Filtered By:
Specialty: General Medicine
Therapy: Stem Cell Therapy

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 48 results found since Jan 2013.

Cell therapy for cerebral hemorrhage: Five year follow-up report.
Authors: Chang Z, Mao G, Sun L, Ao Q, Gu Y, Liu Y Abstract The aim of the study was to examine treatment of cerebral hemorrhages with bone-marrow or human umbilical cord-derived mesenchymal stem cells (BMSCs or Hu-MSCs) and conventional surgical approaches, and determine and compare the effectiveness, feasibility, safety and reproducibility of each method. A retrospective analysis was performed on a cohort of cell-treated cerebral hemorrhage patients from October 1, 2007 to October 1, 2009. A total of 24 patients, all of whom received conventional surgical treatment, were classified as follows: i) The control group...
Source: Experimental and Therapeutic Medicine - January 20, 2017 Category: Journals (General) Tags: Exp Ther Med Source Type: research

G-CSF and hypoxic conditioning improve the proliferation, neural differentiation and migration of canine bone marrow mesenchymal stem cells.
Authors: Yu J, Liu XL, Cheng QG, Lu SS, Xu XQ, Zu QQ, Liu S Abstract Transplantation using bone marrow mesenchymal stem cells (BMSCs) is emerging as a potential regenerative therapy after ischemic attacks in the brain. However, it has been questioned because very few transplanted BMSCs are detected homing to and survived in the ischemic region. Improving the cell viability and migration ability under the complex ischemic condition seems very important. The aim of our study is to identify whether hypoxic condition and granulocyte colony-stimulating factor (G-CSF) could improve the cell survival and migration ability...
Source: Experimental and Therapeutic Medicine - September 3, 2016 Category: Journals (General) Tags: Exp Ther Med Source Type: research

Mouse Study Suggests Stem Cells May Reverse Stroke Damage
MONDAY, Aug. 22, 2016 -- Research in mice shows it may be possible to reverse brain damage after a stroke. " No one in the stroke field has ever shown this, so I believe this is going to be the gold standard for future studies, " said senior study...
Source: Drugs.com - Daily MedNews - August 22, 2016 Category: Journals (General) Source Type: news

3K3A –activated protein C stimulates postischemic neuronal repair by human neural stem cells in mice
Nature Medicine 22, 1050 (2016). doi:10.1038/nm.4154 Authors: Yaoming Wang, Zhen Zhao, Sanket V Rege, Min Wang, Gabriel Si, Yi Zhou, Su Wang, John H Griffin, Steven A Goldman & Berislav V Zlokovic Activated protein C (APC) is a blood protease with anticoagulant activity and cell-signaling activities mediated by the activation of protease-activated receptor 1 (F2R, also known as PAR1) and F2RL1 (also known as PAR3) via noncanonical cleavage. Recombinant variants of APC, such as the 3K3A-APC (Lys191–193Ala) mutant in which three Lys residues (KKK191–193) were replaced with alanine, and/or its other mutan...
Source: Nature Medicine - August 21, 2016 Category: Journals (General) Authors: Yaoming Wang Zhen Zhao Sanket V Rege Min Wang Gabriel Si Yi Zhou Su Wang John H Griffin Steven A Goldman Berislav V Zlokovic Tags: Letter Source Type: research

Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study
Publication date: Available online 3 August 2016 Source:The Lancet Author(s): Dheeraj Kalladka, John Sinden, Kenneth Pollock, Caroline Haig, John McLean, Wilma Smith, Alex McConnachie, Celestine Santosh, Philip M Bath, Laurence Dunn, Keith W Muir Background CTX0E03 is an immortalised human neural stem-cell line from which a drug product (CTX-DP) was developed for allogeneic therapy. Dose-dependent improvement in sensorimotor function in rats implanted with CTX-DP 4 weeks after middle cerebral artery occlusion stroke prompted investigation of the safety and tolerability of this treatment in stroke patients. Methods We did ...
Source: The Lancet - August 3, 2016 Category: Journals (General) Source Type: research

Age of PISCES: stem-cell clinical trials in stroke
Publication date: Available online 3 August 2016 Source:The Lancet Author(s): Cesar V Borlongan
Source: The Lancet - August 3, 2016 Category: Journals (General) Source Type: research

Comment Age of PISCES: stem-cell clinical trials in stroke
Laboratory studies and limited clinical trials over the past two decades have shown feasibility and safety, and have revealed potential mechanisms of action of stem-cell therapy in ischaemic stroke. Despite consistent efficacy in animal studies, functional benefits after transplantation of stem cells remain to be shown unequivocally in stroke patients.1 Translation of stem-cell therapy from the laboratory to the clinic has been approached with ample caution, in part due to the largely negative outcomes for several stroke therapeutics in human beings compared with those in animals.
Source: LANCET - August 2, 2016 Category: Journals (General) Authors: Cesar V Borlongan Tags: Comment Source Type: research

