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Specialty: Neurology
Education: Study
Therapy: Stem Cell Therapy
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Total 370 results found since Jan 2013.
MCPIP-1 knockdown enhances endothelial colony-forming cell angiogenesis via the TFRC/AKT/mTOR signaling pathway in the ischemic penumbra of MCAO mice
In this study, we performed Proteome Profiler™ Human Angiogenesis Antibody arrays and tandem mass tag protein profiling to investigate the effect of MCPIP-1 on ECFCs. We demonstrated that MCPIP-1 knockdown enhanced the proliferation, migration, and in vivo and in vitro angiogenic capacity of ECFCs by upregulating the transferrin receptor-activated AKT/m-TOR signaling pathway to promote cellular trophic factor secretion. Furthermore, we found that the lateral ventricular transplantation of ECFCs with lentiviral MCPIP-1 knockdown into mice with middle cerebral artery occlusion increased serum vacular endothelial growth fac...
Source: Experimental Neurology - September 9, 2023 Category: Neurology Authors: Xiaoxiong Zou Yu Xie Zhongfei Zhang Zhiming Feng Jianbang Han Qian Ouyang Shiting Hua Sixian Huang Cong Li Zhizheng Liu Yingqian Cai Yuxi Zou Yanping Tang Haijia Chen Xiaodan Jiang Source Type: research
Neuroprotection of Stem Cells Against Ischemic Brain Injury: From Bench to Clinic
AbstractNeurological injuries can have numerous debilitating effects on functional status including sensorimotor deficits, cognitive impairment, and behavioral symptoms. Despite the disease burden, treatment options remain limited. Current pharmacological interventions are targeted at symptom management but are ineffective in reversing ischemic brain damage. Stem cell therapy for ischemic brain injury has shown promising preclinical and clinical results and has attracted attention as a potential therapeutic option. Various stem cell sources (embryonic, mesenchymal/bone marrow, and neural stem cells) have been investigat...
Source: Translational Stroke Research - July 7, 2023 Category: Neurology Source Type: research
Temporal patterns and distribution of pyroptosis-related molecules and effects of human mesenchymal stem cells on pyroptosis following cerebral ischemia/reperfusion in rats
Pyroptosis is a new type of programmed cell death that has a strong proinflammatory effect. The present study investigated the dynamic changes of pyroptosis-related molecules and the effect of mesenchymal stem cells (MSCs) on pyroptosis following cerebral ischemia/reperfusion (I/R).
Source: Journal of Stroke and Cerebrovascular Diseases - May 31, 2023 Category: Neurology Authors: Kuang Pan, Qingxia Peng, Zejia Huang, Zhaofei Dong, Weijye Lin, Yidong Wang Source Type: research
Rat BM-MSCs secretome alone and in combination with stiripentol and ISRIB, ameliorated microglial activation and apoptosis in experimental stroke
CONCLUSION: STP and trans ISRIB, alone and in combination with rat BM-MSCs secretome, might be considered as potential neuroprotective agents in the acute ischemic stroke (AIS) management.DATA AVAILABILITY STATEMENT: Data will be made available on reasonable request.PMID:37146724 | DOI:10.1016/j.bbr.2023.114471
Source: Brain Research - May 5, 2023 Category: Neurology Authors: Neha Dhir Ashish Jain Amit Raj Sharma Sunil Sharma Dhruv Mahendru Ajay Patial Deepti Malik Ajay Prakash Savita Verma Attri Shalmoli Bhattacharyya Bishan Das Radotra Bikash Medhi Source Type: research
Stem Cell Therapy for Ischemic Brain Injury: Early Intranasal Delivery after Cardiac Arrest
AbstractGlobal ischemic brain injury is the leading cause of mortality and long-term disability in patients resuscitated from cardiac arrest. Hypothermia and neuroprotective agents are two strategies partially improve neurological outcomes following resuscitation. However, the therapeutic effects of these treatments are inconsistently reported. Stem cell therapy has emerged as a promising pr otective strategy due to its potential for proliferation and differentiation into functional neural cells. This editorial reviews the current status of stem cell therapy via the intranasal route in primates and clinical studies, alo...
Source: Translational Stroke Research - April 4, 2023 Category: Neurology Source Type: research
Remote ischemic postconditioning ameliorates stroke injury via the SDF-1 α/CXCR4 signaling axis in rats
Brain Res Bull. 2023 Mar 27:S0361-9230(23)00064-3. doi: 10.1016/j.brainresbull.2023.03.011. Online ahead of print.ABSTRACTRemote Ischemic Postconditioning (RIPostC) has become a research hotspot due to its protective effect on the brain in clinical studies related to ischemic stroke. The purpose of this study is to investigate the protective effect of RIPostC after ischemic stroke in rats. The middle cerebral artery occlusion/reperfusion (MCAO/R) model was established by the wire embolization method. RIPostC was obtained by inducing temporary ischemia in the hind limbs of rats. First, based on the results of short-term beh...
Source: Brain Research Bulletin - March 29, 2023 Category: Neurology Authors: Guannan Jiang Xiang Li Meirong Liu Haiying Li Haitao Shen Juan Liao Wanchun You Qi Fang Gang Chen Source Type: research
Evaluation of the effect of mesenchymal stem cells injection in the nucleus accumbens on the morphine reinstatement behavior in a conditioned place preference model in Wistar rat: expression changes of NMDA receptor subunits and NT-3
This study was designed to discover the effect of MSCs injection in the nucleus accumbens (NAc) on the reinstatement of behavior in morphine-induced conditioned place preference (CPP) in male rats. The CPP was induced via intra-peritoneal (i.p.) morphine injection (5mg/kg) for three consecutive days. After being tested for CPP induction, animals received MSCs or culture medium (DMEM F-12) in their NAc using stereotaxic surgery. Following extinction, a priming dose of morphine (2mg/kg) was administered to induce reinstatement. Expression of GluN1, GluN2A, and GluN2B subunits of the NMDA receptor and the NT-3 gene in the NAc...
Source: Brain Research - February 28, 2023 Category: Neurology Authors: Parviz Dousti Kataj Nasim Vousooghi Mahmoud Reza Hadjighassem Maryam Farahmandfar Somayeh Ebrahimi-Barough Source Type: research
