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Self-Reported Body Weight Changes, Perceptions, and Weight Loss Techniques among Stroke Survivors
Background: Little is known about the body weight goals and trends of stroke survivors, despite evidence that overweight and obesity can negatively influence poststroke rehabilitation outcomes. Thus, the purpose of this study was to identify self-reported body weight trends over time in stroke survivors and nonstroke controls (>50 years old) and describe the methods used to attempt to achieve body weight goals. Methods: Self-reported body weight 1) at age 25 years, 2) 10 years prior to the current assessment, 3) 1 year prior to the current assessment, 4) current weight, and 5) age of heaviest body weight were collected fro...
Source: Journal of Stroke and Cerebrovascular Diseases - February 13, 2019 Category: Neurology Authors: Jessica L. Kelleher, Paul Weiss, Amy D. Rodriguez, Joe R. Nocera, Monica C. Serra Source Type: research

A Puzzling Case of Cryptogenic Stroke
Background: Stroke is a common neurological complication of infective endocarditis (IE) and it is associated with increased morbidity and mortality but infective endocarditis in acute stroke setting is hard to discover. Material and methods: A 75-year-old man referred to hospital for the onset of left hemiparesis and dysarthria. His past medical history included hypertension. He had 3 months history of fatigue, fever, and weight loss. Neurological examination revealed left hemiparesis and dysarthria.
Source: Journal of Stroke and Cerebrovascular Diseases - January 17, 2019 Category: Neurology Authors: Marisa Distefano, Rosalinda Calandrelli, Vincenzo Arena, Alessandro Pedicelli, Giacomo Della Marca, Fabio Pilato Tags: Case Report Source Type: research

Three cases of immune ‐mediated necrotizing myopathy with anti‐signal recognition particle antibodies: Extramuscular symptoms preceding progressive muscle weakness
ConclusionsAll three patients visited the internal medicine department before the neurology department. It is important to consider anti ‐SRP myopathy as a differential diagnosis for patients presenting with elevated creatine kinase levels and extramuscular symptoms.
Source: Clinical and Experimental Neuroimmunology - November 21, 2018 Category: Neurology Authors: Yusuke Seino, Takumi Nakamura, Mie Hirohata, Takeshi Kawarabayashi, Mikio Shoji Tags: Case Report Source Type: research

Evaluation of 3K3A-Activated Protein C to Treat Neonatal Hypoxic Ischemic Brain Injury in the Spiny Mouse
In this study, we compared the ability of 3K3A-APC and APC (wild-type (wt)) to attenuate neonatal brain injury, using the spiny mouse (Acomys cahirinus) model of intrapartum asphyxia. Pups were delivered at 38 days of gestation (term  = 39 days), with an intrapartum hypoxic insult of 7.5 min (intrapartum asphyxia cohort), or immediate removal from the uterus (control cohort). After 1 h, pups received a subcutaneous injection of 3K3A-APC or wild-type APC (wtAPC) at 7 mg/kg, or vehicle (saline). At 24 h of age, pups were killed and brain tissue was collected for measurement of inflammation and cell death using RT-qP...
Source: Neurotherapeutics - September 17, 2018 Category: Neurology Source Type: research

Phentermine associated recurrent intracerebral hemorrhage
Awareness of obesity as a risk factor for cardiovascular events has increased in recent years. Many medications have been developed to suppress appetite to achieve weight loss. Phentermine is one of many medications that often used for weight loss. However, the sympathomimetic effect of phentermine can result in palpitations, hypertension, and tachycardia [1]. Neurological complications include irritability, ischemic stroke, posterior reversible encephalopathy syndrome (PRES) and hemorrhagic stroke [2 –6].
Source: Journal of the Neurological Sciences - August 22, 2018 Category: Neurology Authors: Stephanie McNeill, Eyad Almallouhi, Forrest J. Lowe, Tanya N. Turan Tags: Letter to the Editor Source Type: research

Perioperative strokes following combined coronary artery bypass grafting and carotid endarterectomy: A nationwide perspective
Conclusion: A strong association was found to exist between perioperative stroke and in-hospital mortality and morbidity after combined CABG and CEA. CEA procedures are thought to mitigate the high stroke rate of 3-5% post-CABG, but our study found that combined procedures exhibit a similar stroke risk undercutting their effectiveness. Further investigative studies on combined CABG+CEA are needed to assess risk-stratification for better patient selection and examine other preventative strategies to minimize the risk of ischemic strokes.
Source: Neurology India - January 11, 2018 Category: Neurology Authors: Reshmi Udesh Hannah Cheng Amol Mehta Parthasarathy D Thirumala Source Type: research

Delayed 2-hour post-stroke administration of R18 and NA-1 (TAT-NR2B9c) peptides after permanent and/or transient middle cerebral artery occlusion in the rat.
Abstract Following positive results with the poly-arginine peptide R18 when administered intravenously 30 or 60minutes after permanent and/or transient middle cerebral artery occlusion (MCAO; 90min) in the rat, we examined the effectiveness of the peptide when administered 2hours after MCAO. R18 was administered intravenously (1000nmol/kg via jugular vein) after permanent MCAO or a transient 3-hour MCAO or when administered intra-arterially (100nmol/kg via internal carotid artery) immediately after reperfusion following a transient 2-hour MCAO. In the transient MCAO studies, the neuroprotective NA-1 peptide was us...
Source: Brain Research Bulletin - September 27, 2017 Category: Neurology Authors: Milani D, Cross JL, Anderton RS, Blacker DJ, Knuckey NW, Meloni BP Tags: Brain Res Bull Source Type: research

