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Specialty: Reproduction Medicine

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Total 61 results found since Jan 2013.

Postmenopausal Hormone Therapy and the Risks of Coronary Heart Disease, Breast Cancer, and Stroke
Semin Reprod Med 2014; 32: 419-425DOI: 10.1055/s-0034-1384624The principal findings are briefly reviewed from the Women's Health Initiative trials of the most commonly used postmenopausal hormone regimens in the United States—conjugated equine estrogens and these same estrogens plus medroxyprogesterone acetate. A more detailed review is presented for three major clinical outcomes: coronary heart disease (CHD), the primary trial outcome for which a major benefit was hypothesized; invasive breast cancer, the primary safety outcome for which some adverse effect was expected; and stroke which surfaced as an important adverse...
Source: Seminars in Reproductive Medicine - October 16, 2014 Category: Reproduction Medicine Authors: Prentice, Ross L. Source Type: research

Stroke Findings in the Women's Health Initiative
Semin Reprod Med 2014; 32: 438-446DOI: 10.1055/s-0034-1384627The Women's Health Initiative (WHI) clinical trials of estrogen with or without progestin versus placebo in 27,341 postmenopausal women are the largest randomized, placebo-controlled, double-blind clinical trials to look at the effect of hormone therapy on the outcomes of stroke, dementia, and cognition. Data from a parallel prospective observational study of 93,676 women examine biomarkers and risk factors associated with stroke. We summarize the results of 29 published articles in the WHI with stroke or cognition as outcomes of interest. Estrogen alone or in co...
Source: Seminars in Reproductive Medicine - October 16, 2014 Category: Reproduction Medicine Authors: Wassertheil-Smoller, SylviaKaplan, Robert C.Salazar, Christian R. Source Type: research

Prevention of Cardiovascular Disease in Women
Semin Reprod Med 2014; 32: 447-453DOI: 10.1055/s-0034-1384628Cardiovascular disease is the leading cause of death among women. In fact, the cardiovascular disease mortality rate among women exceeds the rate in men. Unfortunately, many minority women are still unaware of the importance of this disease. All women, including those with no history of cardiovascular disease, should have an accurate estimate of the probability of a cardiovascular disease event (death, myocardial infarction, or stroke) usually within the next decade. Such an estimate will help determine if women are candidates for preventive measures and specific...
Source: Seminars in Reproductive Medicine - October 16, 2014 Category: Reproduction Medicine Authors: Bavry, Anthony A.Limacher, Marian C. Source Type: research

New anti-inflammatory therapy for the preterm labor of intrauterine inflammation in mice; the possibility of molecular hydrogen
In this study, it is investigated whether effected uterus tissues in same models.
Source: Placenta - August 29, 2014 Category: Reproduction Medicine Authors: Tomoko Nakano, Tomomi Kotani, Yukio Mano, Takafumi Ushida, Hiroyuki Tsuda, Seiji Sumigama, Hua Li, Fumitaka Kikkawa Tags: Frontmatter Source Type: research

The role of placental growth factor in regulating fetal brain vascular development
Objectives: Maternal plasma in many pre-eclamptic (PE) pregnancies is low in the placenta product “placental growth factor” (PGF). Offspring of PE compared to uncomplicated pregnancies show higher blood pressure, cognitive impairment and stroke. However, mechanisms explaining these differences are undefined. Our studies of Pgf-/- mice indicate that PGF deficiency reduces decidual vessel branching and connectivity. We aimed to determine if PGF deficiency diminishes brain vascular development, impairs cognition and elevates stroke risk.
Source: Placenta - August 29, 2014 Category: Reproduction Medicine Authors: Matthew Rätsep, Bruno Zavan, Nicki Peterson, Leandra Tolusso, Vanessa Kay, Nicole Ventura, Stephen Pang, Albert Jin, Michael Adams, Anne Croy Tags: Frontmatter Source Type: research

Incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization: a population-based cohort study from Sweden
To compare the incidence of hypertension, stroke, coronary heart disease, and diabetes in women who have delivered after in vitro fertilization (IVF) with those who delivered after natural conception.
Source: Fertility and Sterility - July 23, 2014 Category: Reproduction Medicine Authors: Eli Westerlund, Lena Brandt, Outi Hovatta, Håkan Wallén, Anders Ekbom, Peter Henriksson Tags: Original article Source Type: research

