A molecular mechanism governing memory precision
Nature Medicine 24, 390 (2018). doi:10.1038/nm.4532 Authors: Josue Haubrich & Karim Nader A key molecular mechanism has been identified that dictates whether memory will maintain or lose its details over time and that is relevant in post-traumatic stress disorder and dementia. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Josue Haubrich Karim Nader Tags: News and Views Source Type: research

Erratum: Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Nature Medicine 24, 526 (2018). doi:10.1038/nm0418-526c Author: Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut Bertz, Ralph Wäsch, Johanna Haag, Andrea Schmidts, Michael Schultheiss, Dominik Bettinger, Robert Thimme, Evelyn Ullrich, Yakup Tanriver, Giang Lam ...
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A M ü ller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Tags: Erratum Source Type: research

Erratum: The molecular landscape of pediatric acute myeloid leukemia reveals recurrent structural alterations and age-specific mutational interactions
Nature Medicine 24, 526 (2018). doi:10.1038/nm0418-526b Author: Hamid Bolouri, Jason E Farrar, Timothy Triche, Rhonda E Ries, Emilia L Lim, Todd A Alonzo, Yussanne Ma, Richard Moore, Andrew J Mungall, Marco A Marra, Jinghui Zhang, Xiaotu Ma, Yu Liu, Yanling Liu, Jaime M Guidry Auvil, Tanja M Davidsen, Patee Gesuwan, Leandro C Hermida, Bodour Salhia, Stephen Capone, Giridharan Ramsingh, Christian Michel Zwaan, Sanne Noort, Stephen R Piccolo, E Anders Kolb, Alan S Gamis, Malcolm A Smith, Daniela S Gerhard & Soheil Meshinchi (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Hamid Bolouri Jason E Farrar Timothy Triche Rhonda E Ries Emilia L Lim Todd A Alonzo Yussanne Ma Richard Moore Andrew J Mungall Marco A Marra Jinghui Zhang Xiaotu Ma Yu Liu Yanling Liu Jaime M Guidry Auvil Tanja M Davidsen Patee Gesuwan Leandro C Hermida Tags: Erratum Source Type: research

Corrigendum: Colonic organoids derived from human induced pluripotent stem cells for modeling colorectal cancer and drug testing
Nature Medicine 24, 526 (2018). doi:10.1038/nm0418-526a Author: Miguel Crespo, Eduardo Vilar, Su-Yi Tsai, Kyle Chang, Sadaf Amin, Tara Srinivasan, Tuo Zhang, Nina H Pipalia, Huanhuan Joyce Chen, Mavee Witherspoon, Miriam Gordillo, Jenny Zhaoying Xiang, Frederick R Maxfield, Steven Lipkin, Todd Evans & Shuibing Chen (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Miguel Crespo Eduardo Vilar Su-Yi Tsai Kyle Chang Sadaf Amin Tara Srinivasan Tuo Zhang Nina H Pipalia Huanhuan Joyce Chen Mavee Witherspoon Miriam Gordillo Jenny Zhaoying Xiang Frederick R Maxfield Steven Lipkin Todd Evans Shuibing Chen Tags: Corrigendum Source Type: research

Corrigendum: Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed antidiabetic target in mice selected for leanness
Nature Medicine 24, 525 (2018). doi:10.1038/nm0418-525e Author: Nicholas M Morton, Jasmina Beltram, Roderick N Carter, Zoi Michailidou, Gregor Gorjanc, Clare McFadden, Martin E Barrios-Llerena, Sergio Rodriguez-Cuenca, Matthew T G Gibbins, Rhona E Aird, José Maria Moreno-Navarrete, Steven C Munger, Karen L Svenson, Annalisa Gastaldello, Lynne Ramage, Gregorio Naredo, Maximilian Zeyda, Zhao V Wang, Alexander F Howie, Aila Saari, Petra Sipilä, Thomas M Stulnig, Vilmundur Gudnason, Christopher J Kenyon, Jonathan R Seckl, Brian R Walker, Scott P Webster, Donald R Dunbar, Gary A Churchill, Antonio Vidal-Puig, J...
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Nicholas M Morton Jasmina Beltram Roderick N Carter Zoi Michailidou Gregor Gorjanc Clare McFadden Martin E Barrios-Llerena Sergio Rodriguez-Cuenca Matthew T G Gibbins Rhona E Aird Jos é Maria Moreno-Navarrete Steven C Munger Karen L Svenson Annalisa Gas Tags: Corrigendum Source Type: research

