A Perioperative Sintilimab and Chemotherapy in Esophageal Squamous Cell Carcinoma
Conditions: Esophageal Squamous Cell Carcinoma Interventions: Drug: Sintilimab; Drug: Chemotherapy Sponsors: Fudan University; Innovent Biologics (Suzhou) Co. Ltd. Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 1, 2023 Category: Research Source Type: clinical trials

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
Conditions: Non Small Cell Lung Cancer; Triple Negative Breast Cancer; Hodgkin Lymphoma; Head and Neck Squamous Cell Carcinoma; Malignant Melanoma Interventions: Drug: CTX-8371 Sponsors: Compass Therapeutics Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 29, 2023 Category: Research Source Type: clinical trials

A Phase 1, Dose-escalation Study of [225Ac]-FPI-2068 in Adult Patients With Advanced Solid Tumours
Conditions: Advanced Solid Tumor; Metastatic Colorectal Carcinoma; Head and Neck Squamous Cell Carcinoma; Non-small Cell Lung Cancer; Pancreatic Ductal Adenocarcinoma Interventions: Drug: FPI-2053; Drug: [111In]-FPI-2107; Drug: [225Ac]-FPI-2068 Sponsors: Fusion Pharmaceuticals Inc.; AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 27, 2023 Category: Research Source Type: clinical trials

Synchronous or Sequential Radiotherapy for Advanced Esophageal Squamous Cell Carcinoma With Oligometastases.
Conditions: Advanced Esophageal Squamous Carcinoma With Oligometastases Interventions: Radiation: simultaneous with radiotherapy; Radiation: synchronous with radiotherapy Sponsors: West China Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 22, 2023 Category: Research Source Type: clinical trials

Pirfenidone as a Radiosensitizer in the Treatment of Head and Neck Squamous Cell Carcinoma
Conditions: Head and Neck Squamous Cell Carcinoma; Radiotherapy; Radiosensitizer; Pirfenidone Interventions: Drug: Pirfenidone; Drug: Placebo Sponsors: Nanfang Hospital, Southern Medical University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 21, 2023 Category: Research Source Type: clinical trials

A New Mutational and Epigenetic Signature to Predict Early OPSCC Relapse
Conditions: Oropharyngeal Squamous Cell Carcinoma Sponsors: Centro di Riferimento Oncologico - Aviano Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 18, 2023 Category: Research Source Type: clinical trials

Sintilimab and Chemotherapy Sequential Radiotherapy in Advanced Esophageal Cancer
Conditions: Metastatic Esophageal Squamous Cell Carcinoma Interventions: Drug: TP regimen (cis-platinum ; Tocetaxel ) combined with PD-1 inhibitors (Sintilimab) Sponsors: Qingdao Central Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials

Pilot Trial of MR-guided Adaptive Radiotherapy Boost for HNSCC
Conditions: Squamous Cell Carcinoma; Head and Neck Cancer Interventions: Radiation: Intensity-modulated radiotherapy; Other: Magnetic Resonance Guidance Sponsors: H. Lee Moffitt Cancer Center and Research Institute Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials

European Larynx Organ Preservation Study (ELOS) [MK-3475-C44]
Conditions: Squamous Cell Carcinoma of Head and Neck; Hypopharyngeal Squamous Cell Carcinoma; Laryngeal Squamous Cell Carcinoma Stage III; Laryngeal Squamous Cell Carcinoma Stage IV; Squamous Cell Carcinoma of Larynx; Squamous Cell Carcinoma of the Larynx; Squamous Cell Carcinoma of the Larynx Stage III; Squamous Cell Carcinoma of the Larynx Stage IV; Laryngeal Squamous Cell Carcinoma; Laryngectomy; Status; Laryngeal Cancer; Laryngeal Neoplasms Interventions: Biological: KEYTRUDA ® Sponsors: University of Leipzig; University of G öttingen; University of Jena; University of Cologne; University of Ulm; University of Regens...
Source: ClinicalTrials.gov - November 17, 2023 Category: Research Source Type: clinical trials

Neoadjuvant Tirellizumab Combined With Chemotherapy for Early Oral Squamous Cell Carcinoma(HNC-SYSU-004)
Conditions: Oral Cancer; PD-1 Interventions: Drug: PD-1 with chemotherapy; Procedure: upright surgery Sponsors: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 14, 2023 Category: Research Source Type: clinical trials

A Prospective, Single-arm Phase II Clinical Trial of Tislelizumab Combined With Platinum Doublet Neoadjuvant Therapy to Improve Mandibular Preservation in Resectable Locally Advanced Oral Squamous Cell Carcinoma.
Conditions: Oral Squamous Cell Carcinoma Interventions: Drug: Three-Week Treatment Regimen with Trastuzumab in Combination with Docetaxel and Platinum Triple Therapy Sponsors: Xuekui Liu Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials

A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squamous Cell Carcinoma Following Definitive Concurrent Chemoradiotherapy
Conditions: Locally Advanced Head and Neck Squamous Cell Carcinoma Interventions: Drug: volrustomig Sponsors: AstraZeneca Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 13, 2023 Category: Research Source Type: clinical trials

Trajectory Analysis of NLR and Its Association With Efficacy of Immunochemotherapy in ESCC.
Conditions: Esophageal Squamous Cell Carcinoma; Immunotherapy; Chemotherapy Sponsors: Guangdong Provincial People ' s Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2023 Category: Research Source Type: clinical trials

Trajectory Analysis of NLR and Its Association With Efficacy of Immunochemotherapy in ESCC
Conditions: Esophageal Squamous Cell Carcinoma; Immunotherapy; Chemotherapy Sponsors: Guangdong Provincial People ' s Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2023 Category: Research Source Type: clinical trials

PABLIXIMAB as Neoadjuvant Therapy for Head and Neck Squamous-cell Carcinoma
Conditions: Squamous Cell Carcinoma of Head and Neck; Neoadjuvant Therapy; Immunotherapy Sponsors: Xijing Hospital Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 9, 2023 Category: Research Source Type: clinical trials