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Specialty: Neurology
Therapy: Chemotherapy

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Total 36 results found since Jan 2013.

5-Fluorouracil–induced Leukoencephalopathy with Acute Stroke-like Presentation Fulfilling Criteria for Recombinant Tissue Plasminogen Activator Therapy
A 61-year-old man underwent systemic chemotherapy with intravenous infusion of nedaplatin and 5-fluorouracil. On the day after the final drug administration, he suddenly experienced difficulty in speaking followed by left-sided weakness. His National Institutes of Health Stroke Scale score was 12. A computed tomographic scan of the brain performed 4 hours after symptom onset revealed no abnormalities. Because all eligibility criteria were fulfilled, he immediately underwent intravenous recombinant tissue plasminogen activator therapy. He recovered from neurologic complications on day 14. An initial magnetic resonance imagi...
Source: Journal of Stroke and Cerebrovascular Diseases - February 18, 2013 Category: Neurology Authors: Ryuta Kinno, Yoshitaka Kii, Masanobu Uchiyama, Yoshiyuki Owan, Takahiro Yamazaki, Toshiya Fukui Tags: Case Reports Source Type: research

A Case of Posterior Circulation Ischemic Stroke Caused by Heparin-Induced Thrombocytopenia after Detaining Hepatic Arterial Infusion Catheter
In Japan, hepatic arterial infusion chemotherapy (HAIC) using reservoir system is recommended for patients with hepatocellular carcinoma (HCC) whose hepatic spare ability is favorable. Arterial infusion catheter is commonly detained in hepatic artery via femoral or brachial artery. In our hospital, catheter is often inserted by puncturing the left subclavian or brachial artery considering the patient's activities of daily living (ADL) during long-term detaining. However, it rarely causes posterior circulation ischemic stroke because of the left vertebral artery branches on the path of catheter.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2018 Category: Neurology Authors: Koji Hirashita, Atsushi Matsumoto, Satoru Yabuno, Takahiro Kanda, Masatoshi Yunoki, Kimihiro Yoshino Tags: Case Studies Source Type: research

Acute Ischemic Stroke as a Presenting Feature of Multiple Myeloma (P3.279)
Conclusions:Stroke is a leading and preventable cause of disability in the US adult population. The majority of strokes are due to atherosclerotic vascular or cardioembolic disease. Understanding the diagnostic work up of stroke and recognizing rare etiologies like MM is important for stroke prevention. This brings to light the importance of recognizing stroke as an initial presenting feature of multiple myeloma and of multiple myeloma as an important treatable etiology of stroke.Disclosure: Dr. Chung has nothing to disclose. Dr. Ramamoorthy has nothing to disclose. Dr. Kar has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Chung, S., Ramamoorthy, R., Kar, J. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Case Report: Brain Metastasis Confined to the Infarcted Area Following Stroke
Conclusions: Cerebral infarctions can cause neovascularization and disruption of the blood–brain barrier. Moreover, the compartmentalized cavity formed by the ischemic injury may accept a large volume of metastatic tumor cells. Such an altered microenvironment of infarcted tissue would be suitable for the colonization and proliferation of metastatic seed. Further, brain metastases should be considered, in addition to recurrence, when new focal neurological deficits develop in patients with ischemic stroke and comorbid cancer.
Source: Frontiers in Neurology - January 29, 2021 Category: Neurology Source Type: research

Fatal Embolic Stroke Due to Non-Atherothrombotic Mobile Thrombi in the Carotid Artery during Gastric Cancer Chemotherapy: An Autopsy Case Report (P01.255)
CONCLUSIONS: Multiple etiologies for ischemic stroke may exist in cancer patients. A mobile thrombus in the carotid artery should be considered as a possible mechanism for arteriogenic stroke in the clinical settings of malignancy with hypercoagulability. Doppler ultrasonography is the most practical tool to identify these conditions.Disclosure: Dr. Yamada has nothing to disclose. Dr. Yoneda has nothing to disclose. Dr. Arakawa has nothing to disclose. Dr. Adachi has nothing to disclose. Dr. Gotoh has nothing to disclose. Dr. Takagi has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Yamada, A., Yoneda, J., Arakawa, C., Adachi, T., Gotoh, J., Takagi, M. Tags: P01 Cerebrovascular Disease I Source Type: research

