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Total 22 results found since Jan 2013.
Hypothermia Promotes Mitochondrial Elongation In Cardiac Cells Via Inhibition Of Drp1
In conclusion hypothermia promoted elongation of cardiac mitochondria via reduced pDrp1S616 abundance which was also associated with suppression of cellular oxygen consumption. Silencing of TRPV1 in H9c2 cardiomyocytes reproduced the morphological and respirometric phenotype of hypothermia. This report demonstrates a novel mechanism of cold-induced inhibition of mitochondrial fission.PMID:34331901 | DOI:10.1016/j.cryobiol.2021.07.013
Source: Cryobiology - July 31, 2021 Category: Biology Authors: David Taylor Juliana Germano Yang Song Hanane Hadj-Moussa Stefanie Marek-Iannucci Raeesa Dhanji Jon Sin Lawrence S C Czer Kenneth B Storey Roberta A Gottlieb Source Type: research
Coronary blood flow influences tolerance to environmental extremes in fish RESEARCH ARTICLE
Daniel Morgenroth, Tristan McArley, Albin Gräns, Michael Axelsson, Erik Sandblom, and Andreas Ekström Approximately half of all fishes have, in addition to the luminal venous O2 supply, a coronary circulation supplying the heart with fully oxygenated blood. Yet, it is not fully understood how coronary O2 delivery affects tolerance to environmental extremes such as warming and hypoxia. Hypoxia reduces arterial oxygenation, while warming increases overall tissue O2 demand. Thus, as both stressors are associated with reduced venous O2 supply to the heart, we hypothesised that coronary flow benefits hypoxia and...
Source: Journal of Experimental Biology - March 9, 2021 Category: Biology Authors: Morgenroth, D., McArley, T., Gräns, A., Axelsson, M., Sandblom, E., Ekström, A. Tags: RESEARCH ARTICLE Source Type: research
Stroke effort and relative lung volume influence heart rate in diving sea lions RESEARCH ARTICLE
This study assessed the potential role of exercise and relative lung volume in the regulation of heart rate (fH) during dives of adult female California sea lions instrumented with electrocardiogram (ECG), depth and tri-axial acceleration data loggers. A positive relationship between activity (minimum specific acceleration) and fH throughout dives suggested increased muscle perfusion associated with exercise. However, apart from late ascent, fH during dives was still less than or equal to resting fH (on land). In addition, the activity–fH relationship was weaker in long, deep dives consistent with prioritization of b...
Source: Journal of Experimental Biology - March 10, 2020 Category: Biology Authors: McDonald, B. I., Tift, M. S., Hückstädt, L. A., Jeffko, M., Ponganis, P. J. Tags: RESEARCH ARTICLE Source Type: research
The potential of drug repurposing combined with reperfusion therapy in cerebral ischemic stroke: A supplementary strategy to endovascular thrombectomy
Publication date: Available online 11 October 2019Source: Life SciencesAuthor(s): Jenq-Lin Yang, Yun-Ru Yang, Shang-Der ChenAbstractStroke is the major cause of adult disability and the second or third leading cause of death in developed countries. The treatment options for stroke (thrombolysis or thrombectomy) are restricted to a small subset of patients with acute ischemic stroke because of the limited time for an efficacious response and the strict criteria applied to minimize the risk of cerebral hemorrhage. Attempts to develop new treatments, such as neuroprotectants, for acute ischemic stroke have been costly and tim...
Source: Life Sciences - October 13, 2019 Category: Biology Source Type: research
Combined local hypothermia and recanalization therapy for acute ischemic stroke: Estimation of brain and systemic temperature using an energetic numerical model
Publication date: Available online 4 July 2019Source: Journal of Thermal BiologyAuthor(s): Yannick Lutz, Axel Loewe, Stephan Meckel, Olaf Dössel, Giorgio CattaneoAbstractLocal brain hypothermia is an attractive method for providing cerebral neuroprotection for ischemic stroke patients and at the same time reducing systemic side effects of cooling. In acute ischemic stroke patients with large vessel occlusion, combination with endovascular mechanical recanalization treatment could potentially allow for an alleviation of inflammatory and apoptotic pathways in the critical phase of reperfusion. The direct cooling of arterial...
