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Cancer: Adenocarcinoma
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Total 24262 results found since Jan 2013.
Comprehensive analysis of P2Y family genes expression, immune characteristics, and prognosis in pan-cancer
CONCLUSION: P2Ys may be used as potential pan-cancer biomarkers in prognosis and immunology. They may also be new targets for tumor immunotherapy, which has wide clinical implications.PMID:37672858 | DOI:10.1016/j.tranon.2023.101776
Source: Translational Oncology - September 6, 2023 Category: Cancer & Oncology Authors: Chuan Liu Xiaoli Wang Siwei Wang Jiankang Xiang Huabing Xie Zongbiao Tan Xinshu Li Jixiang Zhang Weiguo Dong Source Type: research
ASO Author Reflections: Cancer Stem Cells of Esophageal Adenocarcinoma are Suppressed by Inhibitors of TRPV2 and SLC12A2
Ann Surg Oncol. 2023 Sep 6. doi: 10.1245/s10434-023-14269-7. Online ahead of print.NO ABSTRACTPMID:37672146 | DOI:10.1245/s10434-023-14269-7
Source: Ann Oncol - September 6, 2023 Category: Cancer & Oncology Authors: Atsushi Shiozaki Hiroyuki Inoue Eigo Otsuji Source Type: research
A super-enhancer-regulated RNA-binding protein cascade drives pancreatic cancer
Nat Commun. 2023 Sep 6;14(1):5195. doi: 10.1038/s41467-023-40798-6.ABSTRACTPancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE-mediated RNA-binding protein (RBP) cascade that supports PDAC growth through enhanced mRNA translation. This cascade is driven by a SE associated with the RBP heterogeneous nuclear ribonucleoprotein F, which stabilizes protein arginine methyltransferase 1 (PRMT1) to, in turn, control the translational mediator u...
Source: Cancer Control - September 6, 2023 Category: Cancer & Oncology Authors: Corina E Antal Tae Gyu Oh Stefan Aigner En-Ching Luo Brian A Yee Tania Campos Herv é Tiriac Katherine L Rothamel Zhang Cheng Henry Jiao Allen Wang Nasun Hah Elizabeth Lenkiewicz Jan C Lumibao Morgan L Truitt Gabriela Estepa Ester Banayo Senada Bashi Edga Source Type: research
ASO Author Reflections: Cancer Stem Cells of Esophageal Adenocarcinoma are Suppressed by Inhibitors of TRPV2 and SLC12A2
Ann Surg Oncol. 2023 Sep 6. doi: 10.1245/s10434-023-14269-7. Online ahead of print.NO ABSTRACTPMID:37672146 | DOI:10.1245/s10434-023-14269-7
Source: Ann Oncol - September 6, 2023 Category: Cancer & Oncology Authors: Atsushi Shiozaki Hiroyuki Inoue Eigo Otsuji Source Type: research
Integrated bioinformatics and validation reveal SOX12 as potential biomarker in colon adenocarcinoma based on an immune infiltration-related ceRNA network
CONCLUSION: Through the construction of ceRNA networks and evaluation of TIICs, the study successfully established two risk score models and nomograms. These models serve as valuable tools for understanding the molecular processes and predicting the prognosis of COAD patients. Further validation of hub regulators SOX12 and H19 substantiates their potential role as key biomarkers in COAD.PMID:37668799 | DOI:10.1007/s00432-023-05316-7
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Xinyi Chen Mu Yang Jingyao Tu Xianglin Yuan Source Type: research
Mesonephric-like adenocarcinoma of the female genital tract: possible role of KRAS-targeted treatment-detailed molecular analysis of a case series and review of the literature for targetable somatic KRAS-mutations
CONCLUSION: Because of a specific p.G12C-KRAS somatic mutation, only the minority of MLA (7.9% with uterine and 6.2% with ovarian primary) are potentially targetable by sotarasib in that rare but aggressive subtype of adenocarcinoma of the female genital tract. Until now, the different location of a somatic KRAS-mutation is of no prognostic impact.PMID:37668797 | DOI:10.1007/s00432-023-05306-9
Source: Clinical Genitourinary Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Christine E Brambs Lars-Christian Horn Ruth Hiller Irene Kr ücken Christian Braun Corina Christmann Astrid Monecke Anne Kathrin H öhn Source Type: research
The comprehensive review of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) from diagnosis and treatment
Ann Gastroenterol Surg. 2023 Jun 21;7(5):725-732. doi: 10.1002/ags3.12708. eCollection 2023 Sep.ABSTRACTGastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) was first proposed by Wothley et al. in 2012 as a rare familial gastric cancer syndrome associated with an autosomal dominant form of inheritance. GAPPS is characterized by gastric basal gland polyposis from the hilum to the body of the stomach. Li et al. in 2016 showed that the cause of the disease is a point mutation in the promotor 1B region of the APC gene, and genetic testing was used to confirm the diagnosis. If the patient has already developed g...
Source: Hand Surgery - September 4, 2023 Category: Surgery Authors: Masaaki Iwatsuki Chihiro Matsumoto Koshi Mimori Hideo Baba Source Type: research
Statement of Retraction: A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma
Cancer Biol Ther. 2023 Dec 31;24(1):2240179. doi: 10.1080/15384047.2023.2240179.NO ABSTRACTPMID:37661634 | DOI:10.1080/15384047.2023.2240179
Source: Cancer Biology and Therapy - September 4, 2023 Category: Cancer & Oncology Source Type: research
Prognostic value of genes related to cancer-associated fibroblasts in lung adenocarcinoma
CONCLUSION: An 11-gene model was constructed based on CAF-related genes to predict LUAD prognosis. This model represented an independent prognostic factor for LUAD.PMID:37661904 | DOI:10.3233/THC-230453
Source: Technology and Health Care - September 4, 2023 Category: Medical Devices Authors: Jigui Peng Changjin He Haiqiang Yan Wang Zhou Source Type: research
New insights into molecular signaling pathways and current advancements in prostate cancer diagnostics & amp; therapeutics
Front Oncol. 2023 Aug 17;13:1193736. doi: 10.3389/fonc.2023.1193736. eCollection 2023.ABSTRACTProstate adenocarcinoma accounts for more than 20% of deaths among males due to cancer. It is the fifth-leading cancer diagnosed in males across the globe. The mortality rate is quite high due to prostate cancer. Despite the fact that advancements in diagnostics and therapeutics have been made, there is a lack of effective drugs. Metabolic pathways are altered due to the triggering of androgen receptor (AR) signaling pathways, and elevated levels of dihydrotestosterone are produced due to defects in AR signaling that accelerate th...
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: Neha Thakur Sameer Quazi Bindu Naik Saurabh Kumar Jha Pallavi Singh Source Type: research
Identification of cancer stemness and M2 macrophage-associated biomarkers in lung adenocarcinoma
CONCLUSION: Our study identified CBFA2T3 and DENND3 as key genes associated with mRNAsi and M2 macrophages in LUAD and investigated the potential molecular mechanisms underlying this relationship.PMID:37662825 | PMC:PMC10472008 | DOI:10.1016/j.heliyon.2023.e19114
Source: Cancer Control - September 4, 2023 Category: Cancer & Oncology Authors: XiaoFang Wang Xuan Luo ZhiYuan Wang YangHao Wang Juan Zhao Li Bian Source Type: research