Stroke-like migraine attacks in long term survivors of high grade glioma. (P1.174)
Conclusions:Stroke-like migraine attacks are difficult to treat and the pathophysiology is unknown. With more sophisticated imaging techniques, a better understanding of this phenomenon will aid in the treatment and prophylaxis of the syndrome with a goal of improving quality of life for this small but slowly growing population.Disclosure: Dr. New has nothing to disclose. Dr. Mirza has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: New, P., Mirza, H. Tags: Neuro-oncology: Gliomas I Source Type: research

Stroke like migraine attacks after radiation therapy (SMART) syndrome a case series of three patients (P6.179)
Conclusions:Our patients represent the first case series of SMART syndrome in a single institution. Our cases share similarities to the prior reports in the literature and highlights the clinical and MRI triad of acute onset headaches, neurological deficits and MRI findings of transient contrast enhancement of the cortex with white matter sparing in a previous radiation field.Disclosure: Dr. rauf has nothing to disclose. Dr. Boulter has nothing to disclose. Dr. Imitola has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Rauf, Y., Boulter, D., Imitola, J. Tags: Neurologic Complications of Cancer Source Type: research

Real Eyes Realize Real Lies (P1.148)
Conclusions:In this case, CT Perfusion scanning was used to disprove vascular etiology and ultimately led to the appropriate diagnosis through further diagnostic testing.Disclosure: Dr. E-Ghanmh has nothing to disclose. Dr. Niazi has nothing to disclose. Dr. Ermak has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: El-Ghanem, M., Niazi, M., Ermak, D. Tags: General Neurology: The Eyes Have It and White Matter Matters Source Type: research

Methotrexate Encephalopathy as a Cause of Alternating Hemiplegia (P3.143)
CONCLUSIONS: Transient neurologic dysfunction with reversible MRI abnormality is a recognized consequence of intrathecal methotrexate chemotherapy in childhood ALL. Patients present with dramatic fluctuating neurologic symptoms with associated MRI changes and may be mistaken for stroke or a seizure disorder. Once the syndrome is recognized patients typically recover with supportive management and rehabilitation.Disclosure: Dr. Sullivan has nothing to disclose. Dr. Quealy has nothing to disclose. Dr. Olsevskaite has nothing to disclose. Dr. MacEneaney has nothing to disclose. Dr. Ryan has nothing to disclose. Dr. O'Toole ha...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Sullivan, C., Quealy, J., Olsevskaite, J., MacEneaney, P., Ryan, C., O'Toole, O. Tags: Neuro-oncology: CNS Lymphoma and Other Hematologic Malignancies Source Type: research

Migration of bone marrow‐derived cells into the CNS in models of neurodegeneration
This study confirms that bone marrow‐derived cells infiltrate the CNS in animal models for stroke and Alzheimer's disease and that peripheral cells can be targeted to treat affected regions of the CNS. J. Comp. Neurol., 2013. © 2013 Wiley Periodicals, Inc. Using a myeloablative chemotherapy regimen, the authors have investigated the capacity of bone marrow derived cells to enter into the central nervous system. These cells migrated specifically to sites of injuries in models of stroke and Alzheimer's disease but did not repopulate the entire parenchyma.
Source: The Journal of Comparative Neurology - May 16, 2013 Category: Neurology Authors: Antoine Lampron, Pedro M. Pimentel‐Coelho, Serge Rivest Tags: Research Article Source Type: research

