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A nationwide cohort study comparing the effectiveness of diuretics and calcium channel blockers on top of renin-angiotensin system inhibitors on chronic kidney disease progression and mortality.
It is unknown whether initiating diuretics on top of renin-angiotensin system inhibitors (RASi) is superior to alternative antihypertensive agents such as calcium channel blockers (CCBs) in patients with chronic kidney disease (CKD). For this purpose, we emulated a target trial in the Swedish Renal Registry 2007-2022 that included nephrologist-referred patients with moderate-advanced CKD and treated with RASi, who initiated diuretics or CCB. Using propensity score-weighted cause-specific Cox regression, we compared risks of major adverse kidney events (MAKE; composite of kidney replacement therapy [KRT], experiencing over ...
Source: Kidney International - June 15, 2023 Category: Urology & Nephrology Authors: Anne-Laure Faucon, Edouard L. Fu, B énédicte Stengel, Faizan Mazhar, Marie Evans, Juan-Jesús Carrero Tags: clinical investigation Source Type: research

Targeting TMEM16A-encoded Ca2+-activated Cl − channels: a new paradigm for antihypertensive therapy?
Hypertension is the leading risk factor for the development of heart diseases and stroke. Many hypertensive patients experience undesirable side effects to conventional antihypertensive pharmacotherapy. Cil et  al. documented the antihypertensive profile of a novel molecule, TMinh-23 (2-bromodifluoroacetylamino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid o-tolylamide), in the spontaneously hypertensive rat model of systemic hypertension. They showed that this agent reduces blood pressu re by inhibiting transmembrane member 16A–encoded calcium-activated chloride channels in vascular myocytes from resistance arteries.
Source: Kidney International - July 19, 2021 Category: Urology & Nephrology Authors: Normand Leblanc Tags: Commentary Source Type: research

Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats.
CONCLUSION: Berberine treatment improved short-term memory in hyperlipidemia by increasing neuronal proliferation and inhibiting neuronal apoptosis. Berberine treatment also improved lipid metabolism. PMID: 31795609 [PubMed]
Source: International Neurourology Journal - December 6, 2019 Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research

Serum lipoprotein(a) and risk of hemorrhagic stroke among incident peritoneal dialysis patients: a large study from a single center in China.
Conclusions: Among patients with incident PD, a higher serum Lp(a) level may predict a lower risk of hemorrhagic stroke. PMID: 31498021 [PubMed - in process]
Source: Renal Failure - September 10, 2019 Category: Urology & Nephrology Tags: Ren Fail Source Type: research

The Renal Molecular Clock: Broken by Aging and Restored by Exercise.
Abstract The mammalian circadian clock governs physiological, endocrine, and metabolic responses coordinated in a 24h rhythmic pattern by the suprachiasmatic nucleus (SCN) of the anterior hypothalamus. The SCN also dictates circadian rhythms in peripheral tissues like the kidney. The kidney has several important physiological functions including removing waste and filtering the blood, regulation of: fluid volume, blood osmolarity, blood pressure and calcium metabolism, all of which are under tight control of the molecular/circadian clock. Normal aging has a profound influence on both renal function, central and pe...
Source: Am J Physiol Renal P... - August 27, 2019 Category: Urology & Nephrology Authors: Schmitt EE, Johnson EC, Yusifova M, Bruns DR Tags: Am J Physiol Renal Physiol Source Type: research

Add-On Antihypertensive Medications to Angiotensin-Aldosterone System Blockers in Diabetes: A Comparative Effectiveness Study.
CONCLUSIONS: Compared with thiazide diuretics, calcium channel blockers were associated with a lower risk of significant kidney events and a similar risk of cardiovascular events. PODCAST: This article contains a podcast at https://www.asn-online.org/media/podcast/CJASN/2018_03_23_CJASNPodcast_18_5_S.mp3. PMID: 29572286 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - March 23, 2018 Category: Urology & Nephrology Authors: Schroeder EB, Chonchol M, Shetterly SM, Powers JD, Adams JL, Schmittdiel JA, Nichols GA, O'Connor PJ, Steiner JF Tags: Clin J Am Soc Nephrol Source Type: research

Nutrient intake and urinary incontinence in Korean women: A propensity score ‐matched analysis from the Korea National Health and Nutrition Examination Survey data
ConclusionHigh carbohydrate intake seems to be significantly related to female urinary incontinence in the Korean population.
Source: International Journal of Urology - August 28, 2017 Category: Urology & Nephrology Authors: Jun Ho Lee, Hyo Serk Lee Tags: Original Article Source Type: research

Summary: International Kidney Cancer Symposium
Conclusions:  Ideal ischemia time is 20-25 minutes or less improves short and long term renal function. >25 minutes carried 5 year risk of new onset stage 4 CKD No differences on GFR for cold vs. warm ischemia times Preoperative GFR and the percent of kidney preserved was a better predictor of post op GFR.  No ischemia preserves renal function better than warm. Longer cold ischemia times were equivalent to shorter warm ischemia times. Quality and quantity of the remaining kidney is associated with ultimate renal function. Robotics in RCC Surgery Gennady Bratslavsky, MD The opening question ...
Source: Kidney Cancer Association - December 15, 2011 Category: Urology & Nephrology Source Type: news