• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

A review of combined neuromodulation and physical therapy interventions for enhanced neurorehabilitation
Rehabilitation approaches for individuals with neurologic conditions have increasingly shifted toward promoting neuroplasticity for enhanced recovery and restoration of function. This review focuses on exercise strategies and non-invasive neuromodulation techniques that target neuroplasticity, including transcranial magnetic stimulation (TMS), vagus nerve stimulation (VNS), and peripheral nerve stimulation (PNS). We have chosen to focus on non-invasive neuromodulation techniques due to their greater potential for integration into routine clinical practice. We explore and discuss the application of these interventional stra...
Source: Frontiers in Human Neuroscience - July 21, 2023 Category: Neuroscience Source Type: research

Real world evidence of improved attention and cognition during physical therapy paired with neuromodulation: a brain vital signs study
DiscussionThe current study highlighted real-world neuromodulation improvements in neurophysiological correlates of attention. Overall, the real-world findings support the concept of neuromodulation-related improvements extending beyond physical therapy to include potential attention benefits for cognitive rehabilitation.
Source: Frontiers in Human Neuroscience - June 9, 2023 Category: Neuroscience Source Type: research

A brief review of motor imagery and bimanual coordination
Motor imagery is increasingly being used in clinical settings, such as in neurorehabilitation and brain computer interface (BCI). In stroke, patients lose upper limb function and must re-learn bimanual coordination skills necessary for the activities of daily living. Physiotherapists integrate motor imagery with physical rehabilitation to accelerate recovery. In BCIs, users are often asked to imagine a movement, often with sparse instructions. The EEG pattern that coincides with this cognitive task is captured, then used to execute an external command, such as operating a neuroprosthetic device. As such, BCIs are dependent...
Source: Frontiers in Human Neuroscience - November 11, 2022 Category: Neuroscience Source Type: research

Enhanced Visual Feedback Using Immersive VR Affects Decision Making Regarding Hand Use With a Simulated Impaired Limb
This study aimed to investigate the effect of IVR-reinforced physical therapy that incorporates positive reinforcement components in motor coordination. To simulate affected upper limb function loss in patients, a wrist weight was attached to the dominant hand of participant. Participants were asked to choose their right or left hand to reach toward a randomly allocated target. The movement of the virtual image of the upper limb was reinforced by visual feedback to participants, that is, the participants perceived their motor coordination as if their upper limb was moving to a greater degree than what was occurring in ever...
Source: Frontiers in Human Neuroscience - June 11, 2021 Category: Neuroscience Source Type: research

Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy
Conclusion This proof-of-principle study evaluated the influence of cathodal contralesional tDCS on corticospinal excitability in pediatric participants with UCP. A hypothesized decrease in contralesional excitability was noted in participants in the Active+CIMT group, however, the efficacy of tDCS to modulate corticospinal excitability was not statistically different than the Sham+CIMT group. A more detailed understanding of how tDCS impacts M1 neurophysiology will be essential to inform future clinical trials on the optimal dosing parameters, based on individual brain circuitry, to explore the potential functional benef...
Source: Frontiers in Human Neuroscience - April 23, 2019 Category: Neuroscience Source Type: research

Neurophysiological Analysis of Intermanual Transfer in Motor Learning
In this study, MEPs were induced during the subject’s imaged kinesthetic MI. This involves recalling muscle contraction based on a muscle sensory image and was reported to indicate the activity of brain regions similar to those involved in actual muscle contraction (Ruby and Decety, 2001). In the transfer training group, the muscle sensory image evaluation correlated to the actual task execution with the right hand. As a result, it was easy to recall the kinesthetic MI for the training task, thus affecting MI of the non-trained limbs so that MEP changes occurred in the left hand’s MI. In addition, brain exc...
Source: Frontiers in Human Neuroscience - April 17, 2019 Category: Neuroscience Source Type: research

Comparison of Muscular Activity and Movement Performance in Robot-Assisted and Freely Performed Exercises
End-effector-based robotic systems are, in particular, suitable for extending physical therapy in stroke rehabilitation. An adequate therapy and thus the recovery of movement can only be guaranteed if the physiological muscular activation and movement performance are influenced as little as possible by the robot itself. Yet, this relation has not been investigated in the literature. Therefore, 20 healthy subjects performed free and robot-assisted exercises under different control settings supported by an end-effector-based system. The control settings differed concerning changes in the end-effector velocity and the stiffne...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - January 1, 2019 Category: Neuroscience Source Type: research

A Soft Exosuit for Flexible Upper-Extremity Rehabilitation
For stroke survivors and many other people with upper-extremity impairment, daily life can be difficult without properly functioning arms. Some modern physical therapy exercises focus on rehabilitating people with these troubles by correcting patients’ perceptions of their own body to eventually regain complete control and strength over their arms again. Augmentative wearable robots, such as the upper-extremity exoskeletons and exosuits, may be able to assist in this endeavor. A common drawback in many of these exoskeletons, however, is their inability to conform to the natural flexibility of the human body without ...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - August 1, 2018 Category: Neuroscience Source Type: research

