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Design and synthesis of sulfonamides incorporating a biotin moiety: Carbonic anhydrase inhibitory effects, antiproliferative activity and molecular modeling studies
Bioorg Med Chem. 2023 Sep 7;94:117467. doi: 10.1016/j.bmc.2023.117467. Online ahead of print.ABSTRACTSulfonamides constitute an important class of classical carbonic anhydrase (CA, EC 4.2.1.1) inhibitors. Herein we have accomplished the conjugation of biotin with an ample number of sulfonamide motifs with the aim of testing them in vitro as inhibitors of the human carbonic anhydrase (hCA) isoforms I and II (cytosolic isozymes), as well as hCA IX and XII (transmembrane, tumor-associated enzymes). Most of these newly synthesized compounds exhibited interesting inhibition profiles, with activities in the nanomolar range. The ...
Source: Bioorganic and Medicinal Chemistry - September 18, 2023 Category: Chemistry Authors: Paloma Begines Alessandro Bonardi Alessio Nocentini Paola Gratteri Simone Giovannuzzi Roberto Ronca Camilla Tavani Maria Luisa Massardi Óscar López Claudiu T Supuran Source Type: research

Schweinfurthiamide, a new alkaloid isolated from the tuber roots of Asparagus flagellaris Baker (Liliaceae)
Nat Prod Res. 2023 Sep 18:1-7. doi: 10.1080/14786419.2023.2257358. Online ahead of print.ABSTRACTThe phytochemical investigations of the tuber roots of Asparagus flagellaris led to the isolation of a new alkaloid, schweinfurthiamide (1) and eight known compounds. The structures of the isolated compounds were elucidated using spectroscopic techniques 1D and 2D NMR (1H, 13C, COSY, HMBC, HMQC, HSQC-TOCSY). The absolute configuration of 1 was unambiguously determined using DP4+ calculations. Compound 1 showed significant cytotoxicity against MCF-7 (breast cancer), NCI-H460 (lung cancer), and Hela (cervical cancer) cancer cell ...
Source: Natural Product Research - September 18, 2023 Category: Biochemistry Authors: Elodie Nguelami Kamdeu Ad èle Nicaise Menye Nomo Abdou Tchoukoua Orleans Ngomo Pascal Djimeli Douanla Marguerite Hortence Tchuendem Kenmogne Yoshihito Shiono Turibio Kuiate Tabopda Source Type: research

Real-world evidence of neoadjuvant chemotherapy for breast cancer treatment in a Brazilian multicenter cohort: Correlation of pathological complete response with overall survival
CONCLUSION: The pCR rate and its prognostic value varied across BC subtypes. In our study, pCR could be used as a surrogate of favorable clinical outcome, as it was associated with higher OS and DFS rates.PMID:37722319 | DOI:10.1016/j.breast.2023.103577
Source: Breast - September 18, 2023 Category: Cancer & Oncology Authors: Marcelo Antonini Andr é Mattar Fernanda Grace Bauk Richter Gabriel Duque Pannain Marina Di ógenes Teixeira Andressa Gon çalves Amorim Odair Ferraro Reginaldo Coelho Guedes Lopes Luiz Henrique Gebrim Juliana Monte Real Source Type: research

Artificial intelligence in breast imaging: potentials and challenges
Phys Med Biol. 2023 Sep 18. doi: 10.1088/1361-6560/acfade. Online ahead of print.ABSTRACTBreast cancer, which is the most common type of malignant tumor among humans, is a leading cause of death in females. Standard treatment strategies, including neoadjuvant chemotherapy, surgery, postoperative chemotherapy, targeted therapy, endocrine therapy, and radiotherapy, are tailored for individual patients. Such personalized therapies have tremendously reduced the threat of breast cancer in females. Furthermore, early imaging screening plays an important role in reducing the treatment cycle and improving breast cancer prognosis. ...
Source: Physics in Medicine and Biology - September 18, 2023 Category: Physics Authors: Jiawei Li Danli Sheng Jiangang Chen Chao You Shuai Liu Huixiong Xu Cai Chang Source Type: research

