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Migraine and risk of premature myocardial infarction and stroke among men and women: A Danish population-based cohort study
by Cecilia Hvitfeldt Fuglsang, Lars Pedersen, Morten Schmidt, Jan P. Vandenbroucke, Hans Erik B øtker, Henrik Toft Sørensen BackgroundMigraine carries risk of myocardial infarction (MI) and stroke. The risk of premature MI (i.e., among young adults) and stroke differs between men and women; previous studies indicate that migraine is mainly associated with an increased risk of stroke among young women. The aim of this study was to examine impact of migraine on the risk of premature (age ≤60 years) MI and ischemic/hemorrhagic stroke among men and women. Methods and findingsUsing Danish medical registries, we conducted a ...
Source: PLoS Medicine - June 13, 2023 Category: Internal Medicine Authors: Cecilia Hvitfeldt Fuglsang Source Type: research

Bereavement in childhood and young adulthood and the risk of atrial fibrillation: a population-based cohort study from Denmark and Sweden
Adverse childhood life events are associated with increased risks of hypertension, ischemic heart disease, and stroke later in life. Limited evidence also suggests that stress in adulthood may increase the ris...
Source: BMC Medicine - January 5, 2023 Category: Internal Medicine Authors: Hua Chen, Imre Janszky, Mikael Rostila, Dang Wei, Fen Yang, Jiong Li and Krisztina D. L ászló Tags: Research article Source Type: research

Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease : A Case-Crossover Study
CONCLUSION: From 2000 to 2018, the use of PDE5 inhibitors increased 20-fold among Danish patients with IHD who were taking nitrates. A statistically significant association between concomitant use of these medications and cardiovascular adverse events could not be identified.PRIMARY FUNDING SOURCE: Ib Mogens Kristiansens Almene Fond and Helsefonden.PMID:35436155 | DOI:10.7326/M21-3445
Source: Annals of Internal Medicine - April 18, 2022 Category: Internal Medicine Authors: Anders Holt Paul Blanche Aksel Karl Georg Jensen Nina Nouhravesh Deepthi Rajan Mads Hashiba Jensen Mohammed El-Sheikh Anne-Marie Schjerning Morten Schou Gunnar Gislason Christian Torp-Pedersen Patricia McGettigan Morten Lamberts Source Type: research

Ginkgol Biloba extract as an adjunctive treatment for ischemic stroke: A systematic review and meta-analysis of randomized clinical trials
Conclusions: GBE appears to improve neurological function and dependence compared with conventional therapy for ischemic stroke at different stages and appears generally safe for clinical application. The lack of improvement in recurrence rate was confirmed by trial sequential analysis. Due to the generally weak evidence, further large, rigorous trials are warranted.
Source: Medicine - January 1, 2020 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research

Effect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation.
Conclusion: Variation in published AF stroke rates for patients not receiving anticoagulant therapy results in multifold variation in the net clinical benefit of anticoagulation. Guidelines should better reflect the uncertainty in current thresholds of stroke risk score for recommending anticoagulation. Primary Funding Source: None. PMID: 30264130 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - September 25, 2018 Category: Internal Medicine Authors: Shah SJ, Eckman MH, Aspberg S, Go AS, Singer DE Tags: Ann Intern Med Source Type: research

Long ‐term use of proton pump inhibitors, dose–response relationship and associated risk of ischemic stroke and myocardial infarction
ConclusionUse of PPIs was associated with increased risks of first‐time ischemic stroke and MI, particularly amongst long‐term users and at high doses.
Source: Journal of Internal Medicine - November 7, 2017 Category: Internal Medicine Authors: T. S. G. Sehested, T. A. Gerds, E. L. Fosb øl, P. W. Hansen, M. G. Charlot, N. Carlson, M. A. Hlatky, C. Torp‐Pedersen, G. H. Gislason Tags: Original Article Source Type: research

Long ‐term use of Proton Pump Inhibitors, Dose‐response Relationship, and Associated Risk of Ischemic Stroke and Myocardial Infarction
ConclusionUse of PPIs was associated with increased risks of first‐time ischemic stroke and MI, particularly among long‐term users and at high doses.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - October 1, 2017 Category: Internal Medicine Authors: Thomas S. G. Sehested, Thomas A. Gerds, Emil L. Fosb øl, Peter W. Hansen, Mette G. Charlot, Nicholas Carlson, Mark A. Hlatky, Christian Torp‐Pedersen, Gunnar H. Gislason Tags: Original Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.
Source: Journal of Internal Medicine - September 21, 2017 Category: Internal Medicine Authors: L. Staerk, T. A. Gerds, G. Y. H. Lip, B. Ozenne, A. N. Bonde, M. Lamberts, E. L. Fosb øl, C. Torp‐Pedersen, G. H. Gislason, J. B. Olesen Tags: Original Article Source Type: research

Important factors affecting the choice of an oral anticoagulant may be missed in database studies
This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 7, 2017 Category: Internal Medicine Authors: Emma Aarnio, Risto Huupponen, Maarit Jaana Korhonen Tags: Letter to the Editor Source Type: research

Standard and reduced doses of dabigatran, rivaroxaban, and apixaban for stroke prevention in atrial fibrillation: a nationwide cohort study
ConclusionsStandard and reduced dose NOACs, respectively, showed no significant risk difference for associated stroke/thromboembolism. Rivaroxaban was associated with higher bleeding risk compared with dabigatran and apixaban, and dabigatran was associated with lower intracranial bleeding risk compared with rivaroxaban and apixaban.This article is protected by copyright. All rights reserved.
Source: Journal of Internal Medicine - September 1, 2017 Category: Internal Medicine Authors: Laila Staerk, Thomas A Gerds, Gregory Y H Lip, Brice Ozenne, Anders N Bonde, Morten Lamberts, Emil L Fosb øl, Christian Torp‐Pedersen, Gunnar H Gislason, Jonas B Olesen Tags: Original Article Source Type: research