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Specialty: Neurosurgery
Therapy: Stem Cell Therapy

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Total 83 results found since Jan 2013.

Diffusion mr correlates of motor function recovery after stroke: a systematic review
Conclusions FA is the most commonly measured metric but there was considerable heterogeneity in study design and analysis. Most studies were cross–sectional, confined to sub–cortical, ischaemic strokes at late stages, and involved younger patients than typical of the stroke population. Further evaluation of the utility of DTI as a biomarker for use in stroke recovery trials is needed.
Source: Journal of Neurology, Neurosurgery and Psychiatry - October 9, 2013 Category: Neurosurgery Authors: Kalladka, D., Muir, K. Tags: Stroke, Radiology, Radiology (diagnostics) Association of British Neurologists (ABN) joint meeting with the Royal College of Physicians (RCP), London, 23-24 October 2013 Source Type: research

Cell Therapy for Stroke: Review of Previous Clinical Trials and Introduction of Our New Trials.
In this study, we introduce the preparation of a new clinical trial, the Research on Advanced Intervention using Novel Bone marrow stem cell (RAINBOW) study. The trial will start in 2016, and we hope that it will not only be helpful for treating patients but also for clarifying the therapeutic mechanisms. Moreover, we review stem cell therapeutics as an emerging paradigm in stroke (STEPS) and the guidelines for the development of cell therapy for stroke in the United States as well as introduce the development of new guidelines in Japan. These guidelines are expected to encourage the development of cell therapy for stroke ...
Source: Neurologia Medico-Chirurgica - June 17, 2016 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Two-year safety and clinical outcomes in chronic ischemic stroke patients after implantation of modified bone marrow-derived mesenchymal stem cells (SB623): a phase 1/2a study.
CONCLUSIONSIn this completed 2-year phase 1/2a study, implantation of SB623 cells in patients with stable chronic stroke was safe and was accompanied by improvements in clinical outcomes.Clinical trial registration no.: NCT01287936 (clinicaltrials.gov). PMID: 30497166 [PubMed - as supplied by publisher]
Source: Journal of Neurosurgery - November 1, 2018 Category: Neurosurgery Tags: J Neurosurg Source Type: research

Neurorestoration after stroke.
Abstract Recent advancements in stem cell biology and neuromodulation have ushered in a battery of new neurorestorative therapies for ischemic stroke. While the understanding of stroke pathophysiology has matured, the ability to restore patients' quality of life remains inadequate. New therapeutic approaches, including cell transplantation and neurostimulation, focus on reestablishing the circuits disrupted by ischemia through multidimensional mechanisms to improve neuroplasticity and remodeling. The authors provide a broad overview of stroke pathophysiology and existing therapies to highlight the scientific and c...
Source: Neurosurgical Focus - April 30, 2016 Category: Neurosurgery Authors: Azad TD, Veeravagu A, Steinberg GK Tags: Neurosurg Focus Source Type: research

Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats.
Authors: Oshita J, Okazaki T, Mitsuhara T, Imura T, Nakagawa K, Otsuka T, Kurose T, Tamura T, Abiko M, Takeda M, Kawahara Y, Yuge L, Kurisu K Abstract We analyzed the cell characteristics, neuroprotective, and transplantation effects of human cranial bone-derived mesenchymal stem cells (hcMSCs) in ischemic stroke model rats compared with human iliac bone-derived mesenchymal stem cells (hiMSCs). The expressions of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF ) as neurotrophic factors were analyzed in both MSCs. hiMSCs or hcMSCs were intravenously administered into ischemic st...
Source: Neurologia Medico-Chirurgica - January 22, 2020 Category: Neurosurgery Tags: Neurol Med Chir (Tokyo) Source Type: research

Recent Stem Cell Research on Hemorrhagic Stroke : An Update
J Korean Neurosurg Soc. 2022 Feb 24. doi: 10.3340/jkns.2021.0126. Online ahead of print.ABSTRACTAlthough technological advances and clinical studies on stem cells have been increasingly reported in stroke, research targeting hemorrhagic stroke is still lacking compared to that targeting ischemic stroke. Studies on hemorrhagic stroke are also being conducted, mainly in the USA and China. However, little research has been conducted in Korea. In reality, stem cell research or treatment is unfamiliar to many domestic neurosurgeons. Nevertheless, given the increased interest in regenerative medicine and the increase of life exp...
Source: Journal of Korean Neurosurgical Society - February 23, 2022 Category: Neurosurgery Authors: Jong-Tae Kim Dong Hyuk Youn Bong Jun Kim Jong Kook Rhim Jin Pyeong Jeon Source Type: research

Effect of stem cell-based therapy for ischemic stroke treatment: A meta-analysis
Stroke is an important cause of death and disability in adults. Globally, 250 to 400 of every 100,000 people die from stroke every year [1,2]. Additionally, stroke is the third most common cause of death in the United States. More than 750,000 new and recurrent strokes occur each year, and 160,000 people die annually from stroke [3].
Source: Clinical Neurology and Neurosurgery - April 19, 2016 Category: Neurosurgery Authors: Qian Wang, Feng Duan, Ming-xin Wang, Xiao-dong Wang, Peng Liu, Li-zhi Ma Source Type: research

Clinical outcome and safety of stem cell therapy for ischemic stroke: A systematic review and meta-analysis
CONCLUSION: The results of this study show promising and satisfying efficacy and a relatively low rate of serious adverse events.PMID:35673677 | PMC:PMC9168316 | DOI:10.25259/SNI_1174_2021
Source: Surgical Neurology International - June 8, 2022 Category: Neurosurgery Authors: Andhika Tomy Permana Abdul Hafid Bajamal Muhammad Arifin Parenrengi Nur Setiawan Suroto Pudji Lestari Asra Al Fauzi Source Type: research