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Procedure: Gastroschisis Repair
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The Effect of Distributional Restrictions in Speech Perception: A Case Study From Korean and Taiwanese Southern Min
Lang Speech. 2023 Sep 15:238309231195263. doi: 10.1177/00238309231195263. Online ahead of print.ABSTRACTIn Korean, voiced oral stops can occur intervocalically as allophones of their voiceless lenis counterparts; they can also occur initially as variants of nasal stops as a result of initial denasalization (e.g., /motu/→[bodu] "all"). However, neither [ŋ] nor [ɡ] (the denasalized variant of the velar nasal) is allowed in the initial position due to the phonotactic restriction against initial [ŋ] in Korean. Given the distribution of nasal and voiced stops in Korean, this study draws on the idea of cue informativeness, ...
Source: Language and Speech - September 15, 2023 Category: Speech-Language Pathology Authors: Jiwon Hwang Yu-An Lu Source Type: research
Allele-specific expression reveals genetic drivers of tissue regeneration in mice
Cell Stem Cell. 2023 Sep 13:S1934-5909(23)00293-X. doi: 10.1016/j.stem.2023.08.010. Online ahead of print.ABSTRACTIn adult mammals, skin wounds typically heal by scarring rather than through regeneration. In contrast, "super-healer" Murphy Roths Large (MRL) mice have the unusual ability to regenerate ear punch wounds; however, the molecular basis for this regeneration remains elusive. Here, in hybrid crosses between MRL and non-regenerating mice, we used allele-specific gene expression to identify cis-regulatory variation associated with ear regeneration. Analyzing three major cell populations (immune, fibroblast, and endo...
Source: Cell Stem Cell - September 15, 2023 Category: Stem Cells Authors: Katya L Mack Heather E Talbott Michelle F Griffin Jennifer B L Parker Nicholas J Guardino Amanda F Spielman Michael F Davitt Shamik Mascharak Mauricio Downer Annah Morgan Caleb Valencia Deena Akras Mark J Berger Derrick C Wan Hunter B Fraser Michael T Lon Source Type: research
Centromere: A Trojan horse for genome stability
DNA Repair (Amst). 2023 Sep 7;130:103569. doi: 10.1016/j.dnarep.2023.103569. Online ahead of print.ABSTRACTCentromeres play a key role in the maintenance of genome stability to prevent carcinogenesis and diseases. They are specialized chromosome loci essential to ensure faithful transmission of genomic information across cell generations by mediating the interaction with spindle microtubules. Nonetheless, while fulfilling these essential roles, their distinct repetitive composition and susceptibility to mechanical stresses during cell division render them susceptible to breakage events. In this review, we delve into the pr...
Source: DNA Repair - September 14, 2023 Category: Genetics & Stem Cells Authors: Andrea Scelfo Daniele Fachinetti Source Type: research
Disrupted HSF1 regulation in normal and exceptional brain aging
Biogerontology. 2023 Sep 14. doi: 10.1007/s10522-023-10063-w. Online ahead of print.ABSTRACTBrain aging is a major risk factor for cognitive diseases such as Alzheimer's disease (AD) and vascular dementia. The rate of aging and age-related pathology are modulated by stress responses and repair pathways that gradually decline with age. However, recent reports indicate that exceptional longevity sustains and may even enhance the stress response. Whether normal and exceptional aging result in either attenuated or enhanced stress responses across all organs is unknown. This question arises from our understanding that biologica...
Source: Biogerontology - September 14, 2023 Category: Geriatrics Authors: Rachana Trivedi Bailey Knopf Sharlene Rakoczy Gunjan D Manocha Holly Brown-Borg Donald A Jurivich Source Type: research
Clinical Analysis of Supraclavicular Flaps for the Repair of the Pharyngeal Fistula
Conclusions: The supraclavicular flap can achieve excellent results in the repair of pharyngeal fistula.PMID:37705336 | DOI:10.1177/01455613231196667
Source: Ear, Nose and Throat Journal - September 14, 2023 Category: ENT & OMF Authors: Cheng Jiao Ying Tao Bin Zhu Li Chen Dandan Yang Bing Guan Aimin Yu Source Type: research
Role of Serum Inflammatory Cytokines in Sepsis Rats Following BMSCs Transplantation: Protein Microarray Analysis
In this study, we investigated the effects of BMSCs on serum inflammatory cytokines in a rat model of lipopolysaccharide (LPS)-induced sepsis. Sepsis was induced by intravenous injection of LPS, followed by transplantation of BMSCs. We monitored survival rates for 72 h and evaluated organ functions, histopathological changes, and cytokines expression. Sepsis rats showed decreased levels of white blood cells, platelets, lymphocyte ratio, and oxygen partial pressure, along with increased levels of neutrophil ratio, carbon dioxide partial pressure, lactic acid, alanine aminotransferase, and aspartate aminotransferase. Histolo...