Genetic Inhibition of Receptor Interacting Protein Kinase-1 Reduces Cell Death and Improves Functional Outcome After Intracerebral Hemorrhage in Mice Basic Sciences
Conclusions—The data show that the kinase domain of RIPK1 is a disease driver of ICH, mediating both acute cell death and functional outcome, and support development of RIPK1 inhibitors as therapeutic agents for human ICH.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Sevda Lule, Limin Wu, Lauren M. McAllister, William J. Edmiston III, Joon Yong Chung, Emily Levy, Yi Zheng, Peter J. Gough, John Bertin, Alexei Degterev, Eng H. Lo, Michael J. Whalen Tags: Basic Science Research, Genetically Altered and Transgenic Models, Intracranial Hemorrhage Original Contributions Source Type: research

Sustained Neurological Recovery After Stroke in Aged Rats Treated With a Novel Prostacyclin Analog Basic Sciences
Conclusions—Our data suggest that targeting the IP receptor with MRE-269 is a novel strategy to reduce cerebral ischemia injury and promote long-term neurological recovery in ischemic stroke.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Changjun Yang, Kelly M. DeMars, Jon C. Alexander, Marcelo Febo, Eduardo Candelario-Jalil Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Tumor Treating Fields (TTF) with Triple Chemotherapy for Recurrent Glioblastoma (P1.177)
Conclusions:Therapies with TTF plus TBC demonstrates superior OS benefit for recurrent GBM with moderate, but manageable side effects. A prospective study of TTF plus TBC for recurrent GBM is warranted.Study Supported by: Dr. Marnie Rose FoundationDisclosure: Dr. Zhu has received personal compensation for activities with Novocure, and Prime Oncology. Dr. Zhu has received research support from Novocure, Inc., Five Prime Therapeutics, Immuno-Cellular Inc., DEKK-TEC. Dr. Lu has nothing to disclose. Dr. Rao has nothing to disclose. Dr. Zhu has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Zhu, J.-J., Lu, G., Rao, M., Zhu, P. Tags: Neuro-oncology: Gliomas I Source Type: research

Giant-Cell Arteritis Presenting as Isolated Bilateral CN-VI Palsies: A Rare Case Report of a 65 Year Male. (P2.378)
Conclusions:GCA is the most prevalent systemic vasculitis in the elderly. It can present with a wide variety of symptoms ranging from fatigue, headache, visual loss, and even stroke. However as noted in this case, isolated CN-VI palsy can be a very rare, early manifestation of GCA. As GCA responds well to corticosteroid therapy, prompt diagnosis and treatment is critical to prevent and/or limit neurologic sequelae. As highlighted by this case, in the event of recurrent incidents and absence of other diagnosis; GCA should be considered even if headache is absent.Disclosure: Dr. Lunagariya has nothing to disclose. Dr. Patel ...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Lunagariya, A., Patel, U., Kotadiya, F., Wilson, C. Tags: CNS Inflammatory Diseases and Differential Diagnosis II Source Type: research

Clinical Reasoning: Myriad manifestations of a global infectious disease
A 21-year-old right-handed Cambodian woman with no history of headache presented with 2 weeks of progressive bifrontal headache. She had no sick contacts or recent travel. She moved to the United States at age 3 years. She had no fever, nuchal rigidity, photophobia, phonophobia, nausea, or vomiting. She had a recent history of weight loss and palpitations. There was no tobacco or illicit drug use or high-risk sexual behavior. She was not pregnant and denied contraception use.
Source: Neurology - June 5, 2016 Category: Neurology Authors: Prabhu, A. M., Raghupathi, R., Dissin, J. Tags: Stroke in young adults, Vasculitis, Meningitis RESIDENT AND FELLOW SECTION Source Type: research

Enteral feeding in neurological disorders.
Abstract Malnutrition and weight loss, due to suboptimal oral intake, are common in patients with neurological disorders and are associated with increased morbidity, disability and mortality. The nutritional management of neurological patients is crucial, and enteral feeding is commonly used to provide nutritional support. This review presents the different methods of enteral tube feeding and discusses its practice and efficacy in terms of clinical outcomes in the context of motor neurone disease, Parkinson's disease, Alzheimer's disease and other dementias, and stroke. PMID: 27152026 [PubMed - as supplied by publisher]
Source: Practical Neurology - May 4, 2016 Category: Neurology Authors: Stavroulakis T, McDermott CJ Tags: Pract Neurol Source Type: research

Spinal cord and cranial Bing-Neel Syndrome complicated by cerebral ischemia: A case report
Waldenström's macroglobulinemia (WM) is a B-cell malignancy characterized by lymphoplasmacytic lymphoma (LPL) within the bone marrow and an IgM monoclonal gammopathy in the blood. Symptoms may include weakness or fatigue, anorexia and weight loss, bleeding from the gums and nose, headache, blurred vision, peripheral neuropathy, and even stroke from hyperviscosity. The direct infiltration of the central nervous system (CNS), either as a diffuse leptomeningeal form or tumoral form is an exceedingly rare complication of WM, recognized as Bing-Neel Syndrome (BNS) [1].
Source: Journal of the Neurological Sciences - April 24, 2016 Category: Neurology Authors: Alejandro Vargas, Karan S. Dixit, John G. Quigley, Fernando D. Testai Tags: Letter to the Editor Source Type: research

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