Corrigendum: Sex-specific transcriptional signatures in human depression
Nature Medicine 24, 525 (2018). doi:10.1038/nm0418-525d Author: Benoit Labonté, Olivia Engmann, Immanuel Purushothaman, Caroline Menard, Junshi Wang, Chunfeng Tan, Joseph R Scarpa, Gregory Moy, Yong-Hwee E Loh, Michael Cahill, Zachary S Lorsch, Peter J Hamilton, Erin S Calipari, Georgia E Hodes, Orna Issler, Hope Kronman, Madeline Pfau, Aleksandar L J Obradovic, Yan Dong, Rachael L Neve, Scott Russo, Andrew Kasarskis, Carol Tamminga, Naguib Mechawar, Gustavo Turecki, Bin Zhang, Li Shen & Eric J Nestler (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Benoit Labont é Olivia Engmann Immanuel Purushothaman Caroline Menard Junshi Wang Chunfeng Tan Joseph R Scarpa Gregory Moy Yong-Hwee E Loh Michael Cahill Zachary S Lorsch Peter J Hamilton Erin S Calipari Georgia E Hodes Orna Issler Hope Kronman Madeline Tags: Corrigendum Source Type: research

Corrigendum: Positively selected enhancer elements endow osteosarcoma cells with metastatic competence
Nature Medicine 24, 525 (2018). doi:10.1038/nm0418-525c Author: James J Morrow, Ian Bayles, Alister P W Funnell, Tyler E Miller, Alina Saiakhova, Michael M Lizardo, Cynthia F Bartels, Maaike Y Kapteijn, Stevephen Hung, Arnulfo Mendoza, Gursimran Dhillon, Daniel R Chee, Jay T Myers, Frederick Allen, Marco Gambarotti, Alberto Righi, Analisa DiFeo, Brian P Rubin, Alex Y Huang, Paul S Meltzer, Lee J Helman, Piero Picci, Henri H Versteeg, John A Stamatoyannopoulos, Chand Khanna & Peter C Scacheri (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: James J Morrow Ian Bayles Alister P W Funnell Tyler E Miller Alina Saiakhova Michael M Lizardo Cynthia F Bartels Maaike Y Kapteijn Stevephen Hung Arnulfo Mendoza Gursimran Dhillon Daniel R Chee Jay T Myers Frederick Allen Marco Gambarotti Alberto Righi An Tags: Corrigendum Source Type: research

Corrigendum: Suppression of luteinizing hormone enhances HSC recovery after hematopoietic injury
Nature Medicine 24, 525 (2018). doi:10.1038/nm0418-525b Author: Enrico Velardi, Jennifer J Tsai, Stefan Radtke, Kirsten Cooper, Kimon V Argyropoulos, Shieh Jae-Hung, Lauren F Young, Amina Lazrak, Odette M Smith, Sophie Lieberman, Fabiana Kreines, Yusuke Shono, Tobias Wertheimer, Robert R Jenq, Alan M Hanash, Prema Narayan, Zhenmin Lei, Malcolm A Moore, Hans-Peter Kiem, Marcel R M van den Brink & Jarrod A Dudakov (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Enrico Velardi Jennifer J Tsai Stefan Radtke Kirsten Cooper Kimon V Argyropoulos Shieh Jae-Hung Lauren F Young Amina Lazrak Odette M Smith Sophie Lieberman Fabiana Kreines Yusuke Shono Tobias Wertheimer Robert R Jenq Alan M Hanash Prema Narayan Zhenmin Le Tags: Corrigendum Source Type: research

Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types
Nature Medicine 24, 525 (2018). doi:10.1038/nm0418-525a Author: Ronald J Hause, Colin C Pritchard, Jay Shendure & Stephen J Salipante (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Ronald J Hause Colin C Pritchard Jay Shendure Stephen J Salipante Tags: Corrigendum Source Type: research

Current understanding of the human microbiome
Nature Medicine 24, 392 (2018). doi:10.1038/nm.4517 Authors: Jack A Gilbert, Martin J Blaser, J Gregory Caporaso, Janet K Jansson, Susan V Lynch & Rob Knight (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Jack A Gilbert Martin J Blaser J Gregory Caporaso Janet K Jansson Susan V Lynch Rob Knight Tags: Review Source Type: research

Transplanted neural progenitors bridge gaps to benefit cord – injured monkeys
Nature Medicine 24, 388 (2018). doi:10.1038/nm.4531 Author: Steven A Goldman Human neural progenitor cells have been grafted successfully into rhesus monkeys with spinal cord hemisection, resulting in anatomic integration and improved neurological function. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Steven A Goldman Tags: News and Views Source Type: research

Catalyzing the field of precision oncology, one basket at a time
Nature Medicine 24, 387 (2018). doi:10.1038/nm.4530 Authors: William Pao & Imola Fodor A bedside strategy to overcome the limitations of testing in preclinical models and to determine the role of gene mutations and their targetability directly in patients is presented. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: William Pao Imola Fodor Tags: News and Views Source Type: research

