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A Lengthy, Stable Marriage May Boost Stroke Survival
Lifelong singles fared the worst, study finds
Source: Fertility News - Doctors Lounge - December 13, 2016 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Cardiology, Family Medicine, Neurology, Reproductive Medicine, News, Source Type: news

Mitochondrial variations in the MT-ND4 and MT-TL1 genes are associated with male infertility.
Abstract Mitochondrial gene mutations have been reported to be associated with sperm motility and the quality of semen. The aim of this study was to investigate whether the two mitochondrial genes (MT-ND4 and MT-TL1) are involved in Chinese male infertility. A total of 97 asthenospermia patients and 80 fertile controls were recruited in this case-control study. Genomic DNA were extracted from the sperm of all participants. Two mitochondrial DNA genes (MT-ND4 and MT-TL1) were amplified by using polymerase chain reaction (PCR) with the gene-specific primers and sequenced on an ABI 3730XL DNA sequencer. For the MT-ND...
Source: Systems Biology in Reproductive Medicine - December 13, 2016 Category: Reproduction Medicine Authors: Ni F, Zhou Y, Zhang WX, Wang XM, Song XM, Jiang H Tags: Syst Biol Reprod Med Source Type: research

Common diseases as determinants of menopausal age
STUDY QUESTION Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively. STUDY DESIGN, SIZE, DURATION All women attending mammography screening or clinical mammography at four hospitals in Sweden were in...
Source: Human Reproduction - November 16, 2016 Category: Reproduction Medicine Authors: Li, J., Eriksson, M., Czene, K., Hall, P., Rodriguez-Wallberg, K. A. Tags: Reproductive Epidemiology Source Type: research

Low-dose oral contraceptive-induced acute myocardial infarction.
CONCLUSION: Low-dose OCs may also be responsible for acute MI even in a very young female without any cardiovascular risk factors. Therefore, the clinicians should be aware of this mortal events during follow-up of the patient using OCs. PMID: 27608962 [PubMed - as supplied by publisher]
Source: The European Journal of Contraception and Reproductive Health Care - September 8, 2016 Category: Reproduction Medicine Authors: Aslan AN, Süygün H, Sivri S, Keleş T Tags: Eur J Contracept Reprod Health Care Source Type: research

Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency
Conclusions: Apelin levels mirror the cardiovascular changes seen in pregnancy. Serum and placental apelin levels are decreased in IUGR.
Source: Reproductive Sciences - July 12, 2016 Category: Reproduction Medicine Authors: Van Mieghem, T., Doherty, A., Baczyk, D., Drewlo, S., Baud, D., Carvalho, J., Kingdom, J. Tags: Original Articles Source Type: research

Vaginal estradiol use and the risk for cardiovascular mortality
STUDY QUESTION Does the use of post-menopausal vaginal estradiol (VE) affect the mortality risk for coronary heart disease (CHD) and stroke. SUMMARY ANSWER The use of VE reduces the risk for cardiovascular mortality. WHAT IS KNOWN ALREADY A growing number of women use VE for post-menopausal genitourinary symptoms. Although this therapy is intended to have only local effects, estrogen is absorbed into the blood circulation and thus VE use may also have systemic effects. STUDY DESIGN, SIZE, DURATION We studied a nationwide cohort in Finland 1994–2009 during which post-menopausal women (n = 195 756) initiated the use...
Source: Human Reproduction - March 15, 2016 Category: Reproduction Medicine Authors: Mikkola, T. S., Tuomikoski, P., Lyytinen, H., Korhonen, P., Hoti, F., Vattulainen, P., Gissler, M., Ylikorkala, O. Tags: Puberty, Aging and HRT Source Type: research

Stress of Caring for Sick Spouse May Raise Stroke Risk
Husbands, wives need support to reduce strain, researchers say
Source: Fertility News - Doctors Lounge - March 5, 2016 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Neurology, Nursing, Physiotherapy, Psychiatry, Reproductive Medicine, News, Source Type: news