Source: Journal of Thermal Biology - July 6, 2019 Category: Biology Source Type: research
ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology
by Yongliang Cao, Haochen Xu, Yuanbo Zhu, Mei-Juan Shi, Lixiang Wei, Jin Zhang, Shuo Cheng, Yiqian Shi, Haiyang Tong, Lijing Kang, Lu Lu, Haiyu Luo, Xing Yang, Xiaofei Bai, Ranran Wang, Yuanyuan Ma, Yun Wang, Zhongfeng Wang, Kai Zhong, Bing-Qiao Zhao, Wenying Fan
Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I mo tif, member 13 (ADAMTS13) plays a significant protective effect in...
Source: PLoS Biology: Archived Table of Contents - June 10, 2019 Category: Biology Authors: Yongliang Cao Source Type: research
Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts RESEARCH ARTICLE
William Joyce, Michael Axelsson, and Tobias Wang
Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtles more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here, we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (T...
Source: Journal of Experimental Biology - March 20, 2019 Category: Biology Authors: Joyce, W., Axelsson, M., Wang, T. Tags: RESEARCH ARTICLE Source Type: research
Dynamics of blood circulation during diving in the bottlenose dolphin (Tursiops truncatus): the role of the retia mirabilia RESEARCH ARTICLE
Marco Bonato, Paola Bagnoli, Cinzia Centelleghe, Mike Maric, Ginevra Brocca, Sandro Mazzariol, and Bruno Cozzi
The retia mirabilia are vascular nets composed of small vessels dispersed among numerous veins, allowing blood storage, regulation of flow and pressure damping effects. Here, we investigated their potential role during the diving phase of the bottlenose dolphin (Tursiops truncatus). To this effect, the whole vertebral retia mirabilia of a series of dolphins were removed during post-mortem analysis and examined to assess vessel diameters, and estimate vascular volume and flow rate. We formulated a new hemodynamic ...
Source: Journal of Experimental Biology - March 6, 2019 Category: Biology Authors: Bonato, M., Bagnoli, P., Centelleghe, C., Maric, M., Brocca, G., Mazzariol, S., Cozzi, B. Tags: RESEARCH ARTICLE Source Type: research
Contraction of atrial smooth muscle reduces cardiac output in perfused turtle hearts RESEARCH ARTICLE
William Joyce, Michael Axelsson, and Tobias Wang Unusual undulations in resting tension (tonus waves) were described in isolated atria from freshwater turtle more than a century ago. These tonus waves were soon after married with the histological demonstration of a rich layer of smooth muscle on the luminal side of the atrial wall. Research thereafter waned and the functional significance of this smooth muscle has remained obscure. Here we provide evidence that contraction of the smooth muscle in the atria may be able to change cardiac output in turtle hearts. In in situ perfused hearts of the red-eared slider turtle (Trac...
Source: Journal of Experimental Biology - February 20, 2019 Category: Biology Authors: Joyce, W., Axelsson, M., Wang, T. Tags: RESEARCH ARTICLE Source Type: research
Dynamics of blood circulation during diving in the bottlenose dolphin (Tursiops truncatus). The role of the retia mirabilia RESEARCH ARTICLE
Marco Bonato, Paola Bagnoli, Cinzia Centelleghe, Mike Maric, Ginevra Brocca, Sandro Mazzariol, and Bruno Cozzi The retia mirabilia are vascular nets composed by small vessels dispersed among numerous veins, allowing blood storage, regulation of flow, and pressure damping effects. Here we investigated their potential role during the diving phase of the bottlenose dolphin (Tursiops truncatus). To this effect, the whole vertebral retia mirabilia of a series of dolphins were removed during post-mortem analysis and examined to assess vessel diameters, estimate vascular volume, and flow rate. Here we formulate a new hemodynamic ...
