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Cancer: Prostate Cancer
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Total 25217 results found since Jan 2013.
Androgen receptor and hyaluronan-mediated motility receptor as new molecular targets of baicalein: new molecular mechanisms for its anticancer properties
Arch Pharm Res. 2023 Sep 10. doi: 10.1007/s12272-023-01461-2. Online ahead of print.ABSTRACTNatural compounds known as phytochemicals have served as valuable resources for the development of new anti-cancer drugs and treatment of malignancies. Among these phytochemicals, baicalein is an emerging anti-tumor flavonoid obtained from Scutellaria baicaleinsis (Lamiaceae), but its underlying mechanisms of action and molecular targets have not yet been completely elucidated. Here, we identified new mechanisms for the anti-tumor activities of baicalein, providing evidence that hyaluronan-mediated motility receptor (HMMR) and andro...
Source: Archives of Pharmacal Research - September 10, 2023 Category: Drugs & Pharmacology Authors: Mingyue Jiang Suman Poudel Kyung Song Source Type: research
Patient-reported outcome measures compared to clinician reported outcomes regarding incontinence and erectile dysfunction in localized prostate carcinoma after robot assisted radical prostatectomy: Impact on management
CONCLUSIONS: This is to our knowledge the first study that compared the PROs with clinician reported functional outcomes and the impact of discrepancies on the management of side effects of RARP in prostate cancer. Observed discrepancies between the PROs and CROs did not affect offered management and counseling of UI and ED.PMID:37690935 | DOI:10.1016/j.urolonc.2023.08.001
Source: Urologic Oncology - September 10, 2023 Category: Urology & Nephrology Authors: C N Tillier A H Boekhout H Veerman B M Wollersheim Pam Groen H G van der Poel L V van de Poll-Franse Source Type: research
Clinical Significance of Radical Prostatectomy in Clinical Lymph Node Metastasis in Prostate Cancer
CONCLUSION: Radical prostatectomy can confirm lymph node metastasis. Although pathologic diagnosis has no effect on time to BCR and CPRC, because it affects BCR rate, CRPC rate, and CSS, an accurate pathological diagnosis obtained through surgery is beneficial in the treatment of clinical lymph node metastasis prostate cancer.PMID:37689608 | DOI:10.1245/s10434-023-14137-4
Source: Ann Oncol - September 9, 2023 Category: Cancer & Oncology Authors: Dongwon Kim Bumjin Lim Jungyo Suh Dalsan You In Gab Jeong Jun Hyuk Hong Hanjong Ahn Source Type: research
Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report
CONCLUSION: This case is the first report of clinical significance regarding the crucial role of estrogen and estrogen receptor β in malignant lymphoma in a patient with IgG4-related disease. Our report aims to raise awareness of the need to carefully select treatment options for prostate cancer patients with IgG4-related disease or lymphoma.PMID:37688628 | DOI:10.1007/s00432-023-05292-y
Source: Cell Research - September 9, 2023 Category: Cytology Authors: Hajime Sasagawa Kazuyuki Numakura Mizuki Mori Mizuki Kobayashi Soki Kashima Ryohei Yamamoto Taketoshi Nara Mitsuru Saito Shintaro Narita Hiroshi Nanjo Tomonori Habuchi Source Type: research
External Validation of the IMPROD-MRI Volumetric Model to Predict the Utility of Systematic Biopsies at the Time of Targeted Biopsy
Conclusions: This study supports the potential value of a model relying on MRI volumetric measurements for selecting individuals with clinical suspicion of prostate cancer who would benefit from undergoing a standard biopsy in addition to a targeted biopsy.PMID:37685815 | DOI:10.3390/jcm12175748
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Antonella Ninivaggi Francesco Guzzi Alessio Degennaro Anna Ricapito Carlo Bettocchi Gian Maria Busetto Francesca Sanguedolce Paola Milillo Oscar Selvaggio Luigi Cormio Giuseppe Carrieri Ugo Giovanni Falagario Source Type: research
Prostate Biopsy in the Case of PIRADS 5-Is Systematic Biopsy Mandatory?
J Clin Med. 2023 Aug 28;12(17):5612. doi: 10.3390/jcm12175612.ABSTRACTCombining systematic biopsy (SB) with targeted biopsy (TB) in the case of a positive result from multiparametric magnetic resonance imaging (mpMRI) is a matter of debate. The Prostate Imaging Reporting and Data System (PIRADS) score of 5 indicates the highest probability of clinically significant prostate cancer (csPC) detection in TB. Potentially, omitting SB in the case of PIRADS 5 may have a marginal impact on the csPC detection rate. The aim of this study was to determine whether SB can be avoided in the case of PIRADS 5 and to identify potential fac...
