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Investigation of Combined Carotid Endarterectomy and Coronary Artery Bypass Graft Surgery Outcomes and Adverse Event Risk Factors in the Vascular Quality Initiative
CONCLUSIONS: Combined CEA and CABG provides excellent long-term mortality prevention in patients with co-existing severe coronary and carotid atherosclerosis. Simultaneous CEA and CABG provides equivalent stroke prevention and long-term survival to both a cohort of patients undergoing coronary revascularization within 5 years of CEA and patients undergoing isolated CEA or CABG in the literature. The two most impactful modifiable risk factors towards long-term stroke and mortality prevention for patients undergoing simultaneous CEA-CABG are patch placement at CEA site and adherence to statin medication therapy.PMID:37303074...
Source: Atherosclerosis - June 11, 2023 Category: Cardiology Authors: Ashley Penton Jonathan Lin Grant Kolde Matthew DeJong Matthew Blecha Source Type: research

Aetiology of extracranial carotid free-floating thrombus in a prospective multicentre cohort
CONCLUSIONS: The majority of symptomatic carotid artery FFT are likely caused by local plaque rupture, more than half of which are associated with moderate to severe carotid stenosis requiring revascularisation. However, a significant number of FFTs are caused by non-atherosclerotic mechanisms warranting additional investigations.PMID:36368714 | DOI:10.1136/svn-2022-001639
Source: Atherosclerosis - November 11, 2022 Category: Cardiology Authors: Dar Dowlatshahi Cheemun Lum Bijoy K Menon Aditya Bharatha Prasham Dave Paulo Puac-Polanco Dylan Blacquiere Grant Stotts Michel Shamy Franco Momoli Rebecca Thornhill Ronda Lun Carlos Torres Source Type: research

Feasibility of Sentinel Cerebral Embolic Protection Device Deployment During Transfemoral Transcatheter Aortic Valve Replacement
Cerebral embolic protection has emerged as a preventive measure for procedural stroke in transcatheter aortic valve replacement (TAVR).1 The Sentinel System (Boston Scientific Corp. Boston, Massachusetts), a 2-filter debris-capturing system, has been the only commercially available protection device in the United States since its approval by the Food and Drug Administration in 2017. In the Sentinel trial, the largest randomized trial (n  = 363) so far, the device was successfully deployed in 94.7% of patients.
Source: The American Journal of Cardiology - October 1, 2022 Category: Cardiology Authors: Toshiaki Isogai, Husitha Reddy Vanguru, Amar Krishnaswamy, Ankit Agrawal, Nikolaos Spilias, Shashank Shekhar, Anas M. Saad, Beni Rai Verma, Rishi Puri, Grant W. Reed, Zoran B. Popovi ć, Shinya Unai, James J. Yun, Ken Uchino, Samir R. Kapadia Source Type: research

Impact of Hospital Volume on Utilization and Outcomes of Sentinel Cerebral Protection System During Transcatheter Aortic Valve Implantation
Stroke remains a serious complication of transcatheter aortic valve implantation (TAVI) with a significant impact on long-term morbidity and mortality. Although the etiology of strokes is multifactorial, most are a result of embolization of debris during the procedure.1 Multiple devices have emerged aiming to reduce the incidence of stroke through cerebral embolic protection. The Sentinel cerebral protection system (CPS) is the only Food and Drug Administration-approved device in the United States.
Source: The American Journal of Cardiology - July 13, 2022 Category: Cardiology Authors: Agam Bansal, Toshiaki Isogai, Mohamed M. Gad, Grant W. Reed, Rishi Puri, Amar Krishnaswamy, Samir R. Kapadia Source Type: research

Po-641-05 safety and in-hospital outcomes of left atrial appendage closure device in patients with heart failure: an analysis from the national inpatient sample database 2015-2018
Left atrial appendage occlusion (LAAO) is a procedure that has been shown to be non-inferior to oral anticoagulation for stroke prevention for patients with atrial fibrillation. There is limited data about the safety of left atrial appendage occlusion (LAAO) in patients with heart failure (HF).
Source: Heart Rhythm - April 29, 2022 Category: Cardiology Authors: Carlos Vergara Sanchez, Michael Dangl, Michael Albosta, Ian Ergui, Karla Inestroza, Jennifer Maning, Louis Thomas Vincent, Jelani K. Grant, Bertrand Ebner, Rosario Colombo Source Type: research

Impact of Cerebral Embolic Protection Devices on the Incidence and Outcomes of Delirium After Transcatheter Aortic Valve Implantation
Postoperative delirium is a well-recognized complication after transcatheter aortic valve implantation (TAVI) that is associated with a significantly increased mortality and prolonged hospitalization stay.1 Ischemic brain injury has been hypothesized to be one of the predominant mechanisms responsible for delirium after TAVI. Brain injury during TAVI involves microinfarctions caused by cerebral embolization of the aortic plaque or valve particles dislodged during the prosthesis deployment.1,2 The role of cerebral embolic protection (CEP) devices has been studied in preventing stroke during TAVI.
Source: The American Journal of Cardiology - April 15, 2022 Category: Cardiology Authors: Agam Bansal, Anirudh Kumar, Grant W. Reed, Rishi Puri, Amar Krishnaswamy, Axel Linke, James Yun, Samir R. Kapadia Source Type: research

