Testing the Addition of an Investigational Drug, Xevinapant, to Usual Radiation Therapy Plus Cisplatin/Carboplatin for Patients With Head and Neck Cancer
Conditions: Head and Neck Squamous Cell Carcinoma; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma; Oral Cavity Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma; Stage III Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage III Hypopharyngeal Carcinoma AJCC v8; Stage III Laryngeal Cancer AJCC v8; Stage III Lip and Oral Cavity Cancer AJCC v8; Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8; Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8; Stage IV Hypopharyngeal Carcinoma AJCC v8; Stage IV Laryngeal Cancer AJCC v8; Stage IV Lip and Or...
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials

Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400
Conditions: Hepatocellular Carcinoma; Pancreatic Ductal Adenocarcinoma; Biliary Tract Cancers; Esophageal Squamous Cell Carcinoma; Triple Negative Breast Cancer; Hormone Receptor+/Human Epidermal Growth Factor Receptor 2 Negative Breast Cancer; Head and Neck Squamous-Cell Carcinoma Interventions: Drug: ABBV-400 Sponsors: AbbVie Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 16, 2023 Category: Research Source Type: clinical trials

Toripalimab in Combined With Cetuximab ,Chemotherapy for Conversion Therapy of Locally Nonresectable OCSCC
Conditions: Squamous Cell Carcinoma of Head and Neck Interventions: Drug: Toripalimab Sponsors: First Affiliated Hospital of Zhejiang University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2023 Category: Research Source Type: clinical trials

Study of Zanzalintinib (XL092) + Pembrolizumab vs Pembrolizumab in Subjects With PD-L1 Positive Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
Conditions: Head and Neck Squamous Cell Carcinoma Interventions: Drug: Zanzalintinib; Drug: Zanzalintinib-matched Placebo; Biological: Pembrolizumab Sponsors: Exelixis Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2023 Category: Research Source Type: clinical trials

Penpulimab Combined With Chemotherapy for Neoadjuvant and Adjuvant Therapy in Patients With Resectable HNSCC
Conditions: Head and Neck Squamous Cell Carcinoma Interventions: Drug: Penpulimab injection; Drug: cisplatin; Drug: albumin-paclitaxel Sponsors: Shanghai Ninth People ' s Hospital Affiliated to Shanghai Jiao Tong University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 13, 2023 Category: Research Source Type: clinical trials

IBI110 Combined With Sintilimab in Second-line Advanced or Metastatic Esophageal Squamous Cell Carcinoma(ESCC)
Conditions: Esophageal Squamous Cell Carcinoma (ESCC); PD-1 Inhibitors Interventions: Drug: IBI110+Sintilimab Sponsors: The First Affiliated Hospital of Zhengzhou University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2023 Category: Research Source Type: clinical trials

Molecular Characterization of Penile Cancers in Developing Countries
Conditions: Penile Squamous Cell Carcinoma Sponsors: Latin American Cooperative Oncology Group; Roche Pharma AG Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 5, 2023 Category: Research Source Type: clinical trials

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
Conditions: Metastatic Head-and-neck Squamous-cell Carcinoma; Recurrent Head and Neck Squamous Cell Carcinoma Interventions: Biological: Ficlatuzumab; Biological: Cetuximab; Other: Placebo Sponsors: AVEO Pharmaceuticals, Inc. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials

High-concentration Small-volume Versus Low-concentration Large-volume Iodine Solution for Esophageal Chromoendoscopy
Conditions: Esophageal Squamous Cell Carcinoma Interventions: Drug: 1% Lugol ' s iodine solution; Drug: 5% Lugol ' s iodine solution Sponsors: Xijing Hospital of Digestive Diseases; Ankang Central Hospital; The First Affiliated Hospital of ShiheziI University; Xi ' an International Medical Center Hospital; Air Force 986 Hospital; Xianyang Central Hospital (the second people ' s Hospital of Xianyang City) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2023 Category: Research Source Type: clinical trials

Phase 2 Platform Study of Novel Immunotherapy Combinations as First-Line Treatment in Participants With PD-L1 Positive Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck
Conditions: Neoplasms, Head and Neck Interventions: Drug: Dostarlimab; Drug: Belrestotug; Drug: GSK6097608 Sponsors: GlaxoSmithKline Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 2, 2023 Category: Research Source Type: clinical trials

PBI-MST-01(NCT04541108) Substudy TAK-02: Intratumoral Microdosing of TAK-676 in HNSCC
Conditions: Head and Neck Squamous Cell Carcinoma Interventions: Drug: TAK-676; Drug: Carboplatin; Drug: 5-FU; Drug: Paclitaxel; Combination Product: TAK-676 + Carboplatin; Combination Product: Carboplatin + Paclitaxel; Combination Product: Carboplatin + 5-FU; Combination Product: TAK-676 + Carboplatin + 5-FU; Combination Product: TAK-676 + Carboplatin + Paclitaxel Sponsors: Presage Biosciences; Takeda Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 2, 2023 Category: Research Source Type: clinical trials

Identification of Individual Histological and Blood Markers in Patients With Recurrent or Metastatic Upper Aerodigestive Tract Squamous Cell Carcinoma in Response to Immunotherapies
Conditions: Squamous Cell Carcinoma of the Oropharynx Interventions: Procedure: Tumor Biopsy Sponsors: Fondation H ôpital Saint-Joseph Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 29, 2023 Category: Research Source Type: clinical trials

Risk Factors of Relapse in Esophageal Squamous Cell Cancers Who Achieve PCR to Neoadjuvant Chemoradiotherapy
Conditions: Esophageal Cancer Interventions: Other: follow up Sponsors: Sun Yat-sen University Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 29, 2023 Category: Research Source Type: clinical trials

Perioperative Tislelizumab Plus Chemotherapy for Resectable Thoracic Oesophageal Squamous Cell Carcinoma
Conditions:   Esophageal Squamous Cell Carcinoma;   Neoadjuvant Chemoimmunotherapy;   Adjuvant Therapy Intervention:   Drug: Tislelizumab Sponsor:   Guo Xufeng Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 27, 2023 Category: Research Source Type: clinical trials

People Living With HIV, Oral and Oropharyngeal Cancer, and Health Equity
Conditions: HIV Infections; Oral Squamous Cell Carcinoma; Oropharyngeal Squamous Cell Carcinoma Interventions: Other: Group Meeting (Focus Group); Other: Questionnaires Sponsors: University of California, San Francisco; National Institute of Dental and Craniofacial Research (NIDCR) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - September 27, 2023 Category: Research Source Type: clinical trials