Migration of Bone Marrow‐Derived Cells Into the Central Nervous System in Models of Neurodegeneration
This study confirms that BMDC infiltrate the CNS in animal models for stroke and Alzheimer's disease and that peripheral cells can be targeted to treat affected regions of the CNS. J. Comp. Neurol. 521:3863–3876, 2013. © 2013 Wiley Periodicals, Inc. Using a myeloablative chemotherapy regimen, the authors have investigated the capacity of bone marrow‐derived cells to enter into the central nervous system. These cells migrated specifically to sites of injuries in models of stroke and Alzheimer's disease but did not repopulate the entire parenchyma.
Source: The Journal of Comparative Neurology - October 7, 2013 Category: Neurology Authors: Antoine Lampron, Pedro M. Pimentel‐Coelho, Serge Rivest Tags: Research Article Source Type: research

From Chemotherapy-Induced Emesis to Neuroprotection: Therapeutic Opportunities for 5-HT 3 Receptor Antagonists
Abstract 5-HT3 receptor antagonists are extensively used as efficacious agents in counteracting chemotherapy-induced emesis. Recent investigations have shed light on other potential effects (analgesic, anxiolytic, and anti-psychotic). Some studies have reported neuroprotective properties for the 5-HT3 receptor antagonists in vitro and in vivo. When administered to Aβ-challenged rat cortical neurons, 5-HT3 receptor antagonists substantially abated apoptosis, elevation of cytosolic Ca2, glutamate release, reactive oxygen species (ROS) generation, and caspase-3 activity. In addition, in vivo studies show that 5-HT3 ...
Source: Molecular Neurobiology - November 7, 2014 Category: Neurology Source Type: research

Dural puncture: an overlooked cause of cerebral venous thrombosis
Abstract Cerebral venous thrombosis (CVT) accounts for 0.5–1 % of all strokes. Although dural puncture is proposed as one of the rare risk factors, this association has only been mentioned in anecdotal reports. Headache, i.e., usually the first and the most frequent clinical symptom on admission, is often attributed to the dural puncture itself. We investigated the frequency of CVT following a recent dural puncture in our stroke database, together with the other risk factors. The computerized medical records of patients (n = 10,740) registered in our tertiary-care neurology clinic stroke database were review...
Source: Acta Neurologica Belgica - March 1, 2015 Category: Neurology Source Type: research

Chapter 15 Vascular complications in glioma patients
Publication date: 2016 Source:Handbook of Clinical Neurology, Volume 134 Author(s): Emilie Le Rhun, James R. Perry Vascular complications in patients with glioma most commonly include venous and arterial thromboembolism; however, treatment-induced vasculopathies are also problematic, especially in long-term survivors. The interactions between treatment such as radiation and chemotherapy, the coagulation cascade, endothelium, and regulators of angiogenesis are complex, drive glioma growth and invasion, and create common management problems in the clinic. We review the incidence of thrombotic complications in glioma, the...
Source: Handbook of Clinical Neurology - March 4, 2016 Category: Neurology Source Type: research

Capecitabine-induced acute toxic leukoencephalopathy.
Abstract A 45-year-old woman was treated by Capecitabine (Xeloda(®)) during 6days for breast cancer with metastatic bone lesions when she presented with nausea, headaches, muscle cramps, dysarthria and swallowing disorders. A stroke was first suspected. Brain CT was normal. MRI showed bilateral and symmetric high signal intensities of deep white matter, corpus callosum and corticospinal tracts on diffusion-weighted imaging and T2 fluid-attenuated inversion recovery (FLAIR) sequence, similar to 5-FU acute leukoencephalopathy. An acute toxic leukoencephalopathy was diagnosed prompting to discontinue capecitabine, w...
Source: Neurotoxicology - May 6, 2017 Category: Neurology Authors: Obadia M, Leclercq D, Wasserman J, Galanaud D, Dormont D, Sahli-Amor M, Psimaras D, Pyatigorskaya N, Law-Ye B Tags: Neurotoxicology Source Type: research