Predicting leukemia relapse
Nature Medicine 24, 385 (2018). doi:10.1038/nm.4529 Author: José Ignacio Martín-Subero Mass cytometry of acute B cell lymphoblastic leukemias at diagnosis reveals intrapatient phenotypic heterogeneity and specific signatures that mimic cell developmental stage and predict future relapse. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Jos é Ignacio Mart í n-Subero Tags: News and Views Source Type: research

Inflammation weakens HIV prevention
Nature Medicine 24, 384 (2018). doi:10.1038/nm.4534 Author: Thomas J Hope The presence of multiple inflammatory cytokines predicts the failure of a topical 1% tenofovir microbicide gel to protect women against HIV infection. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Thomas J Hope Tags: News and Views Source Type: research

A new site of attack for a malaria vaccine
Nature Medicine 24, 382 (2018). doi:10.1038/nm.4533 Authors: Simon J Draper & Matthew K Higgins A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Simon J Draper Matthew K Higgins Tags: News and Views Source Type: research

Experimenting with blockchain: Can one technology boost both data integrity and patients' pocketbooks?
Nature Medicine 24, 378 (2018). doi:10.1038/nm0418-378 Author: Katharine Gammon (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Katharine Gammon Tags: News Source Type: research

A tale of two diseases: Aging HIV patients inspire a closer look at Alzheimer's disease
Nature Medicine 24, 376 (2018). doi:10.1038/nm0418-376 Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research

A checkup for the flu vaccine
Nature Medicine 24, 375 (2018). doi:10.1038/nm.4535 Influenza causes almost 650,000 deaths worldwide each year, yet a long-lasting, protective vaccine remains elusive. Global investment—both scientific and financial—in a universal flu vaccine is overdue. (Source: Nature Medicine)
Source: Nature Medicine - April 10, 2018 Category: General Medicine Tags: Editorial Source Type: research

Targeting hepatic glutaminase activity to ameliorate hyperglycemia
Nature Medicine 24, 518 (2018). doi:10.1038/nm.4514 Authors: Russell A Miller, Yuji Shi, Wenyun Lu, David A Pirman, Aditi Jatkar, Matthew Blatnik, Hong Wu, César Cárdenas, Min Wan, J Kevin Foskett, Junyoung O Park, Yiyi Zhang, William L Holland, Joshua D Rabinowitz & Morris J Birnbaum Glucagon levels increase under homeostatic, fasting conditions, promoting the release of glucose from the liver by accelerating the breakdown of glycogen (also known as glycogenolysis). Glucagon also enhances gluconeogenic flux, including from an increase in the hepatic consumption of amino acids. In type 2 diabetes, dy...
Source: Nature Medicine - March 26, 2018 Category: General Medicine Authors: Russell A Miller Yuji Shi Wenyun Lu David A Pirman Aditi Jatkar Matthew Blatnik Hong Wu C é sar C á rdenas Min Wan J Kevin Foskett Junyoung O Park Yiyi Zhang William L Holland Joshua D Rabinowitz Morris J Birnbaum Tags: Letter Source Type: research

Combinatorial inhibition of PTPN12-regulated receptors leads to a broadly effective therapeutic strategy in triple-negative breast cancer
Nature Medicine 24, 505 (2018). doi:10.1038/nm.4507 Authors: Amritha Nair, Hsiang-Ching Chung, Tingting Sun, Siddhartha Tyagi, Lacey E Dobrolecki, Rocio Dominguez-Vidana, Sarah J Kurley, Mayra Orellana, Alexander Renwick, David M Henke, Panagiotis Katsonis, Earlene Schmitt, Doug W Chan, Hui Li, Sufeng Mao, Ivana Petrovic, Chad J Creighton, Carolina Gutierrez, Julien Dubrulle, Fabio Stossi, Jeffrey W Tyner, Olivier Lichtarge, Charles Y Lin, Bing Zhang, Kenneth L Scott, Susan G Hilsenbeck, Jinpeng Sun, Xiao Yu, C Kent Osborne, Rachel Schiff, James G Christensen, David J Shields, Mothaffar F Rimawi, Matthew J Ellis, Chad...
Source: Nature Medicine - March 26, 2018 Category: General Medicine Authors: Amritha Nair Hsiang-Ching Chung Tingting Sun Siddhartha Tyagi Lacey E Dobrolecki Rocio Dominguez-Vidana Sarah J Kurley Mayra Orellana Alexander Renwick David M Henke Panagiotis Katsonis Earlene Schmitt Doug W Chan Hui Li Sufeng Mao Ivana Petrovic Chad J C Tags: Letter Source Type: research

