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Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Prostate cancer-related sexual dysfunction - the significance of social relations in men's reconstructions of masculinity
Cult Health Sex. 2023 Sep 4:1-15. doi: 10.1080/13691058.2023.2250410. Online ahead of print.ABSTRACTNarrating illness experiences in a culturally acceptable manner is essential for retaining quality of life after the disruptive event of being diagnosed for prostate cancer. Psychological pressures caused by treatment side-effects such as erectile dysfunction require reinterpretation of the meanings and impacts of these side-effects on masculinity. This helps maintain coherence in men's lives. We studied how men employ culturally available discursive strategies (compensation, redefinition, recontextualisation, and normalisat...
Source: Culture, Health and Sexuality - September 4, 2023 Category: International Medicine & Public Health Authors: Anna-Maija Talvitie Hanna Ojala Teuvo Tammela Ilkka Pietil ä Source Type: research
Emerging role of miRNA in prostate cancer: A future era of diagnostic and therapeutics
Gene. 2023 Sep 2:147761. doi: 10.1016/j.gene.2023.147761. Online ahead of print.ABSTRACTProstate cancer (PCa) is the most common cancer in men (20%) and is responsible for 6.8% (1/5) of all cancer-related deaths in men around the world. The development and spread of prostate cancer are driven by a wide variety of genomic changes and extensive epigenetic events. Because of this, the MicroRNA (miRNA) and associated molecular mechanisms involved in PCa genesis and aggressive were only partially identified until today. The miRNAs are a newly discovered category of regulatorsthat have recently been recognized to have a signific...
Source: Gene - September 4, 2023 Category: Genetics & Stem Cells Authors: Mohd Mabood Khan Vineeta Sharma Mohammad Serajuddin Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Emerging role of miRNA in prostate cancer: A future era of diagnostic and therapeutics
Gene. 2023 Sep 2:147761. doi: 10.1016/j.gene.2023.147761. Online ahead of print.ABSTRACTProstate cancer (PCa) is the most common cancer in men (20%) and is responsible for 6.8% (1/5) of all cancer-related deaths in men around the world. The development and spread of prostate cancer are driven by a wide variety of genomic changes and extensive epigenetic events. Because of this, the MicroRNA (miRNA) and associated molecular mechanisms involved in PCa genesis and aggressive were only partially identified until today. The miRNAs are a newly discovered category of regulatorsthat have recently been recognized to have a signific...
Source: Gene - September 4, 2023 Category: Genetics & Stem Cells Authors: Mohd Mabood Khan Vineeta Sharma Mohammad Serajuddin Source Type: research
Prostate cancer-related sexual dysfunction - the significance of social relations in men's reconstructions of masculinity
Cult Health Sex. 2023 Sep 4:1-15. doi: 10.1080/13691058.2023.2250410. Online ahead of print.ABSTRACTNarrating illness experiences in a culturally acceptable manner is essential for retaining quality of life after the disruptive event of being diagnosed for prostate cancer. Psychological pressures caused by treatment side-effects such as erectile dysfunction require reinterpretation of the meanings and impacts of these side-effects on masculinity. This helps maintain coherence in men's lives. We studied how men employ culturally available discursive strategies (compensation, redefinition, recontextualisation, and normalisat...
Source: Culture, Health and Sexuality - September 4, 2023 Category: International Medicine & Public Health Authors: Anna-Maija Talvitie Hanna Ojala Teuvo Tammela Ilkka Pietil ä Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Prostate cancer-related sexual dysfunction - the significance of social relations in men's reconstructions of masculinity
Cult Health Sex. 2023 Sep 4:1-15. doi: 10.1080/13691058.2023.2250410. Online ahead of print.ABSTRACTNarrating illness experiences in a culturally acceptable manner is essential for retaining quality of life after the disruptive event of being diagnosed for prostate cancer. Psychological pressures caused by treatment side-effects such as erectile dysfunction require reinterpretation of the meanings and impacts of these side-effects on masculinity. This helps maintain coherence in men's lives. We studied how men employ culturally available discursive strategies (compensation, redefinition, recontextualisation, and normalisat...
Source: Culture, Health and Sexuality - September 4, 2023 Category: International Medicine & Public Health Authors: Anna-Maija Talvitie Hanna Ojala Teuvo Tammela Ilkka Pietil ä Source Type: research
Establishment of survival models of primary prostate cancer and colorectal cancer based on random survival forest
Asian J Surg. 2023 Sep 2:S1015-9584(23)01307-6. doi: 10.1016/j.asjsur.2023.08.156. Online ahead of print.NO ABSTRACTPMID:37666701 | DOI:10.1016/j.asjsur.2023.08.156
Source: Asian Journal of Surgery - September 4, 2023 Category: Surgery Authors: Bingqing Ma Biao Chen Chengjun Cai Jinxiang Zhang Source Type: research
Emerging role of miRNA in prostate cancer: A future era of diagnostic and therapeutics
Gene. 2023 Sep 4;888:147761. doi: 10.1016/j.gene.2023.147761. Online ahead of print.ABSTRACTProstate cancer (PCa) is the most common cancer in men (20%) and is responsible for 6.8% (1/5) of all cancer-related deaths in men around the world. The development and spread of prostate cancer are driven by a wide variety of genomic changes and extensive epigenetic events. Because of this, the MicroRNA (miRNA) and associated molecular mechanisms involved in PCa genesis and aggressive were only partially identified until today. The miRNAs are a newly discovered category of regulatorsthat have recently been recognized to have a sign...
Source: Gene - September 4, 2023 Category: Genetics & Stem Cells Authors: Mohd Mabood Khan Vineeta Sharma Mohammad Serajuddin Source Type: research
Inhibition of AKR1Cs by liquiritigenin and the structural basis
Chem Biol Interact. 2023 Sep 2:110654. doi: 10.1016/j.cbi.2023.110654. Online ahead of print.ABSTRACTIn vivo and in vitro studies have confirmed that liquiritigenin (LQ), the primary active component of licorice, acts as an antitumor agent. However, how LQ diminishes or inhibits tumor growth is not fully understood. Here, we report the enzymatic inhibition of LQ and six other flavanone analogues towards AKR1Cs (AKR1C1, AKR1C2 and AKR1C3), which are involved in prostate cancer, breast cancer, and resistance of anticancer drugs. Crystallographic studies revealed AKR1C3 inhibition of LQ is related to its complementarity with ...
Source: Chemico-Biological Interactions - September 4, 2023 Category: Molecular Biology Authors: Huan Liu Ziqing Yao Mingna Sun Chao Zhang Yi-You Huang Hai-Bin Luo Deyan Wu Xuehua Zheng Source Type: research
Repeatability of quantitative individual lesion and total disease multiparametric whole-body MRI measurements in prostate cancer bone metastases
CONCLUSIONS: APC bone metastases' ADC, rFF% and maximum diameter, tDV and gADC show good repeatability.ADVANCES IN KNOWLEDGE: APC bone metastases' mean ADC and rFF% measurements of single lesions and global disease volumes are repeatable, supporting their potential role as quantitative biomarkers in metastatic bone disease.PMID:37660399 | DOI:10.1259/bjr.20230378
Source: The British Journal of Radiology - September 3, 2023 Category: Radiology Authors: Ricardo Donners Antonio Candito Matthew Blackledge Mihaela Rata Christina Messiou Dow-Mu Koh Nina Tunariu Source Type: research
