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Reflections on the Future of Medicine
Recently, I traveled through China. I climbed mountains, hiked through forests, crossed deep valleys. I visited cities of every size. I floated across lakes and traveled beautiful shorelines churning with life. As a man of a certain age, I began to compare the permanence of the timeless landscape with the evanescence of my own existence. Yet, as a scientist, I knew these reflections were flawed.
Scientists are trained to think in terms of aeons, millenia, and lifetimes. Consider the paradox. Is it the solid mountain or fragile the forest that is permanent? Is it the massive shoreline cliffs or the teeming shore life that...
Source: Science - The Huffington Post - January 9, 2017 Category: Science Source Type: news
Lasting Impact of an Ephemeral Organ: The Role of the Placenta in Fetal Programming
Recent advances in molecular and imaging technologies, “omics” fields, and data sciences are offering researchers an unprecedented look at the placenta, the master regulator of the fetal environment.© EPA/National Geographic Channel/Alamy
Studies of infants conceived during the Dutch “Hunger Winter” provided some of the earliest clues that prenatal stress could affect health much later in life.© Nationaal Archief
© Evan Oto/Science Source
In one study, the placental microbiome had a similar taxonomic profile as the oral microbiome, illustrated here by...
Source: EHP Research - July 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Featured Focus News July 2016 Source Type: research
Transfusion strategy in hematological intensive care unit: study protocol for a randomized controlled trial
Background:
Packed red blood cell (PRBC) transfusion is required in hematology patients treated with chemotherapy for acute leukemia, autologous (auto) or allogeneic (allo) hematopoietic stem cell transplantation (HSCT). In certain situations like septic shock, hip surgery, coronary disease or gastrointestinal hemorrhage, a restrictive transfusion strategy is associated with a reduction of infection and death. A transfusion strategy using a single PRBC unit has been retrospectively investigated and showed a safe reduction of PRBC consumption and costs. We therefore designed a study to prospectively demonstrate that the tra...
Source: Trials - November 23, 2015 Category: Journals (General) Authors: Sylvain ChantepieJean-Baptiste MearLydia GuittetBenoît DervauxJean-Pierre MarolleauFabrice JardinJean-Jacques DutheilJean-Jacques ParientiJean-Pierre VilqueOumedaly Reman Source Type: research
Disrupting Today's Healthcare System
This week in San Diego, Singularity University is holding its Exponential Medicine Conference, a look at how technologists are redesigning and rebuilding today's broken healthcare system. Healthcare today is reactive, retrospective, bureaucratic and expensive. It's sick care, not healthcare. This blog is about why the $3 trillion healthcare system is broken and how we are going to fix it. First, the Bad News: Doctors spend $210 billion per year on procedures that aren’t based on patient need, but fear of liability. Americans spend, on average, $8,915 per person on healthcare – more than any other count...
Source: Healthy Living - The Huffington Post - November 9, 2015 Category: Consumer Health News Source Type: news
Traumatic Brain Injuries, Stem Cells and Children: A Conversation With Dr. Charles Cox
One of the world's leading experts on cellular therapies for traumatic brain injury (TBI), Dr. Cox directs the Pediatric Surgical Translational Laboratories and Pediatric Program in Regenerative Medicine at the University of Texas Medical School at Houston, as well as the Pediatric Trauma Program at the University of Texas-Houston/Children's Memorial Hermann Hospital in the Texas Medical Center. He is the author of over 120 scientific publications and 20 book chapters and has served on scientific study sections/review groups for the NIH, American Heart Association, Veterans Affairs MERIT Awards, Department of Defense and C...
Source: Healthy Living - The Huffington Post - February 13, 2015 Category: Consumer Health News Source Type: news
How Can You Mend a Broken Brain - Neurorestorative Approaches to Stroke Recovery
Background: Stroke is a devastating disorder that strikes approximately 15 million people worldwide. While most patients survive stroke, many are left with lifelong impairments, thereby making stroke the leading cause of permanent neurological disability. Despite this, there are a few options for treatment of acute stroke. Restoration of blood flow using clot-dissolving drugs has produced impressive benefits in some patients. However, for these drugs to be effective, they must be given soon after stroke onset and relatively only a few stroke patients reach hospital within this time. Side effects of these compounds further ...
Source: Cerebrovascular Diseases - November 13, 2014 Category: Neurology Source Type: research
How Can You Mend a Broken Brain? - Neurorestorative Approaches to Stroke Recovery
Background: Stroke is a devastating disorder that strikes approximately 15 million people worldwide. While most patients survive stroke, many are left with lifelong impairments, thereby making stroke the leading cause of permanent neurological disability. Despite this, there are a few options for treatment of acute stroke. Restoration of blood flow using clot-dissolving drugs has produced impressive benefits in some patients. However, for these drugs to be effective, they must be given soon after stroke onset and relatively only a few stroke patients reach hospital within this time. Side effects of these compounds further ...
