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Specialty: Internal Medicine
Condition: Liver Disease

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Total 12 results found since Jan 2013.

Randomized, double-blind, placebo-controlled, crossover trial of oral doxycycline for epistaxis in hereditary hemorrhagic telangiectasia
Vascular malformations in hereditary hemorrhagic telangiectasia (HHT) lead to chronic recurrent bleeding, hemorrhage, stroke, heart failure, and liver disease. There is great interest in identifying novel ther...
Source: Orphanet Journal of Rare Diseases - November 7, 2022 Category: Internal Medicine Authors: K. P. Thompson, J. Sykes, P. Chandakkar, P. Marambaud, N. T. Vozoris, D. A. Marchuk and M. E. Faughnan Tags: Research Source Type: research

Incidence of nonvalvular atrial fibrillation and oral anticoagulant prescribing in England, 2009 to 2019: A cohort study
ConclusionsThe incidence of NVAF increased between 2009 and 2015, before plateauing. Underprescribing of OACs in NVAF is associated with a range of comorbidities, ethnicity, and socioeconomic factors, demonstrating the need for initiatives to reduce inequalities in the care for AF patients.
Source: PLoS Medicine - June 7, 2022 Category: Internal Medicine Authors: Alyaa M. Ajabnoor Source Type: research

Association between the liver fat score (LFS) and cardiovascular diseases in the national health and nutrition examination survey 1999-2016
CONCLUSIONS: NAFLD is usually asymptomatic, but this large study of a large general population shows that LFS is associated with CHD, CHF, angina pectoris, cardiovascular and all-cause mortality. Determining the LFS is worthwhile, as it identifies people with NAFLD, who may also be at increased cardiovascular risk.Key MessagesLiver fat score (LFS), a non-invasive marker of non-alcoholic fatty liver disease (NAFLD), is associated with coronary heart disease (CHD), congestive heart failure (CHF) and angina.LFS is also associated with increased cardiovascular and all-cause mortality.Determining the LFS is worthwhile as it ide...
Source: Annals of Medicine - June 29, 2021 Category: Internal Medicine Authors: Chun-On Lee Hang-Long Li Man-Fung Tsoi Ching-Lung Cheung Bernard Man Yung Cheung Source Type: research

Reflux esophagitis is associated with higher risks of acute stroke and transient ischemic attacks in patients hospitalized with atrial fibrillation: A nationwide inpatient sample analysis
Reflux esophagitis (RE) is a subset of gastroesophageal reflux disease (GERD) with endoscopic evidence of esophageal inflammation, which has been linked to an increased incidence of atrial fibrillation (AF). However, data on the effect of RE on patient outcomes is limited. We sought to examine the potential association of RE with outcomes of patients with AF in a nationwide study. The National Inpatient Sample (NIS) database was queried to identify hospitalized adult patients with AF and RE between 2010 and 2014. Primary outcomes included inpatient mortality, length of stay (LOS), and total hospital charges. AF related ...
Source: Medicine - June 25, 2021 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Association between iron metabolism and cognitive impairment in older non-alcoholic fatty liver disease individuals: A cross-sectional study in patients from a Chinese center
This study examined whether iron metabolism is associated with cognitive impairment in older individuals. A cross-sectional study was held in patients from a Chinese center. Individuals with NAFLD aged over 60 years were included if they did not have excessive alcohol intake and were free of stroke or dementia. Their cognitive function was assessed by the same neurologist. 3.0T H proton magnetic resonance spectroscopy (1H-MRS) was performed to evaluate the hippocampus of the participants without contraindication. t test and Chi-square test were used to analyze the data. Binary logistic regression was used for correlation ...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The Emergence of Non-communicable Disease in Indonesia.
Authors: Purnamasari D Abstract Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged >14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population. The mortality rate in  Indonesia is dominated by non-com...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

