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Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis.
CONCLUSION: MEG3/miR-485/AIM2 axis contributes to pyroptosis via activating caspase1 signaling during cerebral I/R, suggesting that this axis may be a potent therapeutic target in ischemic stroke. PMID: 31794744 [PubMed - as supplied by publisher]
Source: Experimental Neurology - November 29, 2019 Category: Neurology Authors: Liang J, Wang Q, Li JQ, Guo T, Yu D Tags: Exp Neurol Source Type: research

C-Reactive Protein and Risk of Parkinson's Disease: A Systematic Review and Meta-Analysis
Conclusions: This meta-analysis revealed that PD is associated with an increase of CRP levels. CRP might be a risk factor for PD or PD leads to an inflammatory response. Introduction Parkinson's disease (PD) is one of the most complex neuro-degenerative disorders next to Alzheimer's disease. It is characterized by bradykinesia, tremor, rigidity, abnormal postural, and gait (1). PD has been recognized by the selective loss of dopaminergic neurons within the substantia nigra pars compacta, whereas the exact etiology remains elusive (2). Previously, multiple inferences have reviewed the environmental a...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

Association of Cancer Cell Type and Extracellular Vesicles With Coagulopathy in Patients With Lung Cancer and Stroke Brief Report
Conclusions—Our findings indicate that cancer cell type is associated with circulating EV levels and coagulopathy in patients with lung cancer and stroke.
Source: Stroke - April 23, 2018 Category: Neurology Authors: Jong-Won Chung, Yeon Hee Cho, Myung-Ju Ahn, Mi Ji Lee, Gyeong-Moon Kim, Chin-Sang Chung, Oh Young Bang Tags: Biomarkers, Mechanisms, Translational Studies, Cerebrovascular Disease/Stroke, Thrombosis Brief Reports Source Type: research

Recurrent Stroke Due to Metastatic Pulmonary Tumor Emboli as an Important Clinical Entity
We present an autopsy case of repetitive stroke due to tumor emboli, indistinguishable from thromboembolism with a hypercoagulable state in its clinical course. A 72-year-old man diagnosed with stage IVA oropharyngeal squamous cell carcinoma received chemoradiotherapy. Follow-up imaging revealed mediastinal lymph nodes and pulmonary metastasis. One year later, the patient experienced right arm weakness, and brain magnetic resonance imaging showed acute ischemic lesions in multiple vascular territories.
Source: Journal of Stroke and Cerebrovascular Diseases - March 30, 2017 Category: Neurology Authors: Junji Takasugi, Manabu Sakaguchi, Naoki Oyama, Yasufumi Gon, Yasukazu Terasaki, Tsutomu Sasaki, Susumu Nakahara, Kenji Ohshima, Yumiko Hori, Eiichi Morii, Hideki Mochizuki Tags: Case Studies Source Type: research

Cytosolic Receptor Melanoma Differentiation-Associated Protein 5 Mediates Preconditioning-Induced Neuroprotection Against Cerebral Ischemic Injury Brief Reports
Conclusions— Poly-ICLC preconditioning is mediated by melanoma differentiation–associated protein 5 and its adaptor molecule IFN-promoter stimulator 1. This is the first evidence that a cytosolic receptor can mediate neuroprotection, providing a new target for the development of therapeutic agents to protect the brain from ischemic injury.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Gesuete, R., Christensen, S. N., Bahjat, F. R., Packard, A. E. B., Stevens, S. L., Liu, M., Salazar, A. M., Stenzel-Poore, M. P. Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Neuroprotectants Brief Reports Source Type: research

Mortality and comorbidities in patients with multiple sclerosis compared with a population without multiple sclerosis: An observational study using the US department of defense administrative claims database
Conclusions Rates of mortality and several comorbidities are higher in the MS versus non-MS cohort. Early recognition and management of comorbidities may reduce premature mortality and improve quality of life in patients with MS.
Source: Multiple Sclerosis and Related Disorders - August 19, 2015 Category: Neurology Source Type: research

Corrections Corrections
Traylor M, Farrall M, Holliday EG, et al, on behalf of the International Stroke Genetics Consortium. Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies. Lancet Neurol 2012; 11: 951–62—In this Article, the last sentence of the VISP section in the acknowledgments section should have been “Control data for comparison with VISP cases were obtained through the database of genotypes and phenotypes (dbGAP) High Density SNP Association Analysis of Melanoma: Case-Control and Outcomes Investigation (phs000187.v1.p1).
Source: Lancet Neurology - July 13, 2015 Category: Neurology Tags: Corrections Source Type: research

Clinical Outcomes of Metastatic Intra-cerebral Hemorrhage and Role of Acute Radiotherapy (P3.077)
CONCLUSIONS: Early recognition of metastatic disease as the etiology of ICH is important, particularly when it is the presenting manifestation. Despite the overall poor prognosis of metastatic cancer, early radiotherapy may increase survival and offer quality of life in selected group of patients. A larger case series is needed.Disclosure: Dr. Afzal has nothing to disclose. Dr. Mendoza has nothing to disclose. Dr. Latorre has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Afzal, U., Mendoza, M., Latorre, J. Tags: Cerebrovascular Disease and Interventional Neurology: Hemorrhagic and Ischemic Stroke Source Type: research