Senolytic Treatment with Dasatinib and Quercetin Confirmed to Reduce the Burden of Senescent Cells in Human Patients
Setting aside the mice genetically engineered to destroy senescent cells, the combination of dasatinib and quercetin is the oldest of the senolytic treatments used in animal studies. Senolytic therapies are those that selectively destroy senescent cells in old tissues in order to produce rejuvenation, turning back the progression of numerous age-related conditions. Unusually for early stage research, these initial senolytics are actually quite effective, considered in the grand scheme of things. Thus they have moved directly to human trials in some cases. The first data on their ability to produce the same outcomes in huma...
Source: Fight Aging! - September 18, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Don ’t give up hope: Bob Saget talks about Scleroderma in NIH MedlinePlus
In the recently posted issue of NIH MedlinePlus magazine, comedian Bob Saget tells about his long-time advocacy for scleroderma, a complex disease that causes thick, hard scar tissue to form either on the outer skin or inside the body, around major organs. In an ironic twist of fate, his sister was diagnosed with scleroderma just a few… (Source: NLM In Focus)
Source: NLM In Focus - February 28, 2019 Category: Databases & Libraries Authors: Posted by NLM in Focus Tags: Publications Source Type: blogs
Fight Aging! Newsletter, February 11th 2019
We report that the bone marrow stromal cell senescence is driven by p16INK4a expression. The p16INK4a-expressing senescent stromal cells then feedback to promote AML blast survival and proliferation via the SASP.
Importantly, selective elimination of p16INK4a-positive senescent bone marrow stromal cells in vivo improved the survival of mice with leukemia. Next, we find that the leukemia-driven senescent tumor microenvironment is caused by AML induced NOX2-derived superoxide. Finally, using the p16-3MR mouse model we show that by targeting NOX2 we reduced bone marrow stromal cell senescence and consequently reduced A...
Source: Fight Aging! - February 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
PU.1 Inhibition as a Potential Therapy to Suppress Fibrosis
Researchers here suggest that PU.1 is a master regulator of fibrosis, and thus inhibition could be an effective treatment for the various fibrotic diseases that presently lack good options for patients. Fibrosis is a dsyregulation of the normal processes of tissue maintenance, in which scar-like deposits of collagen are formed, disrupting tissue structure and function. When this progresses far enough, it is ultimately fatal: consider the fibrotic diseases of heart, lungs, and kidney, for example. There is evidence for the presence of senescent cells to contribute to fibrotic diseases. Given this new information about PU.1 ...
Source: Fight Aging! - February 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, November 12th 2018
This study's researchers approached all people turning 85 in 2006 in two cities in the UK for participation. At the beginning of the study in 2006-2007, there were 722 participants, 60 percent of whom were women. The participants provided researchers with information about what they ate every day, their body weight and height measurements, their overall health assessment (including any level of disability), and their medical records.
The researchers learned that more than one-quarter (28 percent) of very old adults had protein intakes below the recommended dietary allowance. The researchers noted that older adults w...
Source: Fight Aging! - November 11, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Notes on the 2018 Longevity Forum in London
The Longevity Forum, hosted by investor Jim Mellon and company yesterday in London, was a reminder that we still have a way to go when it comes to guiding the conversation on longevity and rejuvenation in a useful direction. On the one hand, most people give medicine and aging little serious thought until it is too late, and if we want large-scale funding for the goal of human rejuvenation through realization of the SENS research agenda, then the public at large really has to be on board in the same way that they are reflexively in favor of doing something about cancer and Alzheimer's disease. On the other hand, the first ...
Source: Fight Aging! - November 6, 2018 Category: Research Authors: Reason Tags: Activism, Advocacy and Education Source Type: blogs
Fight Aging! Newsletter, July 23rd 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - July 22, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
MD2 Blockade to Prevent TLR4 Signaling Reverses Fibrosis in Mice
Researchers appear to have found a novel way to sabotage fibrosis, the condition in which regenerative processes run awry with age and cells begin building scar-like structures that disrupt normal tissue function. The approach involves blocking TLR4 signaling. Fibrosis is a feature of the decline of many organs; liver, lung, kidney, heart, and so forth. If it can be turned off comparatively simply, that would produce noteworthy gains for the health of older individuals, even when the underlying causes of regenerative disarray are not addressed. The question is always whether or not there is a good way to interfere without ...