Source: Journal of Experimental Biology - February 13, 2019 Category: Biology Authors: Bonato, M., Bagnoli, P., Centelleghe, C., Maric, M., Brocca, G., Mazzariol, S., Cozzi, B. Tags: RESEARCH ARTICLE Source Type: research
Analysis of vascular mechanical properties of the yellow anaconda reveals increased elasticity and distensibility of the pulmonary artery during digestion RESEARCH ARTICLE
Renato Filogonio, Tobias Wang, and Carl Christian Danielsen
In animals with functional division of blood systemic and pulmonary pressures, such as mammals, birds, crocodilians and a few non-crocodilian reptiles, the vessel walls of systemic and pulmonary arteries are exquisitely adapted to endure different pressures during the cardiac cycle, systemic arteries being stronger and stiffer than pulmonary arteries. However, the typical non-crocodilian reptile heart possesses an undivided ventricle that provides similar systolic blood pressure to both circuits. This raises the question whether in these species the systemic and ...
Source: Journal of Experimental Biology - August 23, 2018 Category: Biology Authors: Filogonio, R., Wang, T., Danielsen, C. C. Tags: RESEARCH ARTICLE Source Type: research
Clinical Imaging of Hypoxia: Current Status and Future Directions.
Abstract
Tissue hypoxia is a key feature of many important causes of morbidity and mortality. In pathologies such as stroke, peripheral vascular disease and ischaemic heart disease, hypoxia is largely a consequence of low blood flow induced ischaemia, hence perfusion imaging is often used as a surrogate for hypoxia to guide clinical diagnosis and treatment. Importantly, ischaemia and hypoxia are not synonymous conditions as it is not universally true that well perfused tissues are normoxic or that poorly perfused tissues are hypoxic. In pathologies such as cancer, for instance, perfusion imaging and oxygen concent...
Source: Free Radical Biology and Medicine - August 18, 2018 Category: Biology Authors: Bonnitcha P, Grieve S, Figtree G Tags: Free Radic Biol Med Source Type: research
Analysis of vascular mechanical properties from the yellow anaconda indicates increased elasticity and distensibility of the pulmonary artery during digestion RESEARCH ARTICLE
Renato Filogonio, Tobias Wang, and Carl Christian Danielsen In animals with functional division of blood systemic and pulmonary pressures, such as mammals, birds, crocodilians and a few exceptions among non-crocodilian reptiles, the vessel walls of systemic and pulmonary arteries are exquisitely adapted to endure different pressures during the cardiac cycle, systemic arteries being stronger and stiffer than pulmonary arteries. However, the typical non-crocodilian reptile heart possesses an undivided ventricle that provides similar systolic blood pressures to both circuits. This raises the question whether in these species ...
Source: Journal of Experimental Biology - June 25, 2018 Category: Biology Authors: Filogonio, R., Wang, T., Danielsen, C. C. Tags: RESEARCH ARTICLE Source Type: research
The role of glutamate in neuronal ion homeostasis: A case study of spreading depolarization
by Niklas H übel, Mahshid S. Hosseini-Zare, Jokūbas Žiburkus, Ghanim Ullah
Simultaneous changes in ion concentrations, glutamate, and cell volume together with exchange of matter between cell network and vasculature are ubiquitous in numerous brain pathologies. A complete understanding of pathological conditions as well as normal brain function, therefore, hinges on eluc idating the molecular and cellular pathways involved in these mostly interdependent variations. In this paper, we develop the first computational framework that combines the Hodgkin–Huxley type spiking dynamics, dynamic ion concentrations and glutama...
Source: PLoS Computational Biology - October 12, 2017 Category: Biology Authors: Niklas H übel Source Type: research