Articles Human neural stem cells in patients with chronic ischaemic stroke (PISCES): a phase 1, first-in-man study
Single intracerebral doses of CTX-DP up to 20 million cells induced no adverse events and were associated with improved neurological function. Our observations support further investigation of CTX-DP in stroke patients.
Source: LANCET - August 2, 2016 Category: Journals (General) Authors: Dheeraj Kalladka, John Sinden, Kenneth Pollock, Caroline Haig, John McLean, Wilma Smith, Alex McConnachie, Celestine Santosh, Philip M Bath, Laurence Dunn, Keith W Muir Tags: Articles Source Type: research

Stem Cells May Offer New Hope to Stroke Survivors
THURSDAY, June 2, 2016 -- Preliminary research suggests that injecting adult stems cells directly into the brain may give stroke patients a new shot at recovery long after their stroke occurred. "We don't want to oversell this," stressed study lead...
Source: Drugs.com - Daily MedNews - June 2, 2016 Category: Journals (General) Source Type: news

Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial
Background: Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs. We therefore designed a study to prospectively demonstrate that the tra...
Source: Trials - November 23, 2015 Category: Journals (General) Authors: Sylvain ChantepieJean-Baptiste MearLydia GuittetBenoît DervauxJean-Pierre MarolleauFabrice JardinJean-Jacques DutheilJean-Jacques ParientiJean-Pierre VilqueOumedaly Reman Source Type: research

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spacial learning and memory in mouse middle cerebral artery occlusion model
IntroductionGrowing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of the most appropriate for stroke treatment. However, previous experimental data could not reach to an agreement on the efficacy of ADSC transplantation for treating stroke in vivo as well as its mechanism which hinders their further clinical translational application. Methods: To explore their in vivo mechanism of hADSC administration on neurological injury, hADSC were labeled with EGFP expressing FG12 len...
Source: BioMed Central - May 8, 2015 Category: Journals (General) Authors: Fei ZhouShane GaoLin WangChenxi SunLu ChenPing YuanHaiyang ZhaoYi YiYing QinZhiqiang DongLimei CaoHaiyan RenLiang ZhuQiang LiBing LuAibin LiangGuotong XuHongwen ZhuZhengliang GaoJie MaJun XuXu Chen Source Type: research

Implantation of human umbilical cord mesenchymal stem cells for ischemic stroke: perspectives and challenges
Abstract Ischemic stroke is a focal cerebral insult that often leads to many adverse neurological complications severely affecting the quality of life. The prevalence of stroke is increasing throughout the world, while the efficacy of current pharmacological therapies remains unclear. As a neuroregenerative therapy, the implantation of human umbilical cord mesenchymal stem cells (hUC-MSCs) has shown great possibility to restore function after stroke. This review article provides an update role of hUC-MSCs implantation in the treatment of ischemic stroke. With the unique “immunosuppressive and immunoprivilege” ...
Source: Frontiers of Medicine - December 9, 2014 Category: Journals (General) Source Type: research

Adipose-derived stem cells in stroke treatment: translational possibility and mechanism.
PMID: 25316245 [PubMed - in process]
Source: Chinese Medical Journal - October 1, 2014 Category: Journals (General) Authors: Zhou F, Gao S, Sun C, Cao L, Ren H, Li Q, Wang G, Dong C, Zhu L, Yang D, Wang X, Xu J, Chen X Tags: Chin Med J (Engl) Source Type: research

Chronic variable stress activates hematopoietic stem cells
Nature Medicine 20, 754 (2014). doi:10.1038/nm.3589 Authors: Timo Heidt, Hendrik B Sager, Gabriel Courties, Partha Dutta, Yoshiko Iwamoto, Alex Zaltsman, Constantin von zur Muhlen, Christoph Bode, Gregory L Fricchione, John Denninger, Charles P Lin, Claudio Vinegoni, Peter Libby, Filip K Swirski, Ralph Weissleder & Matthias Nahrendorf Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis. Although incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking stress and disease inception and progression. Known cross-...
Source: Nature Medicine - June 22, 2014 Category: Journals (General) Authors: Timo HeidtHendrik B SagerGabriel CourtiesPartha DuttaYoshiko IwamotoAlex ZaltsmanConstantin von zur MuhlenChristoph BodeGregory L FricchioneJohn DenningerCharles P LinClaudio VinegoniPeter LibbyFilip K SwirskiRalph WeisslederMatthias Nahrendorf Tags: Letter Source Type: research

Stem cell therapy for chronic ischaemic heart disease and congestive heart failure.
CONCLUSIONS: This systematic review and meta-analysis found moderate quality evidence that BMSC treatment improves LVEF. Unlike in trials where BMSC were administered following acute myocardial infarction (AMI), we found some evidence for a potential beneficial clinical effect in terms of mortality and performance status in the long term (after at least one year) in people who suffer from chronic IHD and heart failure, although the quality of evidence was low. PMID: 24777540 [PubMed - as supplied by publisher]
Source: Cochrane Database of Systematic Reviews - May 3, 2014 Category: Journals (General) Authors: Fisher SA, Brunskill SJ, Doree C, Mathur A, Taggart DP, Martin-Rendon E Tags: Cochrane Database Syst Rev Source Type: research