After Stroke, Spouse May Also Need Care
If couple disagrees about recovery rate, partner can become depressed, study finds
Source: Fertility News - Doctors Lounge - June 27, 2014 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Neurology, Psychiatry, Reproductive Medicine, News, Source Type: news

Current recommendations: what is the clinician to do?
Menopausal hormone therapy (HT) has complex biologic effects but continues to have an important clinical role in the management of vasomotor and other menopausal symptoms. The rational use of menopausal HT requires balancing the potential benefits and risks of treatment. Findings from the Women's Health Initiative (WHI) and other randomized clinical trials have helped to clarify the benefits and risks of HT and have provided insights to improve decision making. Several clinical characteristics have utility in identifying women for whom benefits of HT are likely to outweigh the risks. Age and time since menopause are strong...
Source: Fertility and Sterility - March 31, 2014 Category: Reproduction Medicine Authors: JoAnn E. Manson Tags: Views and reviews Source Type: research

Diabetes Boosts Stroke Risk for Women, But Not Men: Study
Research finds big gender gap, which one doctor believes is tied to better treatment for men
Source: Fertility News - Doctors Lounge - February 25, 2014 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Cardiology, Gynecology, Neurology, Reproductive Medicine, Diabetes, News, Source Type: news

Death of Partner Boosts Risk for Heart Attack, Stroke, Study Says
The first month is crucial, but then the threat diminishes, researchers say
Source: Fertility News - Doctors Lounge - February 24, 2014 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Cardiology, Neurology, Psychiatry, Reproductive Medicine, News, Source Type: news

Infections Like Colds, Chickenpox Tied to Some Stroke Risk in Kids
The brain attacks are rare in children, experts note, and study found vaccines may offer some protection
Source: Fertility News - Doctors Lounge - February 13, 2014 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Infections, Neurology, Pediatrics, Reproductive Medicine, Fertility, Emergency Medicine, News, Source Type: news

Walking May Cut Stroke Risk in Older Men
British study suggests the number of weekly hours walked, not how fast, is what matters
Source: Fertility News - Doctors Lounge - November 15, 2013 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Neurology, Reproductive Medicine, Sports Medicine, News, Source Type: news

1000 days vs. 100 years: Complexities of programming relevant to placentology
The more we know about fetal programming the more urgent it becomes to understand the placenta's secrets. Discovery is urgent because chronic disease in many countries is on the rise. Back when birth weight was the primary predictor of cardiovascular disease in adulthood, the problem seemed simple. Placental to birth weight ratios were the whole story. However, a new series of discoveries has revealed that: a) the placenta is the key organ that determines the risk for many common chronic diseases and b) our understanding of placental biology is very primitive. We have learned over the past few years that the size, shape, w...
Source: Placenta - August 14, 2013 Category: Reproduction Medicine Authors: Kent L. Thornburg Tags: Frontmatter Source Type: research

Different effects of progesterone and estradiol on chimeric and wild type aldosterone synthase in vitro.
CONCLUSIONS: Our results show an inhibitory action of progesterone in the aldosterone synthesis by chimeric or wild type aldosterone synthase enzymes. This is a novel regulatory mechanism of progesterone action, which could be involved in protecting pregnant women with FH-1 against hypertension. In vitro, both enzymes showed comparable kinetic parameters, but ASWT was more strongly inhibited than ASCE. This study implicates a new role for progesterone in the regulation of aldosterone levels that could contribute, along with other factors, to the maintenance of an adequate aldosterone-progesterone balance in pregnancy. ...
Source: Reproductive Biology - August 13, 2013 Category: Reproduction Medicine Authors: Vecchiola A, Lagos CF, Fuentes CA, Allende F, Campino C, Valdivia C, Tapia-Castillo A, Ogishima T, Mukai K, Owen G, Solari S, Carvajal CA, Fardella CE Tags: Reprod Biol Endocrinol Source Type: research