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Wojciech Malewski Tomasz Milecki Stanis ław Szempliński Omar Tayara Łukasz Kuncman Piotr Kryst Łukasz Nyk Source Type: research
Prevalence and Prognostic Implications of PSA Flares during Radium-223 Treatment among Men with Metastatic Castration Resistant Prostate Cancer
J Clin Med. 2023 Aug 28;12(17):5604. doi: 10.3390/jcm12175604.ABSTRACTRadium-223 (Ra233) prolongs the survival of men with symptomatic bone-predominant metastatic castration-resistant prostate cancer (mCRPC). However, prostate-specific antigen (PSA) response patterns are not closely associated with Ra223 therapy outcomes. Herein, we sought to analyze the impact of Ra223-induced PSA flares on patient outcome. Using a retrospective cohort study of Ra223 treatment in four Ontario/Canada cancer centres, we identified 134 patients grouped into sub-cohorts according to distinct PSA response patterns: (i) initial PSA flare follow...
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Amanjot Sidhu Nabeeha Khan Cameron Phillips Juan Briones Anil Kapoor Pawel Zalewski Neil E Fleshner Edward Chow Urban Emmenegger Source Type: research
The Complexity of Treatments and the Multidisciplinary Team-A Rare Case of Long-Term Progression-Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
CONCLUSIONS: Brain metastases are an unfavorable prognostic factor in prostate cancer. The therapeutic options developed in recent years allow the improvement of survival.PMID:37685646 | DOI:10.3390/jcm12175579
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Roxana-Andreea Rahnea-Nita Laura-Florentina Rebegea Alexandru Nechifor Cristian Mare ș Radu-Valeriu Toma Alexandru-Rares Stoian Anda-Natalia Ciuhu Liliana-Florina Andronache Georgiana Bianca Constantin Gabriela Rahnea-Nita Source Type: research
The Prognostic Nutritional Index (PNI): A New Biomarker for Determining Prognosis in Metastatic Castration-Sensitive Prostate Carcinoma
In this study, we aimed to evaluate the biomarker potential and effect of PNI in determining the prognosis of metastatic castration-sensitive prostate cancer (mCSPC). This retrospective observational study included the complete data of 108 patients with mCPSC who were treated for at least three months between 1 January 2010, and 1 June 2021. The relationships between cancer-specific survival (CSS), overall survival (OS), progression-free survival (PFS), and PNI were evaluated. The Kaplan-Meier method for OS, PFS, and CSS, as well as univariate and multivariate Cox regression models, were used for the statistical analyses. ...
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Halil Ibrahim Ellez Merve Keskinkilic H üseyin Salih Semiz Mehmet Emin Arayici Erdem K ısa Ilhan Oztop Source Type: research
MicroRNA-143 as a potential tumor suppressor in cancer: An insight into molecular targets and signaling pathways
Pathol Res Pract. 2023 Sep 6;250:154792. doi: 10.1016/j.prp.2023.154792. Online ahead of print.ABSTRACTMicroRNAs (MiRNAs), which are highly conserved and small noncoding RNAs, negatively regulate gene expression and influence signaling pathways involved in essential biological activities, including cell proliferation, differentiation, apoptosis, and cell invasion. MiRNAs have received much attention in the past decade due to their significant roles in cancer development. In particular, microRNA-143 (miR-143) is recognized as a tumor suppressor and is downregulated in most cancers. However, it seems that miR-143 is upregula...
Source: Pathology, Research and Practice - September 9, 2023 Category: Pathology Authors: Vahid Asghariazar Mahtab Kadkhodayi Mehdi Sarailoo Amir Ghaffari Jolfayi Behzad Baradaran Source Type: research
Androgen deprivation therapy caused a drastic proliferation of B-cell lymphoma with IgG4-related disease in patients with prostate cancer: a case report
CONCLUSION: This case is the first report of clinical significance regarding the crucial role of estrogen and estrogen receptor β in malignant lymphoma in a patient with IgG4-related disease. Our report aims to raise awareness of the need to carefully select treatment options for prostate cancer patients with IgG4-related disease or lymphoma.PMID:37688628 | DOI:10.1007/s00432-023-05292-y
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Hajime Sasagawa Kazuyuki Numakura Mizuki Mori Mizuki Kobayashi Soki Kashima Ryohei Yamamoto Taketoshi Nara Mitsuru Saito Shintaro Narita Hiroshi Nanjo Tomonori Habuchi Source Type: research