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite
Nature Medicine 24, 408 (2018). doi:10.1038/nm.4512 Authors: Neville K Kisalu, Azza H Idris, Connor Weidle, Yevel Flores-Garcia, Barbara J Flynn, Brandon K Sack, Sean Murphy, Arne Schön, Ernesto Freire, Joseph R Francica, Alex B Miller, Jason Gregory, Sandra March, Hua-Xin Liao, Barton F Haynes, Kevin Wiehe, Ashley M Trama, Kevin O Saunders, Morgan A Gladden, Anthony Monroe, Mattia Bonsignori, Masaru Kanekiyo, Adam K Wheatley, Adrian B McDermott, S Katie Farney, Gwo-Yu Chuang, Baoshan Zhang, Natasha Kc, Sumana Chakravarty, Peter D Kwong, Photini Sinnis, Sangeeta N Bhatia, Stefan H I Kappe, B Kim Lee Sim, Stephen ...
Source: Nature Medicine - March 19, 2018 Category: General Medicine Authors: Neville K Kisalu Azza H Idris Connor Weidle Yevel Flores-Garcia Barbara J Flynn Brandon K Sack Sean Murphy Arne Sch ö n Ernesto Freire Joseph R Francica Alex B Miller Jason Gregory Sandra March Hua-Xin Liao Barton F Haynes Kevin Wiehe Ashley M Trama Kevi Tags: Article Source Type: research

A public antibody lineage that potently inhibits malaria infection through dual binding to the circumsporozoite protein
Nature Medicine 24, 401 (2018). doi:10.1038/nm.4513 Authors: Joshua Tan, Brandon K Sack, David Oyen, Isabelle Zenklusen, Luca Piccoli, Sonia Barbieri, Mathilde Foglierini, Chiara Silacci Fregni, Jessica Marcandalli, Said Jongo, Salim Abdulla, Laurent Perez, Giampietro Corradin, Luca Varani, Federica Sallusto, Betty Kim Lee Sim, Stephen L Hoffman, Stefan H I Kappe, Claudia Daubenberger, Ian A Wilson & Antonio Lanzavecchia (Source: Nature Medicine)
Source: Nature Medicine - March 19, 2018 Category: General Medicine Authors: Joshua Tan Brandon K Sack David Oyen Isabelle Zenklusen Luca Piccoli Sonia Barbieri Mathilde Foglierini Chiara Silacci Fregni Jessica Marcandalli Said Jongo Salim Abdulla Laurent Perez Giampietro Corradin Luca Varani Federica Sallusto Betty Kim Lee Sim St Tags: Article Source Type: research

Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling
Nature Medicine 24, 463 (2018). doi:10.1038/nm.4494 Authors: Pernilla Roswall, Matteo Bocci, Michael Bartoschek, Hong Li, Glen Kristiansen, Sara Jansson, Sophie Lehn, Jonas Sjölund, Steven Reid, Christer Larsson, Pontus Eriksson, Charlotte Anderberg, Eliane Cortez, Lao H Saal, Christina Orsmark-Pietras, Eugenia Cordero, Bengt Kristian Haller, Jari Häkkinen, Ingrid J G Burvenich, Elgene Lim, Akira Orimo, Mattias Höglund, Lisa Rydén, Holger Moch, Andrew M Scott, Ulf Eriksson & Kristian Pietras (Source: Nature Medicine)
Source: Nature Medicine - March 12, 2018 Category: General Medicine Authors: Pernilla Roswall Matteo Bocci Michael Bartoschek Hong Li Glen Kristiansen Sara Jansson Sophie Lehn Jonas Sj ö lund Steven Reid Christer Larsson Pontus Eriksson Charlotte Anderberg Eliane Cortez Lao H Saal Christina Orsmark-Pietras Eugenia Cordero Bengt K Tags: Article Source Type: research

Dentate granule cell recruitment of feedforward inhibition governs engram maintenance and remote memory generalization
Nature Medicine 24, 438 (2018). doi:10.1038/nm.4491 Authors: Nannan Guo, Marta E Soden, Charlotte Herber, Michael TaeWoo Kim, Antoine Besnard, Paoyan Lin, Xiang Ma, Constance L Cepko, Larry S Zweifel & Amar Sahay (Source: Nature Medicine)
Source: Nature Medicine - March 12, 2018 Category: General Medicine Authors: Nannan Guo Marta E Soden Charlotte Herber Michael TaeWoo Kim Antoine Besnard Paoyan Lin Xiang Ma Constance L Cepko Larry S Zweifel Amar Sahay Tags: Article Source Type: research

An immunosuppressive pathway for tumor progression
Nature Medicine 24, 260 (2018). doi:10.1038/nm.4508 Authors: Antoine Marçais & Thierry Walzer An active immunosuppressive pathway is identified in colon cancer that confers immune evasion by the cancer and can be targeted to synergize with immunotherapies. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Antoine Mar ç ais Thierry Walzer Tags: News and Views Source Type: research

