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Total 71 results found since Jan 2013.

A New Angiographic Collateral Grading System for Acute Basilar Artery Occlusion Treated with Endovascular Therapy
AbstractPoor clinical outcomes despite endovascular therapy (EVT) are common in patients with acute basilar artery occlusion (BAO). We aimed to develop a new angiographic collateral grading system for predicting 90-day functional outcomes of acute BAO after EVT. A prospectively registered consecutive cohort of acute BAO patients treated with EVT in our center during a 6-year period was reviewed. The angiographic collateral grading system for BAO (ACGS-BAO) included 4 grades for poor (grade 1 –2), intermediate (grade 3), and good (grade 4) collateral statuses. First, the independent association of ACGS-BAO with 90-day fun...
Source: Translational Stroke Research - June 18, 2021 Category: Neurology Source Type: research

Late Thrombectomy in Clinical Practice
ConclusionIn clinical practice, the high number of patients with a  good clinical outcome after endovascular therapy ≥ 6–24 h as in DAWN/DEFUSE3 could not be achieved. Similar outcomes are seen in patients selected for EVT ≥ 6 h based on factors other than CTP. Patients triaged without CTP showed trends for shorter arrival to reperfusion times and higher rates of independence.
Source: Clinical Neuroradiology - June 7, 2021 Category: Neurology Source Type: research

The clinical and cognitive spectrum of locked-in syndrome: 1-year follow-up of 100 patients
AbstractIn patients with locked-in syndrome (LIS), it is not known exactly to what extent cognitive functions are preserved and it is not known exactly how much it has improved. We aimed to examine the clinical and cognitive features of LIS 1 year after stroke. One hundred patients with locked-in syndrome (LIS) were recruited between January 2008 and May 2019 among 8200 patients with ischemic stroke. Patients were classified into two groups as single pontine infarcts (n = 72), and pontine plus multiple ischemic lesions (PMIL) (n = 28). Since the patients had limited motor and verbal response, the cognitive status o...
Source: Acta Neurologica Belgica - May 13, 2021 Category: Neurology Source Type: research

Combined therapy of intensive statin plus intravenous rt-PA in acute ischemic stroke: the INSPIRE randomized clinical trial
ConclusionThe INSPIRE study indicated that intensive statin therapy may not improve clinical outcomes compared with the low dose of statin therapy in AIS patients undergoing intravenous thrombolysis, and the two groups had similar safety profile.Clinical trial registrationURL:http://www.chictr.org. Unique identifier: ChiCTR-IPR-16008642
Source: Journal of Neurology - February 8, 2021 Category: Neurology Source Type: research

Influence of Including Patients with Premorbid Disability in Acute Stroke Trials: The HeadPoST Experience
Conclusions: Early poststroke functional impairment that exceeded premorbid levels was associated with worse 90-day outcome, and this association increased with greater premorbid functional impairment. Yet, including premorbid impaired patients in the HeadPoST did not materially affect the subsequent treatment effect.Clinical Trial Registration: HeadPoST is registered at http://www.ClinicalTrials.gov (NCT02162017).Cerebrovasc Dis
Source: Cerebrovascular Diseases - January 12, 2021 Category: Neurology Source Type: research

Early apixaban therapy after ischemic stroke in patients with atrial fibrillation
ConclusionsSymptomatic HT rates are likely to be low in randomized trials of DOAC initiation post-stroke. Recurrent ischemic stroke may be the major clinical outcome. These data may be used as expected event rates when calculating sample size requirements for future safety/efficacy trials of early versus late DOAC initiation after AF-related stroke.
Source: Journal of Neurology - January 3, 2021 Category: Neurology Source Type: research

Inter-hospital transfer for mechanical thrombectomy within the supraregional stroke network NEVAS
ConclusionWithin a telemedicine network stroke care can successfully be organized as only a minority of patients has to be transferred. Our data provide clinical evidence that all MT-eligible patients should be shipped with the fastest transportation modality as possible.
Source: Journal of Neurology - September 4, 2020 Category: Neurology Source Type: research

Relationship between ischemic stroke locations, etiology subtypes, neurological outcomes, and autonomic cardiac function.
CONCLUSIONS: HRV measured after admission is related to the AIS infarction basin, TOAST subtypes, and neurological outcomes at discharge suggesting a possible role for HRV in evaluating AIS and identifying high-risk patients. PMID: 32701421 [PubMed - as supplied by publisher]
Source: Neurological Research - July 25, 2020 Category: Neurology Tags: Neurol Res Source Type: research

Mechanical Thrombectomy in Acute Ischemic Stroke Using a  Manually Expandable Stent Retriever (Tigertriever)
ConclusionThe Tigertriever offers a  safe and effective treatment option in ischemic stroke due to LVOs with reperfusion rates and a safety profile similar to alternative devices. The Tigertriever is a promising bail-out tool in complex cases. Its role as a first line device has to be evaluated in further prospective studies.
Source: Clinical Neuroradiology - June 10, 2020 Category: Neurology Source Type: research

Mechanical thrombectomy in acute middle cerebral artery M2 segment occlusion with regard to vessel involvement
ConclusionEVT in patients with acute M2-occlusion is safe and leads to a significant clinical improvement at discharge. No significant differences in clinical outcome or complications were found with regard to the localization of the M2-occlusion.
Source: Neurological Sciences - April 29, 2020 Category: Neurology Source Type: research

Carotid Stenting as Definitive Treatment for Free Floating Thrombus —Review of 7 Cases
ConclusionFree floating thrombus of the carotid arteries can be managed with stenting.
Source: Clinical Neuroradiology - March 26, 2020 Category: Neurology Source Type: research

Relationship of White Matter Lesions with Intracerebral Hemorrhage Expansion and Functional Outcome: MISTIE II and CLEAR III
ConclusionsConcomitant WML does not increase the odds for HE in patients with ICH but increases the odds for poor functional outcome.Clinical Trial Registrationhttp://www.clinicaltrials.gov trial-identifiers: NCT00224770 and NCT00784134.
Source: Neurocritical Care - February 4, 2020 Category: Neurology Source Type: research

Nontraumatic spontaneous intracerebral hemorrhage: Baseline characteristics and early outcomes
ConclusionThe present study showed that SICH is a serious disease causing high mortality and disability, particularly in the early period after event.
Source: Brain and Behavior - January 12, 2020 Category: Neurology Authors: Mohamed Al ‐Khaled, Samer Awwad, Toralf Brüning Tags: ORIGINAL RESEARCH Source Type: research

Recanalization is the Key for Better Outcome of Thrombectomy in Basilar Artery Occlusion
ConclusionReperfusion is the major predictor of functional outcome in BAO in clinical practice. Failed recanalization resulted in a  13-fold increase of the risk of poor outcome. Successful recanalization is crucial to achieve a better functional outcome in BAO.
Source: Clinical Neuroradiology - December 22, 2019 Category: Neurology Source Type: research

Nontraumatic spontaneous intracerebral hemorrhage: Baseline characteristics and early outcomes
ConclusionThe present study showed that SICH is a serious disease causing high mortality and disability, particularly in the early period after event.
Source: Brain and Behavior - December 14, 2019 Category: Neurology Authors: Mohamed Al ‐Khaled, Samer Awwad, Toralf Brüning Tags: ORIGINAL ARTICLE Source Type: research