Source: Cell Transplantation - September 14, 2023 Category: Cytology Authors: Guanghui Xiu Xiuling Li Juan Chen Jintao Li Kun Chen Ping Liu Bin Ling Ying Yang Source Type: research
Transvaginal excision of vaginal paraurethral leiomyoma: A video case report
CONCLUSION: The procedure was successful in obtaining anatomical repair and relieving symptoms. This approach represents a valid procedure for the surgical management of this uncommon condition.PMID:37708657 | DOI:10.1016/j.ejogrb.2023.09.008
Source: Reproductive Biology - September 14, 2023 Category: Reproduction Medicine Authors: Clarissa Costa Marta Barba Alice Cola Matteo Frigerio Source Type: research
Stuck prosthetic mitral valve after AV canal defect repair: Intraoperative 3D transesophageal echocardiography diagnosis
Ann Card Anaesth. 2023 Apr-Jun;26(2):239-240. doi: 10.4103/aca.aca_89_22.NO ABSTRACTPMID:37706399 | DOI:10.4103/aca.aca_89_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Avneet Singh Sunder Negi Sachin Mahajan Source Type: research
Use of extracorporeal membrane oxygenation and cerebral oximetry in a stage 1 norwood repair for hypoplastic left heart syndrome
We report a case where the use of ECMO was beneficial after stage I Norwood palliation with severe ventricular dysfunction. The systemic-to-pulmonary artery shunt was kept open to balance the systemic and pulmonary circulations. Cerebral oximetry can be useful as an additional monitoring modality to guide management, monitor cerebral perfusion, and help detect cerebral steal.PMID:37706390 | DOI:10.4103/0971-9784.320955
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Anam A Kazi Kamlesh B Tailor M C Manoj Smruti Ranjan Mohanty Source Type: research
Outcome of obstructed total anamalous pulmonary venous connection (TAPVC) repair patients with milrinone versus milrinone and inhaled nitric oxide (INO): A prospective randomized observational study
CONCLUSION: Most of the patients with obstructed TAPVC had severe PAH. Management of severe PAH with a combination of milrinone with iNO had a better outcome than milrinone alone.PMID:37706383 | DOI:10.4103/aca.aca_56_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Srikanth Gujja Mrugesh Prajapati Tanya R Chuada Hemang Gandhi Varun Arora Vivek Kaul Sanjay Patel Source Type: research
Correlation of venous to arterial carbon dioxide partial pressure difference with other cardiac output indices in patients undergoing intracardiac repair for tetralogy of fallot
CONCLUSION: AVCO2 is correlated with other CO surrogates like AVO2, ScVO2, and lactate in pediatric patients undergoing ICR for TOF.PMID:37706382 | DOI:10.4103/aca.aca_53_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Guriqbal Singh Jigisha Pujara Visharad Trivedi Dhawalikar Deepti Uday Jyoti Masaniya Mittapalli Jeevan Babu Chanchal Daulal Bhandari Source Type: research
Multifunctional wet-adhesive chitosan/acrylic conduit for sutureless repair of peripheral nerve injuries
This study aimed to develop easily implantable chitosan-based peripheral nerve repair conduits that combine acrylic acid and cleavable N-hydroxysuccinimide to reduce nerve damage during repair. In ex vivo tissue adhesion tests, the conduit achieved maximal interfacial toughness of 705 J m-2 ± 30 J m-2, allowing continuous bridging of the severed nerve ends. Adhesive repair significantly reduces local inflammation caused by conventional sutures, and the positive charge of chitosan disrupts the bacterial cell wall and reduces implant-related infections. This promises to open new avenues for sutureless nerve repair and relia...
Source: International Journal of Biological Macromolecules - September 14, 2023 Category: Biochemistry Authors: Meng Zhang Heng An Zhen Gu Yi-Chong Zhang Teng Wan Hao-Ran Jiang Feng-Shi Zhang Bao-Guo Jiang Na Han Yong-Qiang Wen Pei-Xun Zhang Source Type: research
Atrial septal defect occluder device embolization: Experience of a tertiary care cardiac center
CONCLUSIONS: Once embolization occurs, the risks associated increase manifold. Most of the surgical extractions are uneventful; however, there could be certain complications that may need repair of valvular apparatus, the institution of TCA, or the need for the lateral position. Air embolization though very rare can occur which could be fatal.PMID:37706378 | DOI:10.4103/aca.aca_28_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Sandeep Garre Shrinivas Gadhinglajkar Rupa Sreedhar K M Krishnamoorthy Vivek V Pillai Source Type: research
Inverting the DNA tetrahedron: A novel strategy for sensitive and stable detection of aging-related enzyme MMP2
Anal Chim Acta. 2023 Oct 16;1278:341736. doi: 10.1016/j.aca.2023.341736. Epub 2023 Aug 17.ABSTRACTIn the current study, a novel electrochemiluminescence biosensor based on the entropy-driven DNA tetrahedron for the detection of matrix metalloproteinase 2 (MMP2), an enzyme that regulates extracellular matrix remodeling and affects aging was reported. The biosensor utilizes an inverted DNA tetrahedron structure, which exposes three vertices to the solution, as molecular recognition units for capturing specific biomolecules. The biosensor also employs a ratiometric method and an entropy-driven reaction, which enhance the resp...
Source: Analytica Chimica Acta - September 14, 2023 Category: Chemistry Authors: Jihua Wei Zichun Song Jiuying Cui Yuanxun Gong Qianli Tang Kai Zhang Xinlei Song Xianjiu Liao Source Type: research
Hormesis Defines The Limits Of Lifespan
Ageing Res Rev. 2023 Sep 12:102074. doi: 10.1016/j.arr.2023.102074. Online ahead of print.ABSTRACTThis commentary provides a novel synthesis of how biological systems adapt to a broad spectrum of environmental and age-related stresses that are underlying causes of numerous degenerative diseases and debilitating effects of aging. It proposes that the most fundamental, evolutionary-based integrative strategy to sustain and protect health is based on the concept of hormesis. This concept integrates anti-oxidant, anti-inflammatory and cellular repair responses at all levels of biological organization (i.e., cell, organ and org...
Source: Ageing Research Reviews - September 14, 2023 Category: Genetics & Stem Cells Authors: Edward J Calabrese Naomi Osakabe Rosanna Di Paola Rosalba Siracusa Roberta Fusco Ramona D'Amico Daniela Impellizzeri Salvatore Cuzzocrea Tilman Fritsch Ali S Abdelhameed Uwe Wenzel Claudio Franceschi V Calabrese Source Type: research