Lower-extremity Dynamometry as a Novel Outcome Measure in a Double-blind, Placebo-controlled, Feasibility Trial of Intravenous Immunoglobulin (IVIG) for HIV-associated Myelopathy
Conclusion: We conclude that an adequately powered clinical trial of IVIG for HIVM would likely require a prolonged recruitment period and multiple participating sites. Lower limb dynamometry is a useful outcome measure for HIVM, which might also be useful in other HIV-related gait disorders. KEYWORDS: Dynamometry, intravenous immunoglobulin (IVIG), human immunodeficiency virus (HIV), myelopathy INTRODUCTION Human immunodeficiency virus (HIV)-associated myelopathy (HIVM) is a rare but well-described neurologic complication of HIV; it was first described early in the acquired immunodeficiency syndrome (AIDS) epidemic, and i...
Source: Innovations in Clinical Neuroscience - February 1, 2018 Category: Neuroscience Authors: ICN Online Editor Tags: Assessment Tools Current Issue Demyelinating Disease Movement Disorders Neurodegenerative Disease Neurology Original Research Primary Care Technology Trial Methodology Dynamometry human immunodeficiency virus (HIV) intravenous immu Source Type: research

Focusing on claudin-5: a promising candidate in the regulation of BBB to treat ischemic stroke
Publication date: Available online 5 December 2017 Source:Progress in Neurobiology Author(s): Jianjun Lv, Wei Hu, Zhi Yang, Tian Li, Shuai Jiang, Zhiqiang Ma, Fulin Chen, Yang Yang Claudin-5 is a tight junction (TJ) protein in the blood-brain barrier (BBB) that has recently attracted increased attention. Numerous studies have demonstrated that claudin-5 regulates the integrity and permeability of the BBB. Increased claudin-5 expression plays a neuroprotective role in neurological diseases, particularly in cerebral ischemic stroke. Moreover, claudin-5 might be a potential marker for early hemorrhagic transformation detecti...
Source: Progress in Neurobiology - December 6, 2017 Category: Neuroscience Source Type: research

S185 The effect of bilateral arm training on motor areas excitability in chronic stroke patients
Physical therapy exercises that do not enhance motor areas neuroplasticity lead to motor impairment especially at the upper extremity (UE) in the chronic stroke patients. The aim of this study was to assess the effect of using bilateral arm training on motor areas excitability (neuroplasticity) in the chronic stroke patients.
Source: Clinical Neurophysiology - August 17, 2017 Category: Neuroscience Authors: Walaa Ragab, Moshera Darwish, Mohamed El Tamawy, Ann Abdel Kader Source Type: research

The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke
Stroke is a leading cause of adult disability and many people are left with impairments and are dependent on others for activities of daily living (Dobkin, 2005; DOH, 2007; Veerbeek et al., 2011). Strategies to improve plasticity and enhance motor learning are needed. One potential approach is to use transcranial direct current stimulation (tDCS) to enhance the effect of physical therapy.
Source: Clinical Neurophysiology - March 30, 2017 Category: Neuroscience Authors: Melanie K Fleming, John C Rothwell, Laszlo Sztriha, James T Teo, Di J Newham Source Type: research

Design and Evaluation of a Soft and Wearable Robotic Glove for Hand Rehabilitation
In the modern world, due to an increased aging population, hand disability is becoming increasingly common. The prevalence of conditions such as stroke is placing an ever-growing burden on the limited fiscal resources of health care providers and the capacity of their physical therapy staff. As a solution, this paper presents a novel design for a wearable and adaptive glove for patients so that they can practice rehabilitative activities at home, reducing the workload for therapists and increasing the patient’s independence. As an initial evaluation of the design’s feasibility the prototype was subjected to m...
Source: IEE Transactions on Neural Systems and Rehabilitation Engineering - September 30, 2016 Category: Neuroscience Source Type: research

Repairing the Brain by SCF+G-CSF Treatment at 6 Months Postexperimental Stroke: Mechanistic Determination of the Causal Link Between Neurovascular Regeneration and Motor Functional Recovery
This study provides novel insights into the development of new restorative strategies for stroke recovery.
Source: ASN Neuro - August 8, 2016 Category: Neuroscience Authors: Cui, L., Wang, D., McGillis, S., Kyle, M., Zhao, L.-R. Tags: Original Article Source Type: research

The emerging role of signal transducer and activator of transcription 3 in cerebral ischemic and hemorrhagic stroke
Publication date: Available online 29 December 2015 Source:Progress in Neurobiology Author(s): Zhenxing Liang, Guiling Wu, Chongxi Fan, Jing Xu, Shuai Jiang, Xiaolong Yan, Shouyin Di, Zhiqiang Ma, Wei Hu, Yang Yang Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic transcription factors that mediate intracellular signaling. This signaling is typically generated at cell surface receptors, the activation of which results in the translocation of STATs to the nucleus. STATs are involved in biological events as diverse as embryonic development, programmed cell death, organoge...
Source: Progress in Neurobiology - January 13, 2016 Category: Neuroscience Source Type: research

Pages: 1  2