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Resolvin D2-GPR18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging
Am J Pathol. 2023 Sep 15:S0002-9440(23)00322-X. doi: 10.1016/j.ajpath.2023.08.011. Online ahead of print.ABSTRACTAging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lack GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associate...
Source: Am J Pathol - September 17, 2023 Category: Pathology Authors: Hannah Fitzgerald Jesse L Bonin Sayeed Khan Maya Eid Sudeshna Sadhu Allison Rahtes Masharh Lipscomb Nirupam Biswas Christa Decker Melisande Nabage Ramon Bossardi Ramos Giesse Albeche Duarte Michael Marinello Anne Chen Hasan Basri Aydin Hebe Agustina Mena Source Type: research
New algorithm for the analysis of nucleotide and amino acid evolutionary relationships based on Klein four-group
We present a Klein four-group algorithm (K4A) for the evolutionary analysis of nucleotide and amino acid sequences. Klein four-group set of operators consists of: identity e (U), and three elements-a = transition (C), b = transversion (G) and c = transition-transversion or complementarity (A). We generated Klein four-group based distance matrices of: 1. Cayley table (CK4), 2. Table rows (K4R), 3. Table columns (K4C), and 4. Euclidean 2D distance (K4E). The performance of the matrices was tested on a dataset of RecA proteins in bacteria, eukaryotes (Rad51 homolog) and archaea (RadA homolog). RecA and its functional homologs...
Source: Biosystems - September 17, 2023 Category: Biotechnology Authors: Nikola Štambuk Pa ško Konjevoda Krunoslav Br čić-Kostić Josip Bakovi ć Albert Štambuk Source Type: research
Programming schistosomes - a crisper approach to transgenesis
This study outlines a promising strategy for functional genomics to study this parasite that causes a debilitating and neglected tropical disease.PMID:37718190 | DOI:10.1016/j.pt.2023.09.003
Source: Trends in Parasitology - September 17, 2023 Category: Parasitology Authors: Bernd H Kalinna Source Type: research
Resolvin D2-GPR18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging
Am J Pathol. 2023 Sep 15:S0002-9440(23)00322-X. doi: 10.1016/j.ajpath.2023.08.011. Online ahead of print.ABSTRACTAging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lack GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associate...
Source: The American Journal of Pathology - September 17, 2023 Category: Pathology Authors: Hannah Fitzgerald Jesse L Bonin Sayeed Khan Maya Eid Sudeshna Sadhu Allison Rahtes Masharh Lipscomb Nirupam Biswas Christa Decker Melisande Nabage Ramon Bossardi Ramos Giesse Albeche Duarte Michael Marinello Anne Chen Hasan Basri Aydin Hebe Agustina Mena Source Type: research
Carboplatin-induced upregulation of pan β-tubulin and class III β-tubulin is implicated in acquired resistance and cross-resistance of ovarian cancer
Cell Mol Life Sci. 2023 Sep 17;80(10):294. doi: 10.1007/s00018-023-04943-0.ABSTRACTResistance to platinum- and taxane-based chemotherapy represents a major obstacle to long-term survival in ovarian cancer (OC) patients. Here, we studied the interplay between acquired carboplatin (CBP) resistance using two OC cell models, MES-OV CBP and SK-OV-3 CBP, and non-P-glycoprotein-mediated cross-resistance to paclitaxel (TAX) observed only in MES-OV CBP cells. Decreased platination, mesenchymal-like phenotype, and increased expression of α- and γ-tubulin were observed in both drug-resistant variants compared with parental cells. B...
Source: Cellular and Molecular Life Sciences : CMLS - September 17, 2023 Category: Cytology Authors: Margareta Pernar Kova č Vanja Tadi ć Juran Kralj George E Duran Alessia Stefanelli Darija Stupin Polan čec Sanja Dabeli ć Niko Ba čić Maja T Tomicic Petra Heffeter Branimir I Sikic Anamaria Brozovic Source Type: research
Resolvin D2-GPR18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging
Am J Pathol. 2023 Sep 15:S0002-9440(23)00322-X. doi: 10.1016/j.ajpath.2023.08.011. Online ahead of print.ABSTRACTAging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lack GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associate...
