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A narrative review on the application of high-intensity focused ultrasound for the treatment of occlusive and thrombotic arterial disease
CONCLUSIONS: In current preclinical and clinical data, the safety and efficacy of HIFU shows great promise in the treatment of atherosclerotic arterial disease. Future focused studies are warranted to guide the refinement of HIFU settings for more widespread adoption of this technology.PMID:36276806 | PMC:PMC9579503 | DOI:10.1016/j.jvssci.2022.08.001
Source: Atherosclerosis - October 24, 2022 Category: Cardiology Authors: Anand Brahmandam Shin Mei Chan Alan Dardik Naiem Nassiri Edouard Aboian Source Type: research

Magnetic resonance-guided, high-intensity focused ultrasound sonolysis: potential applications for stroke.
Abstract Stroke is one of the leading causes of death worldwide and a significant source of long-term morbidity. Unfortunately, a substantial number of stroke patients either are ineligible or do not significantly benefit from contemporary medical and interventional therapies. To address this void, investigators recently made technological advances to render transcranial MR-guided, high-intensity focused ultrasound (MRg-HIFU) sonolysis a potential therapeutic option for both acute ischemic stroke (AIS)-as an alternative for patients with emergent large-vessel occlusion (ELVO) who are ineligible for endovascular me...
Source: Neurosurgical Focus - February 1, 2018 Category: Neurosurgery Authors: Ilyas A, Chen CJ, Ding D, Romeo A, Buell TJ, Wang TR, Kalani MYS, Park MS Tags: Neurosurg Focus Source Type: research

High intensity focused ultrasound ablation for atrial fibrillation: results from the National Spanish Registry.
CONCLUSIONS: The Spanish national registry showed an efficacy of AF ablation with the HIFU Epicor system of 66.1%, 63.8%, 63.9% and 45.9% at 6, 12, 24 and 36 months follow-up. There was no device-related complications. PMID: 26006216 [PubMed - as supplied by publisher]
Source: Minerva Cardioangiologica - November 18, 2015 Category: Cardiology Tags: Minerva Cardioangiol Source Type: research

Thrombolysis using multi-frequency high intensity focused ultrasound at MHz range: an in vitro study.
In this study, multi-frequency acoustic waves at MHz range (near 1.5 MHz) were introduced as HIFU excitations to reduce the required power for treatment as well as the treatment time. In vitro bovine blood clots weighing around 150 mg were treated by single-frequency and multi-frequency HIFU. The pulse length was 2 ms for all experiments except the ones where the duty cycle was changed. It was found that dual-frequency thrombolysis efficiency was statistically better than single-frequency under the same acoustic power and excitation condition. When varying the acoustic power but fixing the duty cycle at 5%, it was foun...
Source: Physica Medica - September 9, 2015 Category: Physics Authors: Suo D, Guo S, Lin W, Jiang X, Jing Y Tags: Phys Med Biol Source Type: research

High-Intensity Focused Ultrasound Sonothrombolysis: The Use of Perfluorocarbon Droplets to Achieve Clot Lysis at Reduced Acoustic Power
The purpose of this study was to evaluate use of intravascular perfluorocarbon droplets to reduce the sonication power required to achieve clot lysis with high-intensity focused ultrasound. High-intensity focused ultrasound with droplets was initially applied to blood clots in an in vitro flow apparatus, and inertial cavitation thresholds were determined. An embolic model for ischemic stroke was used to illustrate the feasibility of this technique in vivo. Recanalization with intravascular droplets was achieved in vivo at 24 ± 5% of the sonication power without droplets.
Source: Ultrasound in Medicine and Biology - July 9, 2014 Category: Radiology Authors: Daniel Pajek, Alison Burgess, Yuexi Huang, Kullervo Hynynen Tags: Original Contributions Source Type: research

MR compatible positioning device for guiding a focused ultrasound system for the treatment of brain deseases
ConclusionA simple, cost effective, portable positioning device has been developed which can be used in virtually any clinical MRI scanner since it can be placed on the table of the MRI scanner. This system can be used to treat in the future patients with brain cancer and ischemic stroke. Copyright © 2013 John Wiley & Sons, Ltd.
Source: The International Journal of Medical Robotics and Computer Assisted Surgery - June 7, 2013 Category: Surgery Authors: N. Mylonas, C. Damianou Tags: Original Article Source Type: research