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Inhibition of Transforming Growth Factor-{beta} Attenuates Brain Injury and Neurological Deficits in a Rat Model of Germinal Matrix Hemorrhage Basic Sciences
Conclusions— Increased level of TGF-β1 and activation of the TGF-β pathway associate with the development of brain injury after GMH. SD208 inhibits GMH-induced activation of the TGF-β pathway and leads to an improved developmental profile, partial recovery of cognitive and motor functions, and attenuation of GMH-induced brain atrophy and hydrocephalus.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Manaenko, A., Lekic, T., Barnhart, M., Hartman, R., Zhang, J. H. Tags: Animal models of human disease, Neuroprotectors Basic Sciences Source Type: research

Effects of Normobaric Oxygen on the Progression of Focal Cerebral Ischemia in Rats.
Abstract Normobaric oxygen (NBO) reduces infarction at 24-48hrs in experimental models of focal cerebral ischemia. However, to be clinically relevant, longer term safety and efficacy must be explored. Here, we assessed the effects of NBO on glial activation, neurovascular recovery, and behavioral outcomes at 2weeks after transient focal ischemia in rats. 100min transient focal ischemia was induced by intraluminal occlusion of the middle cerebral artery in adult male Sprague-Dawley rats. Animals were randomized into sham, controls or 85'NBO started 15minutes after ischemic onset. Infarct volumes and behavioral outc...
Source: Experimental Neurology - August 16, 2013 Category: Neurology Authors: Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH Tags: Exp Neurol Source Type: research

Acute Stroke in Young Women Taking Phentermine (P01.249)
CONCLUSIONS: We present here two patients with mild underlying cerebrovascular risk factors who presented with acute stroke after taking diet pills containing phentermine. The public should be aware of the possible association between stroke and phentermine. More long-term outcomes research is necessary to understand the safety of phentermine-containing diet pills. Patients with cerebrovascular risk factors should be cautious about using Phentermine containing diet pills.Disclosure: Dr. Smit has nothing to disclose. Dr. Cutting has received personal compensation for activities with F1000. Dr. Conners has nothing to disclos...
Source: Neurology - February 14, 2013 Category: Neurology Authors: Smit, L., Cutting, S., Conners, J., Lee, V., Song, S. Tags: P01 Cerebrovascular Disease I Source Type: research

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