The Elsevier Trophoblast Research Award Lecture: Impacts of placental growth factor and preeclampsia on brain development, behaviour, and cognition
Preeclampsia (PE) is a significant gestational disorder affecting 3-5% of all human pregnancies. In many PE pregnancies, maternal plasma is deficient in placental growth factor (PGF), a placentally-produced angiokine. Beyond immediate fetal risks associated with acute termination of the pregnancy, offspring of PE pregnancies (PE-F1) have higher long-term risks for hypertension, stroke, and cognitive impairment compared to F1s from uncomplicated pregnancies. At present, mechanisms that explain PE-F1 gains in postpartum risks are poorly understood.
Source: Placenta - February 6, 2016 Category: Reproduction Medicine Authors: Matthew T. Rätsep, Andrew F. Hickman, B. Anne Croy Source Type: research

The Elsevier trophoblast research award lecture: Impacts of placental growth factor and preeclampsia on brain development, behaviour, and cognition
Preeclampsia (PE) is a significant gestational disorder affecting 3 –5% of all human pregnancies. In many PE pregnancies, maternal plasma is deficient in placental growth factor (PGF), a placentally-produced angiokine. Beyond immediate fetal risks associated with acute termination of the pregnancy, offspring of PE pregnancies (PE-F1) have higher long-term risks fo r hypertension, stroke, and cognitive impairment compared to F1s from uncomplicated pregnancies. At present, mechanisms that explain PE-F1 gains in postpartum risks are poorly understood.
Source: Placenta - February 5, 2016 Category: Reproduction Medicine Authors: Matthew T. R ätsep, Andrew F. Hickman, B. Anne Croy Source Type: research

Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat
The stroke prone spontaneously hypertensive rat (SHRSP) is an established model of human cardiovascular risk. We sought to characterise the uteroplacental vascular response to pregnancy in this model and determine whether this is affected by the pre-existing maternal hypertension.
Source: Placenta - November 9, 2015 Category: Reproduction Medicine Authors: Heather Y. Small, Hannah Morgan, Elisabeth Beattie, Sinead Griffin, Marie Indahl, Christian Delles, Delyth Graham Source Type: research

Impact of placental growth factor and preeclampsia on brain development, cognition, and behaviour
Objective: In many preeclamptic (PE) pregnancies, maternal plasma is low in the placentally-produced angiokine “placental growth factor” (PGF). Offspring of PE (PE-F1) compared to uncomplicated pregnancies have higher risks for hypertension, cognitive impairment, and stroke. Mechanisms explaining this are poorly described. Pgf-/- mice have aberrant decidual and placental vascular branching and most experience stroke after unilateral common carotid artery occlusion. We hypothesized that PGF deficiency, which often manifests in PE, diminishes brain vascular development, leading to impaired cognition and elevated postpartum stroke risk.
Source: Placenta - August 26, 2015 Category: Reproduction Medicine Authors: Matthew Rätsep, Vanessa Kay, Rayana Luna, Bruno Zavan, Andrew Hickman, Brandon Maser, Graeme Smith, James Reynolds, Angelina Paolozza, Patrick Stroman, John Sled, Jacob Ellegood, Christian Beaulieu, Dongming Zhou, Nils Forkert, Michael Adams, Anne Croy Source Type: research

Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition
STUDY QUESTION Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? SUMMARY ANSWER Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. WHAT IS KNOWN ALREADY Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. STUDY DESIGN, SIZE, DURATION We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investi...
Source: Human Reproduction - May 19, 2015 Category: Reproduction Medicine Authors: Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J. C., Tjonneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, A., Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Gri Tags: Reproductive epidemiology Source Type: research

Stroke Survivors Who Live Alone Face Higher Risk of Early Death: Study
Men were particularly vulnerable in 12-year follow-up
Source: Fertility News - Doctors Lounge - January 23, 2015 Category: Reproduction Medicine Authors: webmaster at doctorslounge.com Tags: Cardiology, Family Medicine, Neurology, Reproductive Medicine, News, Source Type: news

AHA News: Study Finds Higher Risk of Stroke - Linked Plaque in Men, Possible Test for Women
Source: Fertility News - Doctors Lounge - November 11, 2014 Category: Reproduction Medicine Tags: Gynecology, Neurology, Reproductive Medicine, News, Source Type: news

AHA News: Race and Gender May Tip the Scales on Traditional Stroke Risk Factors
Source: Fertility News - Doctors Lounge - November 11, 2014 Category: Reproduction Medicine Tags: Gynecology, Neurology, Reproductive Medicine, Research, News, Source Type: news

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