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Specialty: Pathology
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Total 1464 results found since Jan 2013.
The influence of COVID-19 on the treatment of patients with acute ischemic stroke: a  retrospective observational study
CONCLUSIONS: The pandemic situation of COVID-19 significantly reduced the number of patients with AIS and prolonged the travel time to the hospital whereas most of the stroke treatment services were maintained.PMID:37587891 | DOI:10.5114/fn.2023.124565
Source: Folia Neuropathologica - August 17, 2023 Category: Pathology Authors: Wei Chen Fangju Lin Wei Zhao Baoling Yang Weihua Jia Source Type: research
Nanoparticle-mediated delivery of microRNAs-based therapies for treatment of disorders
Pathol Res Pract. 2023 Jul 3;248:154667. doi: 10.1016/j.prp.2023.154667. Online ahead of print.ABSTRACTmiRNAs represent appropriate candidates for treatment of several disorders. However, safe and efficient delivery of these small-sized transcripts has been challenging. Nanoparticle-based delivery of miRNAs has been used for treatment of a variety of disorders, particularly cancers as well as ischemic stroke and pulmonary fibrosis. The wide range application of this type of therapy is based on the important roles of miRNAs in the regulation of cell behavior in physiological and pathological conditions. Besides, the ability...
Source: Pathology, Research and Practice - July 9, 2023 Category: Pathology Authors: Soudeh Ghafouri-Fard Hamed Shoorei Leili Noferesti Bashdar Mahmud Hussen Mohammad Hossein Behzad Moghadam Mohammad Taheri Fariborz Rashnoo Source Type: research
Thromboinflammatory challenges in stroke pathophysiology
AbstractDespite years of encouraging translational research, ischemic stroke still remains as one of the highest unmet medical needs nowadays, causing a tremendous burden to health care systems worldwide. Following an ischemic insult, a complex signaling pathway emerges leading to highly interconnected thrombotic as well as neuroinflammatory signatures, the so-called thromboinflammatory cascade. Here, we thoroughly review the cell-specific and time-dependent role of different immune cell types, i.e., neutrophils, macrophages, T and B cells, as key thromboinflammatory mediators modulating the neuroinflammatory response upon...
Source: Seminars in Immunopathology - June 5, 2023 Category: Pathology Source Type: research
The role of circulating cell-free DNA as an inflammatory mediator after stroke
We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.
Source: Seminars in Immunopathology - May 22, 2023 Category: Pathology Source Type: research
Immune compartments at the brain ’s borders in health and neurovascular diseases
AbstractRecent evidence implicates cranial border immune compartments in the meninges, choroid plexus, circumventricular organs, and skull bone marrow in several neuroinflammatory and neoplastic diseases. Their pathogenic importance has also been described for cardiovascular diseases such as hypertension and stroke. In this review, we will examine the cellular composition of these cranial border immune niches, the potential pathways through which they might interact, and the evidence linking them to cardiovascular disease.
Source: Seminars in Immunopathology - May 3, 2023 Category: Pathology Source Type: research
