic or clinical genomic science, and broadly applicable to human health and disease. This FOA supports fundamental genomics research developing innovative analytical methodologies and approaches, early-stage development of tools and software, and refinement or hardening of software and tools of high value to the biomedical ge...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 29, 2021 Category: Research Source Type: funding
Canine Cancer Immunotherapy Network (K9CIN; U01 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-21-050 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support canine clinical studies using immunotherapeutic agents and novel drug combinations together with laboratory correlative studies that seek to characterize and understand the cellular and molecular mechanisms that determine anti-tumor responses (or non-responses) in pet dogs with spontaneous tumors. The goal is to create a network of laboratories and canine clinical trial sites. The proposed clinical studies must include therapeutic modulation ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 27, 2021 Category: Research Source Type: funding
Coordinating Center for Canine Cancer Immunotherapy Network (K9CIN; U24 Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-21-051 from the NIH Guide for Grants and Contracts. Through this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI) will support a coordinating center to facilitate coordination across the Canine Cancer Immunotherapy Network (K9CIN; see U01 awards supported under companion RFA-CA-21-050) that will conduct immunotherapy clinical trials in pet dogs with spontaneous tumors and perform laboratory correlative studies associated with the clinical trials. The network will include a representative from the NCI Comparative Oncology Program (COP) of the NCI's Center for Cancer R...
Source: NIH Funding Opportunities (Notices, PA, RFA) - July 27, 2021 Category: Research Source Type: funding
Further Demographic Analyses of NIH R01 Grant Outcomes of T32 Postdoctoral Participants
Introduction
Postdoctoral NIH T32 programs aim to provide select trainees with experience to enable successful career and research development. In a previous posting, we presented NIH career development, or K award, and R01 equivalent research grant outcomes of participants in post-doctoral T32 programs. We showed that that men with MD-PhD degrees had the highest rates for R01 application submission and award receipt (as PI). Women comprised a greater proportion of trainees over time. Serving as PI on a K-awards predicted a substantially higher rate of later support as PI on R01 awards. Here we present further analyses foc...
Source: NIH Extramural Nexus - July 27, 2021 Category: Research Authors: Mike Lauer Tags: blog Open Mike Source Type: funding
Data on Implementing NIH ’s Next Generation Researchers Initiative
Discussion Rate” is, like the Funding Rate a person-based metric, and is calculated as the percent of applicants (actually people designated as PI’s on an application) who had at least one application make it to the discussion stage of peer review.
As Table 2 indicates, discussion and funding rates in FY 2020 are higher for women in the At Risk and New Not Early groups, but not for the Early Stage and Established groups. Women comprise a greater proportion of Early-Stage Investigator applicants (46%) than any of the other groups including New Investigators, At Risk Investigators and Established Investigators (e.g., wom...
Source: NIH Extramural Nexus - July 12, 2021 Category: Research Authors: Mike Lauer Tags: blog Open Mike at risk investigators Early Stage Investigators ESI funding Funding data NGRI scientific workforce diversity Source Type: funding
Common Data Elements: Increasing FAIR Data Sharing
This article was originally published in the National Library of Medicine’s blog, Musings from the Mezzanine.
Carolina Mendoza-Puccini, MD, CDE Program Officer, Division of Clinical Research, National Institute of Neurological Disorders and Stroke (NINDS)
Kenneth J. Wilkins, PhD, Mathematical Statistician, Biostatistics Program and Office of Clinical Research Support, Office of the Director, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Previous posts published in Musings from the Mezzanine have explained the importance of health data standards and their role as the backbone of interop...
