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Risk factors for cardiovascular disease in primary Sj ögren’s syndrome (pSS): a 20-year follow-up study
ConclusionsExtraglandular involvement was associated with a higher prevalence of arterial hypertension, dyslipidemia, hyperuricemia, and coronary artery disease. Anti-Ro/SSA and anti-La/SSB seropositivity was associated with a higher prevalence of cardiac rhythm abnormalities, hyperuricemia, venous thrombosis, coronary artery disease, and cerebrovascular disease. Raised inflammatory markers, disease activity measured by ESSDAI, extraglandular involvement, serologic markers including hypergammaglobulinemia and low C3, and treatment with corticosteroids were associated with a higher risk for cardiovascular comorbidities.Key ...
Source: Clinical Rheumatology - July 4, 2023 Category: Rheumatology Source Type: research

Patients with rheumatoid arthritis have impaired long-term outcomes after myocardial infarction: a nationwide case-control registry study
ConclusionRA is independently associated with poorer prognosis after MI. RA duration and corticosteroid usage and dosage were independent predictors of mortality after MI in RA. Special attention is needed for improvement of outcomes after MI in this vulnerable population.
Source: Rheumatology - March 1, 2021 Category: Rheumatology Source Type: research

The risks of major cardiac events among patients with psoriatic arthritis treated with apremilast, biologics, DMARDs or corticosteroids
ConclusionIn patients with treated PsA, IRs of MI, stroke and revascularization were low for all systemic treatments evaluated. Although the number of events was small, apremilast exposure did not signal potential acute cardiovascular harm and was not associated with a material increase in the risk of these serious cardiac events.
Source: Rheumatology - November 7, 2020 Category: Rheumatology Source Type: research

Risk Factors for Major Adverse Cardiovascular Events in Phase III and Long ‐Term Extension Studies of Tofacitinib in Patients with Rheumatoid Arthritis
ConclusionIn this post ‐hoc analysis, after 24 weeks of tofacitinib, increased HDL‐c, but not increases in LDL‐c or TC, appeared to be associated with lower future MACE risk. Further data are needed to test the cardiovascular safety of tofacitinib.This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatology - April 16, 2019 Category: Rheumatology Authors: Christina Charles ‐Schoeman, Ryan DeMasi, Hernan Valdez, Koshika Soma, Lie‐Ju Hwang, Mary G. Boy, Pinaki Biswas, Iain B. McInnes Tags: Full Length Source Type: research

Evolution of Risk Factors for Atherosclerotic Cardiovascular Events in Systemic Lupus Erythematosus: A Longterm Prospective Study.
CONCLUSION: The relative importance of atherosclerotic risk factors is significantly differentiated over time in SLE. Disease-related factors seem to dominate CV risk during the early stages while traditional factors, partially related to corticosteroid treatment, play a significant role later in the disease course. PMID: 29093154 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - November 3, 2017 Category: Rheumatology Tags: J Rheumatol Source Type: research

Response to: 'Biologic agents for giant cell arteritis: treat to target by Moiseev et al
We thank Moiseev et al for their interest in our study of ustekinumab in giant cell arteritis (GCA).1 2 Our pilot study reported promising initial results from the use of ustekinumab in GCA.1 GCA is a potentially devastating disease with cranial ischaemic complications such as blindness and stroke occurring in 20%–25% of patients.3 While corticosteroids are effective in reducing the risk of cranial ischaemic complications, they do not fully extinguish the vascular inflammation in patients with GCA4–6 with consequent risk of disease relapse and longer-term consequences such as aortic aneurysms.7 8 Furthermore, c...
Source: Annals of the Rheumatic Diseases - August 9, 2016 Category: Rheumatology Authors: Conway, R., Molloy, E. S. Tags: Electronic pages Source Type: research

Disease activity in rheumatoid arthritis and the risk of cardiovascular events
Conclusions: Reduced time‐averaged disease activity in RA is associated with fewer CV events. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: D.H. Solomon, G Reed, J.M. Kremer, J.R. Curtis, M.E. Farkouh, L.R. Harrold, M.C. Hochberg, P Tsao, J Greenberg Tags: Full Length Source Type: research

A case of PRES in an active lupus nephritis patient after treatment of corticosteroid and cyclophosphamide
Abstract Posterior reversible encephalopathy syndrome (PRES) is primarily a radiological diagnosis. The syndrome is characterized by headache, altered mental status, seizures, and bilateral posterior white matter edema in a nonvascular distribution on neuroimaging with resolution of findings usually in 7–14 days (Casey et al. in AJNR Am J Neuroradiol 21:1199–1206, 2000). In most cases, computed tomography of the brain will show hypodense lesions in the parieto-occipital lobe. Although this syndrome is uncommon, prompt and accurate recognition allows early treatment, which has been shown to produce favorable o...
Source: Rheumatology International - November 12, 2014 Category: Rheumatology Source Type: research

Factors Associated with Major Cardiovascular Events in Patients with Systemic Necrotizing Vasculitides: Results of a Longterm Followup Study.
CONCLUSION: These results suggest that factors associated with a higher MCVE risk in patients with SNV are NCEP/ATP III-defined high-risk status and BMI > 30 kg/m(2). Carotid IMT could help identify patients with SNV at risk of early MCVE. PMID: 24584925 [PubMed - as supplied by publisher]
Source: J Rheumatol - March 1, 2014 Category: Rheumatology Authors: Terrier B, Chironi G, Pagnoux C, Cohen P, Puéchal X, Simon A, Mouthon L, Guillevin L, for the French Vasculitis Study Group Tags: J Rheumatol Source Type: research

Circulating microparticles in neuropsychiatric systemic lupus erythematosus
ConclusionCirculating cell‐derived microparticles are reduced in active NPSLE, although the relative contribution of reduced microparticle production, increased consumption or intravascular sequestration, remain uncertain.
Source: APLAR Journal of Rheumatology - January 18, 2013 Category: Rheumatology Authors: Kendall P. Crookston, Wilmer L. Sibbitt, Wayne. L. Chandler, Clifford R. Qualls, Carlos A. Roldan Tags: Original Article Source Type: research