Source: The American Journal of Pathology - September 17, 2023 Category: Pathology Authors: Hannah Fitzgerald Jesse L Bonin Sayeed Khan Maya Eid Sudeshna Sadhu Allison Rahtes Masharh Lipscomb Nirupam Biswas Christa Decker Melisande Nabage Ramon Bossardi Ramos Giesse Albeche Duarte Michael Marinello Anne Chen Hasan Basri Aydin Hebe Agustina Mena Source Type: research
Analysis of soil pollution characteristics and influencing factors based on ten electroplating enterprises
This study serves as a foundation for conceptualizing site repair technology in the electroplating industry and offers a reference and methodology for pollution and source control in this and related sectors.PMID:37717896 | DOI:10.1016/j.envpol.2023.122562
Source: Environmental Pollution - September 17, 2023 Category: Environmental Health Authors: Jinjin Wei Peili Shi Guannan Cui Xin Li Minke Xu Dongyao Xu Yunfeng Xie Source Type: research
Resolvin D2-GPR18 Enhances Bone Marrow Function and Limits Steatosis and Hepatic Collagen Accumulation in Aging
Am J Pathol. 2023 Sep 15:S0002-9440(23)00322-X. doi: 10.1016/j.ajpath.2023.08.011. Online ahead of print.ABSTRACTAging is associated with non-resolving inflammation and tissue dysfunction. Resolvin D2 (RvD2) is a pro-resolving ligand that acts through the G-protein coupled receptor (GPCR) called GPR18. Unbiased RNA sequencing revealed increased Gpr18 expression in macrophages from old mice, and in livers from elderly humans, which was associated with increased steatosis and fibrosis in middle-aged (MA) and old mice. MA mice that lack GPR18 on myeloid cells had exacerbated steatosis and hepatic fibrosis, which was associate...
Source: Am J Pathol - September 17, 2023 Category: Pathology Authors: Hannah Fitzgerald Jesse L Bonin Sayeed Khan Maya Eid Sudeshna Sadhu Allison Rahtes Masharh Lipscomb Nirupam Biswas Christa Decker Melisande Nabage Ramon Bossardi Ramos Giesse Albeche Duarte Michael Marinello Anne Chen Hasan Basri Aydin Hebe Agustina Mena Source Type: research
Curettage and colour-A technique for defining tumour depth on the ear in the Mohs and non-Mohs setting
Australas J Dermatol. 2023 Sep 15. doi: 10.1111/ajd.14158. Online ahead of print.ABSTRACTFor tumours of the ear that are suspected to involve auricular cartilage, precise definition of the extent of involved deep margin can be difficult. As large resections of cartilage can be cosmetically disfiguring with limited repair options, we propose a simple and effective technique to facilitate a targeted deep margin resection using a curette and a surgical marking pen.PMID:37715356 | DOI:10.1111/ajd.14158
Source: The Australasian Journal of Dermatology - September 16, 2023 Category: Dermatology Authors: Thomas Pagliaro Jazlyn Read Source Type: research
Correction to: ORCHID: A phase II study of Olaparib in Metastatic Renal Cell Carcinoma Patients HarborIng a BAP1 or Other DNA Repair Gene Mutations
Oncologist. 2023 Sep 16:oyad265. doi: 10.1093/oncolo/oyad265. Online ahead of print.NO ABSTRACTPMID:37715956 | DOI:10.1093/oncolo/oyad265
Source: The Oncologist - September 16, 2023 Category: Cancer & Oncology Source Type: research
Live cell transcription-coupled nucleotide excision repair dynamics revisited
In this study, we employ knock-in cell lines designed to target the endogenous CSB gene locus with mClover, a GFP variant. Through live cell imaging, we uncover the intricate molecular dynamics of CSB in response to physiologically relevant UV doses. We showed that the DNA damage-induced association of CSB with chromatin is tightly regulated by the CSA-containing ubiquitin-ligase CRL complex (CRL4CSA). Combining the CSB-mClover knock-in cell line with SILAC-based GFP-mediated complex isolation and mass-spectrometry-based proteomics, revealed novel putative CSB interactors as well as discernible variations in complex compos...
Source: Cancer Control - September 16, 2023 Category: Cancer & Oncology Authors: Diana A Llerena Schiffmacher Katarzyna W Kliza Arjan F Theil Gert-Jan Kremers Jeroen A A Demmers Tomoo Ogi Michiel Vermeulen Wim Vermeulen Alex Pines Source Type: research
Low Expression of A3C and PLP2 Indicating a Favorable Prognosis in Human Gliomas
In conclusion, our results not only confirmed A3C played an important role in glioma development, but the A3C IHC test could successfully predict the therapeutic effects and disease prognosis.PMID:37715423 | DOI:10.14715/cmb/2023.69.7.12
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Jong-Shiaw Jin Yu-Ling Tsai Yu-Chan Chang Wen-Chiuan Tsai Source Type: research
The repair and regeneration mechanism of platelet-rich fibrin-promoting tissue after alveolar bone defect through the notch pathway
Cell Mol Biol (Noisy-le-grand). 2023 Jul 31;69(7):85-90. doi: 10.14715/cmb/2023.69.7.14.ABSTRACTThis work investigated the effects of platelet-rich fibrin (PRF) combined with bone mesenchymal stem cells (BMSCs) on the repair of alveolar bone defect (ABD) and the related mechanism of the Notch1/Wnt3a signaling pathway. 28 healthy male New Zealand white rabbits were selected to prepare the BMSCs and PRF. Rabbits were rolled into a combination group (implanted with PRF + BMSCs for treatment), a PRF group (treated with PRF) a BMSC group (BMSCs for treatment), and a control group (Ctrl group, no material implantation), with 7 r...
Source: Mol Biol Cell - September 16, 2023 Category: Molecular Biology Authors: Tao Li Hui Long Wei Niu Bo Feng Source Type: research