Source: NIH Extramural Nexus - June 24, 2021 Category: Research Authors: Carolina Mendoza-Puccini and Kenneth J. Wilkins Tags: blog Open Mike common data elements Data sharing FAIR Source Type: funding
New and Updated Resources Available to Help Design Rigorous Clinical Trials
David M. Murray, Ph.D., NIH Associate Director for PreventionDirector, Office of Disease Prevention
We have embarked on a series of initiatives at NIH in recent years to enhance the quality, efficiency, accountability, and transparency of our supported clinical research. While we are all making great progress, our concerns about clinical trials that are overly complex, have small sample sizes, or rely on surrogate end points that lack clinical relevance remain. One resource to help address these concerns is the NIH Research Methods Resources website that NIH’s Office of Disease Prevention (ODP) launched in 2017. Since th...
Source: NIH Extramural Nexus - June 9, 2021 Category: Research Authors: David Murray Tags: blog Open Mike Clinical Trials New Resources webinar Source Type: funding
BRAIN Initiative: Optimization of Transformative Technologies for Recording and Modulation in the Nervous System (U01 Clinical Trials Not Allowed)
Funding Opportunity RFA-NS-21-027 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-019: Understanding the dynamic activity of neural circuits is central to the NIH BRAIN Initiative. The invention, proof-of-concept investigation, and optimization of new technologies through iterative feedback from end users are key components of the BRAIN Initiative. This FOA seeks applications to optimize existing or emerging technologies through iterative testing with end users. The technologies and approaches should have potential to address major challenges associated with recording and modulation (including various ...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 8, 2021 Category: Research Source Type: funding
BRAIN Initiative: New Technologies and Novel Approaches for Recording and Modulation in the Nervous System (R01 Clinical Trial Not Allowed)
Funding Opportunity RFA-NS-21-026 from the NIH Guide for Grants and Contracts. Reissue of RFA-NS-18-020: Understanding the dynamic activity of brain circuits is central to the NIH BRAIN Initiative. This FOA seeks applications for proof-of-concept testing and development of new technologies and novel approaches for recording and modulation (including various modalities for stimulation/activation, inhibition and manipulation) of cells (i.e., neuronal and non-neuronal) and networks to enable transformative understanding of dynamic signaling in the central nervous system (CNS). This FOA seeks exceptionally creative approach...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 8, 2021 Category: Research Source Type: funding
An Updated Look at Applications Submitted During the Pandemic
In a previous post, we looked at the gender distribution of designated principal investigators (PI’s) of R01 and Research Project Grant (RPG) applications submitted before and after the onset of the COVID-19 pandemic. Since that time, we have paid close attention to the well-being of the extramural biomedical research workforce, in part through our survey of institutional leaders and scientists. Others have followed preprint postings and publications, finding evidence of the pandemic’s disproportionate effects. Here we look at NIH R01 and RPG application patterns for January 1 through April 8 over the past 6 years...
Source: NIH Extramural Nexus - June 1, 2021 Category: Research Authors: Mike Lauer Tags: blog Open Mike Award Programs COVID-19 Diversity Funding data R01 RPG Source Type: funding
The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed)
Funding Opportunity RFA-CA-21-035 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to solicit applications for Biomarker Characterization Centers (BCCs), one of the three scientific units of the Early Detection Research Network (EDRN). The EDRN is a national infrastructure to discover, develop, and validate biomarkers and imaging methods for early cancer detection and risk assessment. BCCs will (1) discover, develop, characterize and test new biomarkers or refine existing biomarkers, (2) develop, refine and/or standardize biomarker assays, (3) provide resources a...
Source: NIH Funding Opportunities (Notices, PA, RFA) - June 1, 2021 Category: Research Source Type: funding
CDC Health Science Fellowship
A research training opportunity with the Centers for Disease Control to conduct statistical analyses in the field of injury public health, including projects examining variations in fatal and nonfatal injury rates between rural and urban populations. Geographic coverage: Nationwide -- Centers for Disease Control and Prevention, Oak Ridge Institute for Science and Education, U.S. Department of Health and Human Services (Source: Funding opportunities via the Rural Health Information Hub)
Source: Funding opportunities via the Rural Health Information Hub - May 28, 2021 Category: American Health Source Type: funding
