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Total 1260 results found since Jan 2013.
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a Pharmacology
Stroke is the second-leading cause of death worldwide, yet there are no drugs available to protect the brain from stroke-induced neuronal injury. Acid-sensing ion channel 1a (ASIC1a) is the primary acid sensor in mammalian brain and a key mediator of acidosis-induced neuronal damage following cerebral ischemia. Genetic ablation and selective...
Source: Proceedings of the National Academy of Sciences - April 4, 2017 Category: Science Authors: Irene R. Chassagnon, Claudia A. McCarthy, Yanni K.–Y. Chin, Sandy S. Pineda, Angelo Keramidas, Mehdi Mobli, Vi Pham, T. Michael De Silva, Joseph W. Lynch, Robert E. Widdop, Lachlan D. Rash, Glenn F. King Tags: Biological Sciences Source Type: research
Helistroke service: Flying the physician to the stroke patient works
Flying a stroke specialist by helicopter to a nearby stroke patient for emergency care is feasible, saves money and, most importantly, gets critical care to patients faster than transporting the patient to a hospital first, according to a single-patient, proof-of-concept study.
Source: ScienceDaily Headlines - May 3, 2017 Category: Science Source Type: news
Wear and performance analysis of a 4-stroke diesel engine employing nanolubricants
Publication date: Available online 15 October 2017 Source:Particuology Author(s): Ankit Kotia, Sheeba Borkakoti, Subrata Kumar Ghosh In the present study, the performance of a 4-stroke diesel engine was experimentally evaluated upon adding Al2O3 or SiO2 nanoparticles to the engine oil (SAE15W40). The viscosity and density of the resulting nanolubricants were determined while varying both the nanoparticle volume fraction and the temperature. Field emission scanning electron microscopy (FE–SEM) showed that the nanoparticles had a spherical morphology and dynamic light scattering analysis determined some aggregation of the...
Source: Particuology - October 20, 2017 Category: Science Source Type: research
Even one cigarette a day greatly raises cardiovascular risk, experts warn
Impact of one daily cigarette on risk of heart disease and stroke greater than previously thoughtSmoking just one cigarette a day is more dangerous than commonly thought, say researchers who have found it still raises the risk of coronary heart disease or stroke to about half the risk from smoking 20 a day.The team behind the study say that the findings emphasise that cutting out cigarettes, rather than just cutting down, is necessary to dramatically reduce the chance of cardiovascular problems – akey cause of premature death among smokers.Continue reading...
Source: Guardian Unlimited Science - January 24, 2018 Category: Science Authors: Nicola Davis Tags: Smoking Heart disease Society Health Stroke Medical research Science Source Type: news
Could this drug help the brain recover after a stroke?
Despite years of effort, researchers have so far failed to find a pill you could take or a food you could eat to harden your brain against the injury that could be caused by a stroke.But new research offers the prospect of limiting a stroke ’s long-term damage in a different way: with a drug that...
Source: Los Angeles Times - Science - April 6, 2018 Category: Science Authors: Melissa Healy Source Type: news
Elastic coupling power stroke mechanism of the F1-ATPase molecular motor Biochemistry
The angular velocity profile of the 120° F1-ATPase power stroke was resolved as a function of temperature from 16.3 to 44.6 °C using a ΔμATP = −31.25 kBT at a time resolution of 10 μs. Angular velocities during the first 60° of the power stroke (phase 1) varied inversely with...
Source: Proceedings of the National Academy of Sciences - May 29, 2018 Category: Science Authors: James L. Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, Wayne D. Frasch Tags: Biological Sciences Source Type: research
'Fake news and ageism' keeping statins from older people
Offering statins to all over-75s could prevent 8,000 deaths from heart failure and stroke, researchers sayThousands of deaths and the wrecking of many lives by disability could be averted if doctors routinely offered a daily statin pill to older people, scientists say.They blame misinformation about the side-effects of statins, together with society ’s ageism, for the low uptake among older people, who are at highest risk of heart attacks, heart failure and stroke.Continue reading...
Source: Guardian Unlimited Science - January 31, 2019 Category: Science Authors: Sarah Boseley Health editor Tags: Statins Heart attack Heart disease Stroke Older people Health Medical research Society Science UK news Source Type: news
Region-specific and activity-dependent regulation of SVZ neurogenesis and recovery after stroke Neuroscience
Stroke is the leading cause of adult disability. Neurogenesis after stroke is associated with repair; however, the mechanisms regulating poststroke neurogenesis and its functional effect remain unclear. Here, we investigate multiple mechanistic routes of induced neurogenesis in the poststroke brain, using both a forelimb overuse manipulation that models a clinical...
