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Specialty: Biochemistry
Condition: Diabetes
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Total 384 results found since Jan 2013.
Exploring the role of lipoprotein(a) in cardiovascular diseases and diabetes in Chinese population
Int J Biol Macromol. 2023 Feb 7:123586. doi: 10.1016/j.ijbiomac.2023.123586. Online ahead of print.ABSTRACTA high level of lipoprotein (a) in the plasma has been associated with a variety of cardiovascular diseases and is considered to be an independent predictor of some other diseases. Based on recent studies, the concentration levels of Lp(a) in the Chinese population exhibit a distinctive variation from other populations. In the Chinese population, a high level of Lp(a) indicates a higher incidence of revascularization, platelet aggregation, and thrombogenicity following PCI. Increased risk of atherosclerotic cardiovasc...
Source: International Journal of Biological Macromolecules - February 9, 2023 Category: Biochemistry Authors: Zubair Hussain Hongcai Liu Junaid Iqbal Hou-De Zhou Source Type: research
The role of miRNAs in insulin resistance and diabetic macrovascular complications - A review
Int J Biol Macromol. 2023 Jan 6:123189. doi: 10.1016/j.ijbiomac.2023.123189. Online ahead of print.ABSTRACTDiabetes is the most prevalent metabolic disturbance disease and has been regarded globally as one of the principal causes of mortality. Diabetes is accompanied by several macrovascular complications, including stroke, coronary artery disease (CAD), and cardiomyopathy as a consequence of atherosclerosis. The onset of type 2 diabetes is closely related to insulin resistance (IR). miRNAs have been linked to various metabolic processes, including glucose homeostasis, regulation of lipid metabolism, gluconeogenesis, adipo...
Source: International Journal of Biological Macromolecules - January 9, 2023 Category: Biochemistry Authors: Sherif S Abdel Mageed Ahmed S Doghish Ahmed Ismail Ahmed A El-Husseiny Sylvia F Fawzi Abdulla M A Mahmoud Hesham A El-Mahdy Source Type: research
Identification of ligustrazine-based analogs of piperlongumine as potential anti-ischemic stroke agents
Fitoterapia. 2022 Dec 20:105398. doi: 10.1016/j.fitote.2022.105398. Online ahead of print.ABSTRACTPiper longum has a specific aroma and spicy taste. In addition to edible value, current studies have shown that piper longum also has pharmacological activities such as anti-platelet aggregation, anti-inflammation, anti-cancer, anti-diabetes and anti-depression. Piperlongumine is an alkaloid isolated from Piper longum. Based on our previous studies, four Piperlongumine analogs were synthesized, and their anti-platelet aggregation activities were evaluated. Among them, compound 8 has the strongest anti-platelet aggregation acti...
Source: Fitoterapia - December 23, 2022 Category: Biochemistry Authors: Tan Lijuan Cao Xiaolu Wan Xin He Yuying Lan Xi Yang Xiliang Wang Ting Min Zhenli Zou Yu Source Type: research
The neuroprotective and antidiabetic effects of trigonelline: A review of signaling pathways and molecular mechanisms
Biochimie. 2022 Oct 15:S0300-9084(22)00274-7. doi: 10.1016/j.biochi.2022.10.009. Online ahead of print.ABSTRACTThe global epidemic of diabetes has brought heavy pressure on public health. New effective anti-diabetes strategies are urgently needed. Trigonelline is the main component of fenugreek, which has been proved to have a good therapeutic effect on diabetes and diabetic complications. Trigonelline achieves amelioration of diabetes, the mechanisms of which include the modulation of insulin secretion, a reduction in oxidative stress, and the improvement of glucose tolerance and insulin resistance. Besides, trigonelline ...
Source: Biochimie - October 18, 2022 Category: Biochemistry Authors: Youdan Liang Xiaolin Dai Yi Cao Xian Wang Jing Lu Long Xie Kai Liu Xiaofang Li Source Type: research
Synthesis, Docking Study and Biological Evaluation of Amide-Based Soluble Epoxide Hydrolase Inhibitors with Novel Secondary Pharmacophore of Pyrimidin-2-ol
Chem Biodivers. 2022 Sep 24. doi: 10.1002/cbdv.202200231. Online ahead of print.ABSTRACTSoluble epoxide hydrolase enzyme (sEH) is one of the most promising and emerging targets to develop drugs for multiple disease indications, including hypertension, diabetes, stroke, dyslipidemia, pain, and etc. Most inhibitor scaffolds have a urea or amide moiety to mimic the active-site transition state. In this regard, we developed a series of amide sEH inhibitors with a pyrimidin-2-ol ring as a new secondary pharmacophore, which was subjected to in vitro evaluation. Compound 4w (4-chloro-N-(4-(6-(4-chlorophenyl)-2-hydroxypyrimidin-4-...
Source: Chemistry and Biodiversity - September 24, 2022 Category: Biochemistry Authors: Leila Hejazi Ebrahim Ebadi Zeynab Fakhar Maryam Nazari Elham Rezaee Sayyed Abbas Tabatabai Source Type: research
The Emerging Role of Copeptin
Clin Biochem Rev. 2021 Feb;42(1):17-25. doi: 10.33176/AACB-20-00001.ABSTRACTDirect measurement of the nonapeptide vasopressin has been limited by analyte instability ex vivo and in vivo rapid degradation, low serum concentrations requiring a sensitive assay and inherent secretory pulsatility. Copeptin is a 39 amino acid glycopeptide cleavage product of vasopressin synthesis with high stability, providing a marker of vasopressin secretion. Copeptin measurement has applications in diagnosis of diabetes insipidus and other diseases with altered vasopressin secretion. This review summarises our current understanding of serum c...
Source: The Clinical Biochemist. Reviews - June 20, 2022 Category: Biochemistry Authors: R Jalleh D J Torpy Source Type: research