Source: Cerebrovascular Diseases - November 12, 2014 Category: Neurology Source Type: research
Novel treatment for stroke and possibly other neurological diseases
In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute. The new study is published online in the current issue of Journal of Cerebral Blood Flow and Metabolism...
Source: Health News from Medical News Today - August 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
New, 'robust' treatment for stroke uses genetic material from bone marrow
In this study we pioneered a totally new treatment for stroke, and possibly for all neurological disease," says Michael Chopp, Ph.D., scientific director of the Henry Ford Neuroscience Institute.
Source: EurekAlert! - Medicine and Health - August 26, 2013 Category: Global & Universal Source Type: news
Stem cells: what happened to the radical breakthroughs?
Much was promised in the late 1990s, but the challenge of advances such as growing whole human organs has been difficult to deliverIt's 1998 and science is taking big strides. The first cloned mammal, Dolly the Sheep, has just had her first lamb; the first robotically assisted heart surgery has been completed; Furbys have hit the shelves. In a bold announcement, biomedical engineer Professor Michael Sefton declared that within 10 years, scientists would have grown an entire heart, fit for transplant. "We're shooting big," he said. "Our vision is that we'll be able to pop out a damaged heart and replace it as easily as you ...
Source: Guardian Unlimited Science - August 10, 2013 Category: Science Authors: Simon Roach Tags: Biology Medical research Features Stem cells The Observer Science Source Type: news
Stem Cells Aid In The Brain's Recovery After Stroke
A specific MicroRNA, a short set of RNA (ribonuclease) sequences, naturally packaged into minute (50 nanometers) lipid containers called exosomes, are released by stem cells after a stroke and contribute to better neurological recovery according to a new animal study by Henry Ford Hospital researchers. The important role of a specific microRNA transferred from stem cells to brain cells via the exosomes to enhance functional recovery after a stroke was shown in lab rats...
Source: Health News from Medical News Today - June 17, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
Researchers gain new molecular-level understanding of the brain's recovery after stroke
This study provides fundamental new insight into how stem cells affect injured tissue and also offers hope for developing novel treatments for stroke and neurological diseases, the leading cause of long-term disability in adult humans.
Source: EurekAlert! - Medicine and Health - June 13, 2013 Category: Global & Universal Source Type: news
Long-Term Outcome and Evaluation of Organ Function in Pediatric Patients Undergoing Haploidentical and Matched Related Hematopoietic Cell Transplantation for Sickle Cell Disease
We report the long-term outcomes of 22 pediatric patients who underwent related donor HSCT for SCD at St. Jude Children's Research Hospital, either a myeloablative sibling MRD HSCT (n = 14) or reduced-intensity parental haploidentical donor HSCT (n = 8). The median patient age was 11.0 ± 3.9 years in the MRD graft recipients and 9.0 ± 5.0 years in the haploidentical donor graft recipients. The median follow-up was 9.0 ± 2.3 years, with an overall survival (OS) of 93% and a recurrence/graft failure rate of 0%, for the MRD cohort and 7.4 ± 2.4 years, with an OS of 75%, disease-free survival of 38%, and disease recurren...
Source: Biology of Blood and Marrow Transplantation - February 18, 2013 Category: Hematology Authors: Mari H. Dallas, Brandon Triplett, David R. Shook, Christine Hartford, Ashok Srinivasan, Joseph Laver, Russell Ware, Wing Leung Tags: Clinical Research Source Type: research
Northwestern Medicine researchers investigate stem cell therapy for stroke
(Northwestern Memorial Hospital) Clinical trial seeks to enroll people with disabling effects of ischemic stroke.
Source: EurekAlert! - Medicine and Health - February 11, 2013 Category: Global & Universal Source Type: news
First Stroke Patients In Florida Treated In UM Stem Cell Trial
The first two stroke patients have been enrolled in a phase 2 clinical trial of a revolutionary new treatment for ischemic stroke being conducted at the University of Miami/Jackson Memorial Hospital. The trial, using a patient's own bone marrow stem cells, is the first intra-arterial stroke stem cell trial in the U.S., and the two UM/Jackson patients are the first in Florida to participate. Led by Dileep Yavagal, M.D...
Source: Health News from Medical News Today - January 29, 2013 Category: Consumer Health News Tags: Stroke Source Type: news