A previously undetected pathology of Zika virus infection
Nature Medicine 24, 258 (2018). doi:10.1038/nm.4510 Authors: Kimberly M Christian, Hongjun Song & Guo-li Ming In a nonhuman primate model of Zika virus infection, structural and cellular pathology deficits that could have a long-lasting impact on neural development and neurocognitive function are detected in offspring of infected mothers. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Kimberly M Christian Hongjun Song Guo-li Ming Tags: News and Views Source Type: research

A human cellular model of amyotrophic lateral sclerosis
Nature Medicine 24, 256 (2018). doi:10.1038/nm.4509 Authors: Rebecca M Marton & Sergiu P Paşca Stem cell–derived human motor neurons were used to investigate the cellular mechanisms underlying C9ORF72-related amyotrophic lateral sclerosis. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Rebecca M Marton Sergiu P Pa ş ca Tags: News and Views Source Type: research

The intestinal microbiome influences checkpoint blockade
Nature Medicine 24, 254 (2018). doi:10.1038/nm.4511 Authors: Cynthia L Sears & Drew M Pardoll Studies in metastatic melanoma, non-small-cell lung carcinoma and renal cell carcinoma indicate certain bacteria within the gut microbiota enhance clinical responses to checkpoint blockade. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Cynthia L Sears Drew M Pardoll Tags: News and Views Source Type: research

Gut checkpoint: A rising cancer treatment may get a boost from intestinal bacteria
Nature Medicine 24, 251 (2018). doi:10.1038/nm0318-251 Author: Anna Azvolinsky (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Anna Azvolinsky Tags: News Source Type: research

Going live: How microRNAs might bring living vaccines back into the fold
Nature Medicine 24, 248 (2018). doi:10.1038/nm0318-248 Author: Shraddha Chakradhar (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Authors: Shraddha Chakradhar Tags: News Source Type: research

Stimulus package
Nature Medicine 24, 247 (2018). doi:10.1038/nm.4515 Therapies for Alzheimer's disease and other neurodegenerative diseases are desperately needed. Yet, a string of disappointments in the neurodegenerative therapy space has meant that several companies over the years have ended their investment in the field. Some companies have diversified their research and development (R&D) models to hedge their bets. Maintaining this diversity to bring down the silos between big pharma and smaller research teams may be necessary to jumpstart and sustain progress in combatting neurodegenerative conditions. (Source: Nature Medicine)
Source: Nature Medicine - March 6, 2018 Category: General Medicine Tags: Editorial Source Type: research

SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors
Nature Medicine 24, 512 (2018). doi:10.1038/nm.4497 Authors: Leila Dardaei, Hui Qin Wang, Manrose Singh, Paul Fordjour, Katherine X Shaw, Satoshi Yoda, Grainne Kerr, Kristine Yu, Jinsheng Liang, Yichen Cao, Yan Chen, Michael S Lawrence, Adam Langenbucher, Justin F Gainor, Luc Friboulet, Ibiayi Dagogo-Jack, David T Myers, Emma Labrot, David Ruddy, Melissa Parks, Dana Lee, Richard H DiCecca, Susan Moody, Huaixiang Hao, Morvarid Mohseni, Matthew LaMarche, Juliet Williams, Keith Hoffmaster, Giordano Caponigro, Alice T Shaw, Aaron N Hata, Cyril H Benes, Fang Li & Jeffrey A Engelman Most anaplastic lymphoma kinase (ALK)...
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Leila Dardaei Hui Qin Wang Manrose Singh Paul Fordjour Katherine X Shaw Satoshi Yoda Grainne Kerr Kristine Yu Jinsheng Liang Yichen Cao Yan Chen Michael S Lawrence Adam Langenbucher Justin F Gainor Luc Friboulet Ibiayi Dagogo-Jack David T Myers Emma Labro Tags: Letter Source Type: research

Single-cell developmental classification of B cell precursor acute lymphoblastic leukemia at diagnosis reveals predictors of relapse
Nature Medicine 24, 474 (2018). doi:10.1038/nm.4505 Authors: Zinaida Good, Jolanda Sarno, Astraea Jager, Nikolay Samusik, Nima Aghaeepour, Erin F Simonds, Leah White, Norman J Lacayo, Wendy J Fantl, Grazia Fazio, Giuseppe Gaipa, Andrea Biondi, Robert Tibshirani, Sean C Bendall, Garry P Nolan & Kara L Davis (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Zinaida Good Jolanda Sarno Astraea Jager Nikolay Samusik Nima Aghaeepour Erin F Simonds Leah White Norman J Lacayo Wendy J Fantl Grazia Fazio Giuseppe Gaipa Andrea Biondi Robert Tibshirani Sean C Bendall Garry P Nolan Kara L Davis Tags: Article Source Type: research

Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
Nature Medicine 24, 450 (2018). doi:10.1038/nm.4499 Authors: Bin Zhang, Le Xuan Truong Nguyen, Ling Li, Dandan Zhao, Bijender Kumar, Herman Wu, Allen Lin, Francesca Pellicano, Lisa Hopcroft, Yu-Lin Su, Mhairi Copland, Tessa L Holyoake, Calvin J Kuo, Ravi Bhatia, David S Snyder, Haris Ali, Anthony S Stein, Casey Brewer, Huafeng Wang, Tinisha McDonald, Piotr Swiderski, Estelle Troadec, Ching-Cheng Chen, Adrienne Dorrance, Vinod Pullarkat, Yate-Ching Yuan, Danilo Perrotti, Nadia Carlesso, Stephen J Forman, Marcin Kortylewski, Ya-Huei Kuo & Guido Marcucci (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Bin Zhang Le Xuan Truong Nguyen Ling Li Dandan Zhao Bijender Kumar Herman Wu Allen Lin Francesca Pellicano Lisa Hopcroft Yu-Lin Su Mhairi Copland Tessa L Holyoake Calvin J Kuo Ravi Bhatia David S Snyder Haris Ali Anthony S Stein Casey Brewer Huafeng Wang Tags: Article Source Type: research

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy
Nature Medicine 24, 427 (2018). doi:10.1038/nm.4500 Authors: Nisha M Badders, Ane Korff, Helen C Miranda, Pradeep K Vuppala, Rebecca B Smith, Brett J Winborn, Emmanuelle R Quemin, Bryce L Sopher, Jennifer Dearman, James Messing, Nam Chul Kim, Jennifer Moore, Brian D Freibaum, Anderson P Kanagaraj, Baochang Fan, Heather Tillman, Ping-Chung Chen, Yingzhe Wang, Burgess B Freeman III, Yimei Li, Hong Joo Kim, Albert R La Spada & J Paul Taylor (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Nisha M Badders Ane Korff Helen C Miranda Pradeep K Vuppala Rebecca B Smith Brett J Winborn Emmanuelle R Quemin Bryce L Sopher Jennifer Dearman James Messing Nam Chul Kim Jennifer Moore Brian D Freibaum Anderson P Kanagaraj Baochang Fan Heather Tillman Pi Tags: Article Source Type: research

Nociceptor sensory neurons suppress neutrophil and γ δ T cell responses in bacterial lung infections and lethal pneumonia
Nature Medicine 24, 417 (2018). doi:10.1038/nm.4501 Authors: Pankaj Baral, Benjamin D Umans, Lu Li, Antonia Wallrapp, Meghna Bist, Talia Kirschbaum, Yibing Wei, Yan Zhou, Vijay K Kuchroo, Patrick R Burkett, Bryan G Yipp, Stephen D Liberles & Isaac M Chiu (Source: Nature Medicine)
Source: Nature Medicine - March 5, 2018 Category: General Medicine Authors: Pankaj Baral Benjamin D Umans Lu Li Antonia Wallrapp Meghna Bist Talia Kirschbaum Yibing Wei Yan Zhou Vijay K Kuchroo Patrick R Burkett Bryan G Yipp Stephen D Liberles Isaac M Chiu Tags: Article Source Type: research

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women
Nature Medicine 24, 491 (2018). doi:10.1038/nm.4506 Authors: Lyle R McKinnon, Lenine J Liebenberg, Nonhlanhla Yende-Zuma, Derseree Archary, Sinaye Ngcapu, Aida Sivro, Nico Nagelkerke, Jose Gerardo Garcia Lerma, Angela D Kashuba, Lindi Masson, Leila E Mansoor, Quarraisha Abdool Karim, Salim S Abdool Karim & Jo-Ann S Passmore (Source: Nature Medicine)
Source: Nature Medicine - February 26, 2018 Category: General Medicine Authors: Lyle R McKinnon Lenine J Liebenberg Nonhlanhla Yende-Zuma Derseree Archary Sinaye Ngcapu Aida Sivro Nico Nagelkerke Jose Gerardo Garcia Lerma Angela D Kashuba Lindi Masson Leila E Mansoor Quarraisha Abdool Karim Salim S Abdool Karim Jo-Ann S Passmore Tags: Article Source Type: research