Source: Fight Aging! - July 17, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Stem-cell transplant: A possible high-risk/high-reward treatment for scleroderma
In this study, 36 people with severe scleroderma received stem-cell transplantation and were compared with 39 otherwise similar people who received a year of standard immune-suppressing medication.
After 4.5 years, those assigned to receive stem-cell transplantation had
improved overall survival compared with standard treatment (79% vs. 50%)
less need for immune-suppressing medication (9% vs. 44%)
fewer deaths related to worsening scleroderma (11% vs. 28%)
more deaths related to treatment — (3% vs. 0%).
These findings suggest that stem-cell transplantation may be much better than standard treatment for people with seve...
Source: Harvard Health Blog - February 16, 2018 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Autoimmune diseases Health Skin and Hair Care Source Type: blogs
MKSAP: 32-year-old woman with weight loss, abdominal cramping, and loose stools
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 32-year-old woman is evaluated for a 2-month history of weight loss, abdominal cramping, and loose stools. Her stools are malodorous, but she has not noted any blood associated with her bowel movements. Although her appetite is good, she has lost 3.2 kg (7.0 lb). She has an 8-year history of diffuse cutaneous systemic sclerosis.
On physical examination, temperature is normal, blood pressure is 146/92 mm Hg, pulse rate is 94/min, and respiration rate is 16/min. BMI is 19. Cardiopulmonary examination is normal. ...
Source: Kevin, M.D. - Medical Weblog - October 21, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Gastroenterology Rheumatology Source Type: blogs
Cardiology MCQ Test 4
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Source: Cardiophile MD - October 21, 2017 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Having access to health care saved this patient ’s life
Now more than ever, health insurance is a staple story in the 24-hour news cycle. Opinions vary widely on the issue, as do politician’s thoughts on the matter. Debates rage, tensions grow, and deeper divides are formed as our government wrestles with this colossal dispute. Nestled at the heart of it all though is a basic question:
Is health insurance a right or a privilege in the United States?
I’m alive today because my school district, where I’ve now taught for 20 years, offers the “Cadillac” of insurance plans. On April 26, 2006, I checked into the hospital for a scheduled C-section. Due to scleroderma...
Source: Kevin, M.D. - Medical Weblog - May 16, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/lisa-goodman-helfand" rel="tag" > Lisa Goodman-Helfand < /a > Tags: Patient Patients Source Type: blogs
Fight Aging! Newsletter, April 24th 2017
This study identified 1,497 genes with significantly different expression at different ages. Gene sets with a defined age-associated expression pattern provide information about molecular processes with altered activity during aging and provide a valuable diagnostic tool for determining individual biological rate of aging and predicting risk of age-associated disease, as demonstrated in follow-up analyses. On a gene-by-gene basis, differential expression alone is insufficient to distinguish between genes that play a causative role in aging and genes that merely respond to the altered physiological environment in an aging o...
Source: Fight Aging! - April 23, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Blocking CD47 Reverses the Progression of Fibrosis
Expression of the cell surface marker CD47 helps to protect cells from destruction by the immune system. It is abused by a variety of cancers, and thus blocking CD47 is the basis for a line of research into cancer therapies that might be broadly effective. Other researchers have found that this same approach might help to reduce the size of atherosclerotic plaques, so it seems that it isn't just cancerous cells in which excess CD47 is preventing beneficial destruction. Here, researchers discover that the cells making up the scar tissue of fibrosis are similarly protecting themselves with CD47, and blocking its activity cau...
Source: Fight Aging! - April 18, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Towards Therapies Capable of Reversing the Progression of Fibrosis
Fibrosis is a significant component of many age-related conditions, a failure of the normal regenerative process that leads to the formation of increasing amounts of scar-like, fibrous connective tissue in organs. This disrupts normal tissue structure and degrades proper function. It features prominently in common forms of heart disease, kidney failure, and liver disease, among others. As is the case for many specific aspects of aging, there is no good treatment for fibrosis, if by this we mean a reliable way to turn back its progression and restore failing tissues to their former state.
The causes of fibrosis lie s...
Source: Fight Aging! - February 23, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