Erratum to: Comprehensive serum lipidomic analyses reveal potential biomarkers for malignant breast cancer: A case-control study
Cancer Biomark. 2023 Sep 14. doi: 10.3233/CBM-239003. Online ahead of print.NO ABSTRACTPMID:37718782 | DOI:10.3233/CBM-239003
Source: Cancer Biomarkers : Section A of Disease Markers - September 18, 2023 Category: Cancer & Oncology Source Type: research

The necessity of proactive measures from healthcare providers highlighted by delayed breast cancer diagnosis due to COVID-19: A case report
Clin Case Rep. 2023 Sep 15;11(9):e7919. doi: 10.1002/ccr3.7919. eCollection 2023 Sep.ABSTRACTKEY CLINICAL MESSAGE: During disasters, multiple factors can cause significant delays in medical visits. Regular patient monitoring, high-risk individual alerts, and telemedicine enhancements can potentially alleviate these issues and ensure timely interventions.ABSTRACT: During the COVID-19 pandemic, a Japanese woman in her 70s delayed her regular breast cancer checkup for over 2 years. During disasters, health priorities tend to decline, necessitating proactive measures from healthcare providers, such as augmenting collaboration ...
Source: Clinical Genitourinary Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Yudai Kaneda Akihiko Ozaki Mira Namba Toyoaki Sawano Masahiro Wada Hiroaki Saito Yoshiaki Kanemoto Tomohiro Kurokawa Masaharu Tsubokura Kazunoshin Tachibana Tetsuya Tanimoto Tohru Ohtake Tomozo Ejiri Hiroaki Shimmura Norio Kanzaki Source Type: research

Efficient TNBC immunotherapy by dual reprogramming tumor-infiltrating dendritic cells and tumor-associated macrophages with stimulus-responsive miR155 nanocomplexes
In this study, pH/ROS-responsive microRNA-155 (miR155) nanocomplexes (MiR@PCPmP NPs) were developed to reprogram TIDCs and TAMs for efficient TNBC immunotherapy. This nanoplatform was based on a pH/ROS cleavable copolymer of poly(ethylene glycol)-carboxydimethyl maleate-poly(ethyleneimine)-peroxalate ester-poly(ε-caprolactone) grafted with mannose moieties (PEG-CDM-PEI[Man]-ox-PCL) which self-assembled with miRNA to form nanocomplexes. In the tumor microenvironment, the nanocomplexes showed selective cellular uptake by TIDCs and TAMs through PEG detachment and mannose exposure, followed by efficient endosomal escape, cyto...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Zhenghui Jing Yanfeng Li Jinxiao Song Xinlong Zang Source Type: research

Diagnostic performance of two versions of an artificial intelligence system in interval breast cancer detection
CONCLUSION: The present study showed that Tranpara v1.7 has a higher specificity, sensitivity and diagnostic performance in IBC determination than v1.6. AI systems can be used in breast screening as a secondary or third reader in screening programs.PMID:37722761 | DOI:10.1177/02841851231200785
Source: Acta Radiologica - September 18, 2023 Category: Radiology Authors: Levent Çelik Davut Can G üner Ömer Özçağlayan Rahmi Çubuk Mustafa Erkin Ar ıbal Source Type: research

 In-vitro anticancer activity of Rauvolfia tetraphylla extract on mcf-7 breast cancer cell lines
Bioinformation. 2023 Jan 31;19(1):43-47. doi: 10.6026/97320630019043. eCollection 2023.ABSTRACTThe medicinal herb Rauwolfia tetraphylla is utilized by South Indian tribes to treat various medical ailments, although its cytotoxicity action has not been studied. As a result, the emphasis of the current investigation is on the anticancer activity of Rauvolfia tetraphylla extracts on MCF-7 breast cancer cell lines, as well as their effects on the levels of gene expression for BCl2 and TGF. The study found that the anticancer activity of R. tetraphylla extract demonstrated significant cytotoxic activity against MCF-7 breast can...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Abraham Sabu Selvaraj J Gayatridevi R Dilipan E Source Type: research

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