Source: Proceedings of the National Academy of Sciences - July 1, 2019 Category: Science Authors: Huixuan Liang, Handi Zhao, Amy Gleichman, Michal Machnicki, Sagar Telang, Sydney Tang, Mary Rshtouni, Jack Ruddell, S. Thomas Carmichael Tags: PNAS Plus Source Type: research
Insomniacs may be at greater risk of heart failure, study finds
People genetically predisposed to sleep problems have greater risk of stroke and coronary artery diseasePeople who struggle with sleep might be at greater risk of developing cardiovascular problems, research suggests.Scientists have found that people who are genetically predisposed to insomnia have a greater risk of heart failure, stroke and coronary artery disease.Continue reading...
Source: Guardian Unlimited Science - August 19, 2019 Category: Science Authors: Nicola Davis Tags: Sleep Health & wellbeing Life and style Science Heart disease Stroke UK news Society Source Type: news
Cardiovascular disease risk greater in people prone to insomnia - study
People genetically predisposed to sleep problems have greater risk of heart failure and stroke, say researchersPeople who struggle with sleep might be at greater risk of developing cardiovascular problems, research suggests.Scientists have found that people who are genetically predisposed to insomnia have a greater risk of heart failure, stroke and coronary artery disease.Continue reading...
Source: Guardian Unlimited Science - August 19, 2019 Category: Science Authors: Nicola Davis Tags: Sleep Health & wellbeing Life and style Science Heart disease Stroke UK news Society Source Type: news
Activity in grafted human iPS cell-derived cortical neurons integrated in stroke-inȷured rat brain regulates motor behavior Neuroscience
Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell–derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell–derived cortical neurons send widespread axonal projections to both hemispheres of rats...
Source: Proceedings of the National Academy of Sciences - April 20, 2020 Category: Science Authors: Sara Palma–Tortosa, Daniel Tornero, Marita Gronning Hansen, Emanuela Monni, Mazin Haȷy, Sopiko Kartsivadze, Sibel Aktay, Oleg Tsupykov, Malin Parmar, Karl Deisseroth, Galyna Skibo, Olle Lindvall, Zaal Kokaia Tags: Biological Sciences Source Type: research
Covid-19 may cause brain complications in some, say doctors
Stroke and psychosis found in small study of patients highlight need for researchCoronavirus – latest updatesSee all our coronavirus coverageBrain complications, including stroke and psychosis, have been linked to Covid-19 in a study that raises concerns about the potentially extensive impact of the disease in some patients.The study is small and based on doctors ’ observations, so cannot provide a clear overall picture about the rate of such complications. However, medical experts say the findings highlight the need to investigate the possible effects of Covid-19 in the brain and studies to explore potential treatment...
Source: Guardian Unlimited Science - June 26, 2020 Category: Science Authors: Hannah Devlin Science correspondent Tags: Medical research Coronavirus outbreak Stroke Neuroscience UK news Health Source Type: news
Agonistic analog of growth hormone-releasing hormone promotes neurofunctional recovery and neural regeneration in ischemic stroke Neuroscience
Ischemic stroke can induce neurogenesis. However, most stroke-generated newborn neurons cannot survive. It has been shown that MR-409, a potent synthetic agonistic analog of growth hormone–releasing hormone (GHRH), can protect against some life-threatening pathological conditions by promoting cell proliferation and survival. The present study shows that long-term treatment with MR-409...
Source: Proceedings of the National Academy of Sciences - November 15, 2021 Category: Science Authors: Yueyang Liu, Jingyu Yang, Xiaohang Che, Jianhua Huang, Xianyang Zhang, Xiaoxiao Fu, Jialing Cai, Yang Yao, Haotian Zhang, Ruiping Cai, Xiaomin Su, Qian Xu, Fu Ren, Renzhi Cai, Andrew V. Schally, Ming-Sheng Zhou Tags: Neuroscience Biological Sciences Source Type: research
New technique helps stroke victims communicate
Researchers have developed a speech technique to aid stroke victims with aphasia.
Source: ScienceDaily Headlines - January 15, 2013 Category: Science Source Type: news
Oxygen chamber can boost brain repair years after stroke or trauma
Through the use of hyperbaric, oxygen-rich chambers, medical researchers have found a way to restore a significant amount of neurological function in brain tissue thought to be chronically damaged by stroke, traumatic injury, and metabolic disorder -- even years after the original injury.
Source: ScienceDaily Headlines - January 23, 2013 Category: Science Source Type: news
