The role of circulating cell-free DNA as an inflammatory mediator after stroke

We report the current understanding for mechanisms of DNA uptake and sensing in the context of post-stroke inflammation. Moreover, we compare possible treatment options targeting cell-free DNA, DNA-sensing pathways, and the downstream mediators. Finally, we describe clinical implications of this inflammatory pathway for stroke patients, open questions, and potential future research directions.
Source: Seminars in Immunopathology - Category: Pathology Source Type: research