Apparent Treatment-Resistant Hypertension Among Stroke Survivors: A Transcontinental Study assessing impact of race and geography
CONCLUSIONS: Future studies are needed to investigate the contribution of socioeconomic disparities in the prevalence aTRH in those with African Ancestry to explore the long-term impact, and evaluate effective therapeutic interventions in this subpopulation.PMID:35366323 | DOI:10.1093/ajh/hpac046
Source: American Journal of Hypertension - April 2, 2022 Category: Cardiology Authors: Fred Stephen Sarfo Esther Olasoji Grant P Banfill Bruce Ovbiagele Alexis N Simpkins Source Type: research

Impact of Timing of Infective Endocarditis After Transcatheter Aortic Valve Implantation on Mortality
It is well established that infective endocarditis (IE) after transcatheter aortic valve implantation (TAVI) is associated with significantly increased mortality (1-year mortality rates as high as 50%) and stroke rates.1,2 Existing studies have determined the predictors of IE after TAVI and mortality in patients with IE after TAVI.1,2 Stortecky et al3 determined that the incidence of IE after TAVI was highest in the early procedural/periprocedural period ( ≤100 days). Similar findings were shown by Mentias et al.
Source: The American Journal of Cardiology - February 11, 2022 Category: Cardiology Authors: Agam Bansal, Anirudh Kumar, Grant W. Reed, Rishi Puri, Amar Krishnaswamy, Samir R. Kapadia Source Type: research

A journey through clinic and research
I started to study Medicine at the University of Genoa, Italy more than 20 years ago and I now realize that I was quite far from understanding what ‘Medicine’ really means. After weeks and weeks spent on books during the first year, I understood that becoming a MD not only requires the willingness to help people with health problems, but also strong motivation and dedication to learn a huge amount of notions. In Italy, as it is the case for several other countries, the University courses last 6 years, during which the MD student is fully engaged by individual study, lessons and seminars, exercises, and internships. Wit...
Source: European Heart Journal - March 29, 2021 Category: Cardiology Source Type: research

Prevalence of In-hospital Stroke Comparing MitraClip and Transcatheter Aortic Valve Implantation
Transcatheter aortic valve implantation (TAVI) and mitraclip (MC) are increasingly utilized for the treatment of aortic stenosis (AS) and mitral regurgitation (MR), respectively. Perioperative stroke is one of the most serious complications following TAVI given the valve calcification and possible embolization during valve implantation, and thus ongoing trials are assessing the use of embolic protection device following TAVI. On the other hand, no such trials are being conducted on MC as the evidence of stroke following MC is lacking and MC does not share the same etiology with TAVI 1.
Source: The American Journal of Cardiology - January 5, 2021 Category: Cardiology Authors: Anas M. Saad, Keerat Rai Ahuja, Omar M. Abdelfattah, Mohamed M. Gad, Toshiaki Isogai, Manpreet Kaur, Grant W. Reed, James Yun, Amar Krishnaswamy, Samir R. Kapadia Source Type: research

Benefit of Single Antiplatelet Therapy Over Dual Antiplatelet Therapy After Transcatheter Aortic Valve Implantation
Current practice guidelines recommend dual antiplatelet therapy with aspirin and clopidogrel for 3-6 months followed by lifelong aspirin after transcatheter aortic valve implantation (TAVI). However, recently published POPular TAVI trial1 and other trials2 –4 that have compared dual antiplatelet therapy (DAPT) with single antiplatelet therapy (SAPT) have shown decreased bleeding events and non-inferiority with respect to ischemic stroke, all-cause mortality, and myocardial infarction (MI) amongst patients receiving SAPT.
Source: The American Journal of Cardiology - December 8, 2020 Category: Cardiology Authors: Agam Bansal, Ashish Kumar, Vardhmaan Jain, Grant W Reed, Amar Krishnaswamy, Ankur Kalra, Rishi Puri, Samir R. Kapadia Source Type: research

Peer Review Practices for Evaluating Biomedical Research Grants: A Scientific Statement From the American Heart Association.
ovascular Surgery and Anesthesia; Council on Clinical Cardiology; Council on Functional Genomics and Translational Biology; Council on Hypertension; Council on Quality of Care and Outcomes Research; and Stroke Council Abstract The biomedical research enterprise depends on the fair and objective peer review of research grants, leading to the distribution of resources through efficient and robust competitive methods. In the United States, federal funding agencies and foundations collectively distribute billions of dollars annually to support biomedical research. For the American Heart Association, a Peer Review Subc...
Source: Circulation Research - July 6, 2017 Category: Cardiology Authors: Liaw L, Freedman JE, Becker LB, Mehta NN, Liscum L, Peer Review Subcommittee of the American Heart Association National Research Committee; Council on Cardiovascular and Stroke Nursing; Council on Cardiovascular Radiology and Intervention; Council on Card Tags: Circ Res Source Type: research

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