Restorative effects of human neural stem cell grafts on the primate spinal cord
Nature Medicine 24, 484 (2018). doi:10.1038/nm.4502 Authors: Ephron S Rosenzweig, John H Brock, Paul Lu, Hiromi Kumamaru, Ernesto A Salegio, Ken Kadoya, Janet L Weber, Justine J Liang, Rod Moseanko, Stephanie Hawbecker, J Russell Huie, Leif A Havton, Yvette S Nout-Lomas, Adam R Ferguson, Michael S Beattie, Jacqueline C Bresnahan & Mark H Tuszynski (Source: Nature Medicine)
Source: Nature Medicine - February 26, 2018 Category: General Medicine Authors: Ephron S Rosenzweig John H Brock Paul Lu Hiromi Kumamaru Ernesto A Salegio Ken Kadoya Janet L Weber Justine J Liang Rod Moseanko Stephanie Hawbecker J Russell Huie Leif A Havton Yvette S Nout-Lomas Adam R Ferguson Michael S Beattie Jacqueline C Bresnahan Tags: Article Source Type: research

H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Nature Medicine 24, 497 (2018). doi:10.1038/nm.4493 Authors: Michael Seiler, Akihide Yoshimi, Rachel Darman, Betty Chan, Gregg Keaney, Michael Thomas, Anant A Agrawal, Benjamin Caleb, Alfredo Csibi, Eckley Sean, Peter Fekkes, Craig Karr, Virginia Klimek, George Lai, Linda Lee, Pavan Kumar, Stanley Chun-Wei Lee, Xiang Liu, Crystal Mackenzie, Carol Meeske, Yoshiharu Mizui, Eric Padron, Eunice Park, Ermira Pazolli, Shouyong Peng, Sudeep Prajapati, Justin Taylor, Teng Teng, John Wang, Markus Warmuth, Huilan Yao, Lihua Yu, Ping Zhu, Omar Abdel-Wahab, Peter G Smith & Silvia Buonamici Genomic analyses of cancer have iden...
Source: Nature Medicine - February 19, 2018 Category: General Medicine Authors: Michael Seiler Akihide Yoshimi Rachel Darman Betty Chan Gregg Keaney Michael Thomas Anant A Agrawal Benjamin Caleb Alfredo Csibi Eckley Sean Peter Fekkes Craig Karr Virginia Klimek George Lai Linda Lee Pavan Kumar Stanley Chun-Wei Lee Xiang Liu Crystal Ma Tags: Letter Source Type: research

A histone deacetylase 3 – dependent pathway delimits peripheral myelin growth and functional regeneration
Nature Medicine 24, 338 (2018). doi:10.1038/nm.4483 Authors: Xuelian He, Liguo Zhang, Luis F Queme, Xuezhao Liu, Andrew Lu, Ronald R Waclaw, Xinran Dong, Wenhao Zhou, Grahame Kidd, Sung-Ok Yoon, Andres Buonanno, Joshua B Rubin, Mei Xin, Klaus-Armin Nave, Bruce D Trapp, Michael P Jankowski & Q Richard Lu (Source: Nature Medicine)
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Xuelian He Liguo Zhang Luis F Queme Xuezhao Liu Andrew Lu Ronald R Waclaw Xinran Dong Wenhao Zhou Grahame Kidd Sung-Ok Yoon Andres Buonanno Joshua B Rubin Mei Xin Klaus-Armin Nave Bruce D Trapp Michael P Jankowski Q Richard Lu Tags: Article Source Type: research

Transcriptional regulation of macrophage cholesterol efflux and atherogenesis by a long noncoding RNA
Nature Medicine 24, 304 (2018). doi:10.1038/nm.4479 Authors: Tamer Sallam, Marius Jones, Brandon J Thomas, Xiaohui Wu, Thomas Gilliland, Kevin Qian, Ascia Eskin, David Casero, Zhengyi Zhang, Jaspreet Sandhu, David Salisbury, Prashant Rajbhandari, Mete Civelek, Cynthia Hong, Ayaka Ito, Xin Liu, Bence Daniel, Aldons J Lusis, Julian Whitelegge, Laszlo Nagy, Antonio Castrillo, Stephen Smale & Peter Tontonoz (Source: Nature Medicine)
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Tamer Sallam Marius Jones Brandon J Thomas Xiaohui Wu Thomas Gilliland Kevin Qian Ascia Eskin David Casero Zhengyi Zhang Jaspreet Sandhu David Salisbury Prashant Rajbhandari Mete Civelek Cynthia Hong Ayaka Ito Xin Liu Bence Daniel Aldons J Lusis Julian Wh Tags: Article Source Type: research

