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Vascular and parenchymal lesions along with enhanced neurogenesis characterize the brain of asymptomatic stroke-prone spontaneous hypertensive rats
Conclusion:Appearance of vascular changes in SHRSPs, before any MRI-detectable brain lesion, is coupled to active neural proliferation in the SVZ. With disease progression, only newborn astrocytes can survive, likely because of the neurotoxicity triggered by brain oedema and oxidative stress.
Source: Journal of Hypertension - July 8, 2013 Category: Cardiology Tags: ORIGINAL PAPERS: Stroke Source Type: research

Minor Changes for a Major Impact: A Review of Epigenetic Modifications in Cell-Based Therapies for Stroke
Int J Mol Sci. 2022 Oct 28;23(21):13106. doi: 10.3390/ijms232113106.ABSTRACTEpigenetic changes in stroke may revolutionize cell-based therapies aimed at reducing ischemic stroke risk and damage. Epigenetic changes are a novel therapeutic target due to their specificity and potential for reversal. Possible targets for epigenetic modification include DNA methylation and demethylation, post-translational histone modification, and the actions of non-coding RNAs such as microRNAs. Many of these epigenetic modifications have been reported to modulate atherosclerosis development and progression, ultimately contributing to stroke ...
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Molly Monsour Jonah Gordon Gavin Lockard Adam Alayli Bassel Elsayed Jacob Connolly Cesar V Borlongan Source Type: research

Strategies for Early Stroke Recovery: What Lies Ahead?
Opinion statement Most patients experience some degree of recovery after a stroke, but the majority of patients still have persistent impairments months later. Most recovery occurs early after a stroke, in the first few weeks to months, corresponding to a period of enhanced neuroplasticity. We are beginning to understand the mechanisms that underlie this recovery process, and how we can take advantage of this plasticity in designing rehabilitative interventions. In this review, we focus on recent behavioral, pharmacological, and brain stimulation strategies that have shown promise in augmenting stroke recovery. S...
Source: Current Treatment Options in Cardiovascular Medicine - November 5, 2014 Category: Cardiology Source Type: research

Ischemic Stroke Activates Hematopoietic Bone Marrow Stem Cells.
Conclusions: Ischemic stroke activates hematopoietic stem cells via increased sympathetic tone, leading to a myeloid bias of hematopoiesis and higher bone marrow output of inflammatory Ly6Chigh monocytes. PMID: 25362208 [PubMed - as supplied by publisher]
Source: Circulation Research - October 31, 2014 Category: Cardiology Authors: Courties G, Herisson F, Sager H, Heidt T, Ye Y, Ying W, Sun Y, Severe N, Dutta P, Scharff J, Scadden D, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M Tags: Circ Res Source Type: research

MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice
CONCLUSIONS: These results suggest that MAGT1 and TRPC6 are functionally linked. Therefore, deficiency or impaired functionality of MAGT1 could be a potential risk factor for arterial thrombosis and stroke.PMID:37381987 | DOI:10.1161/ATVBAHA.122.318115
Source: Arteriosclerosis, Thrombosis and Vascular Biology - June 29, 2023 Category: Cardiology Authors: Sanjeev Kiran Gotru Elmina Mammadova-Bach Georgios Sogkas Michael K Schuhmann Karen Schmitt Peter Kraft Sabine Herterich Medina Mamtimin Akif Pinarci Sarah Beck Simon Stritt Han Chao Pengxuan Ren Jean-No ël Freund Christian Klemann Felix C Ringshausen Jo Source Type: research

Stem Cells Show Promise for Stroke Recovery
Title: Stem Cells Show Promise for Stroke RecoveryCategory: Health NewsCreated: 4/7/2014 4:36:00 PMLast Editorial Review: 4/8/2014 12:00:00 AM
Source: MedicineNet Heart General - April 8, 2014 Category: Cardiology Source Type: news

Waking up the stem cell niche: how hematopoietic stem cells generate inflammatory monocytes after stroke.
PMID: 25634966 [PubMed - in process]
Source: Circulation Research - January 30, 2015 Category: Cardiology Authors: Wolf D, Ley K Tags: Circ Res Source Type: research

Stem Cells May Offer New Hope to Stroke Survivors
Title: Stem Cells May Offer New Hope to Stroke SurvivorsCategory: Health NewsCreated: 6/2/2016 12:00:00 AMLast Editorial Review: 6/3/2016 12:00:00 AM
Source: MedicineNet Heart General - June 3, 2016 Category: Cardiology Source Type: news

Hypoxia-Preconditioned Bone Marrow Mesenchymal Stem Cells Improved Cerebral Collateral Circulation and Stroke Outcome in Mice
CONCLUSIONS: BMSCs increased collateral circulation and improved poststroke outcomes, through the upregulation of Rabep2. These effects were enhanced by hypoxic preconditioning.PMID:37226732 | DOI:10.1161/ATVBAHA.122.318559
Source: Arteriosclerosis, Thrombosis and Vascular Biology - May 25, 2023 Category: Cardiology Authors: Hao Tian Xinxuan Yang Jiahui Zhao Xiran Liu Xin Liu Yuan Cai Alexandra Wehbe Yuchuan Ding Shanping Yu Ling Wei Liping Liu Source Type: research

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