The association of non-alcoholic fatty liver disease and atrial fibrillation: a review.
Authors: Juhani Käräjämäki A, Hukkanen J, Ukkola O Abstract Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes an enormous burden to human health and health-care systems all over the world. A great proportion of this burden results from increased risk of cardiovascular diseases. Atrial fibrillation (AF) is the most common chronic heart arrhythmia globally and it increases the risk of embolic stroke and heart failure. Recent studies have explored the association between NAFLD and AF with somewhat conflicting results. However, ultrasound-verified prospective studies concur that NAFLD is asso...
Source: Annals of Medicine - June 26, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Preoperative treatment with {beta}-blockers is associated with elevated postoperative mortality and cardiac morbidity in patients with uncomplicated hypertension undergoing non-cardiac surgery
Commentary on: Jørgensen ME, Hlatky MA, Køber L, et al.. β-Blocker-associated risks in patients with uncomplicated hypertension undergoing noncardiac surgery. JAMA Intern Med 2015;175:1923–31. Context The role of β-blockers in preventing cardiovascular complications of non-cardiac surgery is controversial. Early enthusiasm was dampened by accumulating trial data and concerns about the scientific validity of several trials. When studies with uncertain validity are excluded, meta-analyses of randomised trials show that perioperative β-blockers (started within 1 day before surgery) prev...
Source: Evidence-Based Medicine - May 22, 2016 Category: Internal Medicine Authors: Wijeysundera, D. N. Tags: Liver disease, Epidemiologic studies, Drugs: cardiovascular system, Stroke, Hypertension, Chemotherapy, Ischaemic heart disease Aetiology/Harm Source Type: research

Relation Between Hepatitis C Virus Exposure and Risk of Osteoporosis: A Nationwide Population-Based Study
Abstract: The effect of hepatitis C virus (HCV) exposure on bone mineral density without advanced liver disease remains debated. Thus, we assessed the relation between HCV exposure and the risk of osteoporosis. From 2000 to 2011, patients aged>20 years with HCV exposure were identified from the Longitudinal Health Insurance Database 2000. Of the 51,535 sampled patients, 41,228 and 10,307 patients were categorized as the comparison and the HCV exposure cohorts, respectively. The overall incidence of osteoporosis in the HCV exposure cohort was higher than in the comparison cohort (8.27 vs 6.19 per 1000 person-years; crude ha...
Source: Medicine - November 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

Modest cancer prevention benefit with long-term multivitamin supplementation: Physicians' Health Study II results warrant cautious interpretation
Commentary on Gaziano JM, Sesso HD, Christen WG, et al.. Multivitamins in the prevention of cancer in men: the Physicians’ Health Study II randomised controlled trial. JAMA 2012;308:1871–80. Context Various vitamins and minerals have been shown to inhibit carcinogenesis or reduce cancer risk in preclinical experiments and observational studies. Such work has given rise to several chemoprevention trials of isolated nutrients, many of which (eg, Alpha-Tocopherol and Beta-Carotene (ATBC) Trial, Carotene and Retinol Efficacy Trial (CARET) and Selenium and Vitamin E Cancer Prevention Trial (SELECT)) have produced d...
Source: Evidence-Based Medicine - November 21, 2013 Category: Internal Medicine Authors: Demark-Wahnefried, W. Tags: Liver disease, Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Stroke, Diet, Prevention, Complementary medicine, Dermatology, Prostate Therapeutics Source Type: research

Daily multivitamin supplements did not reduce risk for major CV events over > 10 years in men.
CONCLUSION Daily multivitamin supplements did not affect risk for major cardiovascular events over > 10 years in male physicians in the USA.Daily multivitamin supplements vs placebo in male physicians in the USA‡OutcomesMultivitaminPlaceboAt a median 11.2 yRRI (95% CI)§NNHMajor CV events12.0%11.7%1% (-8 to 9)NSFatal and nonfatal stroke4.5%4.2%6% (-9 to 22)NSRRR (CI)§NNTFatal and nonfatal MI4.3%4.6%7% (-9 to 20)NSAll-cause mortality18%19%5% (-2 to 11)NS‡CV = cardiovascular; MI = myocardial infarction; NS = not significant; other abbreviations defined in Glossary. RRI, RRR, and CI calculated from adjusted hazar...
Source: Annals of Internal Medicine - February 19, 2013 Category: Internal Medicine Authors: Fairfield KM Tags: Ann Intern Med Source Type: research

Albumin: Pathophysiologic basis of its role in the treatment of cirrhosis and its complications
Abstract Since the introduction of human serum albumin as a plasma expander in the 1940s, considerable research has allowed a better understanding of its biochemical properties and potential clinical benefits. Albumin has a complex structure, which is responsible for a variety of biological functions. In disease, albumin molecule is susceptible to modifications that may alter its biological activity. During the last decades, different methods to measure albumin function have been developed. Recent studies have shown that not only albumin concentration but also albumin function is reduced in liver failure. This observation ...
Source: Hepatology - February 19, 2013 Category: Internal Medicine Authors: Rita Garcia‐Martinez, Paolo Caraceni, Mauro Bernardi, Pere Gines, Vicente Arroyo, Rajiv Jalan Tags: Liver Failure, Cirrhosis and Portal Hypertension Source Type: research