Sorafenib promotes graft-versus-leukemia activity in mice and humans through IL-15 production in FLT3-ITD-mutant leukemia cells
Nature Medicine 24, 282 (2018). doi:10.1038/nm.4484 Authors: Nimitha R Mathew, Francis Baumgartner, Lukas Braun, David O'Sullivan, Simone Thomas, Miguel Waterhouse, Tony A Müller, Kathrin Hanke, Sanaz Taromi, Petya Apostolova, Anna L Illert, Wolfgang Melchinger, Sandra Duquesne, Annette Schmitt-Graeff, Lena Osswald, Kai-Li Yan, Arnim Weber, Sonia Tugues, Sabine Spath, Dietmar Pfeifer, Marie Follo, Rainer Claus, Michael Lübbert, Christoph Rummelt, Hartmut Bertz, Ralph Wäsch, Johanna Haag, Andrea Schmidts, Michael Schultheiss, Dominik Bettinger, Robert Thimme, Evelyn Ullrich, Yakup Tanriver, Giang Lam Vuo...
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Nimitha R Mathew Francis Baumgartner Lukas Braun David O'Sullivan Simone Thomas Miguel Waterhouse Tony A M ü ller Kathrin Hanke Sanaz Taromi Petya Apostolova Anna L Illert Wolfgang Melchinger Sandra Duquesne Annette Schmitt-Graeff Lena Osswald Kai-Li Yan Tags: Article Source Type: research

DKK2 imparts tumor immunity evasion through β -catenin-independent suppression of cytotoxic immune-cell activation
Nature Medicine 24, 262 (2018). doi:10.1038/nm.4496 Authors: Qian Xiao, Jibo Wu, Wei-Jia Wang, Shiyang Chen, Yingxia Zheng, Xiaoqing Yu, Katrina Meeth, Mahnaz Sahraei, Alfred L M Bothwell, Lieping Chen, Marcus Bosenberg, Jianfeng Chen, Veronika Sexl, Le Sun, Lin Li, Wenwen Tang & Dianqing Wu (Source: Nature Medicine)
Source: Nature Medicine - February 12, 2018 Category: General Medicine Authors: Qian Xiao Jibo Wu Wei-Jia Wang Shiyang Chen Yingxia Zheng Xiaoqing Yu Katrina Meeth Mahnaz Sahraei Alfred L M Bothwell Lieping Chen Marcus Bosenberg Jianfeng Chen Veronika Sexl Le Sun Lin Li Wenwen Tang Dianqing Wu Tags: Article Source Type: research

Macrophages and platelets join forces to release kidney-damaging DNA traps
Nature Medicine 24, 128 (2018). doi:10.1038/nm.4486 Author: Dominik Hartl A recent study in mice dissects the mechanisms through which muscle damage leads to kidney dysfunction and identifies macrophage extracellular trap (MET) formation as a new pathogenic driver and potential therapeutic target. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Dominik Hartl Tags: News and Views Source Type: research

Selective enhancer changes in osteosarcoma lung metastasis
Nature Medicine 24, 126 (2018). doi:10.1038/nm.4487 Author: Heinrich Kovar A recent study investigates the contribution of epigenomic plasticity to lung metastasis in osteosarcoma. Changes in the enhancer landscape were found to be nonrandom and driven by selective forces in the microenvironment. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Heinrich Kovar Tags: News and Views Source Type: research

A new vaccine for tuberculosis in rhesus macaques
Nature Medicine 24, 124 (2018). doi:10.1038/nm.4488 Authors: Stephen M Carpenter & Samuel M Behar In a recent study using cytomegalovirus (CMV)-vectored vaccines in rhesus macaques, prevention of tuberculosis in over 40% of vaccinated animals is shown and is attributed to reprogrammed innate immunity and CMV's maintenance of vaccine-elicited effector memory T cells. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Stephen M Carpenter Samuel M Behar Tags: News and Views Source Type: research

A potential biomarker for anti-PD-1 immunotherapy
Nature Medicine 24, 123 (2018). doi:10.1038/nm.4489 Authors: Sangeeta Goswami, Sreyashi Basu & Padmanee Sharma A recent study identifies an immune cell type known as classical monocytes in the peripheral blood as a potential biomarker for response to anti-PD-1 immune checkpoint therapy in metastatic melanoma. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Sangeeta Goswami Sreyashi Basu Padmanee Sharma Tags: News and Views Source Type: research

Gene therapies for hemophilia hit the mark in clinical trials
Nature Medicine 24, 121 (2018). doi:10.1038/nm.4492 Authors: Adrian K Pickar & Charles A Gersbach Two recent studies describe clinical successes for single-dose gene therapy in trials for two forms of hemophilia. (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Adrian K Pickar Charles A Gersbach Tags: News and Views Source Type: research

A shot at contraception: In India, a nonagenarian renews testing of a birth control vaccine
Nature Medicine 24, 118 (2018). doi:10.1038/nm0218-118 Author: Killugudi Jayaraman (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Authors: Killugudi Jayaraman Tags: News Source Type: research

Correction
Nature Medicine 24, 117 (2018). doi:10.1038/nm0218-117 (Source: Nature Medicine)
Source: Nature Medicine - February 7, 2018 Category: General Medicine Tags: News Source Type: research