Filtered By:
Management: Food and Drug Administration (FDA)
This page shows you your search results in order of date.
Order by Relevance | Date
Total 7385 results found since Jan 2013.
The locus coeruleus contributes to the anorectic, nausea, and autonomic physiological effects of glucagon-like peptide-1
Sci Adv. 2023 Sep 22;9(38):eadh0980. doi: 10.1126/sciadv.adh0980. Epub 2023 Sep 20.ABSTRACTIncreasing the therapeutic potential and reducing the side effects of U.S. Food and Drug Administration-approved glucagon-like peptide-1 receptor (GLP-1R) agonists used to treat obesity require complete characterization of the central mechanisms that mediate both the food intake-suppressive and illness-like effects of GLP-1R signaling. Our studies, in the rat, demonstrate that GLP-1Rs in the locus coeruleus (LC) are pharmacologically and physiologically relevant for food intake control. Furthermore, agonism of LC GLP-1Rs induces illn...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Samantha M Fortin Jack C Chen Marisa C Petticord Forrest J Ragozzino James H Peters Matthew R Hayes Source Type: research
Pathophysiological Aspects and Therapeutic Armamentarium of Alzheimer's Disease: Recent Trends and Future Development
Cell Mol Neurobiol. 2023 Sep 19. doi: 10.1007/s10571-023-01408-7. Online ahead of print.ABSTRACTAlzheimer's disease (AD) is the primary cause of dementia and is characterized by the death of brain cells due to the accumulation of insoluble amyloid plaques, hyperphosphorylation of tau protein, and the formation of neurofibrillary tangles within the cells. AD is also associated with other pathologies such as neuroinflammation, dysfunction of synaptic connections and circuits, disorders in mitochondrial function and energy production, epigenetic changes, and abnormalities in the vascular system. Despite extensive research con...
Source: Cellular and Molecular Neurobiology - September 19, 2023 Category: Cytology Authors: Bhavarth P Dave Yesha B Shah Kunal G Maheshwari Kaif A Mansuri Bhadrawati S Prajapati Humzah I Postwala Mehul R Chorawala Source Type: research
International responses addressing the under-representation of older people in clinical research
This article provides an overview and critique of the current approaches to the inclusion of older people in clinical research and highlights policy gaps and limitations of current strategies.PMID:37724905 | DOI:10.1111/ajag.13234
Source: Australasian Journal on Ageing - September 19, 2023 Category: Geriatrics Authors: Susan C Markham Justin McNab Kate O'Loughlin Lindy Clemson Source Type: research
HDAC inhibitors: Promising agents for leukemia treatment
Biochem Biophys Res Commun. 2023 Sep 14;680:61-72. doi: 10.1016/j.bbrc.2023.09.023. Online ahead of print.ABSTRACTThe essential role of epigenetic modification in the pathogenesis of a series of cancers have gradually been recognized. Histone deacetylase (HDACs), as well-known epigenetic modulators, are responsible for DNA repair, cell proliferation, differentiation, apoptosis and angiogenesis. Studies have shown that aberrant expression of HDACs is found in many cancer types. Thus, inhibition of HDACs has provided a promising therapeutic approach alternative for these patients. Since HDAC inhibitor (HDACi) vorinostat was ...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Yun Deng Qian Cheng Jing He Source Type: research
Chronic Prurigo Including Prurigo Nodularis: New Insights and Treatments
AbstractChronic prurigo (CPG) is a neuroinflammatory, fibrotic dermatosis that is defined by the presence of chronic pruritus (itch lasting longer than 6 weeks), scratch-associated pruriginous skin lesions and history of repeated scratching. Patients with CPG experience a significant psychological burden and a notable impairment in their quality of life. Chronic prurigo of nodular type (CNPG; synonym: prurigo nodularis) represents the most common subtype of CPG. As CNPG is representative for all CPG subtypes, we refer in this review to both CNPG and CPG. We provide an overview of the clinical characteristics and assessment...
Source: American Journal of Clinical Dermatology - September 17, 2023 Category: Dermatology Source Type: research
Hidradenitis suppurativa: New insights into disease mechanisms and an evolving treatment landscape
Br J Dermatol. 2023 Sep 16:ljad345. doi: 10.1093/bjd/ljad345. Online ahead of print.ABSTRACTHidradenitis suppurativa (HS), also known as acne inversa, is a chronic disabling and debilitating inflammatory disease with high unmet medical need. The prevalence of HS is 1-2% in most studies, although it is likely underreported and estimates vary globally due to variance in data collection methods, ethnicity, geographical location, and underdiagnosis. HS is characterized by persistent, painful cutaneous nodules, abscesses, and draining tunnels commonly affecting the axillary, anogenital, inguinal, and perianal/gluteal areas. Ove...
Source: The British Journal of Dermatology - September 16, 2023 Category: Dermatology Authors: James G Krueger John Frew Gregor B E Jemec Alexa B Kimball Brian Kirby Falk G Bechara Kristina Navrazhina Errol Prens Kristian Reich Eva Cullen Kerstin Wolk Source Type: research
Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions
World Psychiatry. 2023 Oct;22(3):394-412. doi: 10.1002/wps.21120.ABSTRACTTreatment-resistant depression (TRD) is common and associated with multiple serious public health implications. A consensus definition of TRD with demonstrated predictive utility in terms of clinical decision-making and health outcomes does not currently exist. Instead, a plethora of definitions have been proposed, which vary significantly in their conceptual framework. The absence of a consensus definition hampers precise estimates of the prevalence of TRD, and also belies efforts to identify risk factors, prevention opportunities, and effective inte...
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Roger S McIntyre Mohammad Alsuwaidan Bernhard T Baune Michael Berk Koen Demyttenaere Joseph F Goldberg Philip Gorwood Roger Ho Siegfried Kasper Sidney H Kennedy Josefina Ly-Uson Rodrigo B Mansur R Hamish McAllister-Williams James W Murrough Charles B Neme Source Type: research
