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Management: Food and Drug Administration (FDA)
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Total 7385 results found since Jan 2013.
Current Status of Robotic Gastrointestinal Surgery
This article reviews current trends and potential developments in robotic surgery.PMID:37690822 | DOI:10.1272/jnms.JNMS.2023_90-404
Source: Journal of Nippon Medical School - September 10, 2023 Category: Universities & Medical Training Authors: Keisuke Minamimura Keisuke Hara Satoshi Matsumoto Tomohiko Yasuda Hiroki Arai Daisuke Kakinuma Yukio Ohshiro Youichi Kawano Masanori Watanabe Hideyuki Suzuki Hiroshi Yoshida Source Type: research
COVID-19: An Overview of SARS-CoV-2 Variants-The Current Vaccines and Drug Development
Biomed Res Int. 2023 Aug 29;2023:1879554. doi: 10.1155/2023/1879554. eCollection 2023.ABSTRACTThe world is presently in crisis facing an outbreak of a health-threatening microorganism known as COVID-19, responsible for causing uncommon viral pneumonia in humans. The virus was first reported in Wuhan, China, in early December 2019, and it quickly became a global concern due to the pandemic. Challenges in this regard have been compounded by the emergence of several variants such as B.1.1.7, B.1.351, P1, and B.1.617, which show an increase in transmission power and resistance to therapies and vaccines. Ongoing researches are ...
Source: Biomed Res - September 7, 2023 Category: Research Authors: Narjess Bostanghadiri Pardis Ziaeefar Morvarid Golrokh Mofrad Parsa Yousefzadeh Ali Hashemi Davood Darban-Sarokhalil Source Type: research
Revision of fluoroquinolone breakpoints used for interpretation of antimicrobial susceptibility testing of canine bacterial isolates
Am J Vet Res. 2023 Sep 6:1-7. doi: 10.2460/ajvr.23.07.0159. Online ahead of print.ABSTRACTThe fluoroquinolone antimicrobial agents, enrofloxacin and marbofloxacin, were US Food and Drug Administration (FDA) approved in the United States for use in dogs in 1988 and 1999, respectively. There have been many advances since then concerning the pharmacokinetic-pharmacodynamic (PK-PD) evaluation of fluoroquinolones, and there are data available on the susceptibility of targeted pathogens since the original approval. Using this information, the Clinical and Laboratory Standards Institute (CLSI) Veterinary Antimicrobial Susceptibil...
Source: American Journal of Veterinary Research - September 6, 2023 Category: Veterinary Research Authors: Mark G Papich Lacie A Gunnett Brian V Lubbers Source Type: research
Evidence based optimal dosing of intravenous artesunate in children with severe falciparum malaria
In this study, we performed population pharmacokinetic modeling of plasma concentration data from 80 children with severe falciparum malaria in the Democratic Republic of Congo who were given 2.4 mg/kg of artesunate intravenously. Bayesian hierarchical modeling and a two-compartment parent drug-metabolite pharmacokinetic model for artesunate were used to describe the population pharmacokinetics of artesunate and its main biologically active metabolite dihydroartemisinin. We then generated a virtual population representative of the target population in which the drug is used and simulated the total first-dose exposures. Our...
Source: Clinical Pharmacology and Therapeutics - September 4, 2023 Category: Drugs & Pharmacology Authors: Ali Haghiri David J Price Phoebe Fitzpatrick Saber Dini Megha Rajasekhar Caterina Fanello Joel Tarning James Watson Nicholas J White Julie A Simpson Source Type: research
Enhanced stability and photothermal efficiency of Indocyanine Green J-aggregates by nanoformulation with Calix4arene for photothermal therapy of cancers
Colloids Surf B Biointerfaces. 2023 Aug 15;230:113516. doi: 10.1016/j.colsurfb.2023.113516. Online ahead of print.ABSTRACTPhotothermal therapy (PTT) is a method of growing attention, owing to its controllable process, high efficiency and minimal side effect. Indocyanine Green (ICG) is as Food and Drug Administration (FDA) approved agent that stands on the frontline of further developments of PTT toward clinics. However, the applicability of ICG-mediated PTT is limited by the rapid in vivo clearance and photo-degradation of ICG. To improve those parameters, nanosized ICG-loaded nanoparticles (ICG-J/CX) were fabricated in th...
Source: Colloids and Surfaces - September 3, 2023 Category: Biotechnology Authors: Marie Millard Yann Bernhard Nadia Canilho St éphanie Grandemange St éphane Parant Maxime Mourer Henri-Pierre Lassalle Andreea Pasc Source Type: research
In vitro and in vivo evaluation of immune response of poly(lactic acid) nanoparticles with different end groups
Int J Biol Macromol. 2023 Aug 31:126593. doi: 10.1016/j.ijbiomac.2023.126593. Online ahead of print.ABSTRACTPoly(lactic acid) (PLA) has excellent properties of biodegradability and biocompatibility, which is a US Food and Drug Administration (FDA) approved biopolymer for the preparation of safe and effective vaccines, drugs, and gene delivery systems. However, there still exists a great problem whether and how the end group affects the immune response of PLA vaccines. Therefore, the aim of this study was to evaluate the in vitro and in vivo of immune response of PLA nanoparticles (NPs) with carboxyl (COOH) and ester (COOR)...
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Yuan Gao Jun Yang Yaru Zhang Ying Zhao Xin Zhao Xining Zhang Jing Zhang Li Mao Hongjun Wang Huimei Wang Lianyan Wang Source Type: research
Breast cancer immunotherapy: a comprehensive review
Clin Exp Med. 2023 Sep 1. doi: 10.1007/s10238-023-01177-z. Online ahead of print.ABSTRACTCancer remains a major health problem despite numerous new medical interventions that have been introduced in recent years. One of the major choices for cancer therapy is so-called adoptive cell therapy (ACT). ACT can be performed using both innate immune cells, including dendritic cells (DCs), natural killer (NK) cells, and γδ T cells and acquired immune T cells. It has become possible to utilize these cells in both their native and modified states in clinical studies. Because of considerable success in cancer treatment, ACT now pla...
Source: Clinical Genitourinary Cancer - September 1, 2023 Category: Cancer & Oncology Authors: Samaneh Keshavarz Jack R Wall Somayeh Keshavarz Elham Vojoudi Reza Jafari-Shakib Source Type: research
